Update on the Progress of Musashi-2 in Malignant Tumors by Yiting Niu, Tao Zhou, Yanjun Li

“…Since the discovery of the Musashi (MSI) protein, its ability to affect the mitosis of Drosophila progenitor cells has garnered significant interest among scientists. …”
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Evaluation of Type III Adhesive Mortar (ACIII) and Gypsum as Precipitating Agents of Copper and Lead by Jefferson Luiz Alves Marinho, Henrique Douglas Melo Coutinho, Raimundo Nonato Pereira Teixeira, Jorge Marcell Coelho Menezes, Francisco José de Paula Filho, Francisco Assis Bezerra da Cunha

“…Therefore, the present study aimed to assess the potential of gypsum and adhesive mortar type III (ACIII) as precipitating agents for lead (Pb) and copper (Cu) ions, as well as to evaluate the toxicity of precipitation products on Drosophila melanogaster. Experiments using ACIII mortar waste as a precipitating agent for Cu ions were obtained using a glass filter composed of 04 chambers and 04 antechambers, while the potential of gypsum as a Pb ion precipitant was evaluated by adding gypsum powder to a beaker containing a Pb ions solution. …”
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DICER1: The Argonaute Endonuclease Family Member and Its Role in Pediatric and Youth Pathology by Consolato M. Sergi, Fabrizio Minervini

“…In 2001, two enzyme-encoding genes were recognized in the fruit fly <i>Drosophila melanogaster</i>. The genetic material, labeled <i>Dicer-1</i> and <i>Dicer-2</i>, encodes ribonuclease-type enzymes with slightly diverse target substrates. …”
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Spatially Distributed Morphogen Production and Morphogen Gradient Formation by Arthur D. Lander, Qing Nie, Frederic Y. M. Wan

“…Partial differential equations and auxiliaryconditions governing the activities of the morphogen Dpp in Drosophila wingimaginal discs were formulated and analyzed as Systems B, R, and C in[7][9][10]. …”
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Patient-derived cornea organoid model to study metabolomic characterization of rare disease: aniridia-associated keratopathy by Ali Can Koc, Vedat Sari, Gamze Kocak, Tuba Recber, Emirhan Nemutlu, Daniel Aberdam, Sinan Güven

“…Animal models, such as drosophila, zebrafish, and rodents, have been used to study aniridia through Pax6 deletions. …”
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Unravelling a mechanistic link between mitophagy defect, mitochondrial malfunction, and apoptotic neurodegeneration in Mucopolysaccharidosis VII by Nishan Mandal, Apurba Das, Rupak Datta

“…We aimed to bridge this knowledge gap by employing the β-glucuronidase-deficient (CG2135−/−) Drosophila model of MPS VII. Taking cues from our initial observation that the adult CG2135−/− flies displayed enhanced susceptibility to starvation, we investigated potential impairments in the autophagy-lysosomal clearance machinery in their brain to dissect the underlying cause of neurodegeneration. …”
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Transcriptional regulation by CHIP/LDB complexes. by Revital Bronstein, Liron Levkovitz, Nir Yosef, Michaela Yanku, Eytan Ruppin, Roded Sharan, Heiner Westphal, Brian Oliver, Daniel Segal

“…Here we use the powerful genetics of Drosophila combined with microarray and bioinformatics analyses to tackle this challenge. …”
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The complete mitochondrial genome of Leptopilina myrica (Hymenoptera: Figitidae) by Junwei Zhang, Zhaohe Lu, Zhi Dong, Haiyang Wang, Jieyu Shan, Zixuan Xu, Jianhua Huang, Jiani Chen

“…The nucleotide sequences of 13 PCGs and 2 rRNAs from L. myrica and another 10 Drosophila parasitoid species were used for phylogenetic analysis by MrBayes, with one species from Drosophilidae as an outgroup. …”
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Toward the Development of the Trojan Female Technique in Pest Insects: Male‐Specific Influence of Mitochondrial Haplotype on Reproductive Output in the Seed Beetle Acanthoscelides... by Lea Vlajnić, Uroš Savković, Jelena Jović, Sanja Budečević, Biljana Stojković, Mirko Đorđević

“…Although TFT has been theoretically substantiated, empirical work to date has focused only on Drosophila melanogaster populations, while the existence of male‐biased mutations and the TFT approach in economically important pest species remain unexplored. …”
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The piRNA protein Asz1 is essential for germ cell and gonad development in zebrafish and exhibits differential necessities in distinct types of germ granules. by Adam Ahmad, Yoel Bogoch, Gal Shvaizer, Noga Guler, Karine Levy, Yaniv M Elkouby

“…Asz1 is a piRNA protein in Drosophila and mice. Zebrafish Asz1 localizes to both piRNA and Bb granules, with yet unknown functions. …”
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Functional properties of the Su(Hw) complex are determined by its regulatory environment and multiple interactions on the Su(Hw) protein platform by L. S. Melnikova, M. V. Kostyuchenko, V. V. Molodina, P. G. Georgiev, A. K. Golovnin

“…The Su(Hw) protein was first identified as a DNA-binding component of an insulator complex in Drosophila. Insulators are regulatory elements that can block the enhancer-promoter communication and exhibit boundary activity. …”
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Igf2/H19 Imprinting Control Region (ICR): An Insulator or a Position-Dependent Silencer? by Subhasis Banerjee, Alan Smallwood, Scott Lamond, Stuart Campbell, Geeta Nargund

“…Furthermore, a localised folded chromatin structure resulting from juxtaposition of two disparate regulatory sequences (enhancer ICR) could be the mechanistic basis of ICR-mediated position-dependent (ICR-promoter) transcriptional repression in transgenic Drosophila.…”
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Deterministic genetic barcoding for multiplexed behavioral and single-cell transcriptomic studies by Jorge Blanco Mendana, Margaret Donovan, Lindsey Gengelbach O'Brien, Benjamin Auch, John Garbe, Daryl M Gohl

“…We describe a straightforward genetic barcoding approach that takes advantage of the powerful genetic tools in Drosophila to allow in vivo tagging of defined cell populations. …”
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Microbiome response to cadmium and copper ingestion in the spider Steatoda grossa (Theridiidae): short-term and long-term effects of metal intoxication by G. Wilczek, M. Malicka, K. Kasperkiewicz, J. Łukasiak, C. A. Panek, J. Strzelczyk

“…The purpose of our study was to quantitatively and qualitatively evaluate changes in the microbiome of the opisthosoma of the spider Steatoda grossa (Theridiidae) in response to short-term (4 weeks) and long-term (12 months) exposure to copper, as a biogenic element, and cadmium, as a xenobiotic, administered under controlled laboratory conditions using Drosophila hydei flies as prey. Regardless of the duration of exposure to metals-contaminated food, their concentrations in the bodies of the tested individuals significantly exceeded control values. …”
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A single-cell atlas of the Culex tarsalis midgut during West Nile virus infection. by Emily A Fitzmeyer, Taru S Dutt, Silvain Pinaud, Barb Graham, Emily N Gallichotte, Jessica L Hill, Corey L Campbell, Hunter Ogg, Virginia Howick, Mara K N Lawniczak, Erin Osborne Nishimura, Sarah Hélène Merkling, Marcela Henao-Tamayo, Gregory D Ebel

“…We identified 20 cell states comprising 8 distinct cell types, consistent with existing descriptions of Drosophila and Aedes aegypti midgut physiology. Most midgut cell populations were permissive to WNV infection. …”
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Dysfunctional BCAA degradation triggers neuronal damage through disrupted AMPK-mitochondrial axis due to enhanced PP2Ac interaction by Shih-Cheng Wu, Yan-Jhen Chen, Shih-Han Su, Pai-Hsiang Fang, Rei-Wen Liu, Hui-Ying Tsai, Yen-Jui Chang, Hsing-Han Li, Jian-Chiuan Li, Chun-Hong Chen

“…We investigated this by generating Drosophila mutants lacking BCAA-catabolic activity, resulting in elevated BCAA levels and neurological dysfunction, mimicking disease-relevant symptoms. …”
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The ubiquitin-conjugating enzyme UBE2D maintains a youthful proteome and ensures protein quality control during aging by sustaining proteasome activity. by Liam C Hunt, Michelle Curley, Kudzai Nyamkondiwa, Anna Stephan, Jianqin Jiao, Kanisha Kavdia, Vishwajeeth R Pagala, Junmin Peng, Fabio Demontis

“…Here, we find that E2s have diverse roles in handling a model aggregation-prone protein (huntingtin-polyQ) in the Drosophila retina: while some E2s mediate aggregate assembly, UBE2D/effete (eff) and other E2s are required for huntingtin-polyQ degradation. …”
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The effect of AKT inhibition in α-synuclein-dependent neurodegeneration by Bedri Ranxhi, Zoya R. Bangash, Zachary M. Chbihi, Sokol V. Todi, Sokol V. Todi, Peter A. LeWitt, Peter A. LeWitt, Peter A. LeWitt, Wei-Ling Tsou

“…Here, we investigated the effect of AKT inhibition in a Drosophila model of synucleinopathy. We observed that administration of the AKT inhibitor, A-443654 led to mild improvements in both survival and motor function in flies expressing human α-Syn. …”
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Synaptic enrichment and dynamic regulation of the two opposing dopamine receptors within the same neurons by Shun Hiramatsu, Kokoro Saito, Shu Kondo, Hidetaka Katow, Nobuhiro Yamagata, Chun-Fang Wu, Hiromu Tanimoto

“…Dopamine can play opposing physiological roles depending on the receptor subtype. In the fruit fly Drosophila melanogaster, Dop1R1 and Dop2R encode the D1- and D2-like receptors, respectively, and are reported to oppositely regulate intracellular cAMP levels. …”
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Fieldwork on animals living in extreme conditions as a source of biomedical innovation by Yvon Le Maho, Aurélie Tasiemski, Fabrice Bertile, Philippe Bulet

“…Most biomedical research on animals is based on the handful of the so-called standard model organisms, i.e. laboratory mice, rats or Drosophila, but the keys to some important biomedical questions may simply not be found in these. …”
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