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1701
Genetic analysis of ocular tumour-associated genes using large genomic datasets: insights into selection constraints and variant representation in the population
Published 2024-04-01“…Pathway analysis revealed significant enrichment in cellular proliferation, differentiation and division. Encoded proteins of ocular tumour-associated genes were generally longer than the median of the UniProt database.Conclusion Our findings highlight the importance of negative selection in ocular tumour genes, supporting cranial gene conservation. …”
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1702
Characterizing the regulatory effects of H2A.Z and SWR1-C on gene expression during hydroxyurea exposure in Saccharomyces cerevisiae.
Published 2025-01-01“…Chromatin structure and DNA accessibility are partly modulated by the incorporation of histone variants. H2A.Z, encoded by the non-essential HTZ1 gene in S. cerevisiae, is an evolutionarily conserved H2A histone variant that is predominantly incorporated at transcription start sites by the SWR1-complex (SWR1-C). …”
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1703
Rhipicephalus simus ticks: new hosts for phleboviruses
Published 2024-08-01“…Its RNA-dependent RNA polymerase (RdRp) encoding region carried conserved RdRp and endonuclease domains characteristic of phenuiviridae viruses. …”
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1704
An In silico Approach towards Finding the Cancer-Causing Mutations in Human MET Gene
Published 2023-01-01“…Mesenchymal–epithelial transition (MET) factor is a proto-oncogene encoding tyrosine kinase receptor with hepatocyte growth factor (HGF) or scatter factor (SF). …”
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1705
Heterologous Expression of Laccase1 from Cryphonectria parasitica in Saccharomyces cerevisiae
Published 2025-01-01“…To obtain high and stable expression of fungal laccases, we cloned the gene encoding an extracellular laccase (Laccase1) of C. parasitica into a yeast episomal vector, used the resulting vectors to transform S. cerevisiae, and optimized the culture conditions of the selected transformants for Laccase1 production. …”
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1706
Chromatin remodeling (SWI/SNF) complexes, cancer, and response to immunotherapy
Published 2022-09-01“…Significantly, ~20% of malignancies harbor alterations in >1 of these subunits, making the genes encoding SWI/SNF family members among the most vulnerable to genomic aberrations in cancer. …”
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1707
AFN-Net: Adaptive Fusion Nucleus Segmentation Network Based on Multi-Level U-Net
Published 2025-01-01“…Firstly, we introduce a Weighted Feature Enhancement Unit (WFEU) in the encoder decoder fusion stage of U-Net. By assigning learnable weights to different feature maps, the network can adaptively enhance key features and suppress irrelevant or secondary features, thus maintaining high-precision segmentation performance in complex backgrounds. …”
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1708
Vehicle Detection Algorithm Based on Embedded Video Image Processing in the Background of Information Technology
Published 2022-01-01“…The primary problem in embedding digital video in applications is that the complexity of video encoding and decoding far exceeds that of simple image and audio compression and decompression. …”
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1709
Operational Deflection Shape Extraction from Broadband Events of an Aircraft Component Using 3D-DIC in Magnified Images
Published 2019-01-01“…Moreover, phase-based motion magnification (PMM) is a methodology which, based on a sequence of images, magnifies a periodic motion encoded in phase time-domain signals of the complex steerable pyramid filters employed to decompose the images. …”
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1710
Speech Emotion Recognition Model Based on Joint Modeling of Discrete and Dimensional Emotion Representation
Published 2025-01-01“…The architecture employs parallel feature extraction through independent encoders, designed to capture unique features from multiple modalities, including Mel-frequency Cepstral Coefficients (MFCC), Short-term Features (STF), Mel-spectrograms, and raw audio signals. …”
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1711
Immunopathology of Airway Surface Liquid Dehydration Disease
Published 2019-01-01“…As an alternative, the Scnn1b transgenic (Scnn1b-Tg+) mouse model overexpressing a transgene encoding sodium channel nonvoltage-gated 1, beta subunit (Scnn1b) in airway club cells is available. …”
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1712
CSE-8, a filamentous fungus-specific Shr3-like chaperone, facilitates endoplasmic reticulum exit of chitin synthase CHS-3 (class I) in Neurospora crassa
Published 2025-01-01“…The Neurospora crassa genome encodes two orthologues of Chs7: chitin synthase export (CSE) proteins CSE-7 (NCU05720) and CSE-8 (NCU01814), both of which are highly conserved among filamentous fungi. …”
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1713
Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Clinicopathologic Analysis with Evaluation of the E-Cadherin/β-Catenin Complex and Associated Genetic Alterations
Published 2021-01-01“…The CDH1 gene, which encodes the E-cadherin protein, is the best known gene associated with these tumors. …”
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1714
Online resources on gene networks containing human and animal data
Published 2018-01-01“…Gene networks are molecular genetic systems that ensure the formation of phenotypic characteristics of organisms (molecular, biochemical, structural, morphological, behavioral, etc.) based on information encoded in their genomes. Reconstruction of gene networks provides a methodological basis for modern systems biology. …”
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1715
KAI2-dependent signaling controls vegetative reproduction in Marchantia polymorpha through activation of LOG-mediated cytokinin synthesis (14)
Published 2025-02-01“…We find that KAI2-dependent signaling positively controls the expression of MpLONELY GUY (MpLOG), encoding a cytokinin biosynthesis enzyme. Disruption of the MpLOG function decreases endogenous cytokinin levels and causes defects similar to KAI2-dependent signaling mutants. …”
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1716
Exploring the Credibility of Large Language Models for Mental Health Support: Protocol for a Scoping Review
Published 2025-01-01“… BackgroundThe rapid evolution of large language models (LLMs), such as Bidirectional Encoder Representations from Transformers (BERT; Google) and GPT (OpenAI), has introduced significant advancements in natural language processing. …”
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1717
Significant abundance of bacterial flagellin and expression of its surface localized receptor toll-like receptor 5 and cytokine interleukin-22 in South African infants with poor or...
Published 2025-01-01“…The abundance of flagellin and expression of flagellin-encoding fliC, TLR5 and NLRC4, IL-22 and IL-18 genes was determined by qPCR. …”
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1718
Replication-transcription complex of coronaviruses: functions of individual viral non-structural subunits, properties and architecture of their complexes
Published 2022-04-01“…The enzymes and effector proteins that make up the replicationtranscription complex (RTC) of coronaviruses are encoded by a large replicase gene. These enzymes and effector proteins represent promising targets for potential therapeutic drugs. …”
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1719
Rotting Sounds . Artistic Research Practice in Experimental Sound Art
Published 2022-12-01“…The digital-analog interface, information encoding, as well as the deep time perspective are specifically highlighted. …”
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1720
miR-126 and miR-126*: New Players in Cancer
Published 2010-01-01“…Further, the two biologically active miRNAs miR-126 and its complement miR-126*, which are encoded by intron 7 of the egfl7 gene, have been described to mediate vascular functions. …”
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