Anthracyclines disaggregate and restore mutant p63 function: a potential therapeutic approach for AEC syndrome by Fabiana Boncimino, Ludovica D’Auria, Kristina Todorova, Sabina Y. van der Zanden, Jacques Neefjes, Anna Mandinova, Caterina Missero, Stefano Sol

“…Abstract Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate (AEC) syndrome is a rare genetic disorder caused by mutations in the TP63 gene, which encodes a transcription factor essential for epidermal gene expression. …”
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Methionine-driven methylation modification overcomes plasmid-mediated high-level tigecycline resistance by Dan Fang, Tianqi Xu, Fulei Li, Yue Sun, Jingyi Sun, Yanqing Yin, Haijie Zhang, Zhiqiang Wang, Yuan Liu

“…Consistently, the potentiation of Met to tigecycline is abolished in tet(X4)-carrying E. coli Δdcm but restored in dcm-complementary bacteria, which encodes DNA-cytosine methyltransferase. In multiple animal models of infection, Met markedly potentiates the effectiveness of tigecycline against pathogenic E. coli and K. pneumoniae. …”
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RNA Virus Discovery Sheds Light on the Virome of a Major Vineyard Pest, the European Grapevine Moth (<i>Lobesia botrana</i>) by Humberto Debat, Sebastian Gomez-Talquenca, Nicolas Bejerman

“…The bi-segmented and highly divergent sobemo-like virus showed a distinctive evolutionary trajectory of its encoding proteins at the periphery of recently reported invertebrate Sobelivirales. …”
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A novel roseosiphovirus infecting dinoroseobacter shibae DFL12T represents a new genus by Nana Wei, Longfei Lu, Yingying Li, Bo Ding, Lanlan Cai, Yunlan Yang

“…R26L possesses a circular, double-stranded DNA genome of 79,534 bp with a G + C content of 62.6%, encoding a total of 116 open reading frames. Notably, seven auxiliary metabolic genes (AMGs), including those related to phosphate metabolism and queuosine biosynthesis, were identified. …”
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Characterization and genomic insights into bacteriophages Kpph1 and Kpph9 against hypervirulent carbapenem-resistant Klebsiella pneumoniae by Ye Huang, Yuan Huang, Zhiping Wu, Ziyue Fan, Fanglin Zheng, Yang Liu, Xinping Xu

“…In summary, our findings emphasize the therapeutic promise of phages Kpph1 and Kpph9, as well as their encoded proteins, in the context of research on phage therapy targeting hypervirulent carbapenem-resistant Klebsiella pneumoniae.…”
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In silico comparative genomic analysis unravels a new candidate protein arsenal specifically associated with Fusarium oxysporum f. sp. albedinis pathogenesis by Hafida Ayada, Boutayna Dhioui, Hamid Mazouz, Abdelhay El harrak, Fatima Jaiti, Bouchra Ouhmidou, Mohammed Diouri, Mohieddine Moumni

“…Those include effectors encoded by Foa unique genes that are involved in Foa penetration (Egh16-like family), host defense mechanisms suppression (lysM family) and pathogen protection (cysteine-rich protein family). …”
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Gene Expression Pattern and Regulatory Network of α-Toxin Treatment in Bombyx mori by Tieshan Feng, Ping Lin, Jiao Gong, Dong Cheng, Xi Yang, Quan Zhang, Tingcai Cheng

“…The upregulated genes in fatbody were also involved in peptidoglycan catabolic process, but they were for a different peptidoglycan subtype. Further, genes encoding cecropins were enriched in the fatbody. The downregulated genes were mainly involved in the metabolic pathways of fundamental substances such as cellular protein metabolic process and nucleobase-containing compound metabolic process. …”
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Two Novel CYP11B1 Gene Mutations in Patients from Two Croatian Families with 11β-Hydroxylase Deficiency by Katja Dumic, Tony Yuen, Zorana Grubic, Vesna Kusec, Ingeborg Barisic, Maria I. New

“…Mutations in the CYP11B1 gene, which encodes steroid 11β-hydroxylase, are responsible for this autosomal recessive disorder. …”
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Dysregulation of transposable elements and PIWI-interacting RNAs in myelodysplastic neoplasms by Zdenek Krejcik, David Kundrat, Jiri Klema, Andrea Hrustincova, Iva Trsova, Monika Belickova, Jaroslav Cermak, Anna Jonasova, Jiri Dostal, Michaela Dostalova Merkerova

“…Importantly, the upregulation of PIWIL2, which encodes a key factor in the piRNA pathway, independently predicted poor prognosis in MDS patients, underscoring its potential as a valuable disease marker. …”
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Semantic Segmentation Method for High-Resolution Tomato Seedling Point Clouds Based on Sparse Convolution by Shizhao Li, Zhichao Yan, Boxiang Ma, Shaoru Guo, Hongxia Song

“…To address these challenges, we propose an innovative encoding-decoding structure, incorporating voxel sparse convolution (SpConv) and attention-based feature fusion (VSCAFF) to enhance semantic segmentation of the point clouds of high-resolution tomato seedling images. …”
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Fertility differences between two wild-type <i>Drosophila melanogaster</i> lines correlate with differences in the expression of the <i>Jheh</i> gene, which codes for an enzyme deg... by O. V. Andreenkova, N. V. Adonyeva, V. M. Efimov, N.  E. Gruntenko

“…The present study is devoted to the analysis of the expression of two juvenile hormone metabolism genes encoding enzymes of its synthesis and degradation, juvenile hormone acid O-methyltransferase ( jhamt) and juvenile hormone epoxide hydrase (Jheh1), respectively, in four wild-type D. melanogaster lines, two of them being infected with Wolbachia. …”
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Genome-wide identification and expression analysis of the PIN gene family in the pepper pedicel abscission zone and during root development by HE Lei, YAN Xi, LAI Wei, LIU Chongzheng, YANG Hong, HE Jianwen

“…These genes are distributed across seven chromosomes, with CaPIN9 remaining unanchored. The proteins encoded by these genes exhibit amino acid length ranging from 358 to 654 residues, molecular weight from 39 251.05 D to 71 170.91 D, and isoelectric point from 6.40 to 9.38. …”
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Systems biology analysis of the WOX5 gene and its functions in the root stem cell niche by E. A. Oshchepkova, N. A. Omelyanchuk, M. S. Savina, T. Pasternak, N. A. Kolchanov, E. V. Zemlyanskaya

“…WUSCHEL RELATED HOMEOBOX 5 (WOX5) gene encodes the transcription factor, which is one of the key regulators, maintaining structure and functioning of the stem cell niche in plant root tips. …”
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Performance Analysis of Iteratively Decoded Convergent Source Mapping with Sphere Packing-Assisted Differential Space-Time Spreading Technique for Efficient Video Transmission by Ishtiaque Ahmed, Nasru Minallah, Jaroslav Frnda, Jan Nedoma

“…For the purpose of efficient and higher data rates, we have incorporated compression efficient source encoding along with error resiliency and transmission robustness features. …”
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Government plans in the 2016 and 2021 Peruvian presidential elections: A natural language processing analysis of the health chapters [version 5; peer review: 1 approved, 2 approved... by Rodrigo M. Carrillo-Larco, Jesús Lovón-Melgarejo, Manuel Castillo-Cara

“…We used five NLP algorithms to extract keywords and phrases from each plan: Term Frequency–Inverse Document Frequency (TF-IDF), Latent Dirichlet Allocation (LDA), TextRank, Keywords Bidirectional Encoder Representations from Transformers (KeyBERT), and Rapid Automatic Keywords Extraction (Rake). …”
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Effects of polyamines and indole on the expression of ribosome hibernation factors in <i>Escherichia coli</i> at the translational level by E. A. Khaova, A. G. Tkachenko

“…Previously, we showed that polyamines upregulated the transcription of genes encoding the ribosome hibernation factors RMF, RaiA, SRA, EttA and RsfS in Escherichia coli. …”
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Kaposi's sarcoma-associated herpesvirus (KSHV) gB dictates a low-pH endocytotic entry pathway as revealed by a dual-fluorescent virus system and a rhesus monkey rhadinovirus expres... by Shanchuan Liu, Sarah Schlagowski, Anna K Großkopf, Natalia Khizanishvili, Xiaoliang Yang, Scott W Wong, Elina M Guzmán, Marija Backovic, Stefano Scribano, Arne Cordsmeier, Armin Ensser, Alexander S Hahn

“…These findings were corroborated by comparison of RRV-YFP wildtype reporter virus and RRV-YFP encoding KSHV gB in place of RRV gB. While RRV wt infection of receptor-overexpressing cells was unaffected by inhibition of vesicle acidification, RRV-YFP expressing KSHV gB was sensitive to Bafilomycin A1, an inhibitor of vacuolar acidification. …”
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Transformer-based travel time estimation method for plateau and mountainous environments by Guangjun Qu, Kefa Zhou, Rui Wang, Dong Li, Yingpeng Lu, Zhihong Lv, Dequan Zhao, Aijun Zhang, Qing Zhang

“…The model simultaneously integrates positional encoding and multi-head self-attention mechanisms with the objective of enhancing the accuracy of travel time predictions based on a substantial number of trajectory points in wilderness settings. …”
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Prevalence of the polymorphic H-ficolin (FCN3) genes and mannosebinding lectin-associated serine protease-2 (MASP2) in indigenous populations from the Russian Arctic regions by M. V. Smolnikova, S. Yu. Tereshchenko

“…Lectins, being the main proteins of the lectin pathway activating the complement system, are encoded by polymorphic genes, wherein point mutations cause the protein conformation and expression to change, which turns out to have an effect on the functionality and ability to respond to the pathogen. …”
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Gene regulatory patterning codes in early cell fate specification of the C. elegans embryo by Alison G Cole, Tamar Hashimshony, Zhuo Du, Itai Yanai

“…These results suggest that the C. elegans embryo is patterned by a juxtaposition of distinct lineage-specific gene regulatory programs each with a unique encoding of cell location and fate. This use of homologous gene regulatory patterning codes suggests a deep homology of cell fate specification programs across diverse modes of development.…”
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