Serum assisted PD-L1 aptamer screening for improving its stability by Yu Zhou, Haozhe Zhang, Yujing Ding, Changyuan Yu, Hao Li

“…Abstract Aptamers have shown potential for diagnosing clinical markers and targeted treatment of diseases. However, their limited stability and short half-life hinder their broader applications. …”
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Projecting the Potential Budget Impact Analysis of Paliperidone Palmitate in Egyptian Adult Patients with Schizophrenia by Gihan Elsisi, Mohamed Ezzat, Mohamed Ramadan

“…**Background:** Schizophrenia is a serious mental disorder that has greater negative consequences on role functioning than many other severe chronic diseases. **Objective:** We evaluated the economic impact of long-acting injections of paliperidone palmitate (PP) vs daily oral antipsychotics to treat chronic schizophrenia from a societal perspective over a 2-year period. …”
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Progress in the Application of Resting-State Functional Magnetic Resonance Imaging in Chronic Nonspecific Low Back Pain by XU Ting, XUE Qin, LÜ Ying, TU Jianchun, DAI Dechun

“…Chronic Nonspecific Low Back Pain (CNLBP) is one of the common diseases in orthopedics and rehabilitation medicine. …”
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The Association between Birth Weight and Gestational Age and Asthma in 6-7- and 13-14-Year-Old Children by Zamani Raheleh, Alikhani Ahmad, Heydarzadeh Abtin, Zare Roghaye, Hashemain Sara, Rahimi Siavash

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Association of Phthalate Exposure with Thyroid Function and Thyroid Homeostasis Parameters in Type 2 Diabetes by Yi Chen, Wen Zhang, JingSi Chen, Ningjian Wang, Chi Chen, Yuying Wang, Heng Wan, Bo Chen, Yingli Lu

“…Concurrent urine and blood samples were collected from 639 participants with type 2 diabetes in the METAL (Environmental Pollutant Exposure and Metabolic Diseases in Shanghai) study. We measured urinary concentrations of thirteen phthalate metabolites along with serum levels of thyroid-stimulating hormone (TSH), total T4 and T3, free T4 (FT4) and T3 (FT3), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb). …”
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Food habit, physical activity and nutritional status of adolescents in selected schools of Madhyapur Thimi municipality, Nepal: A cross-sectional study. by Samiksha Baral, Anil Kumar Singh, Arjun Aryal, Jwala Subedi, Utsav Dhakal, Anita Khanal

“…Focusing on the nutritional needs of adolescents could be a significant step toward breaking the vicious cycle of malnutrition, chronic diseases, and poverty. This study aims to assess food habit, levels of physical activity and nutritional status of adolescents in Madhyapur Thimi Municipality, Bhaktapur. …”
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Downregulation of miR-223 promotes HMGB2 expression and induces oxidative stress to activate JNK and promote autophagy in an in vitro model of acute lung injury by Hao-Yu Tan, Bei Qing, Xian-Mei Luo, Heng-Xing Liang

“…Previous studies have shown that microRNAs (miRs) are involved in regulating autophagy in several diseases. This study aimed to determine the role of miR-223 in excessive autophagic activity in alveolar epithelial cells and the underlying mechanism to identify a novel therapeutic targets for the development of new drugs to treat acute respiratory distress syndrome (ARDS). …”
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Determinants of inappropriate antibiotic prescription in primary care in developed countries with general practitioners as gatekeepers: a systematic review and construction of a fr... by Mattijs E Numans, Frederike L Büchner, Martijn Sijbom, Nicholas H Saadah, Mark G J de Boer

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Drug consumption and treatment costs of the glaucoma therapy in the Republic of Serbia by Ćoškov Aleksandra D., Savanović Dijana R., Todorović Nemanja B., Lalić-Popović Mladena N., Tomić Nataša Z., Milijašević Boris Ž.

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Association of Metabolic Syndrome with the Adiponectin to Homeostasis Model Assessment of Insulin Resistance Ratio by Yu-Song Ding, Shu-Xia Guo, Ru-Lin Ma, Shu-Gang Li, Heng Guo, Jing-Yu Zhang, Mei Zhang, Jia-Ming Liu, Jia He, Yi-zhong Yan, Wen-Jie Zhang, Lie-Gang Liu

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Use of the Hyperbaric Chamber Versus Conventional Treatment for the Prevention of Amputation in Chronic Diabetic Foot and the Influence on Fitting and Rehabilitation: A Systematic... by María Dolores Apolo-Arenas, Laura Guerrero-Nogales, César Luis Díaz-Muñoz, Berta Caro-Puértolas, José Alberto Parraca, Alejandro Caña-Pino

“…Diabetes mellitus (DM) is one of the most common chronic endocrine diseases, characterized by hyperglycemia, due to abnormal nitric oxide synthesis. …”
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Microbial signatures in head and neck squamous cell carcinoma: an in silico study by Loganathan KAVITHA, Manogaran KUZHALMOZHI, Jayaseelan VIJAYASHREE PRIYADHARSINI, Arunachalam ARUN KUMAR, Krishna Mohan Rao UMADEVI, Kannan RANGANATHAN

“…Dysbiosis of oral and gut microbiota is associated with several oral and systemic pathologies, such as cancer, obesity, diabetes, atherosclerosis and gastrointestinal diseases. Imbalance in the oral-gut microbial axis has been associated with head and neck squamous cell carcinoma (HNSCC). …”
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Prevalence of Gastric and Small-Intestinal Mucosal Injury in Elderly Patients Taking Enteric-Coated Aspirin by Magnetically Controlled Capsule Endoscopy by Feng Gao, Xue Chen, Jie Zhang

“…Sixty-eight patients (34 per group) taking enteric-coated aspirin were recruited, and the elderly and middle-aged groups did not differ significantly in sex, history of smoking, history of alcohol consumption, body mass index, or accompanying diseases. In the elderly and middle-aged groups, the gastric Lanza scores were 2.0 (2.0, 3.0) and 2.0 (1.0, 3.0; P=0.192), the numbers of patients with small-intestinal mucosal injuries (at least one erosion and/or ulcer) were 30 (88.2%) and 15 (44.1%; P<0.001), the numbers of patients with more severe small-intestinal mucosal injuries (larger erosion and/or ulcer) were 11 (32.4%) and 3 (8.8%; P=0.033), the numbers of patients with ileal erosion were 22 (64.7%) and 8 (23.5%; P=0.001), and the durations of aspirin use were 30.0 (12.0, 120.0) and 10.5 (2.0–48.0) months (P=0.007), respectively. …”
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Anticataract Effect of the Aqueous Extract of the Flowers of Aspilia africana in Murine Model of Diabetic and Age-Related Cataracts by Adwoa Frema Amanfo, Samuel Kyei, Yaw Duah Boakye, Clement Osei Akoto, Justice Kwaku Addo, Kofi Oduro Yeboah, Newman Osafo

“…The use of Aspilia africana in traditional medicine for the management of ocular diseases has been reported in India and some indigenous communities of Africa. …”
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Effects of dietary supplementation of combined safflower meal and sunflower meal on fattening performance and carcass quality characteristics in quails by Tuba Bulbul, Elmas Ulutas, Vural Ozdemir, Aziz Bulbul, Mustafa Evcimen

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A Randomized Comparative Trial on the Therapeutic Efficacy of Topical Aloe vera and Calendula officinalis on Diaper Dermatitis in Children by Yunes Panahi, Mohamad Reza Sharif, Alireza Sharif, Fatemeh Beiraghdar, Zahra Zahiri, Golnoush Amirchoopani, Eisa Tahmasbpour Marzony, Amirhossein Sahebkar

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NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation by Agata Habas, Srinivasa Reddy Natala, Jon K. Bowden-Verhoek, Emily M. Stocking, Diana L. Price, Wolfgang Wrasidlo, Douglas W. Bonhaus, Martin B. Gill

“…A growing body of evidence suggests that excessive TLR-mediated innate immune system activation can lead to neuronal damage and precipitate or perpetuate neurodegenerative diseases. Among TLR subtypes, both TLR2 and TLR9 have been implicated in neurodegenerative disorders with increased expression of these receptors in the central nervous system being associated with pro-inflammatory signaling and increased burdens of pathologic aggregated proteins. …”
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Developing a Robust Model Based on the Gaussian Process Regression Approach to Predict Biodiesel Properties by Inna Pustokhina, Amir Seraj, Hafsan Hafsan, Seyed Mojtaba Mostafavi, S. M. Alizadeh

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A Co-Evolutionary Genetic Algorithm Approach to Optimizing Deep Learning for Brain Tumor Classification by Abdelmgeid A. Ali, Mohamed T. Hammad, Hassan S. Hassan

“…Brain tumors are among the deadliest diseases, leading researchers to focus on improving the accuracy of tumor classification&#x2014;a critical task for prompt diagnosis and effective treatment. …”
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Genebanks and market participation: evidence from groundnut farmers in Malawi by Martin Paul Jr. Tabe-Ojong, Melinda Smale, Nelissa Jamora, Vania Azevedo

“…Our analysis indicates that access to genetic resources from genebanks has resulted in the development of improved varieties with traits that are preferred by farmers such as higher yields and resistance to diseases. The adoption of these improved varieties led to increased production surplus and reduced transaction costs, allowing farmers to better participate in local groundnut markets. …”
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