Development and external validation of the SMA2SH2ERS risk prediction model for aneurysmal subarachnoid haemorrhage in the general population: a population-based prospective cohort... by Kristiina Rannikmäe, Vita M. Klieverik, Jos P. Kanning, Ina L. Rissanen, Amy E. Martinsen, Bendik S. Winsvold, Mirjam I. Geerlings, Ynte M. Ruigrok

“…A total of 456 856 individuals from the UK Biobank and 46 483 individuals from the HUNT Study were included.Primary and secondary outcome measures Incident ASAH identified using the International Classification of Diseases codes, ICD-9 430 and ICD-10 I600 to I609 codes.Results In the development cohort, ASAH occurred in 738 (0.2%) during 5 407 909 person-years of follow-up. …”
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Identification of the Transcriptional Networks and the Involvement in Angiotensin II-Induced Injury after CRISPR/Cas9-Mediated Knockdown of Cyr61 in HEK293T Cells by Junjie Wang, Dongdong Fu, Soulixay Senouthai, Yan Jiang, Rentong Hu, Yanwu You

“…Functional mechanisms of the differentially expressed lncRNAs and mRNAs as well as identification of metabolic pathways will provide new therapeutic targets for Cyr61-realated diseases.…”
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Companion animal and equine clinical research: a Nordic perspective by Bodil Ström Holst, Alejandro Engelmann, Gittan Gröndahl, Lotta Gunnarsson, Anita Haug Haaland, Anna Hielm-Björkman, Lars Moe, Marie Rhodin, Henrik Rönnberg, Marie Stråhle, Ylva Toljander, Annemarie Thuri Kristensen, Malin Hagberg Gustavsson

“…The scientific areas cardiology, infectious diseases, reproduction, and surgery were prominent for all three species. …”
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Improper lung volume-dose parameters are risk factors for acute fatal radiation pneumonitis among esophageal cancer patients receiving chemoradiotherapy: a case-control study by Ruinuo Jia, Liuyan Li, Xiaoyi Liu, Junqian Zhang, Shuoguo Li, Ziqi Wang, Jingxia Li, Bingyi Xu, Manxi Sheng, Lei Ni, Danni Yang, Shegan Gao, Shegan Gao, Shegan Gao

“…Participants were enrolled using the International Classification of Diseases Codes Searching and then verified by medical record review. …”
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Maternal age-related declines in live birth rate following single euploid embryo transfer: a retrospective cohort study by Wei Jiang, Zichen Zheng, Nan Yan, Shuang Yao, Qijun Xie, Danyu Ni, Shanren Cao, Chun Zhao, Xiufeng Ling

“…Patients with severe uterine pathologies, immune disorders, or endocrine diseases were excluded. The cycles were categorized into three age groups: <35 years, 35–37 years, and ≥ 38 years. …”
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Genetic divergence of hot pepper lines (Capsicum spp.) in hybrid combinations by Šević Biljana, Cvikić Dejan, Slađana Savić, Tupajić Ivan, Ugirnović Milan, Bajagić Marija, Luković Kristina, Stojiljković Jelena

“…Breeding programs for developing new genotypes emphasize earliness, fruit quality, yield potential, resistance to economically significant diseases, tolerance to abiotic stress, and plant morphology. …”
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Salvia deserti Decne., an endemic and rare subshrub from Arabian desert: antidiabetic and antihyperlipidemic effects of leaf hydroethanolic extracts by Arbi Guetat, Slimen Selmi, Abdelrhman T. Abdelwahab, Marwa A. Abdelfattah, Abd Ealrhman M. Elhaj, Roaa T. Mogharbel, M. J. A. Abualreish, Abdullah F. Alanazi, Karim Hosni, Naceur Mejri, Abdennacer Boulila

“…Although their effectiveness, the antidiabetic drugs have many side effects such as cardiovascular diseases, kidney failure, and hepatic complications. …”
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Topologically constrained DNA-mediated one-pot CRISPR assay for rapid detection of viral RNA with single nucleotide resolutionResearch in context by Yanan Li, Ru Xu, Fenglei Quan, Yonghua Wu, Yige Wu, Yongyuan Zhang, Yan Liang, Zhenzhong Zhang, Hua Gao, Ruijie Deng, Kaixiang Zhang, Jinghong Li

“…Interpretation: Our study provides a rapid and accurate molecular diagnostic tool for point-of-care testing, epidemiological screening, and the detection of diseases associated with other RNA biomarkers with excellent single nucleotide differentiation, high sensitivity, and simplicity. …”
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Prevalence of depression symptoms and its influencing factors among pregnant women in late pregnancy in urban areas of Hengyang City, Hunan Province, China: a cross-sectional study by Huilan Xu, Zhao Hu, Xidi Zhu, Baohua Zheng, Yunhan Yu, Wensu Zhou, Shilin Yin

“…Objectives To evaluate the prevalence of depressive symptoms and its influencing factors in late pregnancy.Design Cross-sectional study.Setting Fourteen community in urban areas of Hengyang City.Participants The study conducted from July to October 2019, and surveyed 813 women in late pregnancy who lived in urban areas of Hengyang for more than 6 months, signed an informed consent and were without cognitive disorders, severe mental illnesses or other serious diseases.Measures Perinatal depression symptoms were evaluated using the Patient Health Questionnaire-9, and perinatal anxiety symptoms were evaluated using the Generalised Anxiety Disorder-7 Scale. …”
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Combined 25-hydroxyvitamin D concentrations and physical activity on mortality in US stroke survivors: findings from the NHANES by Junqi Liao, Jingyi Chen, Huimin Wu, Qing Zhu, Xiaogang Tang, Li Li, Aimei Zhang, Peiyi Mo, Yan Liu, Xinyi Yang, Yang Han, Zhaoyao Chen, Wenlei Li, Yuan Zhu, Minghua Wu

“…These findings provide new ideas and possibilities for the prevention and treatment of cardiovascular and cerebrovascular diseases, offering a reference for development of clinical practice guidelines in the future.…”
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Clinical validation of an artificial intelligence algorithm for classifying tuberculosis and pulmonary findings in chest radiographs by Thiago Fellipe Ortiz de Camargo, Thiago Fellipe Ortiz de Camargo, Guilherme Alberto Sousa Ribeiro, Guilherme Alberto Sousa Ribeiro, Maria Carolina Bueno da Silva, Luan Oliveira da Silva, Pedro Paulo Teixeira e Silva Torres, Denise do Socorro Rodrigues da Silva, Mayler Olombrada Nunes de Santos, William Salibe Filho, Marcela Emer Egypto Rosa, Magdala de Araujo Novaes, Thiago Augusto Massarutto, Osvaldo Landi Junior, Elaine Yanata, Marcio Rodrigues da Cunha Reis, Gilberto Szarf, Pedro Vieira Santana Netto, Joselisa Peres Queiroz de Paiva

“…BackgroundChest X-ray (CXR) interpretation is critical in diagnosing various lung diseases. However, physicians, not specialists, are often the first ones to read them, frequently facing challenges in accurate interpretation. …”
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A prospective study to evaluate the clinical specificity of the cobas® MPX test kit for screening for HIV RNA, HCV RNA, and HBV DNA in blood donation samples using the cobas® 6800... by Lei Zhou, Lin Wang, Xiaofang Gong, Xiaochun Liu, Yaxuan Zou, Yingying Wang, Jinfeng Zeng, Liang Zang

“…Background: Nucleic acid testing (NAT) is widely used for screening blood donors for infectious diseases to enhance transfusion safety. Roche's advanced cobas® MPX assay detects human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis B virus (HBV) using the cobas® 6800/5800 Systems, based on real-time PCR technology, providing improved sensitivity. …”
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Deciphering the role of IL17RA in psoriasis and chronic mucocutaneous candidiasis: shared pathways and distinct manifestations by Ayat Kadhi, Ayat Kadhi, Ayat Kadhi, Edward Eid, Michel J. Massaad, Inaam El-Rassy, Dana Maria Khoury, Yutaka Shimomura, Nelly Rubeiz, Mazen Kurban, Mazen Kurban, Mazen Kurban, Georges Nemer, Georges Nemer

“…Our findings bridge a critical knowledge gap and provide insights into the molecular mechanisms connecting these diseases. This discovery not only advances our understanding of their pathophysiology but also lays the groundwork for personalized therapeutic strategies, heralding a new era of precision medicine for patients with intertwined psoriasis and CMC.…”
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Cell culture expansion media choice affects secretory, protective and immuno-modulatory features of adipose mesenchymal stromal cell-derived secretomes for orthopaedic applications by Enrico Ragni, Andrea Papait, Michela Maria Taiana, Paola De Luca, Giulio Grieco, Elsa Vertua, Pietro Romele, Cecilia Colombo, Antonietta Rosa Silini, Ornella Parolini, Laura de Girolamo

“…Introduction: Mesenchymal stromal cells (MSCs) gained attention for their anti-inflammatory and trophic properties, with musculoskeletal diseases and osteoarthritis (OA) being among the most studied conditions. …”
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Effect of a Sodium and Calcium DL-β-Hydroxybutyrate Salt in Healthy Adults by Tobias Fischer, Ulrike Och, Ira Klawon, Tim Och, Marianne Grüneberg, Manfred Fobker, Ursula Bordewick-Dell, Thorsten Marquardt

“…The intake of ketone bodies is often discussed in relation to rare metabolic diseases, such as multiple acyl-CoA dehydrogenase deficiency (MADD), that have no alternatives for treatment. …”
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Determining the intention of receiving the influenza vaccine: a cross-sectional survey among international and domestic college students in the USA by Charles Liu, Jiying Ling, ChengChing Liu, Angela Chia-Chen Chen, Nagwan Zahry, Ravichandran Ammigan, Loveleen Kaur

“…Objective Vaccination is the most effective strategy for preventing infectious diseases, yet it is underused in young adults. College students are important targets for the influenza vaccine given this population’s low vaccination rates; however, limited research has focused on international college students’ vaccination status. …”
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User-Oriented Requirements for Artificial Intelligence–Based Clinical Decision Support Systems in Sepsis: Protocol for a Multimethod Research Project by Pascal Raszke, Godwin Denk Giebel, Carina Abels, Jürgen Wasem, Michael Adamzik, Hartmuth Nowak, Lars Palmowski, Philipp Heinz, Silke Mreyen, Nina Timmesfeld, Marianne Tokic, Frank Martin Brunkhorst, Nikola Blase

“… BackgroundArtificial intelligence (AI)–based clinical decision support systems (CDSS) have been developed for several diseases. However, despite the potential to improve the quality of care and thereby positively impact patient-relevant outcomes, the majority of AI-based CDSS have not been adopted in standard care. …”
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Prognostic value of matrix metalloproteinases and transforming growth factor – β in kidney cancer by A. I. Tarasenko, A. N. Rossolovskiy, O. L. Berezinets, A. B. Bucharskaya, S. S. Pakhomiy, A. O. Efimova, G. N. Maslyakova

“…The control group consisted of 15 healthy volunteers without chronic kidney diseases. All patients signed an informed consent to participate in the study. …”
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Determinants of Anemia among Pregnant Women at Public Hospitals in West Shewa, Central Ethiopia: A Case-Control Study by Berhanu Senbeta Deriba, Elias Teferi Bala, Gizachew Abdissa Bulto, Tinsae Abeya Geleta, Agumas Fentahun Ayalew, Addis Adera Gebru, Habtamu Oljira Desta, Mengistu Benayew Shiferaew, Lidya Zerihun Sahile

“…Family size >5 (AOR = 2.95, 95% CI: 1.34–6.50), peptic ulcer diseases (PUD) (AOR = 2.85, 95% CI: 1.14–7.13), having the previous history of abortion (AOR = 2.84, 95% CI: 1.08–7.47), birth interval <2 years (AOR = 2.61, 95% CI: 1.20–5.70), antepartum hemorrhage (APH) (AOR = 6.05, 95% CI: 1.95–18.81), and not using latrine (AOR = 3.45, 95% CI: 1.30–9.24) were the identified determinants of anemia. …”
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Assessing the determinants of out-of-pocket health expenditures among Cambodian households in informal employment using survey data by Andrea Hannah Kaiser, Sovathiro Mao, Jesper Sundewall, Marlaina Ross, Sokunthea Koy, Searivoth Vorn, Pichenda Koeut, Bjoern Ekman

“…Important health contributors included illness severity and the presence of chronic illnesses or noncommunicable diseases. Conclusions Our findings emphasize the necessity of integrating nonpoor informal workers and their dependents into formal prepayment schemes to reduce OOPE and enhance financial protection on Cambodia’s path toward universal health coverage. …”
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