Convergent origin and accelerated evolution of vesicle-associated RhoGAP proteins in two unrelated parasitoid wasps by Colinet, Dominique, Cavigliasso, Fanny, Leobold, Matthieu, Pichon, Apolline, Urbach, Serge, Cazes, Dominique, Poullet, Marine, Belghazi, Maya, Volkoff, Anne-Nathalie, Drezen, Jean-Michel, Gatti, Jean-Luc, Poirié, Marylène

“…We show that the gene encoding the cellular RacGAP1 is at the origin of the virulent RhoGAP families found in Leptopilina sp. and V. canescens. …”
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Analysis of expression and transport activity of sugar transporter gene HpSWEET7 from red pitaya by ZHENG Qianming, YAN Shuang, XIE Pu, WANG Honglin, MA Yuhua

“…[Results] The ORF of HpSWEET7 was 771 bp, encoding 256 amino acid residues. HpSWEET7 contained two MtN3_saliva (Pfam No. …”
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Dysregulation of the NLRP3 Inflammasome and Promotion of Disease by IL-1β in a Murine Model of Sandhoff Disease by Nick Platt, Dawn Shepherd, David A. Smith, Claire Smith, Kerri-Lee Wallom, Raashid Luqmani, Grant C. Churchill, Antony Galione, Frances M. Platt

“…Sandhoff disease (SD) is a progressive neurodegenerative lysosomal storage disorder characterized by GM2 ganglioside accumulation as a result of mutations in the <i>HEXB</i> gene, which encodes the β-subunit of the enzyme β-hexosaminidase. …”
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Characterization of chemosensory genes in the subterranean pest Gryllotalpa Orientalis based on genome assembly and transcriptome comparison by Amna Chudhary, De-Long Guan, Yandi Xu, Tao Jiang, Lulu Yang, Mengyang Chen, Muhammad Salabat Khan, Wenhui Zhu, Sheng-Quan Xu

“…Results We present a draft genome of G. orientalis at the scaffold level, spanning 2.94 Gb and comprising 10,497 scaffolds. This assembly encodes 19,155 protein-coding genes, including 158 chemosensory genes: 30 odorant receptors (ORs), 64 ionotropic receptors (IRs), ten gustatory receptors (GRs), 28 odorant-binding proteins (OBPs), 25 chemosensory proteins (CSPs), and a single sensory neuron membrane protein (SNMP). …”
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Single-cell RNA sequencing of circulating immune cells supports inhibition of TNFAIP3 and NFKBIA translation as psoriatic arthritis biomarkers by Ameth N. Garrido, Rohan Machhar, Omar F. Cruz-Correa, Darshini Ganatra, Sarah Q. Crome, Sarah Q. Crome, Joan Wither, Joan Wither, Joan Wither, Igor Jurisica, Igor Jurisica, Igor Jurisica, Dafna D. Gladman, Dafna D. Gladman, Dafna D. Gladman

“…Immunoblotting of the proteins encoded in these genes (IκBα and A20, respectively) showed higher levels in PsA CD4+ T cells compared to HC. …”
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Knockdown of hexokinase 2 results in a decreased expression level of the glycolytic enzymes PFKP, BPGM, and GPI in RKO cell line by M. S. Fedorova, I. Y. Karpova, A. V. Lipatova, E. A. Pudova, Z. G. Guvatova, D. V. Kochetkov, A. V. Chaika, B. Y. Alekseev, M. V. Kiseleva, A. D. Kaprin, A. V. Kudryavtseva, A. V.  Snezhkina

“…Quantitative expression analysis of 15 genes (GAPDH, ADPGK, ALDOA, ENO3, PFKL, PGK1, PGAM1, PKM2, ENO1, PDK1, PDK3, PFKP, ENO2, GPI, and BPGM), encoding the key glycolysis enzymes, as well as HIF1A gene was carried out in a modified RKO cell line, which constantly expresses the short hairpin RNA (shRNA) for the inhibition of hexokinase 2. …”
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Gene signatures derived from transcriptomic-causal networks stratify colorectal cancer patients for effective targeted therapy by Akram Yazdani, Heinz-Josef Lenz, Gianluigi Pillonetto, Raul Mendez-Giraldez, Azam Yazdani, Hanna Sanoff, Reza Hadi, Esmat Samiei, Alan P. Venook, Mark J. Ratain, Naim Rashid, Benjamin G. Vincent, Xueping Qu, Yujia Wen, Michael Kosorok, William F. Symmans, John Paul Y. C. Shen, Michael S. Lee, Scott Kopetz, Andrew B. Nixon, Monica M. Bertagnolli, Charles M. Perou, Federico Innocenti

“…Furthermore, the corresponding proteins encoded by the genes within the signatures interact with each other and are functionally related. …”
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Multiscale Adaptively Spatial Feature Fusion Network for Spacecraft Component Recognition by Wuxia Zhang, Xiaoxiao Shao, Chao Mei, Xiaoying Pan, Xiaoqiang Lu

“…The MASFFN comprises a spatial attention-aware encoder (SAE) and a multiscale adaptively spatial feature fusion-based decoder (Multi-ASFFD). …”
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Network and Dataset for Multiscale Remote Sensing Image Change Detection by Shenbo Liu, Dongxue Zhao, Yuheng Zhou, Ying Tan, Huang He, Zhao Zhang, Lijun Tang

“…A multiscale convolution module (MSCM) is investigated, and combined with MSCM, an encoder capable of capturing features of different sizes is designed to efficiently extract multiscale semantic change features. …”
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Clonal dissemination of an NDM-2-producing Acinetobacter baumannii ST103 clone resulting in an outbreak in an intensive care unit of a Lebanese tertiary care hospital by Tania Nawfal Dagher, Linda Hadjadj, Fadi Bittar, Fadi Fenianos, Elias Abdo, Jean-Marc Rolain, Charbel Al-Bayssari

“…Antibiotic susceptibility testing was carried out using the disk diffusion method and carbapenemase-encoding genes were searched for using standard polymerase chain reaction. …”
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Characterization of the C5H11ORF96 gene in chickens: cloning, tissue distribution and investigation of its potential function in stress response regulation by Yiping Wan, Jiannan Zhang, Xiao Zhang, Jiliang He, Ningkun Shi, Yuanyou Li, Juan Li, Yajun Wang

“…Our results showed that: (1) cC5H11ORF96 cDNA encodes a 120 amino acids protein, which shares high sequence identity with that of birds, mammals, reptiles, frogs and fish; (2) cC5H11ORF96 has a fully conserved RFKTQP motif and high proportion of serine, indicating its multiple potential phosphorylation sites; (3) cC5H11ORF96 is widely expressed in various chicken tissues, with high expression levels in the parathyroid gland, adrenal gland, and pituitary; (4) glucocorticoids (GCs) and stress significantly upregulate C5H11ORF96 mRNA and protein expression in the chicken pituitary and hypothalamus, suggesting its involvement in regulating stress response by influencing the negative feedback of GCs on the HPA axis in chickens. …”
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Purpurin suppresses Salmonella invasion of host cells by reducing the secretion of T3SS-1 effector proteins by Zhenxu Shi, Zhimin Guo, Siqi Li, Chenxiao Jiang, Jianfeng Wang, Xuming Deng, Hongtao Liu, Jiazhang Qiu

“…Salmonella pathogenicity island 1 (SPI-1), encoding type three secretion system 1 (T3SS-1), serves as a crucial virulence factor for the invasion of ST into host cells, making it an ideal target for screening anti-Salmonella virulence drugs. …”
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Sporothrix brasiliensis Gp70 is a cell wall protein required for adhesion, proper interaction with innate immune cells, and virulence by Leonardo Padró-Villegas, Manuela Gómez-Gaviria, Iván Martínez-Duncker, Luz A. López-Ramírez, José A. Martínez-Álvarez, Gustavo A. Niño-Vega, Héctor M. Mora-Montes

“…In S. schenckii, this gene encodes a glycoprotein with adhesive properties required for virulence. …”
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A Rewired NADPH-Dependent Redox Shuttle for Testing Peroxisomal Compartmentalization of Synthetic Metabolic Pathways in <i>Komagataella phaffii</i> by Albert Fina, Sílvia Àvila-Cabré, Enrique Vázquez-Pereira, Joan Albiol, Pau Ferrer

“…Co-overexpression of genes encoding a NADPH-dependent redox shuttle from <i>Saccharomyces cerevisiae</i> (<i>IDP2</i>/<i>IDP3</i>) significantly increased 3-HP yields across all substrates, whereas peroxisomal targeting of the <i>S. cerevisiae</i> NADH kinase Pos5 failed to improve 3-HP production. …”
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Reference genome provide insights into sex determination of silver aworana (Osteoglossum bicirrhosum) by Yi Liu, Chao Bian, Ka Yan Ma, Yexin Yang, Yuanyuan Wang, Chao Liu, Guochang Ouyang, Meng Xu, Jinhui Sun, Changwei Shao, Jiehu Chen, Qiong Shi, Xidong Mu

“…., around 26-kb upstream of foxl2 gene (encoding forkhead box L2). Its strong interaction with the neighboring foxl2 on the same chromosome suggests foxl2 as a candidate sex-related gene in silver arowana. …”
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Exploring a high-level programming model for the NWP domain using ECMWF microphysics schemes by S. Ubbiali, C. Kühnlein, C. Schär, L. Schlemmer, T. C. Schulthess, T. C. Schulthess, M. Staneker, H. Wernli

“…<p>We explore the domain-specific Python library GT4Py (GridTools for Python) for implementing a representative physical parametrization scheme and the related tangent-linear and adjoint algorithms from the Integrated Forecasting System (IFS) of ECMWF. GT4Py encodes stencil operators in an abstract and hardware-agnostic fashion, thus enabling more concise, readable, and maintainable scientific applications. …”
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Identification of the Bovine <i>CSN3</i> Core Promoter Region and the Relationships Between <i>CSN3</i> Promoter Polymorphisms and the <i>CSN3</i> A and B Alleles by Wenqing Li, Xiaoyang Wang, Xiuyang Xu, Pinhui Wu, Tong Fu, Liyang Zhang, Tengyun Gao

“…This phenomenon is caused by single-nucleotide polymorphisms (SNPs) in the promoter region of <i>CSN3</i>, which encodes the B variant. Therefore, a series of 5′-deleted promoter plasmids were constructed to define the core promoter of <i>CSN3</i>. …”
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Target-specific peptides for BK virus agnoprotein identified through phage display screening: advancing antiviral therapeutics by Xiaofei Xing, Jingxian Han, Keke Wang, Fuyun Tian, CuiXia Jiang, Wei Liang, Lin Qi, Xin Yue, Yinhang Wen, Yuwei Hu, Hui Qiao

“…Agnoprotein, a small, positively charged protein encoded by the BK virus late gene, functions in the assembly, maturation, and release of the virus. …”
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The Complete Mitochondrial Genome of the American Palm Cixiid, Haplaxius crudus (Hemiptera: Cixiidae) by Lidia Komondy, Jose Huguet-Tapia, Marina S. Ascunce, Ericka E. Helmick, Erica M. Goss, Brian W. Bahder

“…The mitogenome of H. crudus is 15,848 bp long and encodes 37 mitochondrial genes (including 13 protein-coding genes (PCGs), 22 tRNAs, and 2 rRNAs) in addition to a putative noncoding internal control region. …”
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Computational Analysis of nsSNPs of ADA Gene in Severe Combined Immunodeficiency Using Molecular Modeling and Dynamics Simulation by Soukaina Essadssi, Al Mehdi Krami, Lamiae Elkhattabi, Zouhair Elkarhat, Ghita Amalou, Houria Abdelghaffar, Hassan Rouba, Abdelhamid Barakat

“…Severe combined immunodeficiency (SCID) is the most severe form of primary immunodeficiency (PID), characterized by fatal opportunistic infections. The ADA gene encodes adenosine deaminase, an enzyme that catalyzes the irreversible deamination of adenosine and deoxyadenosine in the catabolic pathway of purine. …”
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