Clinical characteristics of female Fabry disease patients with hypertrophic cardiomyopathy with mid-ventricular obstruction by Natsuko Inagaki, Yasuyoshi Takei, Tsuguhisa Hatano, Yasuyuki Takada, Yoshinao Yazaki, Hisanori Kosuge, Masatake Kobayashi, Shinji Suzuki, Tomohiro Umezu, Masahiko Kuroda, Kazuhiro Satomi, Takeharu Hayashi

“…Fabry disease (FD) is an X-linked lysosomal storage disease caused by mutations in GLA, which encodes α-galactosidase A (GLA). The loss or reduced activity of GLA leads to damage to multiple organs, resulting in the intracellular accumulation of globotriaosylceramide in various organs, including the heart, kidneys, and nervous system. …”
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Inherited Thrombocytopenia Related Genes: GPS2 Mediates the Interplay Between ANKRD26 and ETV6 by Valeria Capaci, Melania Eva Zanchetta, Giorgia Fontana, Daniele Ammeti, Roberta Bottega, Michela Faleschini, Anna Savoia

“…The <i>ANKRD26</i> gene, which encodes a protein involved in protein-protein interactions, is downregulated by RUNX1 during megakaryopoiesis. …”
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Transcription factor DREF regulates expression of the microRNA gene <i>bantam in Drosophila melanogaster</i> by M. B.  Schwartz, M. M. Prudnikova, O. V. Andreenkov, E. I. Volkova, I. F. Zhimulev, O. V. Antonenko, S.  A. Demakov

“…The bantam gene encodes a vital microRNA and has a complex expression pattern in various tissues at different stages of Drosophila development. …”
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Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells by Jung-Eun Park, Tae-Sung Kim, Yan Zeng, Melissa Mikolaj, Jong Il Ahn, Muhammad S. Alam, Christina M. Monnie, Victoria Shi, Ming Zhou, Tae-Wook Chun, Frank Maldarelli, Kedar Narayan, Jinwoo Ahn, Jonathan D. Ashwell, Klaus Strebel, Kyung S. Lee

“…Abstract HIV-1 infection elevates the risk of developing various cancers, including T-cell lymphoma. Whether HIV-1-encoded proteins directly contribute to oncogenesis remains unknown. …”
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Exploring <i>RNF213</i> in Ischemic Stroke and Moyamoya Disease: From Cellular Models to Clinical Insights by Benjamin Y. Q. Tan, Charlene H. P. Kok, Megan B. J. Ng, Shaun Loong, Eric Jou, Leonard L. L. Yeo, Weiping Han, Christopher D. Anderson, Chiea Chuen Khor, Poh San Lai

“…Initially identified as the primary susceptibility gene for MMD, <i>RNF213</i>—notably the p.R4810K variant—has been strongly linked to intracranial artery stenosis (ICAS) and various ischemic stroke subtypes, particularly in East Asian populations. This gene encodes an E3 ubiquitin ligase with diverse roles in angiogenesis, vascular remodeling, lipid metabolism, and cerebral blood flow regulation, yet its exact mechanisms in cerebrovascular pathology remain incompletely understood. …”
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Morphological and Molecular Identification of Obligatory Myiasis-Causing Species in Wild Cervids in Croatia by Ema Gagović, Daria Jurković Žilić, Krunoslav Pintur, Adnan Hodžić, Šimun Naletilić, Relja Beck

“…Partial sequencing of the gene-encoding mitochondrial cytochrome oxidase subunit I confirmed the taxonomic classification of <i>C. stimulator</i> and <i>P. picta</i> but was unable to confirm that of <i>H. diana</i> for lack of previously published sequences. …”
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Temporal Changes in Gene Expression Profile during Mature Adipocyte Dedifferentiation by Julie Anne Côté, Frédéric Guénard, Julie Lessard, Marc Lapointe, Simon Biron, Marie-Claude Vohl, André Tchernof

“…Dedifferentiation is associated with downregulation of transcripts encoding proteins involved in mature adipocyte functions and upregulation of genes involved in matrix remodeling, cellular development, and cell cycle.…”
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Genome-wide identification of HbVQ proteins and their interaction with HbWRKY14 to regulate the expression of HbSRPP in Hevea brasiliensis by Jiahong Zhu, Long Qu, Liwang Zeng, Ying Wang, Huiliang Li, Shiqing Peng, Dong Guo

“…Transient co-expression of HbVQ4 or HbVQ5 and HbWRKY14 resulted in relieved HbWRKY14-mediated transcription inhibition of the gene encoding small rubber particle protein (HbSRPP), whereas transient co-expression of HbVQ21 and HbWRKY14 resulted in increased HbWRKY14-mediated HbSRPP transcription inhibition. …”
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Comprehensive Analysis of Word Embedding Models and Design of Effective Feature Vector for Classification of Amazon Product Reviews by B. Priya Kamath, M. Geetha, U. Dinesh Acharya, Dipesh Singh, Ayush Rao, Shwetha Rai, Roopashri Shetty

“…This study examines the implementation of different traditional feature extraction models such as Bag of Words (BoW), Term Frequency-Inverse Document Frequency (TF-IDF), N-grams, and word embeddings like Word2Vec and Bidirectional Encoder Representations from Transformers (BERT) on an Amazon review dataset. …”
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Comparative Genomics Analysis of Plasmid pPV989-94 from a Clinical Isolate of Pantoea vagans PV989 by Lei Xu, Min Yin, Tingyuan Zhu, Yabo Liu, Yuanyuan Ying, Junwan Lu, Chaoqing Lin, Jianchao Ying, Teng Xu, Liyan Ni, Qiyu Bao, Shunfei Lu

“…Interestingly, a fragment (R4′) in R4, mediated by phage integrase and phage integrase family site-specific recombinase and encoding 9 genes related to glycometabolism, resistance, and DNA repair, was unique in pPV989-94. …”
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Genomic Characterization of <i>Laodelphax striatellus</i> Permutotetra-like Virus and Self-Cleavage Function of Viral Capsid Protein by Jun Piao, Jiarui Zhang, Lujie Zhang, Jingai Piao, Haitao Wang, Yilin Xie, Shuo Li

“…It was found that the LsPLV genome was 4667 nt in length, encoding two proteins, RNA-dependent RNA polymerase (RdRP) and CP, and the palm subdomain conserved region in RdRp was arranged in a “C–A–B” permutation pattern, exhibiting the typical characteristics of permutotetra-like viruses. …”
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A Korean Patient With Leber Congenital Amaurosis and a Homozygous RPE65 Variant Originating From a Paternal Uniparental Isodisomy by Hane Lee, Dongseok Moon, Rin Khang, Go Hun Seo, Chang Ki Yoon, Un Chul Park, Kyu Hyung Park, Eun Kyoung Lee

“…RPE65, one of the causative genes for LCA, encodes retinoid isomerohydrolase, an enzyme that plays a critical role in regenerating visual pigment in photoreceptor cells. …”
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Elucidation of the Inhibitory Effect of Phytochemicals with Kir6.2 Wild-Type and Mutant Models Associated in Type-1 Diabetes through Molecular Docking Approach by Manaswini Jagadeb, V Badireenath Konkimalla, Surya Narayan Rath, Rohit Pritam Das

“…Mutations in the KCNJ11 gene, encoding the kir6.2 channel, are reported to be associated with congenital hyperinsulinism, having a major impact in causing type 1 diabetes, and due to the lack of its 3D structure, an attempt has been made to predict the structure of kir6.2, applying fold recognition methods. …”
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Albino lethal 13, a chloroplast‐imported protein required for chloroplast development in rice by Xiaoqiong Guo, Chunli Wang, Qian Zhu, Wenhua Dongchen, Xiaoling Zhang, Wei Li, Hui Zhang, Cui Zhang, Zar Ni Naing Nant Nyein, Mengting Li, Lijuan Chen, Dongsun Lee

“…Molecular cloning revealed that OsAL13 encodes a novel rice protein with no homologous gene or known conserved domain. …”
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A Quantum-Classical Collaborative Training Architecture Based on Quantum State Fidelity by Ryan L'Abbate, Anthony D'Onofrio, Samuel Stein, Samuel Yen-Chi Chen, Ang Li, Pin-Yu Chen, Juntao Chen, Ying Mao

“…The classical component employs a tensor network for compression and feature extraction, enabling higher dimensional data to be encoded onto logical quantum circuits with limited qubits. …”
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Identification and Characterization of the Diverse Stress-Responsive R2R3-RMYB Transcription Factor from Hibiscus sabdariffa L. by Bahaeldeen Babikar Mohamed, Beenish Aftab, Muhammad Bilal Sarwar, Bushra Rashid, Zarnab Ahmad, Sameera Hassan, Tayyab Husnain

“…We identified and characterized the salt stress-responsive R2R3 type RMYB transcription factor from Hibiscus sabdariffa which has an open reading frame of 690 bp, encoding 229 long chain amino acids. In silico analysis confirmed the conserved R2 and R3 domain as well as an NLS-1 localization site. …”
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Quantum-Based Feature Selection for Multiclassification Problem in Complex Systems with Edge Computing by Wenjie Liu, Junxiu Chen, Yuxiang Wang, Peipei Gao, Zhibin Lei, Xu Ma

“…First, all features of each sample are encoded into a quantum state by performing operations CMP and Ry, and then the amplitude estimation is applied to calculate the similarity between any two quantum states (i.e., two samples). …”
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Symptom-based depression subtypes: brain dynamic specificity and its association with gene expression profiles by Qunjun Liang, Zhifeng Zhou, Shengli Chen, Shiwei Lin, Xiaoshan Lin, Ying Li, Yingli Zhang, Bo Peng, Gangqiang Hou, Yingwei Qiu

“…Finally, gene expression underlying the CCA model, along with its biological encoding process, performed using a postmortem gene expression atlas revealed distinct gene enrichments for different subtypes. …”
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<i>Pseudomonas syringae</i> Pathovar <i>syringae</i> Infection Reveals Different Defense Mechanisms in Two Sweet Cherry Cultivars by Claudia Carreras, Alan Zamorano, Luis Villalobos-González, Paula Pimentel, Lorena Pizarro, María Francisca Beltrán, Weier Cui, Manuel Pinto, Franco Figueroa, Carlos Rubilar-Hernández, Analia Llanes, Assunta Bertaccini, Nicola Fiore

“…<i>syringae</i> is linked to the timeliness of pathogen recognition, limiting the bacteria’s dispersion through modeling its cell wall, and regulation of genes encoding photosynthesis pathway. Through this study, it has been possible to progress the knowledge of relevant factors related to the susceptibility of the two studied cherry cultivars to <i>P. syringae</i> pv. …”
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Investigating resistance to 5-Azacytidine and Venetoclax in PDX models of MDS/AML by Petra Bašová, Lubomír Minařík, Lubomír Minařík, Silvia Carina Magalhaes-Novais, Jana Balounová, Zuzana Zemanová, Tatiana Aghová, Martin Špaček, Anna Jonášová, Kristýna Gloc Pimková, Jan Procházka, Radislav Sedláček, Tomáš Stopka, Tomáš Stopka

“…PDX were created in NSGS mice via intraosseal injection of luciferase-encoding Lentivirus-infected MDS/AML primary cells from patient bone marrow. …”
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