Antibacterial Effect of Sea Buckthorn ( Hippophae rhamnoides L.) Fruit Extract on Radish Seeds Prior to Sprouting by Katarzyna Rajkowska, Emilia Rykała, Agata Czyżowska

“…However, they can be sources of foodborne bacterial diseases, including sprout-related outbreaks caused primarily by Shiga toxin-producing Escherichia coli and Salmonella spp. …”
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Value-based healthcare for social insurance medicine: key enablers for adoption in practice by Sylvia J van der Burg-Vermeulen, Philip J van der Wees, Jan L Hoving, Nina Zipfel, Marijke Melles, Marije E Hagendijk

“…Background Driven by rising retirement age and increasing prevalence of chronic diseases impacting work participation, there is an increasing need for quality and efficiency improvement in social insurance medicine (SIM). …”
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Long-Term Results After Laparoscopic Lavage for Perforated Diverticulitis Purulent Peritonitis in Sweden: A Population-Based Observational Study by Andreas Samuelsson, MD, David Bock, PhD, Mattias Prytz, MD, PhD, Carolina Ehrencrona, BSc, Anette Wedin, RN, Eva Angenete, MD, PhD, Eva Haglind, MD, PhD

“…The cohort was retrieved from the national patient register by a definition based on the Classification of Diseases and Related Health Problems-10 code plus the surgical procedural code. …”
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Unique pharmacological properties of etrasimod among S1P receptor modulators by Ibragim Gaidarov, H. Kiyomi Komori, Dariusz T. Stepniak, Karin Bruinsma, Huong Dang, Xiaohua Chen, Todd Anthony, Joel Gatlin, Lisa Karimi‐Naser, Anh‐Tuan Ton, Tim Indersmitten, Paul E. Miller, Andre Ghetti, Najah Abi‐Gerges, David Unett, Hussien Al‐Shamma, Christopher J. Rabbat, Catherine Crosby, John W. Adams

“…Etrasimod (ADP334) is an oral, once‐daily, selective sphingosine 1‐phosphate (S1P)1,4,5 receptor modulator for the treatment of moderately to severely active ulcerative colitis and in development for the treatment of immune‐mediated inflammatory diseases. Interaction between S1P and its five receptor subtypes (S1P1–S1P5) plays a role in several physiologic systems, including the cardiovascular and immune systems. …”
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Integrated course on ocular anatomy for ophthalmology clerkship by Li Huang, Xinyu Liu, Yuxian Zou, Xianchai Lin, Zhen Mao

“…Abstract Background Obtaining a full understanding of the anatomical structure of the eyeball and the contents within the eye plays a crucial role in learning eye diseases. However, it can be challenging for beginners to quickly learn, memorize, and apply this anatomical knowledge. …”
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Evaluation of Melatonin and Antioxidant Levels in the Serum of Breast Cancer Patients by Amjad Mahmood Qadir, Arzu Karatepe, Ayşegül Yazici, Rzgar Farooq Rashid, Pelin Koparir, Rebaz A. Omer, Shamal R. Hama

“…Metabolites and antioxidants can be altered in patients with various diseases, particularly in those with cancer. This study aims to measure melatonin and total antioxidant levels in the serum of breast cancer patients and compare them with a healthy control group. …”
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THE POSSIBILITIES OF TREATMENT OF PATIENTS WITH MALIGNANT NEOPLASMS OF THE FEMALE REPRODUCTIVE SYSTEM WITH METASTATIC BRAIN LESION by A. M. Zaytsev, E. G. Novikova, O. N. Kirsanova, M. I. Kurzhupov, E. A. Potapova

“…The Union of our own experience of treatment of patients with ovarian cancer (OC), cervical cancer (СС) and endometrial cancer (EC) with brain metastases and data from literature to develop the tactics of conducting patients with these diseases. Patients and methods. The neurosurgical department of P. …”
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Obesity and Cardiometabolic Risk Stratification in Schoolchildren from Santa Clara by Elizabeth Fernández Martínez, Clara Luz Rodríguez Cervera, Emilio González Rodríguez, Yosvani García Nóbrega, Alianny Rodríguez Urrutia, Merlin Gari Llanes

“…<p><strong>Background:</strong> noncommunicable diseases have been among the leading causes of morbidity and mortality in the world and in Cuba for more than 20 years. …”
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Impact of tiered restrictions in December 2020 on COVID-19 hospitalisations in England: a synthetic control study by Daniel Hungerford, Benjamin Barr, Mark Green, Marta García-Fiñana, Iain Buchan, Xingna Zhang

“…Our findings suggest that regionally targeted restrictions can be effective in managing infectious diseases.…”
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Isoproterenol mechanisms in inducing myocardial fibrosis and its application as an experimental model for the evaluation of therapeutic potential of phytochemicals and pharmaceutic... by Lujain Bader Eddin, Mohamed Fizur Nagoor Meeran, Niraj Kumar Jha, Samer N. Goyal, Shreesh Ojha

“…Abstract Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fibrosis, which appears to be a leading cause of cardiovascular diseases. Cardiac fibrosis is characterized by the accumulation of extracellular matrix proteins, mainly collagen in the cardiac interstitium. …”
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PRMT5-Mediated ALKBH5 Methylation Promotes Colorectal Cancer Immune Evasion via Increasing CD276 Expression by Sen Meng, Hao Liu, Jiayu Xu, Chuyin Deng, Xingyou Qian, Sufang Chu, Wei-Guo Zhu, Jiuling Zhu, Hongmei Yong, Zhongwei Li, Jin Bai

“…Numerous diseases have been connected to protein arginine methylations mediated by protein arginine methyltransferase 5 (PRMT5). …”
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Rationale and design for the thoracic Paravertebral Adjunctive Dexamethasone Palmitate Reducing chronic pain After cardiac surgery (PANDORA) trial: a parallel-group, double-blinded... by Jing Zhao, Hui Zhang, Ziyu Zheng, Baobao Gao, Lini Wang, Chong Lei, Hailong Dong, Taoyuan Zhang, Jiao Gao, Lihong Hou

“…The primary endpoint is the incidence of chronic postoperative pain at 3 months following surgery defined as per the updated International Classification of Diseases. CPSP is defined as a new development of pain or increase in the intensity of pain at the surgical area or projected onto the innervation area of a nerve in this area after a surgical procedure that persists for at least 3 months. …”
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Whole-of-community interventions that address alcohol-related harms: protocol for a scoping review by Asha S George, Tanya Doherty, Mark Tomlinson, Nandi Siegfried, Ida Okeyo, Ulla Walmisley, Michelle De Jong, Carmen Späth, Nadine Harker

“…Introduction Alcohol-related harm is a rising global concern particularly in low-income and middle-income countries where alcohol use fuels the high rates of violence, road traffic accidents and is a risk factor for communicable diseases such as HIV/AIDS and tuberculosis. Existing evidence to address alcohol-related harm recommends the use of intersectoral approaches, however, previous efforts have largely focused on addressing individual behaviour with limited attention to whole-of-community approaches. …”
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Effect of oxytocin nasal spray pretreatment on postoperative acute stress disorder in patients with accidental traumatic fracture: a single-centre prospective randomised controlled... by Ling Ren, Qingqing Huang, Hengdi Zhang, Jingzheng Zeng, Yi Wen, Haifeng Shu, Gu Gong

“…Presently, oxytocin nasal spray has shown significant potential in the treatment of stress-related neuropsychiatric diseases. However, there are few reports on the use of oxytocin nasal spray in postoperative ASD, a condition that can potentially develop into a high-risk factor for post-traumatic stress disorder. …”
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miR-149 Alleviates Ox-LDL-Induced Endothelial Cell Injury by Promoting Autophagy through Akt/mTOR Pathway by Zhongsheng Zhu, Jinyu Li, Rui Tong, Xiaorong Zhang, Bo Yu

“…Atherosclerosis is a chronic process that takes place in the vascular wall and causes various cardiovascular diseases (CVDs). Micro-RNA-149 (miR-149) mediates many physiological and pathological processes, including atherosclerosis. …”
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Implant-Supported Rehabilitation Using GBR Combined with Bone Graft on a Reconstructed Maxilla with the Fibula Free Flap by S. Di Carlo, V. Valentini, E. Grasso, F. De Angelis, L. Piccoli, A. Quarato, S. Jamshir, E. Brauner

“…Alveolar ridge augmentation procedures allow restoring jaw defects due to teeth extractions, periodontal diseases, trauma, or outcomes from a previous surgery. …”
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New Insights Into Hepatic Impairment (HI) Trials by Sebastian Haertter, Maximilian Lobmeyer, Brian C. Ferslew, Pallabi Mitra, Thomas Arnhold

“…ABSTRACT Hepatic impairment (HI) trials are traditionally part of the clinical pharmacology development to assess the need for dose adaptation in people with impaired metabolic capacity due to their diseased liver. This review aimed at looking into the data from dedicated HI studies, cluster these data into various categories and connect the effect by HI with reported pharmacokinetics (PK) properties in order to identify patterns that may allow waiver, extrapolations, or adapted HI study designs. …”
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Evaluation of a PCR-based lateral flow device for detecting Aspergillus and Candida species from clinical specimens by Ariff Khalid, Jacinta Santhanam, Mohd Nizam Tzar, Ang-Lim Chua, Sharifah Fadilah Abdul Wahid, Wan Rahiza Wan Mat, Raha Abd Rahman, Petrick Periyasamy

“…Objectives: The diagnosis of invasive fungal diseases (IFDs) is time consuming and lacks sensitivity. …”
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Systematic analysis of co-expression network and gene expression profile of differentially expressed lncRNA-mRNA one week after spinal cord injury by Yi Kang, Yijie Song, Zhongju Shi, Qiang Li, Yigang Lv, Mengfan Hou, Cui Ding, Jing Xie, Yongfu Lou, Chi Zhang, Huan Jian, Xueying Li, Hengxing Zhou, Shiqing Feng

“…Long noncoding RNAs (lncRNAs) have already been proven to play key roles in different diseases of the CNS. Nevertheless, the roles of messenger RNAs (mRNAs) and lncRNAs one week after SCI remain to be elucidated. …”
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Biomimetic bioreactor for potentiated uricase replacement therapy in hyperuricemia and gout by Bin Yang, Bin Yang, Guihu Luo, Tailei Nie, Zhenglan Ban, Quanxin Ning, Jialin Zhang, Xiangru Liu, Yanhua Lin, Xiaochun Xie, Qianyun Chen, Han Zhong, Ying Huang, Pan Liao, Yan Liu, Chenyang Guo, Chuanxu Cheng, Erwei Sun, Erwei Sun

“…This platform holds potential for broader applications in protein or antibody delivery for enzyme replacement therapies in other diseases.…”
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