Transient lymphocyte count decrease correlates with oncolytic adenovirus efficacy in humans: mechanistic and biomarker findings from TUNIMO phase I trial by Tuomo Alanko, Akseli Hemminki, Víctor Cervera-Carrascón, Riikka Havunen, Kristian Taipale, Dafne C A Quixabeira, Jorma Sormunen, Katriina Peltola, Suvi Sorsa, Santeri A Pakola, Elise Jirovec, Lyna Haybout, Claudia Kistler, Tatiana V Kudling, Victor Arias, James H A Clubb, Mirte van der Heijden, Teijo Pellinen, Joao M Santos

“…To induce strong T-cell responses against solid tumors, TILT-123 (Ad5/3-E2F-d24-hTNFa-IRES-hIL2, igrelimogene litadenorepvec) was developed. TILT-123 encodes two transgenes: tumor necrosis alpha (TNFa) and interleukin-2 (IL-2). …”
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Characterisation of <i>Staphylococcus aureus</i> Strains and Their Prophages That Carry Horse-Specific Leukocidin Genes <i>lukP/Q</i> by Stefan Monecke, Sindy Burgold-Voigt, Andrea T. Feßler, Martina Krapf, Igor Loncaric, Elisabeth M. Liebler-Tenorio, Sascha D. Braun, Celia Diezel, Elke Müller, Martin Reinicke, Annett Reissig, Adriana Cabal Rosel, Werner Ruppitsch, Helmut Hotzel, Dennis Hanke, Christiane Cuny, Wolfgang Witte, Stefan Schwarz, Ralf Ehricht

“…All <i>lukP/Q</i> prophages integrated into the <i>lip2</i>=<i>geh</i> gene, and all included also the gene <i>scn-eq</i> encoding an equine staphylococcal complement inhibitor. …”
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Mechanism of Action of <i>Fusarium oxysporum</i> CCS043 Utilizing Allelochemicals for Rhizosphere Colonization and Enhanced Infection Activity in <i>Rehmannia glutinosa</i> by Feiyue Yuan, Fuxiang Qiu, Jiawei Xie, Yongxi Fan, Bao Zhang, Tingting Zhang, Zhongyi Zhang, Li Gu, Mingjie Li

“…Transient overexpression of the two effector-encoding genes in detached <i>R. glutinosa</i> leaves provided further confirmation that ChiC (GME8876_g) and csn (GME9251_g) are key effector proteins responsible for the induction of hypersensitive reactions in <i>R. glutinosa</i> leaf cells. …”
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Gene content of seawater microbes is a strong predictor of water chemistry across the Great Barrier Reef by Marko Terzin, Steven J. Robbins, Sara C. Bell, Kim-Anh Lê Cao, Renee K. Gruber, Pedro R. Frade, Nicole S. Webster, Yun Kit Yeoh, David G. Bourne, Patrick W. Laffy

“…., Rhodospirillaceae, Burkholderiaceae, Flavobacteriaceae, and Rhodobacteraceae) were enriched in reefs with elevated dissolved organic carbon (DOC) and phytoplankton-derived POM, encoding functional genes related to membrane transport, sugar utilization, and energy metabolism. …”
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Deep learning-based CT-free attenuation correction for cardiac SPECT: a new approach by Pei Yang, Zeao Zhang, Jianan Wei, Lisha Jiang, Liqian Yu, Huawei Cai, Lin Li, Quan Guo, Zhen Zhao

“…During training, multi-scale features from non-attenuation-corrected (NAC) SPECT and CT were processed separately and then aligned with the encoded features from NAC SPECT using adversarial learning and distance metric learning techniques. …”
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Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions by Martin Škandík, Lara Friess, Guillermo Vázquez-Cabrera, Lily Keane, Kathleen Grabert, Mireia Cruz De los Santos, Mercedes Posada-Pérez, Austeja Baleviciute, Mathilde Cheray, Bertrand Joseph

“…An in-depth investigation focused on SLC16A3, encoding the high-affinity lactate transporter MCT4, revealed disruptions in extracellular acidification rate and lactate concentration with age. …”
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Characterization of β-Actin Promoter from Nile Tilapia (Oreochromis niloticus) by . Alimuddin, A. Octavera, O.Z. Arifin, K. Sumantadinata

“…Autotransgenic tilapia can be then produced by changing GFP gene fragment of ptiBP-EGFP construct with genes from tilapia encoding important traits in aquaculture. Keywords:  cloning, β-actin promoter, autotransgenic, EGFP, Oreochromis niloticus, Danio rerio   ABSTRAK Promoter merupakan salah satu faktor penentu keberhasilan transgenesis.  …”
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Question–Answer Methodology for Vulnerable Source Code Review via Prototype-Based Model-Agnostic Meta-Learning by Pablo Corona-Fraga, Aldo Hernandez-Suarez, Gabriel Sanchez-Perez, Linda Karina Toscano-Medina, Hector Perez-Meana, Jose Portillo-Portillo, Jesus Olivares-Mercado, Luis Javier García Villalba

“…This study proposes an approach that integrates Prototype-Based Model-Agnostic Meta-Learning(Proto-MAML) with a Question-Answer (QA) framework that leverages the Bidirectional Encoder Representations from Transformers (BERT) model. …”
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Comparison of CT-like MRI sequences for preoperative planning of cochlear implantation using super-high-resolution CT as a reference by Ulysse Puel, Achille Beysang, Gabriella Hossu, Michael Eliezer, Bouchra Assabah, Khalid Ambarki, Pedro Augusto Gondim Teixeira, Alain Blum, Cécile Parietti-Winkler, Romain Gillet

“…Methods Six cadaveric temporal bone specimens were used. 3-T MRI scans were performed using radial volumetric interpolated breath-hold (STARVIBE), pointwise-encoding time reduction with radial acquisition (PETRA), and ultrashort time of echo (UTE) sequences. …”
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Cardiac manifestations of Fabry disease in G3Stg/GlaKO and GlaKO mouse models-Translation to Fabry disease patients. by Abirami Kugadas, Pietro Artoni, Wanida Ruangsiriluk, Meng Zhao, Natalia Boukharov, Rizwana Islam, Dmitri Volfson, Katayoun Derakhchan

“…Fabry disease (FD) is an X-linked disorder of glycosphingolipid metabolism caused by mutations in the GLA gene encoding alpha-galactosidase A (α-Gal). Loss of α-Gal activity leads to progressive lysosomal accumulation of α-Gal substrate, predominately globotriaosylceramide (Gb3) and its deacylated derivative globotriaosylsphingosine (lyso-Gb3). …”
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RNA stability is regulated by both RNA polyadenylation and ATP levels, linking RNA and energy metabolisms in Escherichia coli by Charlotte Roux, Marvin Ramos-Hue, Marjorie Audonnet, Marie-Pierre Duviau, Sébastien Nouaille, Agamemnon J. Carpousis, Sandrine Laguerre, Eliane Hajnsdorf, Muriel Cocaign-Bousquet, Laurence Girbal

“…In this study, we inactivated the pcnB gene encoding PAP I, the major poly(A) polymerase in E. coli, and investigated the effects on RNA stability and energy levels. …”
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Longitudinal genetic studies of cognitive characteristics by R. N. Mustafin, A. V. Kazantseva, R. F. Enikeeva, S. B. Malykh, E. K. Khusnutdinova

“…The content, quantity and arrangement of transposable elements in human genome, which do not affect changes in nucleotide sequences of protein encoding genes, but affect their expression, can be transmitted to the next generation.…”
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Probiotic potential and safety properties of Limosilactobacillus fermentum A51 with high exopolysaccharide production by Guangqiang Wei, Daodian Wang, Daodian Wang, Teng Wang, Gao Wang, Yunmei Chai, Yufang Li, Minhui Mei, Hao Wang, Aixiang Huang

“…PGAAP annotation identified 2,152 protein-encoding genes and 58 rRNAs, 15 tRNAs, and 5 5sRNAs. …”
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Prevalence of Antibiotic Resistance Genes in Differently Processed Smoothies and Fresh Produce from Austria by Sonia Galazka, Valerie Vigl, Melanie Kuffner, Irina Dielacher, Kathrin Spettel, Richard Kriz, Norbert Kreuzinger, Julia Vierheilig, Markus Woegerbauer

“…HPP treatment reduced the microbial loads by ca. 5 logs, also destroying extracellular DNA potentially encoding ARGs that could otherwise be transferred by bacterial transformation. …”
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Hematology of common carp following DNA vaccination and koi herpesvirus challenge test by Sri Nuryati, N.A. Maswan, . Alimuddin, . Sukenda, K. Sumantadinata, F.H. Pasaribu, R.D. Soejoedono, A. Santika

“… The study was aimed to determine the effectiveness of DNA vaccine doses on hematological aspect which represent immune response and its influence on common carp survival rate. DNA vaccines encoding the viral glycoprotein of  koi herpesvirus (KHV) have been proved to highly protect the fish under laboratory condition.  …”
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Analisis Pengaruh Citra Terhadap Kombinasi Kriptografi RSA dan STEGANOGRAFi LSB by Agus Rakhmadi Mido, Erik Iman Heri Ujianto

“…Cryptography is a technique for encoding data into encrypted data that is not understood, while steganography is a technique for hiding data into a medium that aims to protect messages from unauthorized. …”
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Genomic insights into the alphaproteobacterium Georhizobium sp. MAB10 revealed a pathway of Mn(II) oxidation-coupled anoxygenic photoautotrophy: a novel understanding of the biotic... by Xiuli Xu, Litao Zhang, Fuhang Song, Guoliang Zhang, Linlin Ma, Na Yang

“…Preliminary results indicated the presence of genes encoding a functional pheophytin-quinone-type photosynthetic reaction center and a putative key enzyme for Mn(II) oxidation, namely FtsP/CotA-like multicopper oxidase GE001273. …”
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Characterization and functional analysis of conserved non-coding sequences among poaceae: insights into gene regulation and phenotypic variation in maize by Yi Luo, Hang Zhai, Xiu Zhong, Bo Yang, Yang Xu, Tianhong Liu, Qi Wang, Yang Zhou, Yan Mao, Yaxi Liu, Qi Tang, Yanli Lu, Yao Wang, Jie Xu

“…A significant enrichment of transcription factor binding sites was found within CNS sequences, including different transcription factors involved in abiotic stress response, such as OBP (OBF-BINDING PROTEIN) family and Adof1 (Encodes dof zinc finger protein). To investigate the epigenetic modification patterns in CNS, ChIP-Seq data for histone modifications H3K9ac, H3K4me3, H3K36me3, H3K9me3, and H3K27ac were further analyzed to depict the changes along CNS. …”
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Prediction of outpatient rehabilitation patient preferences and optimization of graded diagnosis and treatment based on XGBoost machine learning algorithm by Xuehui Fan, Ruixue Ye, Yan Gao, Kaiwen Xue, Zeyu Zhang, Jing Xu, Jingpu Zhao, Jun Feng, Yulong Wang

“…The steps included handling missing values, data normalization, and encoding conversion. The data were divided into 80% training and 20% test sets using the Scikit-learn library to ensure model independence and prevent overfitting. …”
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LLT1 overexpression renders allogeneic-NK resistance and facilitates the generation of enhanced universal CAR-T cells by Shuxian Zhu, Shiyu Zuo, Chuo Li, Xingjie You, Erlie Jiang, Xiaoming Feng, Yuechen Luo

“…Methods We generated CD38-targeting universal CAR-T cells by transducing T cells with lentiviruses encoding the CD38 CAR and LLT1 constructs. T cells were subjected to CD38, TCR, HLA-I, and HLA-II gene knockdown using CRISPR/Cas9, followed by lentiviral transduction. …”
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