-
2261
Neurohypophysial Receptor Gene Expression by Thymic T Cell Subsets and Thymic T Cell Lymphoma Cell Lines
Published 2004-01-01“…Neurohypophysial receptors belong to the G protein-linked seven-transmembrane receptor superfamily and are encoded by four distinct genes, OTR, V1R, V2R and V3R. …”
Get full text
Article -
2262
Functional Characterization of Sesquiterpene Synthase from Polygonum minus
Published 2014-01-01“…P. minus sesquiterpene synthase (PmSTS) has a complete open reading frame (ORF) of 1689 base pairs encoding a 562 amino acid protein. Similar to other sesquiterpene synthases, PmSTS has two large domains: the N-terminal domain and the C-terminal metal-binding domain. …”
Get full text
Article -
2263
Conserved Nuclear Localization Signal in NS2 Protein of Bombyx Mori Bidensovirus: A Potential Invertebrate ssDNA Virus Trait
Published 2025-01-01“…Bombyx mori bidensovirus (BmBDV), a significant pathogen in the sericulture industry, holds a unique taxonomic position due to its distinct segmented single-stranded DNA (ssDNA) genome and the presence of a self-encoding DNA polymerase. However, the functions of viral non-structural proteins, such as NS2, remain unknown. …”
Get full text
Article -
2264
New digital drilling process monitoring: Instrumentation, validation and calibration
Published 2025-01-01“…The conventional cable encoder for displacement measurement is replaced with a magnetostrictive displacement sensor, which is more reliable in harsh field drilling environments. …”
Get full text
Article -
2265
Genome Sequencing of a Mung Bean Plant Growth Promoting Strain of P. aeruginosa with Biocontrol Ability
Published 2014-01-01“…The draft genome of PGPR2 encoded 6803 open reading frames, of which 5314 were genes with predicted functions, 1489 were genes of known functions, and 80 were RNA-coding genes. …”
Get full text
Article -
2266
Oncogenic PIK3CA corrupts growth factor signaling specificity
Published 2024-12-01“…Abstract Technical limitations have prevented understanding of how growth factor signals are encoded in distinct activity patterns of the phosphoinositide 3-kinase (PI3K)/AKT pathway, and how this is altered by oncogenic pathway mutations. …”
Get full text
Article -
2267
Pleiotropic Associations of RARRES2 Gene Variants and Circulating Chemerin Levels: Potential Roles of Chemerin Involved in the Metabolic and Inflammation-Related Diseases
Published 2018-01-01“…We analyzed the determinants and correlates of retinoic acid receptor responder 2 (RARRES2; encoding chemerin) gene variants and chemerin levels in the Taiwanese population. …”
Get full text
Article -
2268
Inhibition of STING-mediated type I IFN signaling by African swine fever virus DP71L
Published 2025-02-01“…Abstract African swine fever virus (ASFV) is nucleocytoplasmic large DNA arbovirus and encodes many proteins involved in the interaction with host molecules to evade antiviral immune responses. …”
Get full text
Article -
2269
Genetic polymorphisms and related risk factors of ischemic stroke in a Mongolian population in China
Published 2017-11-01“…The association was detected with single nucleotide polymorphisms (SNPs) located within genes NINJ2 (rs12425791) and ALDH2 (rs2238151) as well as intergenic rs9536591 were significantly associated with ischemic stroke, of which SNP rs12425791 of the NINJ2 gene was the strongest association. ALDH2 gene encodes mitochondrial aldehyde dehydrogenase, involved in the oxidative pathway of alcohol metabolism. …”
Get full text
Article -
2270
Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro
Published 2025-01-01“…Moreover, the concomitant loss of the charged amino acids in the alternatively spliced version decreases the affinity of p63 to its cognate DNA element two- to threefold. mRNAs encoding full-length p63, as well as its alternatively spliced version, are present in all tissues that we investigated, albeit in differing ratios. …”
Get full text
Article -
2271
Breast mass classification based on supervised contrastive learning and multi‐view consistency penalty on mammography
Published 2022-11-01“…To exploit the discriminative features from the insufficient mammographic images, the authors learnt an encoder in the classification model to learn the invariable representations from the mammographic breast mass by Supervised Contrastive Learning (SCL) to weaken the side effect of colour jitter and illumination of mammographic breast mass on image quality degradation. …”
Get full text
Article -
2272
TransDeep: Transformer-Integrated DeepLabV3+ for Image Semantic Segmentation
Published 2025-01-01“…This article integrates the Transformer mechanism and CA mechanism into the DeepLabV3+ network and proposes the TransDeep network. In the encoder, two different backbones, Xception and MobileNetV2, are first used for feature extraction, and a better backbone network is selected. …”
Get full text
Article -
2273
CRISPR/Cas9-Mediated Editing of a <i>NODULATION SIGNALING PATHWAY 1</i> Homolog Alters the Production of Strigolactones in Sunflower Roots
Published 2025-01-01“…Here, we used CRISPR/Cas9-mediated genome editing in sunflower hairy roots for a specific knock-out of the gene encoding a GRAS transcription factor (HaNSP1a), acting as a possible regulator of strigolactone biosynthesis, a class of phytohormones known to induce the germination of broomrape seeds. …”
Get full text
Article -
2274
How Antiretroviral Drug Concentrations Could Be Affected by Oxidative Stress, Physical Capacities and Genetics: A Focus on Dolutegravir Treated Male PLWH
Published 2025-01-01“…ROS influence the expression of gene-encoding enzymes and transporters involved in drug biotransformation. …”
Get full text
Article -
2275
The oncolytic adenovirus TILT-123 with pembrolizumab in platinum resistant or refractory ovarian cancer: the phase 1a PROTA trial
Published 2025-02-01“…Originally developed to improve efficacy of T-cell therapies such as immune checkpoint inhibitors and adoptive cell transfer, TILT-123 (Ad5/3-E2F-D24-hTNFα-IRES-hIL-2) is a serotype chimeric oncolytic adenovirus encoding tumor necrosis factor alpha and interleukin-2. …”
Get full text
Article -
2276
Novel adaptive immune systems in pristine Antarctic soils
Published 2025-01-01“…Notably, a Class 2 system featuring type V variants lacks CRISPR arrays, encodes Cas1 and Cas2 adaptation module genes. Phylogenetic analysis of Cas12 effector proteins hints at divergent evolutionary histories compared to classified type V effectors and indicates that TnpB is likely the ancestor of Cas12 nucleases. …”
Get full text
Article -
2277
Practical security of twin-field quantum key distribution with optical phase-locked loop under wavelength-switching attack
Published 2025-01-01“…In this configuration, the reference light, typically located in the untrusted station Charlie, solely provides wavelength reference for OPLL and does not participate in quantum-state encoding. However, the reference light may open a door for Eve to enter the source stations that are supposed to be well protected. …”
Get full text
Article -
2278
RNA-Seq Based Transcriptome Analysis of the Type I Interferon Host Response upon Vaccinia Virus Infection of Mouse Cells
Published 2017-01-01“…Vaccinia virus (VACV) encodes the soluble type I interferon (IFN) binding protein B18 that is secreted from infected cells and also attaches to the cell surface, as an immunomodulatory strategy to inhibit the host IFN response. …”
Get full text
Article -
2279
A High-Quality Phased Genome Assembly of Stinging Nettle (<i>Urtica dioica</i> ssp. <i>dioica</i>)
Published 2025-01-01“…We annotated 20,333 and 20,140 genes for each haplotype, covering over 90% of the complete BUSCO genes and including two copies of a gene putatively encoding the neurotoxic peptide urthionin, which could contribute to nettle’s characteristic sting. …”
Get full text
Article -
2280
Interleukin-12p70 Expression by Dendritic Cells of HIV-1-Infected Patients Fails to Stimulate gag-Specific Immune Responses
Published 2012-01-01“…To this end, mature DCs were (i) co-electroporated with mRNA encoding interleukin (IL)-12p70 mRNA, or (ii) activated with a cytokine cocktail consisting of R848 and interferon (IFN)-γ. …”
Get full text
Article