Glucocorticoid receptor (NR3C1) genetic polymorphisms and the outcomes of sudden sensorineural hearing loss by Chen-Yu Chien, Shu-Yu Tai, Kuan-Hui Li, Hua-Ling Yang, Ling-Feng Wang, Kuen-Yao Ho, Ning-Chia Chang

“…Abstract Background The glucocorticoid receptor gene (NR3C1) encodes the receptor to which cortisol and other glucocorticoids bind. …”
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Association of fatty acid desaturase 2 gene polymorphism (rs28456) with susceptibility to bipolar disorder in the Turkish population: A case-control study by Pirim Dilek, Gümüş Ceren, Boztepe Esra, Akdağ Emine Merve, Şirin Hande

“…The FADS2 gene encodes a key, rate-limiting enzyme involved in polyunsaturated fatty acid (PUFA) metabolism. …”
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A Novel Nonsense Mutation of POU4F3 Gene Causes Autosomal Dominant Hearing Loss by Chi Zhang, Mingming Wang, Yun Xiao, Fengguo Zhang, Yicui Zhou, Jianfeng Li, Qingyin Zheng, Xiaohui Bai, Haibo Wang

“…POU4F3 gene encodes a transcription factor which plays an essential role in the maturation and maintenance of hair cells in cochlea and vestibular system. …”
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Protein C deficiency with recurrent systemic thrombosis associated with compound heterozygous PROC missense variants by Mikio Shiba, Shuichiro Higo, Yu Morishita, Yasuhiro Ichibori, Yoshihiro Kin, Yasushi Sakata, Yoshiharu Higuchi

“…Western blot analysis of Huh-7 and HEK293T cells transfected with expression vectors encoding PROC with or without these variants demonstrated that Gly334Ser-PROC expression levels were significantly decreased in culture media collected from HEK293T cells, while the expression levels of protein C with these variants were not significantly altered in cell lysates. …”
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Saprotrophic Wood Decay Ability and Plant Cell Wall Degrading Enzyme System of the White Rot Fungus <i>Crucibulum laeve</i>: Secretome, Metabolome and Genome Investigations by Alexander V. Shabaev, Olga S. Savinova, Konstantin V. Moiseenko, Olga A. Glazunova, Tatyana V. Fedorova

“…Multiple copies of the family AA1_1, AA3_2, AA7 and LPMOs CAZyme genes, as well as eight genes encoding proteins of the YvrE superfamily (COG3386), which includes sugar lactone lactonases, were predicted in the <i>C. laeve</i> genome. …”
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Bioactive Potential of Some <i>Bacillus thuringiensis</i> Strains from Macapá, Amazon, Brazil, Against the Housefly <i>Musca domestica</i> (Diptera: Muscidae) Under Laboratory Cond... by Tatiane Aparecida Nascimento, Maria José Paes, Fernando Hercos Valicente, Margareth Maria de Carvalho Queiroz

“…PCR was employed to detect genes encoding Cry and Cyt proteins and Vips. Six strains exhibited 70 to 100% larval mortality, with five containing <i>cry</i> genes, none harboring <i>cyt</i> genes, and four carrying <i>vip</i> genes. …”
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Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant by Patsy R Tomlinson, Rachel G Knox, Olga Perisic, Helen Su, Gemma V Brierley, Roger L Williams, Robert K Semple

“…PIK3R1 encodes three regulatory subunits of class IA phosphoinositide 3-kinase (PI3K), each associating with any of three catalytic subunits, namely p110α, p110β, or p110δ. …”
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Evaluating the relative predictive validity of measures of self-referential processing for depressive symptom severity by Ethel Siew Ee Tan, Hong Ming Tan, Kah Vui Fong, Sheryl Yu Xuan Tey, Nikita Rane, Chong Wei Ho, Zhao Yuan Tan, Rachel Jing Min Ong, Chloe Teo, Jerall Yu, Maxine Lee, An Rae Teo, Sin Kee Ong, Xin Ying Lim, Jin Lin Kee, Jussi Keppo, Geoffrey Chern-Yee Tan

“…IntroductionThe self-referential encoding task (SRET) has a number of implicit measures which are associated with various facets of depression, including depressive symptoms. …”
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An IS element-driven antisense RNA attenuates the expression of serotype 2 fimbriae and the cytotoxicity of Bordetella pertussis by Alexandre D’Halluin, Denisa Petráčková, Ivana Čurnová, Jakub Držmíšek, Jan Čapek, Peggy Bouquet, Loïc Henin, Rudy Antoine, Loïc Coutte, Camille Locht, Branislav Večerek, David Hot

“…Here, we describe the regulatory RNA Rfi2, which is transcribed from the Pout promoter of the IS481 gene BP1118 antisense to the adjacent fim2 gene encoding the major serotype 2 fimbrial subunit of B. pertussis. …”
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Biosynthesis of lactacystin as a proteasome inhibitor by Takeshi Tsunoda, Shunkichi Furumura, Haruka Yamazaki, Chitose Maruyama, Yoshimitsu Hamano, Yasushi Ogasawara, Tohru Dairi

“…We also examined the functions of the genes encoding a PKS/NRPS hybrid protein (LctA), NRPS (LctB), ketosynthase-like cyclase (LctC), cytochrome P450 (LctD), MbtH-like protein (LctE), and formyltransferase (LctF) by in vivo and in vitro experiments. …”
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Establishment of a Virus-Induced Gene Silencing System in <i>Abelmoschus manihot</i> L. by Ting Zhang, Jiaqi Hou, Hongtao Chu, Pengyu Guo, Qianzi Sang, Zhongxu Liu, Li Cao

“…Here, a tobacco rattle virus (TRV)–VIGS system was successfully developed for the first time in JHK using the gene encoding phytoene desaturase (<i>AmPDS</i>) as a marker gene. …”
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Dynamics‐Oriented Underwater Mechanoreception Interface for Simultaneous Flow and Contact Perception by Hua Zhong, Yaxi Wang, Jiahao Xu, Yu Cheng, Sicong Liu, Jia Pan, Wenping Wang, Zheng Wang

“…Under different stimuli, REEM encodes stimuli dynamics as its oscillations with distinct spectral attributes. …”
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Genome-Wide Analyses Reveal the Roles of CCT Genes as Regulators of Abiotic Stress Responses in <i>Citrullus lanatus</i> by Yajie Hong, Mengsha Li, Wona Ding, Jun Shi, Zishuo Zheng, Nailin Xing, Qiuping Li

“…Functional diversity was also evident among CCT family genes within a given species as well as among species attributable to changes in the structural features and expression patterns of the genes and the encoded proteins.…”
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Genomic, Evolutionary, and Pathogenic Characterization of a New <i>Polerovirus</i> in Traditional Chinese Medicine <i>Viola philippica</i> by Yuanling Chen, Gaoxiang Chen, Jiaping Yu, Yali Zhou, Shifang Fei, Haorong Chen, Jianxiang Wu, Shuai Fu

“…VPPV possesses a linear, positive-sense, single-stranded RNA genome consisting of 5535 nucleotides (nt) and encodes seven highly overlapping open reading frames (ORFs). …”
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Deep imaging of LepR+ stromal cells in optically cleared murine bone hemisections by Yuehan Ni, Jiamiao Wu, Fengqi Liu, Yating Yi, Xiangjiao Meng, Xiang Gao, Luyi Xiao, Weiwei Zhou, Zexi Chen, Peng Chu, Dan Xing, Ye Yuan, Donghui Ding, Ge Shen, Min Yang, Ronjie Wu, Ling Wang, Luiza Martins Nascentes Melo, Sien Lin, Xiaoguang Cheng, Gang Li, Alpaslan Tasdogan, Jessalyn M. Ubellacker, Hu Zhao, Shentong Fang, Bo Shen

“…Completed within approximately 12 days, this process yields highly transparent tissues that maintain genetically encoded or antibody-stained fluorescent signals. The bone hemisections are compatible with diverse antibody labeling strategies. …”
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Production and characterization of nervous necrosis virus vaccine antigens in wild type and CRISPR/Cas9 genome edited Nicotiana benthamiana and edible crop lettuce Lactuca sativa by Iva Andrasevic, Hang Su, Espen Rimstad, Jihong Liu Clarke

“…In the present study, we report: (1) selection and design of recombinant plasmids encoding the capsid proteins (CPs) of two genotypes of NNV, red-spotted grouper nervous necrosis virus (RGNNV) and striped jack nervous necrosis virus (SJNNV); (2) design and optimization of plasmids for transient expression of NNV vaccine antigens in wild type Nicotiana benthamiana, CRISPR/Cas9 genome edited Nicotiana benthamiana and Lactuca sativa; (3) test of different Agrobacterium strains (LBA4404 and AGL1) for effective production of NNVCPs; (4) the expression patterns of NNVCPs over time post infiltration for different plants and cultivars; (5) successful production of NNV antigens in N. benthamiana lines and lettuce cultivars, indicating the potential of the plants as antigen producers in the development of a plant-based vaccine against VNN.…”
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SensorDBSCAN: Semi-Supervised Active Learning Powered Method for Anomaly Detection and Diagnosis by Petr Ivanov, Maria Shtark, Alexander Kozhevnikov, Maksim Golyadkin, Dmitry Botov, Ilya Makarov

“…The proposed approach combines a transformer-based encoder trained with a triplet-based contrastive learning objective and the classical density-based clustering algorithm DBSCAN, enabling strong feature extraction, efficient and interpretable feature space organization and simple clustering algorithm. …”
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Splicing and expression dynamics of SR genes in hot pepper (Capsicum annuum): regulatory diversity and conservation under stress by Lin Li, Yueqin Zhang, Rui Zhang, Rui Zhang, Xiangtao Cen, Yongxiang Huang, Yongxiang Huang, Hanqiao Hu, Hanqiao Hu, Xingyu Jiang, Xingyu Jiang, Yu Ling, Yu Ling

“…In this study, we identified and characterized 23 genes encoding serine/arginine-rich (SR) protein in hot pepper (Capsicum annuum), named CaSR here. …”
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Multiscale guided attention network for optic disc segmentation of retinal images by A Z M Ehtesham Chowdhury, Andrew Mehnert, Graham Mann, William H. Morgan, Ferdous Sohel

“…The method is named multiscale guided attention network (MSGANet-OD), comprising encoders for extracting multiscale features and decoders for constructing segmentation maps from the extracted features. …”
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Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or α-Tropomyosin Mutation for Hypertrophic Cardiomyopathy by Marisa Ojala, Chandra Prajapati, Risto-Pekka Pölönen, Kristiina Rajala, Mari Pekkanen-Mattila, Jyrki Rasku, Kim Larsson, Katriina Aalto-Setälä

“…To date, over 1400 mutations have been linked to HCM, mostly in genes encoding for sarcomeric proteins. However, the pathophysiological mechanisms of the disease are still largely unknown. …”
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