Lipopolysaccharide inhibits osteoblast formation and receptor activator of nuclear factor-κB ligand degradation via autophagy inhibition by Huaizhi Zhang, Jianhua Lin, Xu Chen, Jianhui Dai, Haibin Lin

“…Our results showed that LPS inhibited autophagy (LC3 conversion and autophagosome formation) and enhanced the protein and mRNA expression of RANKL in MC3T3-E1 osteoblast precursor line. Autophagy upregulation with Rapamycin over BECN1 overexpression rescued LPS-inhibited osteoblast formation and -promoted RANKL protein production in MC3T3-E1 cells. …”
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Design and Synthesis of Two Oxazine Derivatives Using Several Strategies by Figueroa-Valverde Lauro, Díaz-Cedillo Francisco, Rosas-Nexticapa Marcela, García-Cervera Elodia, Pool-Gómez Eduardo, López-Ramos María, Hau-Heredia Lenin, Sarabia-Alcocer Betty

“…Therefore, in this study, two oxazine derivatives (2-chloro-3-{{2-[-(3-chloro-2-oxo-cyclobutyl)-(2,3-dimethoxy-9,10-dihydrostrychnid-10-yl)-amino]-ethyl}-[1,5-dimethyl-4-(1H-naphtho[1,2-e][1,3-oxazin-2-yl)-2-phenyl-2,3-dihydro-1H-pyrazol-3-yl]-amino}-cyclobutanone and 2-chloro-3-{{2-[(3-chloro-2-oxo-cyclobutyl)-(1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl)-amino]-ethyl}-[1,5-dimethyl-4-(1H-naphtho[1,2-e][1,3]oxazin-2-yl)-2-phenyl-2,3-dihydro-1H-pyrazol-3-yl]-amino}-cyclobutanone) were synthesized using several strategies. …”
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Experimental Validation of Antiobesogenic and Osteoprotective Efficacy of Ginsenoside CK via Targeting Lipid and Atherosclerosis Pathways by Md. Niaj Morshed, Reshmi Akter, Imran Mahmud, Ah-Yeong Gwon, Jin Woo Jeang, Yeong-Geun Lee, Dae Won Park, Deok Chun Yang, Yeon Ju Kim, Se-Chan Kang

“…These hypotheses were validated by harvesting and cultivating 3T3-L1 and MC3T3-E1 in adipogenic and osteogenic media with varying concentrations of CK. …”
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Acupuncture and Kinesitherapy Improve Physical Activity More than Kinesitherapy Alone in Patients with Acute Decompensated Chronic Heart Failure with Reduced Ejection Fraction Who... by Dejan Ilic, Zoran Jovic, Zorica Mladenovic, Vesna Pejovic, Branislava Lung, Aleksandra Kozic, Slobodan Obradovic

“…After 5 days, 80%, 50%, and 10% achieved an A test score of 30 or higher, demonstrating functional independence, (<i>p</i> < 0.01) in the E2, E1, and C groups, respectively. At hospital discharge, the E2 group showed significantly better walking endurance compared to the E1 and C groups (<i>p</i> < 0.001). …”
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Exploring the Anti-Osteoporotic Effects of <i>n</i>-Hexane Fraction from <i>Cotoneaster wilsonii</i> Nakai: Activation of Runx2 and Osteoblast Differentiation In Vivo by Soyeon Hong, Hee Ju Lee, Da Seul Jung, Saruul Erdenebileg, Hoseong Hwang, Hak Cheol Kwon, Jaeyoung Kwon, Gyhye Yoo

“…Methods and Results: The alkaline phosphatase (ALP) activity of <i>C. wilsonii</i> extracts and fractions was evaluated in MC3T3-E1 pre-osteoblasts, and the <i>n</i>-hexane fraction (CWH) showed the best properties for ALP activity. …”
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بررسی رابطه واحدهای زمین‌شناسی با شدت فرسایش به کمک دو مدل با ساختار متفاوت (مطالعه موردی: حوزه آبخیز اخترآباد)... by بهارک معتمدوزیری, صادق واله, حسن احمدی

“…بررسی سازندها در مدل فارگاس نشان داده است که واحدهای سنگ چینه‌ای E1t1, E1t2, E2ig3, Q2f, Qt1 و Qt2 دارای شدت فرسایش بسیار شدید بوده‌اند؛ درحالی‌که در مدل پسیاک اصلاح شده واحدهای سنگ چینه‌ای E1t1 ,Qt1 و Qt2 دارای شدت فرسایش زیاد هستند که دلیل آن فرسایش­پذیری سازندها است، همچنین واحدهای سنگ چینه‌ای E1t2 و Q2t دارای شدت فرسایش خیلی زیاد هستند که دلیل آن علاوه بر فرسایش­پذیر بودن سازندها، تراکم بالای زهکشی در آن‌ها نیز هست.…”
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Activation of osteoblast ferroptosis by risperidone accelerates bone loss in mice models of schizophrenia by Hongyan Fan, Zaihong Yang, Lan Pang, Peifan Li, Changrong Duan, Guangyuan Xia, Lei Zheng

“…In addition, ALP staining, ARS staining, and WB were performed to reveal the role of RIS in osteogenic differentiation of MC3T3-E1 and BMSCs cells. Results RIS treatment facilitates bone loss in schizophrenia mice and inhibit osteogenic differentiation of MC3T3-E1 and BMSCs cells. …”
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Fréchet algebras generated by certain of their elements by S. Ouzomgi, L. Redlin, S. Watson

“…We consider F-algebras A that are generated by elements of the form z, (z−λ1e)−1,…,(z−λNe)−1, where e is the identity. If A has no topclogical divisors of zero we show that A is isomorphic to H(Ω), where Ω is finitely connected region. …”
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A historical perspective on the multifunctional outer membrane channel protein TolC in Escherichia coli by Mallory Wright, Mandeep Kaur, Laura K. Thompson, Georgina Cox

“…It also acts as a receptor for specific bacteriophages and the colicin E1 toxin. This review highlights key discoveries over the past six decades and emphasizes the remaining gaps in understanding how TolC contributes to physiological functions in E. coli.…”
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Potencial antioxidante dos ésteres de pequi (Caryocar coriaceum) na criopreservação de sêmen bovino e na fertilização in vitro by Micherlene da Silva Carneiro Lustosa, Yndyra Castelo Branco, Raniel Lustosa de Moura, Marlon de Araújo Castelo Branco, Isolda Márcia Rocha do Nascimento, Jefferson Hallison Lustosa da Silva, Geraldo Magela Cortes Carvalho, Talita Soares Câmara, Samara Dias Cardoso Rodrigues, Bruna Farias Brito, Francisco Cardoso Figueiredo, José Adalmir Torres de Souza

“…Os resultados mostraram que as concentrações de 1,0 e 1,5 mL/L de ésteres de pequi reduziram significativamente a concentração de malondialdeído no sêmen criopreservado. …”
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Cyclosporine A causes gingival overgrowth via reduced G1 cell cycle arrest in gingival fibroblasts. by Reiri Takeuchi, Takatoshi Nomura, Manabu Yaguchi, Noriko Kuwahara, Yuta Amino, Chieko Taguchi, Itaru Suzuki, Haruka Suzuki, Teruaki Nagashima, Kazumune Arikawa, Yuichiro Okada, Takato Nomoto, Koichi Hiratsuka

“…Treatment with cyclosporine A markedly increased cell proliferation, inhibited G1 cell cycle arrest, significantly increased CDC25A and CYCLIN E1 mRNA expression levels, significantly decreased P21, SMAD3 and SMAD4 mRNA expression levels, significantly upregulated the protein expression levels of CDC25A, CYCLIN E1, pCDK2 and pRB1 and significantly downregulated the protein expression levels of P21, SMAD3 and SMAD4. …”
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Effects of Different Vegetation Restoration Measures on the Disintegration Characteristics of Eroded Degraded Land of Pinus massoniana in Red Soil Region by XI Jie, WU Zehua, LIN Qiang, WU Jieling, ZHANG Liu, ZHOU Shiqi, ZHOU Qin, SUN Lili, ZHA Xuan

“…Compared with CK, the soil disintegration coefficient of E1, E2 and E3 measures decreased by 16.3%, 52.5% and 67.2%, respectively. …”
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Isoniazid and Rifampicin Produce Hepatic Fibrosis through an Oxidative Stress-Dependent Mechanism by Ayan Biswas, Suman Santra, Debasree Bishnu, Gopal Krishna Dhali, Abhijit Chowdhury, Amal Santra

“…These were associated with concurrent apoptosis of the hepatocytes, increase in hepatic cytochrome P450 2E1 (CYP2E1), NADPH oxidase (NOX) activity, and development of hepatic oxidative stress. …”
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Tunable High-Frequency Acoustoelectric Current Oscillations in Fluorine-Doped Single-Walled Carbon Nanotubes by Daniel Sekyi-Arthur, Samuel Yeboah Mensah, Kofi Wi-Adu, Kwadwo Anokye Dompreh, Raymond Edziah

“…The study also investigated the influence of various FSWCNT parameters such as the overlapping integrals (Δs and Δz), ac-field E1, and carrier concentration noon the behaviour of the ADC. …”
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High interindividual variability of indoxyl sulfate production identified by an oral tryptophan challenge test by Ting-Yun Lin, Wei-Kai Wu, Szu-Chun Hung

“…There was no significant difference in baseline characteristics or CYP2E1 and SULT1A1-SNP genotyping distributions between the two IS-producing phenotypes. …”
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Crystal structure of (E)-7-hydroxy-2-((6-methoxypyridin-2-yl)methylene)-3,4-dihydronaphthalen-1(2H)-one, C17H15NO3 by Liang Lun-Hai, Zhao Feng-Lan, Meng Qing-Guo

“…C17H15NO3, triclinic, P1‾$P&#x203e;{1}$ (no. 2), a = 7.5016(4) Å, b = 13.6750(8) Å, c = 14.8557(9) Å, α = 115.469(6)°, β = 91.726(5)°, γ = 97.325(5)°, V = 1358.48(15) Å3, Z = 4, Rgt(F) = 0.0442, wRref(F2) = 0.1095, T = 100 K.…”
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Crystal structure of (E)-7-methoxy-2-((6-methoxypyridin-2-yl)methylene)-tetralone, C18H17NO3 by Wang Lei, Meng Qing-Guo, Hou Gui-Ge

“…C18H17NO3, triclinic, P1‾$P&#x203e;{1}$ (no. 2), a = 4.0929(4) Å, b = 12.9527(11) Å, c = 14.4228(12) Å, α = 70.171(8)°, β = 87.229(8)°, γ = 87.567(8)°, V = 718.16(12) Å3, Z = 2, Rgt(F) = 0.0549, wRref(F2) = 0.1526, T = 99.9(3) K.…”
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Impact of expressive intentions on upper-body kinematics in two expert pianists by Craig Turner, Robin Mailly, Fabien Dal Maso, Felipe Verdugo

“…Incorporating expressive intentions also led to jerkier, less smooth wrist movements in lyrical, non-virtuosic musical excerpts (E1–E4). However, in more virtuosic excerpts (E5–E6), there were generally no differences between conditions. …”
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The crystal structure of diaqua-bis(2-(3-(1H-pyrazol-4-yl)-1H-1,2,4-triazol-5-yl)pyridine-κ2 N:N′)-bis(3,5-dicarboxybenzoato-κ1 O)cobalt(II), C38H30CoN12O14 by Yong-Hua Zhang, Wen Meng-Yao, Yan Ke

“…C38H30CoN12O14, triclinic, P1‾ $P&#x203e;{1}$ (no. 2), a = 6.9503(3) Å, b = 7.0244(4) Å, c = 20.1182(9) Å, α = 92.261(4)°, β = 95.206(4)°, γ = 104.600(4)°, V = 944.59(8) Å3, Z = 1, R gt(F) = 0.0408, wR ref(F 2) = 0.0910, T = 287 K.…”
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A Note on the Primitive Roots and the Golomb Conjecture by Yiwei Hou, Hongyan Wang

“…Then, for any positive integer n with p1/2+ɛ≤n<p, there must exist two primitive roots α and β modulo p with 1<α,β≤n−1 such that the equation n=α+β holds, where 0<ɛ<1/2 is a fixed positive number. In other words, n can be expressed as the exact sum of two primitive roots modulo p.…”
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