Cohort profile: the East London Health and Care Partnership Data Repository: using novel integrated data to support commissioning and research by George Howard, Kamaldeep Bhui, Amy Ronaldson, Evangelos Chandakas, Qiongwen Kang, Katie Brennan, Aminat Akande, Irene Ebyarimpa, Eleanor Wyllie, Richard Fradgley, Mark Freestone

“…Data completeness for risk factors (eg, blood pressure, cholesterol) was high in patients with long-term conditions.Future plans The data are being further cleaned and evaluated using imputation, Bayesian and economic methods, principally focusing on specific cohorts, including type II diabetes, depression and personality disorder. Data continue to be collected for the foreseeable future to support commissioning decisions, which will also enable more long-term prospective analysis as data become available at the end of each financial year.…”
Get full text

Problems of healing chronic wounds by N. M. Babenko, O. B. Litvinova, S. B. Pavlov, M. V. Kumechko, V. V. Komarchuk

“…In the case of systemic diseases, such as diabetes, cardiovascular pathology, etc., there is a violation of microcirculation, and as a result, there are violations of the phasing of reparative processes at the cellular level. …”
Get full text

Unveiling the biological activities of Heliotropium indicum L. plant extracts: anti-inflammatory activities, GC–MS analysis, and in-silico molecular docking by Mst. Sadia Afroz Shoily, Md. Ekramul Islam, Nur Mohammad Rasel, Shahnaz Parvin, Jaytirmoy Barmon, Aqibul Hasan Aqib, Debendra Nath Roy, Mst. Shahnaj Parvin

“…Abstract Heliotropium indicum is well-known for its diverse medicinal properties, traditionally utilized to treat ailments such as diabetes, obesity, bacterial infections, inflammation, and diarrhea. …”
Get full text

Impacts of Pta-AckA pathway on CPS biosynthesis and type 3 fimbriae expression in Klebsiella pneumoniae by Tien-Huang Lin, Chen-Yu Wang, Chien-Chen Wu, Ching-Ting Lin

“…Background: Klebsiella pneumoniae is a Gram-negative bacterium that can cause infections, especially in individuals with diabetes. Recently, more hypervirulent strains have emerged, posing a threat even to healthy individuals. …”
Get full text

Characteristics and Outcomes of Younger Adults with Embolic Stroke of Undetermined Source (ESUS): A Retrospective Study by Ali M. Al Khathaami, Bayan Al Bdah, Abdulmjeed Alnosair, Abdulkarim Alturki, Rayan Alrebdi, Shorug Alwayili, Sulaiman Alhamzah, Fahad A. M. AlKhathaami, Nasser Alotaibi

“…Younger adults compared with older adults with ESUS had fewer vascular risk factors, including lower rates of hypertension (43.6% vs. 70.3%; P=0.004), diabetes (35.9% vs. 57.4%; P=0.03), and dyslipidaemia (12.8% vs. 28.7%; P=0.05). …”
Get full text

Risk of pneumonia in patients with isolated minor rib fractures: a nationwide cohort study by Yu-Hsun Wang, Ming-Chih Chou, Sai-Wai Ho, Ying-Hock Teng, Shun-Fa Yang, Han-Wei Yeh, Chao-Bin Yeh

“…This nationwide cohort study investigated the association between IMRFs and the risk of pneumonia in patients with blunt chest traumas.Design Nationwide population-based cohort study.Setting Patients with IMRFs were identified between 2010 and 2011 from the Taiwan National Health Insurance Research Database.Participants Non-traumatic patients were matched through 1:8 propensity-score matching according to age, sex, and comorbidities (namely diabetes, hypertension, cardiovascular disease, asthma and chronic obstructive pulmonary disease (COPD)) with the comparison cohort. …”
Get full text

Association of arm circumference with the prevalence of gallstones in United States adults: a retrospective analysis on US National Health and Nutrition Examination Survey by Jianjun Wang, Xi Chen, Wei He, Xintao Zeng, Pei Yang, Jianping Gong, Decai Wang

“…Dose–response relationships were evaluated using generalized additive models with smoothed curve fitting, and subgroup analyses were conducted to explore effect modification by key covariates such as age, sex, race, hypertension, diabetes, and body mass index.ResultsOverall, a total of 8,081 participants were included in this study, with 849 reporting a history of GS. …”
Get full text

Real-World Assessment of Weight Change in People with HIV-1 After Initiating Integrase Strand Transfer Inhibitors or Protease Inhibitors by Yen-Wen Chen, Helene Hardy, Christopher D. Pericone, Wing Chow

“…At baseline, 46% were <50 years old, 26% were females, 12% had Type II diabetes and 30% had hypertension (mean baseline weight: INSTI: 83 kg (183 lb), PI: 82 kg (181 lb); P = 0.3). …”
Get full text

Dermatosis en pacientes geriátricos by Dagmaris Albear de la Torre, Mayelin Valdivia Ferreira, Ivelin Valle-Yanes, Mayli Barbara del Rio Ysla, Susana María Hernández-Rodríguez, Yulexi Gómez Águila

“…El 46,6 % de los pacientes padecían de afecciones del sistema osteomioarticular, seguido por la hipertensión arterial (18,5 %) y diabetes mellitus (12,6 %). Conclusiones: Predominaron los adultos mayores del sexo masculino de 70 a 79 años, con fototipo cutáneo III. …”
Get full text

Effect of Preoperative Nutritional Risk Screening on Postoperative Recovery in Patients with Laparoscopic-Assisted Radical Resection for Colorectal Cancer by Xiaolong Wang, Jianlin Wu, Sen Lei, Feng Tian, Ce Cao, Guangfeng Shi

“…However, patients with nutritional risk had higher postoperative blood transfusion volumes, albumin infusions, weight difference before and after surgery, and postoperative hospital stays than the nonnutritional risk group (all P<0.05). Smoking, diabetes, and preoperative nutritional risk were the risk factors by the univariate and multivariate logistic regression analyses. …”
Get full text

Home Medication Review among Patients with Chronic Diseases in Rural Villages of Pahang, Malaysia: A Case Report by Norny Syafinaz Ab Rahman, Nur Alyaa Anisa Mat Harom, Nor Ilyani Mohamed Nazar

“…The first case describes a 62-year-old single Malay female with multiple chronic conditions, including Type 2 diabetes mellitus (T2DM), hypertension, dyslipidemia, and bronchial asthma, managed with eight prescribed medications. …”
Get full text

Serum vitamin C levels and their correlation with chronic kidney disease in adults: a nationwide study by Chunli Wang, Jili Zhao, Qiaoqiao Zhou, Jing Li

“…Additionally, they exhibited a higher prevalence of obesity and diabetes. Significantly, participants in the third quartile group experienced a 37.0%, 47.0%, and 46.6% decrease in the risk of developing albuminuria, low estimated glomerular filtration rate (eGFR), and CKD, respectively. …”
Get full text

Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human Diseases by Lorena Martínez-Alcantar, Laura Hernández-Padilla, Alma Laura Díaz-Pérez, Lizbeth Guadalupe Villalón-Magallán, Mayra Xóchitl Durán-Maldonado, César Díaz-Pérez, Marlene E. Campos-Morales, Citlali Figueroa-Guzmán, Jesús Campos-García

“…Nevertheless, modifications in the expression due to mutations or their dysregulation can lead to diseases, including autoimmune disorders, cardiovascular problems, diabetes, neurological diseases, and cancers. Cyclic ultra-short peptides are amazing structures with unique properties. …”
Get full text

Advance in identified targets of berberine by Penghai Sun, Ziyuan Wang, Yinchao Ma, Yuan Liu, Yintong Xue, Yan Li, Xiang Gao, Yuedan Wang, Ming Chu, Ming Chu, Ming Chu, Ming Chu

“…Berberine is an isoquinoline alkaloid, which has demonstrated significant therapeutic potential in the treatment of various diseases, including tumors, acute and chronic infections, autoimmune disorders, and diabetes. Studies have demonstrated that berberine exhibits polypharmacological effects, including antibacterial, anti-inflammatory, antioxidant, and hypoglycemic activities. …”
Get full text

Impact of the abolition of copayments on the GP-centred coordination of care in Bavaria, Germany: analysis of routinely collected claims data by Werner Maier, Antonius Schneider, Lars Schwettmann, Ewan Donnachie, Martin Tauscher, Roman Gerlach, Klaus Linde, Michaela Olm

Get full text

Virtual online consultations: advantages and limitations (VOCAL) study by Trisha Greenhalgh, Joe Wherton, Sara Shaw, Charles Gutteridge, Emma Byrne, Isabel Hodkinson, Shanti Vijayaraghavan, Desirée Campbell-Richards, Satya Bhattacharya, Philippa Hanson, Seendy Ramoutar, Anna Collard, Joanne Morris

“…The study is based in 2 contrasting clinical settings (diabetes and cancer) in a National Health Service (NHS) acute trust in London, UK. …”
Get full text

Identification of individual-level clinical factors associated with increased risk of death during heatwaves: a time-stratified case-crossover study using national primary care rec... by Shakoor Hajat, Ross Thompson, Sari Kovats, Emer O’Connell, Helen Macintyre

“…Conditional logistic regression was used to characterise associations between temperature and the risk of death on hot days.Results Heat mortality risk was modified by a large range of pre-existing conditions, with cardiorespiratory, mental health and cognitive function conditions, diabetes and Parkinson’s, all increasing risk. The most striking increase was observed for depression with an OR of 1.25 (95% CI 1.09 to 1.44), the highest observed for pre-existing conditions. …”
Get full text

Short-term outcome of endovascular stenting for symptomatic vertebrobasilar stenosis by Mohamed Abdel moneim Abdo Tolba, Mohammed Alaswad, Mohamed Mohamed Tawfik, Ahmed Zaki Akl, Mona Ali Eissa, Hala El-khawas, Hani Mahmoud Zaki Eldin, Mohamed Khaled Ahmed Elewa

“…The most prevalent comorbidity was a previous transient ischemic attack (TIA) in 15 patients (88.2%), followed by hypertension in 12 patients (70.6%), diabetes and hyperlipidemia in 10 patients each (58.8% for both). …”
Get full text

Amyloid-β and heart failure in Alzheimer’s disease: the new vistas by Hayder M. Al-Kuraishy, Ghassan M. Sulaiman, Hamdoon A. Mohammed, Sohaib G. Mohammed, Ali I. Al-Gareeb, Ali K. Albuhadily, Retaj A. Dawood, Amer Al Ali, Mohammed H. Abu-Alghayth

“…It has been shown that cardiometabolic conditions such as obesity, type 2 diabetes (T2D), and heart failure (HF) are regarded as possible risk factors for the development of AD and other types of dementia, such as vascular dementia. …”
Get full text

Incidence and risk factors for mortality of vertebral osteomyelitis: a retrospective analysis using the Japanese diagnosis procedure combination database by Hideo Yasunaga, Hirotaka Chikuda, Kiyohide Fushimi, Hiromasa Horiguchi, Toru Akiyama, Kazuo Saita

“…A higher rate of in-hospital mortality was significantly associated with haemodialysis use (ORs, 10.56 (95% CI 8.12 to 13.74)), diabetes (2.37 (1.89 to 2.98)), liver cirrhosis (2.63 (1.49 to 4.63)), malignancy (2.68, (2.10 to 3.42)) and infective endocarditis (3.19 (1.80 to 5.65)).Conclusions Our study demonstrates an increasing incidence of VO, and defines risk factors for death with a nationwide database. …”
Get full text