Identification of Genes Regulating Gene Targeting by a High-Throughput Screening Approach by Fabien Delacôte, Christophe Perez, Valérie Guyot, Catherine Mikonio, Pierrick Potrel, Jean-Pierre Cabaniols, Christophe Delenda, Frédéric Pâques, Philippe Duchateau

“…We showed that siRNAs directed against the ATF7IP gene, encoding a protein involved in chromatin remodeling, stimulated HGT by a factor of three to eight, at various loci and in different cell types. …”
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Driving Style Recognition under Connected Circumstance Using a Supervised Hierarchical Bayesian Model by Depeng Chen, Zhijun Chen, Yishi Zhang, Xu Qu, Mingyang Zhang, Chaozhong Wu

“…Firstly, a novel method is established for driving behavioral encoding and raw driving data mining. Then, the Labeled Latent Dirichlet Allocation (LLDA) is proposed to understand the latent driving styles from individual driving with driving behaviors. …”
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Genetic Basis for Variation of Metalloproteinase-Associated Biochemical Activity in Venom of the Mojave Rattlesnake (Crotalus scutulatus scutulatus) by Ruben K. Dagda, Sardar Gasanov, Ysidro De La OIII, Eppie D. Rael, Carl S. Lieb

“…These findings indicate that differences in nucleotide sequences encoding the mature proteinase domain and noncoding regions contribute to differences in venom metalloproteinase activities among rattlesnakes of the same species.…”
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Bone marrow transplantation reverses metabolic alterations in multiple sulfatase deficiency: a case series by Nishitha R. Pillai, Ning Liu, Xiyuan Li, Xiqi Li, Rebecca Ahrens-Nicklas, Laura Adang, Julie B. Eisengart, Grace Bronken, Ashish Gupta, Troy C. Lund, Chester B. Whitley, Sarah H. Elsea, Paul J. Orchard

“…The activation of all these cellular sulfatases is dependent on the presence of the formylglycine-generating enzyme, which is encoded by the SUMF1 gene. Disease-causing homozygous or compound heterozygous variants in SUMF1 result in MSD. …”
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Essential Role of Thioredoxin 2 in Mitigating Oxidative Stress in Retinal Epithelial Cells by Eriko Sugano, Namie Murayama, Maki Takahashi, Kitako Tabata, Makoto Tamai, Hiroshi Tomita

“…The protective effect of Trx2 against oxidative stress was investigated by assessing cell viability, the kinetics of cell death, mitochondrial metabolic activity, and expression of heat shock proteins (Hsps) in Trx2-overexpressing cell lines generated by transfecting ARPE cells with an adeno-associated virus vector encoding Trx2. We show that overexpression of Trx2 reduced cell death induced by both agents when they were present in low concentrations. …”
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Emergence of mcr-8.1-bearing MDR-hypervirulent Klebsiella pneumoniae ST307 by Jie Sheng, Rory Cave, Mary M. Ter-Stepanyan, Siyu Lu, Yingxiong Wang, Taihang Liu, Hermine V. Mkrtchyan

“…These two isolates also acquired aerobactin siderophore-encoding gene clusters (iucABCD-iutA) and the hypermucoidy locus rmpADC (ARM06 had rmpA fragment). …”
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Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system by Sarah Hollingshead, Gareth McVicker, Maria R. Nielsen, YuGeng Zhang, Giulia Pilla, Rebekah A. Jones, Jonathan C. Thomas, Sarah E. H. Johansen, Rachel M. Exley, Ditlev E. Brodersen, Christoph M. Tang

“…Of note, mutations that confer tolerance to antibiotics in Escherichia coli also map to the DNA-binding domain of VapBC encoded by the chromosomally integrated F plasmid. …”
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Kloning gen virulen Streptococcus agalactiae sebagai bahan dasar vaksin rekombinan by , Sutanti, Retno Damayanti Soejoedono, Irvan Faizal

“…DNA vaccine is a third generation of vaccines based on the gene encoding a vaccine antigen rather than the antigen itself. …”
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Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy by Wenjun Li, Wenjun Li, Junjiang Sun, Susi Feng, Ariana La Rosa, Panli Zhang, Eveline Y. Wu, Richard Loeser, Chengwen Li, Chengwen Li, Chengwen Li

“…PD-L1 is a checkpoint protein that plays important roles in immune regulation and has been implicated in the initiation and progression of multiple autoimmune diseases.MethodIn a previous study, we demonstrated that intra-articular injection with adeno-associated virus (AAV) vectors encoding wild type PD-L1 improved local inflammation in the joint in the collagen-induced arthritis (CIA) mouse model of RA. …”
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A Large PROP1 Gene Deletion in a Turkish Pedigree by Suheyla Gorar, Doga Turkkahraman, Kanay Yararbas

“…Alteration of the gene encoding the PROP1 may affect somatotropes, thyrotropes, and lactotropes, as well as gonadotropes and corticotropes. …”
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SACU-Net: Shape-Aware U-Net for Biomedical Image Segmentation With Attention Mechanism and Context Extraction by Yinuo Cao, Yong Cheng

“…Our model introduces three major modifications to the standard U-Net: 1) a new context extraction module block (MRC) to capture high-level context features, 2) redesigned skip pathways with spatial and channel attention mechanisms to reduce the semantic gap between the feature maps of encoder and decoder sub-networks, and 3) a novel loss function to enhance segmentation accuracy. …”
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Fine-Tuning BERT Models for Multiclass Amharic News Document Categorization by Demeke Endalie

“…Bidirectional encoder representation from transformer (BERT) models are increasingly being employed in the development of natural language processing (NLP) systems, predominantly for English and other European languages. …”
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Universal flops of length 1 and 2 from D2-branes at surface singularities by Marina Moleti, Roberto Valandro

“…The geometry of the total space X of such a family can be encoded in a scalar field Φ, which lives in the corresponding ADE algebra and depends on the deformation parameters. …”
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Response Features Determining Spike Times by Barry J. Richmond, Mike W. Oram, Matthew C. Wiener

“…Interpreting messages encoded in single neuronal responses requires knowing which features of the responses carry information. …”
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A Classification of Basic Helix-Loop-Helix Transcription Factors of Soybean by Karen A. Hudson, Matthew E. Hudson

“…The challenge for future research remains to define functions for the bHLH factors encoded in the soybean genome, which may allow greater flexibility for genetic selection of growth and environmental adaptation in this widely grown crop.…”
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Unsupervised machine and deep learning methods for structural damage detection: A comparative study by Zilong Wang, Young‐Jin Cha

“…., K‐nearest neighbors method, Gaussian mixture models, one‐class support vector machines, density peaks‐based fast clustering method) and one deep learning method using a deep auto‐encoder are selected. Meanwhile, some modifications and improvements are made to enable these methods to detect structural damage in unsupervised novelty detection mode. …”
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Joint Identification and Sensing for Discrete Memoryless Channels by Wafa Labidi, Yaning Zhao, Christian Deppe, Holger Boche

“…Unlike Shannon’s transmission codes, which aim for message decoding, ID codes for a discrete memoryless channel (DMC) are far more efficient; their size grows doubly exponentially with the blocklength when randomized encoding is used. This indicates that when the receiver’s objective does not require decoding, the ID paradigm is significantly more efficient than traditional Shannon transmission in terms of both energy consumption and hardware complexity. …”
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Distance-Ranked Fault Identification of Reconfigurable Hardware Bitstreams via Functional Input by Naveed Imran, Ronald F. DeMara

“…When a complete recovery is not feasible, graceful degradation may be realized which is demonstrated by the PSNR improvement of images processed in a video encoder case study.…”
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Quantum-inspired fluid simulation of two-dimensional turbulence with GPU acceleration by Leonhard Hölscher, Pooja Rao, Lukas Müller, Johannes Klepsch, Andre Luckow, Tobias Stollenwerk, Frank K. Wilhelm

“…Within this quantum-inspired paradigm, velocity is encoded as matrix product states (MPS), effectively harnessing the analogy between interscale correlations of fluid dynamics and entanglement in quantum many-body physics. …”
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Current trends of Carbapenemase Production Amongst Multi-drug Resistant Gram-Negative Bacteria in a Tertiary-Care Hospital in West Bengal by Arunima Chakravarty, Raja Ray, Ananda S. Mondal, Hirak J. Raj

“… Background: Carbapenemase production, being encoded on plasmids, can lead to transferable resistance and outbreaks with a community/hospital setup. …”
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