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601
The Role of the Enterohepatic Circulation of Bile Salts and Nuclear Hormone Receptors in the Regulation of Cholesterol Homeostasis: Bile Salts as Ligands for Nuclear Hormone Recept...
Published 2003-01-01“…It is the coordinated action of LXR and FXR, each dimerized to retinoid X receptor, that signal nuclear DNA response elements to encode proteins that prevent excessive cholesterol accumulation and bile salt toxicity, respectively. …”
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602
Multi-gate neuron-like transistors based on ensembles of aligned nanowires on flexible substrates
Published 2025-01-01“…Abstract The intriguing way the receptors in biological skin encode the tactile data has inspired the development of electronic skins (e-skin) with brain-inspired or neuromorphic computing. …”
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603
Genetic Variants Related to Increased CKD Progression—A Systematic Review
Published 2025-01-01“…Several genetic variants were identified in genes that encode proteins related to metabolic processes, oxidative stress, immune regulation, the renin–angiotensin–aldosterone pathway, and epigenetics, among others. …”
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604
Multi-Level Foreground Prompt for Incremental Object Detection
Published 2025-01-01“…Second, the feature map output by the teacher model is used as a feature-level prompt, with a feature distillation loss guiding the student model to encode new class foreground information in less significant channels of the old feature map, reducing interference. …”
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605
CAG Expansion in Androgen Receptor Gene of Infertile Men in Erbil Governorate
Published 2023-01-01“…This gene has a polymorphism site in Exon1 which encode androgen receptor and have various length of CAG trinucleotide repeat which causes the production of polyglutamine chain in different length of the N-terminal domain of AR protein which reduces producing sperm by disrupting spermatogenesis. …”
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606
Understanding Epistatic Interactions between Genes Targeted by Non-coding Regulatory Elements in Complex Diseases
Published 2014-12-01“…We showed that epistatic single-nucleotide polymorphisms (SNPs) were enriched in enhancers, as well as in DNase I footprints (the Encyclopedia of DNA Elements [ENCODE] Project Consortium 2012), which suggested that the disruption of the regulatory regions where transcription factors bind may be involved in the disease mechanism. …”
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607
Parabrachial CGRP neurons modulate active defensive behavior under a naturalistic threat
Published 2025-01-01“…Our electrophysiological results revealed that CGRP neurons encode the intensity of aversive stimuli through variations in firing durations and amplitudes. …”
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608
Sideroflexin family genes were dysregulated and associated with tumor progression in prostate cancers
Published 2025-02-01“…Abstract Sideroflexin (SFXN) family genes encode for a group of mitochondrial proteins involved in cellular processes such as iron homeostasis, amino acid metabolism, and energy production. …”
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609
Probe‐Based Mechanical Data Storage on Polymers Made by Inverse Vulcanization
Published 2025-02-01“…This property is leveraged in mechanical indentation to encode information, and thermal S─S metathesis and polymer re‐flow to erase. …”
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610
Creativity in children’s speech development: a case study of Persian speaking children
Published 2024-12-01“…Alternatively, the innovations that do not conform to the adult forms indicate that children have not learned the exceptions to the rules and less productive inflections conveying the same meaning; or may tend to convey the message from their own perspectives and to encode the events accordingly. The small sample used was a limitation of this study, nonetheless to arrive at broader generalizations, more supporting evidence from conducting studies on children’s differences, their social interaction with others, and the role of linguistic input are recommended. …”
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611
Marburg virus VP35 can both fully coat the backbone and cap the ends of dsRNA for interferon antagonism.
Published 2012-09-01“…Filoviruses, including Marburg virus (MARV) and Ebola virus (EBOV), cause fatal hemorrhagic fever in humans and non-human primates. All filoviruses encode a unique multi-functional protein termed VP35. …”
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612
Dynamic Spatial–Temporal Graph Neural Network for Cooling Capacity Prediction in HVDC Systems
Published 2025-01-01“…The GNN component captures spatial dependencies by representing the data as a graph, where nodes correspond to system variables, and edges encode their relationships. Temporal dependencies are modeled using temporal convolutional layers and recurrent neural networks (RNNs), enabling the framework to learn both short-term variations and long-term trends. …”
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613
Screening of multi deep learning-based de novo molecular generation models and their application for specific target molecular generation
Published 2025-02-01“…Moreover, we propose an integrated end-to-end neural network learning framework based on one complete encoder-decoder architecture transformer model: Transfer Text-to-Text Transformer (T5), by learning the embedding vector representation space of conditional molecular properties to encode and guide the vector representation of SMILES sequences, resulting in the output of the final decoder block with a softmax output (maximum likelihood objective). …”
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614
Interference of longitudinal and transversal fragmentations in the Josephson tunneling dynamics of Bose–Einstein condensates
Published 2025-01-01“…To this end, we exploit the transverse degree-of-freedom of the junction to encode initial fragmentation to the bosonic cloud. …”
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615
Characterization of Nora Virus Structural Proteins via Western Blot Analysis
Published 2016-01-01“…The coding potentials of the ORFs are not fully characterized, but ORF3 and ORF4 are believed to encode the capsid proteins (VP3, VP4a, VP4b, and VP4c) comprising the virion. …”
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616
Hierarchical Task-Parameterized Learning from Demonstration for Collaborative Object Movement
Published 2019-01-01“…Compared to a standard implementation that encodes all demonstrations together for all test situations, the proposed approach offers four advantages. …”
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617
Devaluing memories of reward: a case for dopamine
Published 2025-02-01“…Abstract Midbrain dopamine cells encode differences in predictive and expected value to support learning through reward prediction error. …”
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618
CUL4-Based Ubiquitin Ligases in Chromatin Regulation: An Evolutionary Perspective
Published 2025-01-01“…Although Cullin (CUL) proteins lack intrinsic enzymatic activity, they participate in the formation of active ubiquitin ligase complexes, known as Cullin-Ring ubiquitin Ligases (CRLs), through their association with ROC1 or ROC2, along with substrate adaptor and receptor proteins. Mammalian genomes encode several CUL proteins (CUL1–9), each contributing to distinct CRLs. …”
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619
Genome characterization through dichotomic classes: An analysis of the whole chromosome 1 of A. thaliana
Published 2012-11-01“…In order to accomplish the task we encode each sequence in the 3 possible reading frames according to the definitions of the dichotomic classes (parity, Rumer and hidden). …”
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620
Mitochondrial diseases: from molecular mechanisms to therapeutic advances
Published 2025-01-01“…Mitochondrial genetic disorders can arise from a wide range of mutations in either mitochondrial or nuclear DNA, which encode mitochondrial proteins or other contents. These genetic defects can lead to a breakdown of mitochondrial function and metabolism, such as the collapse of oxidative phosphorylation, one of the mitochondria’s most critical functions. …”
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