Transcription factor TCF4: structure, function, and associated diseases by R. R. Savchenko, N. A. Skryabin

“…This review focuses on the TCF4 gene that encodes a transcription factor crucial for nervous system development and functioning. …”
Get full text

Rabex-5 E3 and Rab5 GEF domains differ in their regulation of Ras, Notch, and PI3K signaling in Drosophila wing development. by Theresa A Reimels, Mia Steinberg, Hua Yan, Sivan Shahar, Ashley Rosenberg, Kristina Kalafsky, Max Luf, Lindsay Kelly, Stacia Octaviani, Cathie M Pfleger

“…Here we report genetic interactions using Rabex-5 transgenes encoding domain-specific mutations that show that Rabex-5 requires an intact E3 domain to inhibit Notch signaling in the epithelial tissue of the developing wing. …”
Get full text

Tension Recordings from Primary Bronchi in Acta2-GCaMP8.1-mVermilion Transgenic Mice by Qais Khalaf, Srijit Ghosh, Keith Thornbury

“…Transgenic Acta2-GCaMP8.1-mVermilion (GCaMP) mice express a genetically encoded intracellular fluorescent Ca2+ indicator in smooth muscle cells, have been developed to facilitate the study of Ca2+. …”
Get full text

An efficient and lightweight detection method for stranded elastic needle defects in complex industrial environments using VEE-YOLO by Qiaoqiao Xiong, Qipeng Chen, Saihong Tang, Yiting Li

“…Secondly, improvements were made to the model’s feature extraction quality by encoding inter-channel information using efficient multi-Scale attention to consider channel importance. …”
Get full text

DIONYSUS CULT AS A PROTOTYPE OF AUTONOMOUS GENDER by O. O. Poliakova, V. V. Asotskyi

“…Specific sensory and mental qualities encoded in the images of Dionysian madness, vakhtnag of violence and the eternal alien, the awareness of which is determined by the Dionysian thematizes in the cultural consciousness of post-modernism, the research literature presented in fragments. …”
Get full text

Soil-Borne Microbial Functional Structure across Different Land Uses by Eiko E. Kuramae, Jizhong Z. Zhou, George A. Kowalchuk, Johannes A. van Veen

“…Fields with low C : N ratio had an overrepresentation of genes for carbon degradation, carbon fixation, metal reductase, and organic remediation categories, while fields with high C : N ratio had an overrepresentation of genes encoding dissimilatory sulfate reductase, methane oxidation, nitrification, and nitrogen fixation. …”
Get full text

CD63 Promotes Hemocyte-Mediated Phagocytosis in the Clam, Paphia undulata by Mingjia Yu, Shanjun Yang, Hongxia Sun, Qiang Xia

“…The complete cDNA of Pu-CD63 is 1,738 bp in length with an open reading frame (ORF) of 849 bp, encoding a 282 amino acid protein with four putative hydrophobic transmembrane helixes. …”
Get full text

Robust Automated Harmonization of Heterogeneous Data Through Ensemble Machine Learning: Algorithm Development and Validation Study by Doris Yang, Doudou Zhou, Steven Cai, Ziming Gan, Michael Pencina, Paul Avillach, Tianxi Cai, Chuan Hong

“…However, given differences in variable encoding, accurate variable harmonization is difficult. …”
Get full text

HDN-DDI: a novel framework for predicting drug-drug interactions using hierarchical molecular graphs and enhanced dual-view representation learning by Jinchen Sun, Haoran Zheng

“…HDN-DDI integrates an explainable substructure extraction module to decompose drug molecules and represents them using innovative hierarchical molecular graphs, which effectively incorporates information from real chemical substructures and improves molecules encoding efficiency. Furthermore, the enhanced dual-view learning method inspired by the underlying mechanisms of DDIs enables HDN-DDI to comprehensively capture both hierarchical structure and interaction information. …”
Get full text

Emergence of SARS-CoV-2 subgenomic RNAs that enhance viral fitness and immune evasion. by Harriet V Mears, George R Young, Theo Sanderson, Ruth Harvey, Jamie Barrett-Rodger, Rebecca Penn, Vanessa Cowton, Wilhelm Furnon, Giuditta De Lorenzo, Margaret Crawford, Daniel M Snell, Ashley S Fowler, Anob M Chakrabarti, Saira Hussain, Ciarán Gilbride, Edward Emmott, Katja Finsterbusch, Jakub Luptak, Thomas P Peacock, Jérôme Nicod, Arvind H Patel, Massimo Palmarini, Emma Wall, Bryan Williams, Sonia Gandhi, Charles Swanton, David L V Bauer

“…Here, we demonstrate that this TRS leads to the expression of a novel subgenomic mRNA encoding a truncated C-terminal portion of Nucleocapsid, which is an antagonist of type I interferon production and contributes to viral fitness during infection. …”
Get full text

Molecular, Biochemical, and Clinical Characterization of Thirteen Patients with Glycogen Storage Disease 1a in Malaysia by Siti Aishah Abdul Wahab, Yusnita Yakob, Mohd Khairul Nizam Mohd Khalid, Noraishah Ali, Huey Yin Leong, Lock Hock Ngu

“…GSD1a is caused by a mutation in the G6PC gene encoding glucose-6-phosphatase (G6Pase); an enzyme that catalyses the hydrolysis of glucose-6-phosphate (G6P) to phosphate and glucose. …”
Get full text

Optimization of Conditions for Production of Soluble <i>E. coli</i> Poly(A)-Polymerase for Biotechnological Applications by Igor P. Oscorbin, Maria S. Kunova, Maxim L. Filipenko

“…Interestingly, PAP 1 accumulation correlated with an increase in the plasmid copy number encoding the enzyme, indicating its potential utility as a surrogate marker of PAP 1 activity. …”
Get full text

Right Amygdalar and Temporofrontal Activation During Autobiographic, But Not During Fictitious Memory Retrieval by Hans J. Markowitsch, Alexander Thiel, Mechthild Reinkemeier, Josef Kessler, Adem Koyuncu, Wolf-Dieter Heiss

“…Portions of the neural activation found during retrieval might, however, reflect re-encoding processes as well.…”
Get full text

Unsupervised domain adaptation teacher–student network for retinal vessel segmentation via full-resolution refined model by Kejuan Yue, Lixin Zhan, Zheng Wang

“…We reconstructed the encoder and decoder of the network into a full-resolution refined model by computing the training loss at multiple semantic levels and multiple label resolutions. …”
Get full text

Insights into the nuclear-organelle DNA integration in Cicuta virosa (Apiaceae) provided by complete plastid and mitochondrial genomes by Seongjun Park, Yong Hwang, Heesoo Kim, KyoungSu Choi

“…The C. virosa plastome (154,449 bp) is highly conserved, with a quadripartite structure, whereas the mitogenome (406,112 bp) exhibits two chromosomes (352,718 bp and 53,394 bp). The mitochondrial-encoded genes (rpl2, rps14, rps19, and sdh3) were successfully transferred to the nuclear genome. …”
Get full text

Genomic characterization of foodborne Salmonella enterica and Escherichia coli isolates from Saboba district and Bolgatanga Municipality Ghana. by Gabriel Temitope Sunmonu, Frederick Adzitey, Erkison Ewomazino Odih, Boniface Awini Tibile, Rejoice Ekli, Martin Aduah, Anderson O Oaikhena, Olabisi C Akinlabi, Akebe Luther King Abia, Daniel Gyamfi Amoako, Iruka N Okeke

“…While strains belonging to virulence-associated lineages lacked key plasmid-encoded virulence plasmids, several plasmid replicons were detected in most of the E. coli (14/19) strains. …”
Get full text

‘Stupid Girls’ vs. ‘Real Men’: Identity Construction and Social Media Polarization over Revenge Porn by Marta Sánchez Cócera

“…Specifically, victim-blaming ideologies are discursively concealed, whereas traditional ideologies regarding sex are overtly encoded. Moreover, male users affiliate with newer constructions of masculinity and dissociate from the illegal actions attributed to perpetrators. …”
Get full text

Parameter-Efficient Vehicle Trajectory Prediction Based on Attention-Enhanced Liquid Structural Neural Model by Ruochen Wang, Yue Chen, Renkai Ding, Qing Ye

“…First, we introduce a temporal attention-enhanced LTC encoder that effectively captures both long-term temporal dependencies and dynamic behaviors from historical trajectory data. …”
Get full text

Recombinant SpTransformer proteins bind to specific sites on sea urchin phagocytes and modulate SpTransformer gene expression and immune responsiveness by Ryley S. Crow, Leon Grayfer, L. Courtney Smith

“…The SpTrf gene family encodes structurally similar proteins with a wide range of sequence diversity within and among individual sea urchins. …”
Get full text

A database on genes increasing resistance of wheat and relative species against pathogenic fungi by O. G. Smirnova, A. V. Kochetov

“…PRG provides data on the proteins encoded, pathogens and diseases, as well as on the resistance gene expression patterns in response to pathogen inoculations, exposure to hormones and various external stimuli. …”
Get full text