Novel risk loci encompassing genes influencing STAT3, GPCR, and oxidative stress signaling are associated with co-morbid GERD and COPD. by Ava C Wilson, Alison Rocco, Joe Chiles, Vinodh Srinivasasainagendra, Wassim Labaki, Deborah Meyers, Bertha Hidalgo, Marguerite R Irvin, Surya P Bhatt, Hemant Tiwari, Merry-Lynn McDonald

“…Rare variants in ZFP42, encoding key regulators of the IL6/STAT3 pathway, have been previously implicated with GI disorders and were associated with co-morbid GERD and COPD. …”
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Enhancing signal-to-noise ratio in real-time LED-based photoacoustic imaging: A comparative study of CNN-based deep learning architectures by Avijit Paul, Srivalleesha Mallidi

“…In this study, we systematically assess the efficacy of various Encoder-Decoder-based CNN architectures for enhancing SNR in real-time LED-based PA imaging. …”
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Chronic Benign Tubular Albuminuria From Compound Heterozygous Variants in : A Case Report by Adam Pietrobon, Mark D. Elliott

“…Rationale: Albuminuria is a commonly used parameter for predicting decline in kidney filtration function. Cubilin, encoded by CUBN , is a critical protein involved in protein reabsorption in the proximal tubule. …”
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Autoregulation of the glial gene reversed polarity in Drosophila by Jamie L. Wood, Saroj Nepal, Bradley W. Jones

“…Gcm acts on many target genes, one of which is reversed polarity (repo). repo encodes a homeodomain transcription factor and is necessary for the terminal differentiation of glial cells. …”
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EBV-Negative Monomorphic B-Cell Posttransplant Lymphoproliferative Disorder with Marked Morphologic Pleomorphism and Pathogenic Mutations in ASXL1, BCOR, CDKN2A, NF1, and TP53 by Agata M. Bogusz

“…By immunostaining, the malignant cells were immunoreactive for CD45, CD20, CD79a, PAX5, BCL6, MUM1, and p53 and negative for CD15, CD30, latent membrane protein 1 (LMP1), and EBV-encoded RNA (EBER). Flow cytometry demonstrated lambda light chain restricted CD5 and CD10 negative B-cells. …”
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Pan-cancer analysis and single-cell analysis identifies the CENPN as a biomarker for survival prognosis and immunotherapy by Nie Zhang, Zhuoying He, Xuejin Qin, Ke Han, Zhengchun Zhu, Fei Zhong

“…Abstract Background Centromere protein N (CENPN), located on chromosome 16q23.2, encodes vital nucleosome-associated complexes that are essential for dynamic assembly processes. …”
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Motor Control System for Adaptation of Healthy Individuals and Recovery of Poststroke Patients: A Case Study on Muscle Synergies by Fady S. Alnajjar, Juan C. Moreno, Ken-ichi Ozaki, Izumi Kondo, Shingo Shimoda

“…Both mechanisms can be considered as a recall of neural pathways derived from preexisting muscle synergies, already encoded by the brain’s internal model. Our results provide further insight on the fundamental principles of motor control and thus can guide the future development of poststroke therapies.…”
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Implementation Nutrigenomic of Vitamin D in Periodontitis by Hervina Hervina, I Dewa Made Sukrama, I Made Jawi

“…VDR signaling can build transcription of genes encoding proactive cytokines, bypassing the cyclo-oxygenase-2 (COX-2) and prostaglandin pathway, and can inhibit matrix metalloproteinase production. …”
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Actinorhodopsin: an efficient and robust light-driven proton pump for bionanotechnological applications by Nooraldeen Ayoub, Nadia Djabeur, Daniel Harder, Jean-Marc Jeckelmann, Zöhre Ucurum, Stephan Hirschi, Dimitrios Fotiadis

“…Abstract Actinorhodopsins are encoded by a distinct group of microbial rhodopsin (MR) genes predominant in non-marine actinobacteria. …”
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Sparse high-dimensional decomposition of non-primary auditory cortical receptive fields. by Shoutik Mukherjee, Behtash Babadi, Shihab Shamma

“…Our results thus suggest that secondary-cortical stimulus representations can be computed as sparse combinations of primary-cortical features that facilitate encoding natural stimuli. Thus, by adding the primary-cortical representation, we can account for PEG single-unit responses to natural sounds better than bypassing it and considering as input the auditory spectrogram. …”
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Frequency, causes, and factors of maternal mortality in the City of Bunia, North East of the Democratic Republic of the Congo by Clarice Ngavele, B. Mukandu, M. O. Omanyondo

“…The sample consisted of 61 maternal death records selected through multi-stage sampling from a total of 54,330 cases in the Bunia health zone, covering the period from January 1st, 2021 to August 31st, 2024. Data were encoded and analyzed using SPSS version 20, with the Chi-square test. …”
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Leveraging Multilingual Transformer for Multiclass Sentiment Analysis in Code-Mixed Data of Low-Resource Languages by Muhammad Kashif Nazir, Cm Nadeem Faisal, Muhammad Asif Habib, Haseeb Ahmad

“…Subsequently, the Multilingual Bidirectional Encoder Representations from Transformers (mBERT) model was optimized and trained for multiclass sentiment analysis on the code-mixed data. …”
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LysR-Type Transcriptional Regulator VirR Responds to Temperature and pH and Directly Activates the Transcription of virS-Containing Operon in Rhodococcus equi by Tsutomu Kakuda, Takashi Sato, Mari Takuhara, Hirofumi Hagiuda, Yasunori Suzuki

“…Virulent strains of R. equi possess a virulence-associated plasmid, which encodes a 15- to 17-kDa surface protein called virulence-associated protein A (VapA). …”
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Efficient Multi-Task Training with Adaptive Feature Alignment for Universal Image Segmentation by Yipeng Qu, Joohee Kim

“…Nevertheless, prevailing modality-alignment methods rely on large-scale uni-modal encoders for both modalities and an extremely large amount of paired data for training, and therefore it is hard to apply these existing models to lightweight segmentation models and resource-constrained devices. …”
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Decoding the physics of observed actions in the human brain by Moritz F Wurm, Doruk Yiğit Erigüç

“…Cross-decoding between actions and animations revealed that aIPL encodes abstract representations of action effect structures independent of motion and object identity. …”
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<i>shp-2</i> gene knockout upregulates CAR-driven cytotoxicity of YT NK cells by V. G. Subrakova, S. V. Kulemzin, T. N. Belovezhets, A. N. Chikaev, N. A. Chikaev, O. A. Koval, A. A. Gorchakov, A. V. Taranin

“…Here, we took advantage of the CRISPR/Cas9 system to introduce mutations in the coding sequence of the shp-2 (PTPN11) gene encoding the signaling molecule of inhibitory pathways in NK cells. …”
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Subclinical Inflammatory Status in Rett Syndrome by Alessio Cortelazzo, Claudio De Felice, Roberto Guerranti, Cinzia Signorini, Silvia Leoncini, Alessandra Pecorelli, Gloria Zollo, Claudia Landi, Giuseppe Valacchi, Lucia Ciccoli, Luca Bini, Joussef Hayek

“…Rett syndrome (RTT) is a devastating neurodevelopmental disorder, mainly caused by de novo loss-of-function mutations in the gene encoding MeCP2. Here, we investigated plasma acute phase response (APR) in stage II (i.e., “pseudo-autistic”) RTT patients by routine haematology/clinical chemistry and proteomic 2-DE/MALDI-TOF analyses as a function of four major MECP2 gene mutation types (R306C, T158M, R168X, and large deletions). …”
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Association of endothelial nitric oxide synthase (NOS3) rs2070744 variant with advanced retinopathy of prematurity: a case–control study and meta-analysis by Aneta Choręziak-Michalak, Dawid Szpecht, Tomasz Woźniak, Anna Chmielarz-Czarnocińska, Patrycja Gazińska, Anna Gotz-Więckowska, Ewa Strauss

“…Functional variants of genes encoding endothelial NO sythetase (NOS3 rs1799983, rs2070744), endothelin-1 (EDN1 rs5370), and endothelin receptor A (EDNRA rs5335) may influence ROP development or progression. …”
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Safety assessment of a novel marine multi-stress-tolerant yeast Meyerozyma guilliermondii GXDK6 according to phenotype and whole genome-sequencing analysis by Xueyan Mo, Mengcheng Zhou, Yanmei Li, Lili Yu, Huashang Bai, Peihong Shen, Xing Zhou, Haojun Zhu, Huijie Sun, Ru Bu, Chengjian Jiang

“…Major biogenic amines (BAs) encoding genes were absent, except for spermidine synthase (JA9_002594), spermine synthase (JA9_004690), and tyrosine decarboxylase (inx). …”
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APOBEC3C‐mediated NF‐κB activation enhances clear cell renal cell carcinoma progression by Nora Hase, Danny Misiak, Helge Taubert, Stefan Hüttelmaier, Michael Gekle, Marcel Köhn

“…Furthermore, we identified that A3C binds and potentially stabilizes messenger RNAs (mRNAs) encoding positive regulators of the NF‐κB pathway. …”
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