IUPHAR review: Drug repurposing in Schizophrenia – An updated review of clinical trials by Jihan K. Zaki, Jakub Tomasik, Sabine Bahn

“…Drug repurposing—the process of identifying new therapeutic uses for already approved compounds—offers a promising approach to overcoming the lengthy, costly, and high-risk process of traditional CNS drug discovery. This review aims to update our previous findings on the clinical drug repurposing pipeline in schizophrenia. …”
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Narrowing the gap between machine learning scoring functions and free energy perturbation using augmented data by Ísak Valsson, Matthew T. Warren, Charlotte M. Deane, Aniket Magarkar, Garrett M. Morris, Philip C. Biggin

“…However, current models lack robust evaluation and fail on tasks encountered in (hit-to-) lead optimisation, such as ranking the binding affinity of a congeneric series of ligands, thereby limiting their application in drug discovery. Here, we address these issues by first introducing a novel attention-based graph neural network model called AEV-PLIG (atomic environment vector–protein ligand interaction graph). …”
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Phylogeny, Phytomedicines, Phytochemistry, Pharmacological Properties, and Toxicity of Croton gratissimus Burch (Euphorbiaceae) by Kirkland Dingili Magwilu, Joseph Mwanzia Nguta, Isaac Mapenay, Dorine Matara

“…This would give a great indication of discovering new novelties that can give a breakthrough in drug discovery.…”
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Laser-Based Propagation of Human iPS and ES Cells Generates Reproducible Cultures with Enhanced Differentiation Potential by Kristi A. Hohenstein Elliott, Cory Peterson, Anuradha Soundararajan, Natalia Kan, Brandon Nelson, Sean Spiering, Mark Mercola, Gary R. Bright

“…Proper maintenance of stem cells is essential for successful utilization of ESCs/iPSCs as tools in developmental and drug discovery studies and in regenerative medicine. Standardization is critical for all future applications of stem cells and necessary to fully understand their potential. …”
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Anti-Inflammatory Prostanoids: Focus on the Interactions between Electrophile Signaling and Resolution of Inflammation by Beatriz Díez-Dacal, Dolores Pérez-Sala

“…However, their complex structure results in an inter- and intramolecular selectivity of the residues being modified, thus opening the way for structure-activity and drug discovery studies. Detailed characterization of cyPG interactions with cellular proteins will help us to understand their mechanism of action fully and establish their therapeutic potential in inflammation.…”
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Therapeutic molecules for multiple human diseases identified from pigeon pea (Cajanus cajan L. Millsp.) through GCâMS and molecular docking by Deepu Mathew, Lidiya John P., Manila T.M., Divyasree P., Sandhya Rajan V.T.K.

“…Keywords: Breast cancer, Drug discovery, Herbal medicine, In silico, Malaria, Measles, Phyto-compounds, Rheumatoid arthritis, Sickle cell disease, Type II diabetes…”
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Antidiabetic Activity of Benzopyrone Analogues in Nicotinamide-Streptozotocin Induced Type 2 Diabetes in Rats by Yogendra Nayak, Venkatachalam Hillemane, Vijay Kumar Daroji, B. S. Jayashree, M. K. Unnikrishnan

“…Benzopyrones are proven antidiabetic drug candidate in diabetic drug discovery. In this view novel synthetic benzopyrone analogues were selected for testing in experimental diabetes. …”
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Exploiting question-answer framework with multi-GRU to detect adverse drug reaction on social media by Jiao-huang Luo, Ai-hua Yang

“…Abstract Adverse Drug Reactions (ADRs) stand out as a pressing challenge in public health and a critical aspect of drug discovery. The dilemma arises from the inherent impossibility of conducting a comprehensive evaluation of a drug before its market release, constrained by the limitations in scale and duration of clinical trials. …”
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Antimalarial, Antioxidant, and Toxicological Evaluation of Extracts of Celtis africana, Grosseria vignei, Physalis micrantha, and Stachytarpheta angustifolia by Michael Konney Laryea, Lawrence Sheringham Borquaye

“…The activities of these plants obtained in this study partly give credence to their folkloric use in herbal medicines and suggest that they could provide promising lead compounds for malaria drug discovery programs.…”
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Etanercept Attenuates Traumatic Brain Injury in Rats by Reducing Brain TNF-α Contents and by Stimulating Newly Formed Neurogenesis by Chong-Un Cheong, Ching-Ping Chang, Chien-Ming Chao, Bor-Chih Cheng, Chung-Zhing Yang, Chung-Ching Chio

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hpvPDB: An Online Proteome Reserve for Human Papillomavirus by Satish Kumar, Lingaraja Jena, Sangeeta Daf, Kanchan Mohod, Peyush Goyal, Ashok K. Varma

“…Affluent information in this reserve could be of help for researchers involved in structural virology, cancer research, drug discovery, and vaccine design.…”
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Diverse Molecular Genotypes of Mycobacterium tuberculosis Complex Isolates Circulating in the Free State, South Africa by Anneke Van der Spoel van Dijk, Pakiso M. Makhoahle, Leen Rigouts, Kamaldeen Baba

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Natural Cyclic Peptides: Synthetic Strategies and Biomedical Applications by Devan Buchanan, Shogo Mori, Ahmed Chadli, Siva S. Panda

“…Looking ahead, the future of cyclic peptides in drug discovery is bright. Emerging trends, including integrating computational tools for rational design, novel cyclization techniques to improve pharmacokinetic profiles, and interdisciplinary collaboration among chemists, biologists, and computational scientists, promise to expand the scope of cyclic peptide-based therapeutics. …”
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A Phage‐Based Approach to Identify Antivirulence Inhibitors of Bacterial Type IV Pili by Tori M. Shimozono, Nancy J. Vogelaar, Megan T. O'Hara, Zhaomin Yang

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Mining the Proteome of subsp. ATCC 25586 for Potential Therapeutics Discovery: An Approach by Abdul Musaweer Habib, Md. Saiful Islam, Md. Sohel, Md. Habibul Hasan Mazumder, Mohd. Omar Faruk Sikder, Shah Md. Shahik

“…The plethora of genome sequence information of bacteria in recent times has ushered in many novel strategies for antibacterial drug discovery and facilitated medical science to take up the challenge of the increasing resistance of pathogenic bacteria to current antibiotics. …”
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Effects of atractylodin and β-Eudesmol on P-glycoprotein and Caco-2 cells permeability by Artitaya Thiengsusuk, Wiriyaporn Sumsakul, Kesara Na–Bangchang

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Optimizing Extraction, Evaluating Antioxidant Activity, and Analyzing Bioactive Compounds in Trikaysornmas Formula by Suphatson Limsakul, Orawan Monthakantirat, Yaowared Chulikhit, Juthamart Maneenet, Charinya Khamphukdee, Yutthana Chotritthirong, Achiraya Phasomsap, Chantana Boonyarat, Supawadee Daodee

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Features of “All LNA” Duplexes Showing a New Type of Nucleic Acid Geometry by Charlotte Förster, André Eichert, Dominik Oberthür, Christian Betzel, Reinhard Geßner, Andreas Nitsche, Jens P. Fürste

“…LNA-modified nucleic acids provide thus structural and functional features that may be successfully exploited for future application in biotechnology and drug discovery.…”
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Harnessing the immunomodulatory potential of natural products in precision medicine—a comprehensive review by Maya G. Pillai, Helen Antony

“…NPs offer a rich source of potential drug candidates, driving innovation in drug discovery. Recent breakthroughs have reignited interest in harnessing the therapeutic benefits of natural compounds. …”
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Divergent alkynylative difunctionalization of amide bonds through C–O deoxygenation versus C–N deamination by Feng Liu, Xueyuan Yan, Fangfang Cai, Wenjuan Hou, Jianyu Dong, Shuang-Feng Yin, Genping Huang, Tieqiao Chen, Michal Szostak, Yongbo Zhou

“…Abstract The transformation and utilization of amides are significant in organic synthesis and drug discovery. Here we demonstrate a divergent alkynylative difunctionalization of amides in a single transformation. …”
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