Trends in palliative care utilization among older adult decedents with and without cancer in Taiwan: a population-based comparative studyResearch in context by Yu-Tai Lo, Tzu-Jung Chuang, Yu-Tung Huang, Yi-Lin Wu, Yi-Ching Yang, Chung-Yi Li

“…Summary: Background: The leading causes of death among the older adults have shifted from cancer to non-cancer conditions such as ischemia heart diseases, stroke, and dementia, affecting end-of-life care needs. …”
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Effect of rhGH treatment on lipidome and brown fat activity in prepuberal small for gestational age children: a pilot study by Lorena González, Carolina Gonzalez-Riano, Pablo Fernández-García, Rubén Cereijo, Aina Valls, Andrea Soria-Gondek, Nativitat Real, Belén Requena, Joan Bel-Comos, Patricia Corrales, David Jiménez-Pavón, Coral Barbas, Francesc Villarroya, David Sánchez-Infantes, Marta Murillo

“…Exclusion criteria included endocrinological, genetic, or chronic diseases. Untargeted lipidomics analysis was performed using liquid chromatography-mass spectrometry (LC-MS), and serum biomarker levels were measured using ELISA assays. …”
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Evaluation of thiol/disulphide and oxidant–antioxidant status of dairy cows in periparturient and post‐partum period by Burcu Menekse Balkan, Ogunc Meral, Bekir Cetintav, Guzin Ozkurt, Ali Burak Balkan, Tevhide Sel

“…Alterations of oxidative stress in the transition period play an important role in development of some diseases and disorders in dairy cows. Objectives The purpose of this study is to assess the total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), total thiol, native thiol, disulphide and lipid profile in Simmental and Montofon dairy cows (aged 2–3) before and after calving. …”
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Gut microbiome-derived bacterial extracellular vesicles in patients with solid tumours by Surbhi Mishra, Mysore Vishakantegowda Tejesvi, Jenni Hekkala, Jenni Turunen, Niyati Kandikanti, Anna Kaisanlahti, Marko Suokas, Sirpa Leppä, Pia Vihinen, Hanne Kuitunen, Kaisa Sunela, Jussi Koivunen, Arja Jukkola, Ilja Kalashnikov, Päivi Auvinen, Okko-Sakari Kääriäinen, T. Peñate Medina, O. Peñate Medina, Juha Saarnio, Sanna Meriläinen, Tero Rautio, Raila Aro, Reetta Häivälä, Juho Suojanen, Mikael Laine, Pande Putu Erawijattari, Leo Lahti, Peeter Karihtala, Terhi S. Ruuska, Justus Reunanen

“…The diverse composition of bEVs, including their proteins, mRNAs, metabolites, and lipids, makes them useful for investigating diseases such as cancer. However, conventional approaches for studying gut microbiome composition alone may not be accurate in deciphering host–gut microbiome communication. …”
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COVID-19 Recombinant mRNA Vaccines and Serious Ocular Inflammatory Side Effects: Real or Coincidence? by Arash Maleki, Sydney Look-Why, Ambika Manhapra, C. Stephen Foster

“…Conclusion: There may be a correlation between ocular inflammatory diseases with autoimmune mechanism and the mRNA COVID-19 vaccination.…”
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Analysis of medical services provided to patients with ankle sprains in Korea between 2015 and 2017: a cross-sectional study of the health insurance review and assessment service n... by In-Hyuk Ha, Boyoung Jung, Jiyoon Yeo, Dongwoo Nam, Ho-sun Ryu, Jae-Hong Kim

“…Objectives To provide useful information for policy-makers and clinicians by analysing the medical service use—divided into Western medicine (WM) and Korean medicine (KM)—of patients with ankle sprains in South Korea between 2015 and 2017.Design Cross-sectional, retrospective, observational study.Setting Tertiary hospitals, WM hospitals, WM clinics, KM hospitals, KM clinics and others in South Korea.Participants We analysed claim data and patient information from the 2015 to 2017 Health Insurance Review and Assessment National Patient Sample (HIRA-NPS) dataset, including 151 415 patients diagnosed with a ‘dislocation, sprain and strain of joints and ligaments at ankle and foot level’ (10th revision of the International Statistical Classification of Diseases code S93) who used medical services at least once in 3 years between January 2015 and December 2017 in South Korea.Primary and secondary outcome measures Cost of medical care, number of consultations, type of institution visited, types of treatment.Results There were 160 200 consultations and 53 044 patients in 2015, 149 956 consultations and 50 830 patients in 2016 and 140 651 consultations and 47 541 patients in 2017. …”
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Effects of oral Lcarnitine supplementation on liver enzymes in pediatric acute lymphoblastic leukemia patients in the maintenance phase of treatment: a randomized clinical trial st... by Aziz Eghbali, Aygin Eghbali, Neda Ashayeri, Fatemeh Fadayi, Kazem Ghaffari, Kazem Ghaffari, Kazem Ghaffari, Ali Ghasemi, Ali Ghasemi

“…BackgroundGiven that liver diseases and subsequent increases in liver enzymes are among the most frequent complications observed in leukemia patients treated with chemotherapeutic drugs, this study aimed to assess the impact of oral Lcarnitine supplementation on liver enzyme levels the maintenance phase of treatment for pediatric acute lymphoblastic leukemia (ALL) patients.MethodsIn this clinical trial, 100 pediatric patients aged >5 years were divided into two groups after obtaining informed consent. …”
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Relationship Between Body Mass Index and Low Skeletal Muscle Mass in Adults Based on NHANES 2011–2018 by Rong-Zhen Xie, Xu-Song Li, Fang-Di Zha, Guo-Qing Li, Wei-Qiang Zhao, Yu-Feng Liang, Jie-Feng Huang

“…Weighted multivariable logistic regression assessed associations between BMI and low muscle mass, adjusting for confounders such as age, gender, ethnicity, income-to-poverty ratio, and chronic diseases (e.g., diabetes and hypertension). Variance inflation factors (VIF) confirmed the absence of multicollinearity. …”
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A tendency towards leaf rust resistance decrease in common wheat introgression lines with genetic material from Aegilops speltoides Tausch by L. Ya. Plotnikova, L. V. Meshkova, E. I. Gultyaeva, O. Р. Mitrofanova, I. F. Lapochkina

“…The species Aegilops speltoides Tausch (2n = 14, SS) is considered a promising issue of genes to protect bread wheat from diseases. The objective of this study was the monitoring of resistance to leaf rust of Ae. speltoides ac­cessions and introgressive lines and cultivars with genetic material of this species to the Western Siberian popula­tion of fungus. …”
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Prospective surveillance study to detect antimalarial drug resistance, gene deletions of diagnostic relevance and genetic diversity of Plasmodium falciparum in Mozambique: protocol by Alexandra Wharton-Smith, Caterina Guinovart, Pedro Aide, Francisco Saute, Alfredo Mayor, Bryan Greenhouse, Baltazar Candrinho, Joshua L Proctor, Arantxa Roca-Feltrer, Clemente da Silva, Eduard Rovira-Vallbona, Craig Bonnington, Caitlin Bever, Arlindo Chidimatembue, Maria Rodrigues, Neide Canana, Paulo Arnaldo, Simone Boene, Sonia Enosse

“…Introduction Genomic data constitute a valuable adjunct to routine surveillance that can guide programmatic decisions to reduce the burden of infectious diseases. However, genomic capacities remain low in Africa. …”
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Assessing cross-country inequalities in global burden of gastrointestinal cancers: slope and concentration index approach by Haoyun Zhou, Yongbo Wang, Fang Wang, Runtang Meng, Yong Yu, Su Han, Yu Zhang, Yu Wu, Xiaoxue Liu

“…Methods Data from the Global Burden of Diseases Study 2019 were analyzed to examine trends in disability-adjusted life-years (DALYs) for three gastrointestinal cancers with estimated annual percentage change (EAPC) and Joinpoint analysis. …”
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Comparison of prognosis for T4b rectal cancer with different pelvic compartment involvement treated using neoadjuvant chemoradiotherapy and implications for refinement of the curre... by Yang-zi Zhang, Maxiaowei Song, Shuai Li, Jian Tie, Xiang-gao Zhu, Yong-heng Li, Ai-wen Wu, Yong Cai, Wei-hu Wang

“…Purpose: Although classified as one stage, T4b rectal cancer actually represents a group of heterogeneous diseases. Our study aimed to assess the prognosis difference of T4b rectal cancer involving inferior pelvic and other pelvic compartments. …”
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Association of iron deficiency anemia with dental caries in the permanent first molars of children aged 7–12 years in Karachi, Sindh, Pakistan: protocol for an analytical cross-sec... by Iqbal Azam, Ali Faisal Saleem, Farhan Raza Khan, Shiyam S Tikmani, Sadaf Syed, Waseem Ahmed Jamalvi

“…Introduction Iron deficiency anaemia (IDA) and dental caries are prevalent diseases among Pakistani children. Limited research has been done to explore their association with permanent teeth. …”
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Electroacupuncture may protect pulmonary dysplasia in offspring with perinatal nicotine exposure by altering maternal gut microbiota and metabolites by Yana Xie, Yang Fang, Yitian Liu, Bo Ji, Reiko Sakurai, Yifei Wang, Hewen Li, Ling Zhang, Le Wu, Tingting Guo, Ye Quan, Virender K. Rehan

“…BackgroundPerinatal nicotine exposure (PNE) induces pulmonary dysplasia in offspring and it increases the risk of respiratory diseases both in offspring and across generations. …”
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An experimental study of the effects of SNPs in the TATA boxes of the <i>GRIN1, ASCL3</i> and <i>NOS1</i> genes on interactions with the TATA-binding protein by E. B. Sharypova, I. A. Drachkova, I. V. Chadaeva, M. P. Ponomarenko, L. K. Savinkova

“…For instance, these genes contribute to the development of schizophrenia, Alzheimer’s and Parkinson’s diseases, and epilepsy. These genes are also associated with various cancers. …”
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South American species <i>Solanum alandiae</i> Card. and <i>S. okadae</i> Hawkes et Hjerting as potential sources of genes for potato late blight resistance by O. A. Muratova (Fadina), M. P. Beketova, M. A. Kuznetsova, E. V. Rogozina, E. E. Khavkin

“…For several decades, wild species of Solanum L. section Petota Dumort. have been involved in potato cultivar breeding for robust resistance to pests and diseases. Potato late blight (LB) is caused by oomycete Phytophthora infestans (Mont.) de Bary, and the genes for race-specific resistance to P. infestans (Rpi genes) have been introgressed into cultivated potatoes by remote crosses and trans- or cisgenesis, first from S. demissum Buk. and, more recently, from other wild species, such as S. bulbocastanum Dun., S. stoloniferum Schlechtd. et Bché, and S. venturii Hawkes et Hjerting (according to the nomenclature by Hawkes, 1990). …”
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Genotypic and phenotypic characterization of antimicrobial resistance in Salmonella strains isolated from both No-Antibiotics-Ever (NAE) and conventional broiler complexes by Yagya Adhikari, Dianna V. Bourassa, Sabin Poudel, Matthew A. Bailey, Richard J. Buhr, Kenneth S. Macklin

“…Antimicrobial resistance is a serious global public health concern that could endanger the efficacy of antibiotics used for the treatment of diseases in humans, animals, and plants. The objective of this study was to characterize the antimicrobial resistance (AMR) pattern of Salmonella strains isolated from different stages of both No-Antibiotics-Ever (NAE) and conventional integrated broiler complexes. …”
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Quality profile of milk from high producing dairy cows vaccinated against mastitis by M. N. Isakova, U. V. Sivkova, M. V. Ryaposova, I. A. Shkuratova, A. V. Lysov

“…One of the raw milk quality criteria is the count of somatic cells, produced by the cow’s immune system to fight infectious diseases of the mammary gland. The paper presents the analysis of somatic cell count and total bacteria count of milk from cows, vaccinated against mastitis using Startvac vaccine. …”
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The potential of the amaranth collection maintained at VIR in the context of global plant breeding and utilization trends by D. V. Sokolova, A. E. Solovieva, A. M. Zaretsky, T. V. Shelenga

“…Targets of breeding practice for amaranth include such characteristics as large size and nonshattering of seeds, short stem, earliness, high yield, cold hardiness, synchronized maturation, resistance to pests and diseases, and high nutritional value, including the content and quality of protein, lipids, squalene, and bioactive compounds. …”
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Effect of long-term transcutaneous auricular vagus nerve stimulation in multiple system atrophy-cerebellar subtype: a case report by Zhao-Di Wang, Zhao-Di Wang, Xiao-Ping Cheng, Zhen-Yi Liu, Di Wu, Jun Ni, Chuan-Juan Chen, Chuan-Juan Chen, Xin-Yuan Chen, Xin-Yuan Chen

“…In recent years, it has been established that taVNS has significant therapeutic effects on epilepsy, depression, migraine, insomnia, and other diseases. Hence, we performed taVNS treatment for one MSA-C patient to explore whether taVNS could alleviate patient’s motor and non-motor symptoms.Case presentationA 65-year-old woman diagnosed with MSA-C received taVNS treatment for the following duration and course: once a day, 40 min a time, 20 times a month continually for 12 months. …”
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