Non3 is an essential Drosophila gene required for proper nucleolus assembly by E. N. Andreyeva, A. A. Ogienko, A. A. Yushkova, J. V. Popova, G. A. Pavlova, E. N. Kozhevnikova, A. V. Ivankin, M. Gatti, A. V. Pindyurin

“…Consistent with its multiple functions, the nucleolus has been implicated in many human diseases, including cancer and degenerative pathologies of the nervous system and heart. …”
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Correlation between ellipsoid zone thickness and the presence of subretinal drusenoid deposits in age-related macular degeneration by Richard B Rosen, Roland Theodore Smith, Gerardo Ledesma-Gil, Oscar Otero-Marquez, Yuehong Tong, Katy Tai, Gareth M C Lema, Raymond Matthew Bellis, Yang Fei, Brandon Le

“…Purpose Subretinal drusenoid deposits (SDDs) in age-related macular degeneration (AMD) are associated with systemic vascular diseases that compromise ocular perfusion. We demonstrate that SDDs are associated with decreased ellipsoid zone (EZ) thickness, further evidence of hypoxic damage.Methods Post hoc analysis of a cross-sectional study. 165 AMD subjects (aged 51–100; 61% women). …”
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Occurrence of Helicobacter pylori in drinking water sources and antimicrobial resistance profile in the central region of Peru by María Custodio, Raúl Montalvo-Otivo, Jhonatan Crispín-Ayala, Jeampier Bendezu-Meza, Pilar Herrera-Quintana, Heidi De la Cruz, Javier Huarcaya

“…Introduction: Contamination of drinking water by Helicobacter pylori can cause serious diseases, including cancer. The determinants of the infection rate are socioeconomic status, low standard of living and overcrowding. …”
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miR-129-5p Regulates the Immunomodulatory Functions of Adipose-Derived Stem Cells via Targeting Stat1 Signaling by He-Yang Zhang, Yu-Han Wang, Yan Wang, Yan-Nv Qu, Xiao-Hui Huang, Hui-Xin Yang, Chang-Ming Zhao, Youdi He, Si-Wei Li, Jin Zhou, Changyong Wang, Xiao-Xia Jiang

“…ASCs with miR-129-5p knockdown alleviated inflammatory bowel diseases and promoted tumor growth in vivo. Consistently, ASCs that overexpressed miR-129-5p exhibited reduced iNOS expression. …”
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Effects of 3D Bone Models on Anatomy Education: Student Survey by Betül Sevindik, Nadire Ünver Doğan, Mustafa Koplay, İsmail Kapurtu, Mehmet Cengiz Tatar, Büşra Pirinç, Ekrem Solmaz

“…Knowledge of human anatomy plays a critical role in the diagnosis of diseases, surgical interventions, evaluation of the health status of patients, and interpretation of the results of advanced imaging techniques. …”
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Early versus Delayed Phacoemulsification and Intraocular Lens Implantation for Acute Primary Angle-Closure by Yun-Hsuan Lin, Cheng-Hsiu Wu, Shih-Ming Huang, Chen Hsieh, Henry Shen-Lih Chen, Wan-Chen Ku, Ming-Hui Sun, Wei-Wen Su

“…Patients with acute PAC were included in the study, and those with secondary glaucoma, prior ocular trauma, or other ocular diseases and those who had undergone ocular surgeries previously were excluded. …”
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Quercetin Alleviates Hyperglycemic-Generated Endoplasmic Reticulum Stress-Contacted Apoptosis of Rat Nucleus Pulposus Cells by Zhen Yu, Xianfeng Wang, Yusen Hu, Xinfa Wang, Zhenghuan Zhu, Xu Xu, Yiming Wang, Ailiang Zhang

“…Quercetin, a naturally occurring flavonoid, exerts protective effects against degenerative diseases via ER stress. However, the effect of quercetin on NP cell apoptosis remains unclear. …”
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Synthesis and application of zinc oxide nanoparticles in Pieris brassicae larvae as a possible pesticide effect by Isabella Martins Lourenço, Amedea Barozzi Seabra, Marcelo Lizama Vera, Nicolás Hoffmann, Olga Rubilar Araneda, Leonardo Bardehle Parra

“…Formulations of nanopesticides can provide unique characteristics such as size and shape, in addition to having integrated properties in a single material, making them efficient in pest management and protection against diseases in a single material; it can be applied in small volumes, with a greater precision, lower input costs, and a potential reduction in environmental contamination. …”
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A randomized controlled study on the effectiveness of a diabetes self-management app in Bangladesh by Bilkis Banu, Nasrin Akter, Sujana Haque Chowdhury, Nusrat Hossain Sheba, Md. Abdul Hakim Majumder

“…This successful model of intervention holds the potential for nationwide replication, offering a viable approach for self-managing diabetes and other non-communicable diseases to enhance patient outcomes and reduce healthcare burdens.…”
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Influence of prenatal hexachlorobenzene, PCB and selenium levels on growth trajectories in the first year of life: Findings from the NEHO birth cohort by Ilaria Cosentini, Silvia Ruggieri, Paolo Colombo, Fabrizio Bianchi, Liliana Cori, Melania Casella, Elisa Eleonora Tavormina, Fabio Cibella, Gaspare Drago

“…Prenatal exposure to endocrine-disrupting chemicals (EDCs) may impact postnatal growth trajectories, increasing the risk of various diseases later in life. This issue is of particular concern in industrially contaminated areas, where environmental matrices contain mixtures of pollutants. …”
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Molecular Analysis of a Genetic Variants Panel Related to Nutrients and Metabolism: Association with Susceptibility to Gestational Diabetes and Cardiometabolic Risk in Affected Wom... by Marica Franzago, Federica Fraticelli, Antonio Nicolucci, Claudio Celentano, Marco Liberati, Liborio Stuppia, Ester Vitacolonna

“…Women with a GDM history are at increased risk of developing diabetes and cardiovascular diseases. Studies have demonstrated a significant correlation between several genes involved in the metabolic pathway of insulin and environmental factors. …”
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Luteolin Attenuates IL-1β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF-κB and MAPK Pathways by Wen-Chung Huang, Chian-Jiun Liou, Szu-Chuan Shen, Sindy Hu, Chien-Yu Hsiao, Shu-Ju Wu

“…Inflammation is a critical mediator in retinal degeneration (RD) diseases, including age-related macular degeneration (AMD), and RD progression may be prevented through anti-inflammatory activity in RPE cells. …”
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The neutrophil percentage-to-albumin ratio is an independent risk factor for poor prognosis in peritoneal dialysis patients by Mingfan Xu, Jingjia Huan, Lujie Zhu, Jiachun Xu, Kai Song

“…A total of 243 (30.1%) patients passed away, with 128 (52.7%) succumbing to cardio-cerebrovascular diseases. The mortality rates of the Middle and High NPAR groups were significantly greater than that of the Low NPAR group (p < 0.001), and NPAR was independently associated with all-cause mortality and cardio-cerebrovascular mortality. …”
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Identification of compounds against atherosclerosis induced by ox-LDL based on cell extraction/UPLC–MS/MS from mulberry twigs and their mechanistic analysis by Zhihui Jin, Wei Xiang, Xiaowen Shi, Fenglin Jiang, Yanan Jia, Yuansong Zhang, Lingshu Zeng, Xianzhi Huang, Li Xu

“…These compounds hold potential in treating atherosclerosis and related oxidative stress diseases. Graphical Abstract…”
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Key regions aberrantly connected within cerebello-thalamo-cortical circuit and their genetic mechanism in schizophrenia: an fMRI meta-analysis and transcriptome study by Yarui Wei, Ziyu Wang, Kangkang Xue, Xiaoyu Niu, Longyao Ma, Shaoqiang Han, Baohong Wen, Yong Zhang, Huafu Chen, Jingliang Cheng

“…SCZ was characterized by hyperconnectivity of the auditory network, visual system, and sensorimotor areas, and hypoconnectivity of the frontal gyrus, cerebellum, thalamus, and caudate nucleus, which were significantly linked to age, sex, duration of illness, and the severity of symptoms and functionally enriched in domains involving self, sensory, action, and social. 2922 genes were significantly over-expressed in these regions, which were enriched for important molecular functions, biological processes, and cellular components of the neurons/cells in the brain as well as SCZ and other mental diseases. These genes were specially expressed in the brain tissue, in the neurons of the cerebellum, subcortex and cortex and during nearly all developmental stages, and constructed a protein-protein interaction network supported by 85 hub genes with functional significance. …”
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Efficacy of various regimens of bioactive marine fish concentrate, glucosamine sulfate, and chondroitin sulfate in treating knee osteoarthritis by D.G. Rekalov, I.O. Daniuk, R.L. Kulinich, T.M. Tarasenko, E.Yu. Samofal, O.Ye. Akimov, V.O. Kostenko

“…Osteoarthritis (OA) is one of the most common joint diseases worldwide. The search for effective treatment regimens to reduce symptoms and improve joint function is essential. …”
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Evaluating NfL and NTproBNP as predictive biomarkers of intracranial injuries after mild traumatic brain injury in children presenting to emergency departments by Anne-Cécile Chiollaz, Virginie Pouillard, Michelle Seiler, Céline Habre, Fabrizio Romano, Céline Ritter Schenck, Fabian Spigariol, Christian Korff, Fabienne Maréchal, Verena Wyss, Lyssia Gruaz, Joan Montaner, Jean-Charles Sanchez, Sergio Manzano

“…Their performances were comparable to well-known biomarkers, such as S100b, GFAP, or HFABP, with the benefit of already being used in routine tests for other diseases. Further large-scale studies are necessary to verify and validate these results.…”
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Simultaneous Determination of 13 Constituents of Radix Polygoni Multiflori in Rat Plasma and Its Application in a Pharmacokinetic Study by Wenhao Cheng, Yinghui Li, Wei Yang, Siyang Wu, Mengmeng Wei, Yang Gao, Chen Kang, Shuofeng Zhang, Yingfei Li

“…Radix Polygoni Multiflori (RPM) has been widely used to treat various diseases in Asian countries for many centuries. Although, stilbenes and anthraquinones, two major components of RPM, show various bioactive effects, it has been speculated that the idiosyncratic hepatotoxicity induced by RPM may be related to these constituents. …”
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Research on a traditional Chinese medicine case-based question-answering system integrating large language models and knowledge graphs by Yuchen Duan, Qingqing Zhou, Yu Li, Chi Qin, Ziyang Wang, Hongxing Kan, Hongxing Kan, Jili Hu, Jili Hu

“…This study aimed to address these issues by leveraging modern data techniques to improve access and analysis of TCM case records.MethodsA total of 679 case records from Wang Zhongqi, a renowned physician of Xin’an Medicine, a branch of TCM, covering 41 diseases, were selected. The study involved four stages: pattern layer construction, knowledge extraction, integration, and data storage and visualization. …”
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Protective effect of resveratrol on retinal damage in glaucoma: a systematic review and meta-analysis of preclinical studies by Feng Zhang, Feng Zhang, Tao Li, Junli Wan, Junli Wan, Lu Wang, Lu Wang, Wenmei Guo, Wenmei Guo, Yue Hu, Yue Hu, Hao Wang, Hao Wang, Wei Bian, Wei Bian

“…However, given that the animal research models utilized in the study may not fully reflect the intricate scenarios of multiple coexisting diseases in clinical settings, and the administration methods in animal models may differ from those in clinical practice, future studies should aim to provide higher levels of evidence to facilitate the clinical translation of these findings.Systematic Review Registration:identifier [CRD42024535673].…”
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