SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn’s Disease with Significant Inverse Correlation to Disease Activity by Pia Klausen, John Gásdal Karstensen, Mehmet Coskun, Adrian Săftoiu, Peter Vilmann, Jack Bernard Cowland, Lene Buhl Riis

“…To examine the ileal expression levels of SMAD4 and to correlate these with CD disease activity. Methods. The material comprised 29 CD patients (13 with active disease, 16 in remission) and 9 asymptomatic patients referred for ileocolonoscopy as part of an adenoma surveillance program serving as controls. …”
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Disease resistance traits of IPB-D2 chickens: Characterization of IgY concentrations, Newcastle disease antibody titers, and leukocyte profiles by Dwi Lestari, Sri Murtini, Niken Ulupi, Asep Gunawan, Isyana Khaerunnisa, Anneke Anggraeni, Cece Sumantri

“…This study aimed to characterize the disease resistance traits of IPB-D2 chickens by analyzing key immunological parameters, including immunoglobulin Y (IgY) concentration, Newcastle disease (ND) antibody titers, and leukocyte profiles. …”
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Inflammatory bowel diseases and the clinical course of coronavirus disease 2019 – a Polish single-centre experience from the pre-vaccine era by Estera Banasik, Agnieszka Dobrowolska, Barbara Kołodziejczak, Piotr Eder

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Ginsenosides Rg1, Rb1 and rare ginsenosides: Promising candidate agents for Parkinson's disease and Alzheimer's disease and network pharmacology analysis by Mingchun Jiang, Jiaxin Chi, Yifan Qiao, Jinpeng Wang, Zhixin Zhang, Jia Liu, Xinhao Sheng, Liangjie Yuan

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Global, regional, and national epidemiology of allergic diseases in children from 1990 to 2021: findings from the Global Burden of Disease Study 2021 by Jun Zheng, Yi-jing Jin, Cheng-hai Wang, Chu Feng, Xin-yuan Lai, Shu-qing Hua, Jia-hui Tai

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Secular trends of epidemiologic patterns of chronic kidney disease over three decades: an updated analysis of the Global Burden of Disease Study 2019 by Jing Liu, Xue Li, Yongping Liu, Xiaodong Sun, Xiaojin Feng, Ningning Hou, Zhenna Chen

“…Objectives To assess the characteristics of the global death burden imposed by chronic kidney disease (CKD) and the attributable risk factors from 1990 to 2019 to help inform a framework for policy discussions, resource allocation and research priorities.Design A population-based observational study.Setting The death data and relative risk factors were obtained from the Global Burden of Disease (GBD) Study 2019 database.Main outcome measures Based on the GBD database, we estimated the death burden attributable to CKD stratified by sociodemographic index (SDI), geographic location, sex, age group, time period and risk factors from 1990 to 2019.Results Over three decade study period, the global number of CKD-related deaths increased from 0.60 million (95% uncertainty interval (UI): 0.57–0.63 million) in 1990 to 1.43 million (95% UI: 1.31–1.52 million) in 2019. …”
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The COVID-19 Pandemic Heightens Interest in Cytokine Storm Disease and Advances in Machine Learning Diagnosis, Telemedicine, and Primordial Prevention of Rheumatic Diseases by Tomohiro Koga, Shin-Ya Kawashiri, Fumiaki Nonaka, Yoshika Tsuji, Mami Tamai, Atsushi Kawakami

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Global burden of cardiovascular disease mortality attributable to secondhand smoke, 1990-2019: Systematic analysis of the Global Burden of Disease Study 2019. by Juan Dong, Xumin Ma, Xingxin Hu, Mengmeng Yan

“…<h4>Background</h4>Few studies have globally assessed the cardiovascular disease (CVD) mortality burden attributable to secondhand smoke. …”
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Adrenal Insufficiency in Coronavirus Disease 2019 (COVID-19)-Infected Patients without Preexisting Adrenal Diseases: A Systematic Literature Review by Mehrbod Vakhshoori, Maryam Heidarpour, Niloofar Bondariyan, Niyousha Sadeghpour, Zohreh Mousavi

“…Background. Coronavirus disease 2019 (COVID-19) manifestations varied completely from its time of emergence. …”
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Associated Factors of Cholelithiasis among Younger Children with Sickle Cell Disease at the National Reference Center for Sickle Cell Disease in Brazzaville, Congo by Firmine Olivia Galiba Atipo Tsiba, Clément Pacha Mikia, Jennifer Armandine Elira Samba, Jade Vanessa Nziengui Mboumba, Félix Malanda, Clausina Mikolele Ahoui, Alexis Elira Dokekias

“…It was a case-control study carried out between January 2017 and June 2022 at the National Reference Center for Sickle Cell Disease (SCD) “Antoinette Sassou N’guesso” in Brazzaville. …”
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Thumb Arthrodesis in The Arthritis Cases: A Scoping Review by Ghifar Akbar, Viskasari Pintoko Kalanjati, Teddy Heri Wardhana

Subjects: “…neglected disease…”
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The advantages of rare disease biobanking: A localised source of genetic knowledge to benefit the South African rare disease community and related stakeholders worldwide by M Dercksen, E H Conradie, C J Hendriksz, H Malherbe, B C Vorster

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Systemic Lupus Erythematosus with Concurrent Thrombotic Thrombocytopenic Purpura: A Case Report of Diagnostic Challenges and Management Approaches by Sonu Rahul Tej Gaddam, Manideep Katta, Sumana Simarla, Pruthvi Raj Kukunoor, Manichandana Katta

Subjects: “…autoimmune disease…”
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Clinical and anamnestic characteristics of patients with clinical manifestations of peripheral artery disease as a function of Т(–786)С polymorphism of the endothelial NO-synthase gene promoter by V.I. Tseluyko, L.M. Yakovleva, O.D. Yarova

Subjects: “…peripheral artery disease…”
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Plasma amino acid profiles of dogs with the hepatocutaneous syndrome and dogs with other chronic liver diseases by Rommaneeya Leela‐arporn, Karah Burns DeMarle, Cailin R. Heinze, Cynthia R. L. Webster

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Gut-Heart Axis: Microbiome Involvement in Restrictive Cardiomyopathies by Samuel Jaimez-Alvarado, Itzel Ivonn López-Tenorio, Javier Barragán-De los Santos, Dannya Coral Bello-Vega, Francisco Javier Roldán Gómez, Amedeo Amedei, Enrique Alexander Berrios-Bárcenas, María Magdalena Aguirre-García

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Mechanisms of ubiquitin-independent proteasomal degradation and their roles in age-related neurodegenerative disease by Taylor R. Church, Seth S. Margolis, Seth S. Margolis

Subjects: “…neurodegenerative disease…”
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Paget’s Disease of the Male Breast: A Diagnostic Challenge by Eléna Prospero, Marie Jouandet, Jean-Marc Chevallier, Anne Dompmartin, Jean-Matthieu L'Orphelin

Subjects: “…Paget’s disease…”
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