Targeting Transcriptional Regulators Affecting Acarbose Biosynthesis in <i>Actinoplanes</i> sp. SE50/110 Using CRISPRi Silencing by Saskia Dymek, Lucas Jacob, Alfred Pühler, Jörn Kalinowski

“…SE50/110, is an α-glucosidase inhibitor and is used as a medication to treat type 2 diabetes. While the biosynthesis of acarbose has been elucidated, little is known about its regulation. …”
Get full text

Associates of Cardiopulmonary Arrest in the Perihemodialytic Period by Jennifer E. Flythe, Nien-Chen Li, Shu-Fang Lin, Steven M. Brunelli, Jeffrey Hymes, Eduardo Lacson

“…Cases and controls were 1 : 5 matched on age, sex, race, and diabetes. Predictors of cardiopulmonary arrest were considered for logistic model inclusion. …”
Get full text

Changing Landscape of Haemophilus influenzae Meningitis and Implication on Public Health by John Allonce, Mohammed Ahsan, Angelina Browne, Rebecca Witherell, Mark Rasnake

“…Repeat lumbar puncture or ventricular drainage was deferred after discussion with neurosurgery. Diabetes was identified as a comorbidity. The patient’s condition improved after 14 days of antibiotics and dexamethasone. …”
Get full text

Non-Enzymatic Electrochemical Glucose Sensors Based on Metal Oxides and Sulfides: Recent Progress and Perspectives by Haibing Zhu, Feng Shi, Maoying Peng, Ye Zhang, Sitian Long, Ruixin Liu, Juan Li, Zhanjun Yang

“…With the sudden advancement of glucose biosensors for monitoring blood glucose levels for the prevention and diagnosis of diabetes, non-enzymatic glucose sensors have aroused great interest owing to their sensitivity, stability, and economy. …”
Get full text

Prevalence and Factors Associated with Preterm Birth in Urban Areas: Case-Control Study by Rozhan Khezri, Shaker Salarilak, Sepideh Jahanian

“…Multivariable logistic regression analysis revealed a significant association between PTB and the following factors: education levels, antenatal care (ANC) visits [Adjusted Odds Ratio (AOR)=7.91 (95% CI: 2.43–25.71)], premature rupture of membranes (PROM) [AOR=5.25 (95% CI: 2.01–13.74)], gestational diabetes mellitus (GDM) [AOR=5.27 (95% CI: 1.49–18.58)], and preeclampsia [AOR=9.47 (95% CI: 3.02–29.73)].Conclusion: Identifying pregnant women at risk of preterm birth is crucial, and treatments are available to reduce the risk. …”
Get full text

Unsupervised domain adaptation teacher–student network for retinal vessel segmentation via full-resolution refined model by Kejuan Yue, Lixin Zhan, Zheng Wang

“…Changes in vessel morphology are closely associated with hypertension, diabetes, cardiovascular disease and other systemic diseases, and computers can help doctors identify these changes by automatically segmenting blood vessels in fundus images. …”
Get full text

A Case of Idiopathic Acute Pancreatitis in the First Trimester of Pregnancy by Tomomi Hara, Haruhiko Kanasaki, Aki Oride, Tomoko Ishihara, Satoru Kyo

“…Antinuclear antibody and IgG4 were negative and no evidence of hyperlipidemia or diabetes was found. There was also no evidence of viral infection. …”
Get full text

Alterations of amino acids in older adults with Alzheimer’s Disease and Vascular Dementia by Xin Ma, Xin-Meng Wang, Guo-Zhang Tang, Yi Wang, Xue‑Chun Liu, Shuai-Deng Wang, Peng Peng, Xiu-Hong Qi, Xin-Ya Qin, Yue‑Ju Wang, Chen-Wei Wang, Jiang-Ning Zhou

“…Considering comorbidities, cystine levels were higher in AD than in VD among non-diabetic patients, but not in those with diabetes. …”
Get full text

Atypical Presentation of Disseminated Zoster in a Patient with Rheumatoid Arthritis by Nirav Patel, Davinder Singh, Krunal Patel, Shadab Ahmed, Prachi Anand

“…Comorbidities include hypertension, type II diabetes, and dyslipidemia. Patient was on methotrexate 12.5 mg and was not receiving any corticosteroids, anti-TNF therapy, or other biological agents. …”
Get full text

Phylogeny, Phytomedicines, Phytochemistry, Pharmacological Properties, and Toxicity of Croton gratissimus Burch (Euphorbiaceae) by Kirkland Dingili Magwilu, Joseph Mwanzia Nguta, Isaac Mapenay, Dorine Matara

“…It has been used to treat different ailments ranging from respiratory tract infections, urinary tract infections, malaria, diabetes, hypertension, dermatological conditions, arthritis, gastrointestinal disorders, fever, sexually transmitted diseases, and infertility. …”
Get full text

Role of nutrition and healthy lifestyle, for individuals in primary prevention: recent data, gaps in evidence and future directions by Theodora Metsovitis, Marco Bernardi, Eric Bruckert, Federica Fogacci, Arrigo Cicero, Sebastian Garcia-Zamora, Luigi Spadafora, Denis Angoulvant, Giuseppe Biondi-Zoccai, Pierre Sabouret

“…This overview aims to summarize well-established benefits related to lifestyle and nutrition, discuss the current debates in this field in order to improve awareness among the medical community and promote better implementation of non-pharmaceutical measures to prevent the occurrence of atherothrombotic events, by reducing cardiovascular risk factors such as hypertension, diabetes, dyslipidemia, and obesity.…”
Get full text

Community support for injured patients: A scoping review and narrative synthesis. by Rashi Jhunjhunwala, Anusha Jayaram, Carol Mita, Justine Davies, Kathryn Chu

“…<h4>Background</h4>Community-based peer support (CBPS) groups have been effective in facilitating access to and retention in the healthcare system for patients with HIV/AIDS, cancer, diabetes, and other communicable and non-communicable diseases. …”
Get full text

Endometrial Carcinoma in a 26-Year-Old Patient with Bardet-Biedl Syndrome by Olga Grechukhina, Gregory M. Gressel, William Munday, Serena Wong, Alessandro Santin, Alla Vash-Margita

“…Bardet-Biedl Syndrome (BBS) is a rare genetic condition characterized by cognitive impairment, dysmorphism, central obesity, and diabetes mellitus, among other abnormalities. Although some of these characteristics are known independent risk factors for endometrial cancer and its precursors, the association between BBS and endometrial cancer is underreported. …”
Get full text

p38δ MAPK: Emerging Roles of a Neglected Isoform by Carol O’Callaghan, Liam J. Fanning, Orla P. Barry

“…We outline a role for p38δ MAPK in important cellular processes such as differentiation and apoptosis as well as pathological conditions such as neurodegenerative disorders, diabetes, and inflammatory disease. Interestingly, disparate roles for p38δ MAPK in tumour development have also recently been reported. …”
Get full text

Therapeutic molecules for multiple human diseases identified from pigeon pea (Cajanus cajan L. Millsp.) through GCâMS and molecular docking by Deepu Mathew, Lidiya John P., Manila T.M., Divyasree P., Sandhya Rajan V.T.K.

“…Keywords: Breast cancer, Drug discovery, Herbal medicine, In silico, Malaria, Measles, Phyto-compounds, Rheumatoid arthritis, Sickle cell disease, Type II diabetes…”
Get full text

Nonsevere Hypoglycemia Episode Clinical and Economic Outcomes: A Comparison between Sulfonylurea and Sodium-Glucose Cotransporter 2 Inhibitor as Add-On to Metformin from a Canadian... by Pendar Farahani

“…To estimate prevalence of NSHEs and associated economic outcomes attributable to sulfonylurea (SU) versus sodium-glucose cotransporter 2 inhibitor (SGLT2i) initiation after metformin over one year for Canadian patients with type 2 diabetes (T2DM). Methods. Risk difference for NSHEs was calculated for SU and SGLT2i from RCT data. …”
Get full text

Multiple states clustering analysis (MSCA), an unsupervised approach to multiple time-to-event electronic health records applied to multimorbidity associated with myocardial infarc... by Marc Delord, Abdel Douiri

“…MSCA was applied to analyse multimorbidity associated with myocardial infarction using electronic health records of 26 LTCs, including conventional cardiovascular risk factors (CVRFs) such as diabetes and hypertension, collected from south London general practices between 2005 and 2021 in 5087 patients using the MSCA R library. …”
Get full text

Oxidative Stress and Its Association with COVID-19: A Narrative Review by Hardi Rafat Baqi, Halgord Ali M. Farag, Abdel Hamid H. El Bilbeisi, Rafee Habib Askandar, Amany M. El Afifi

“…The outcome of the review proposes a hypothesis that COVID-19 is associated with reactive oxygen species and its comorbidities mostly joined with oxidative stress including hypertension, cardiovascular, thrombosis, obesity, and diabetes besides of chronic obstructive pulmonary disease and asthma. …”
Get full text

Progression of Nonmotor Symptoms in Parkinson’s Disease by Sex and Motor Laterality by Zimple Kurlawala, Paul H. Shadowen, Joseph D. McMillan, Levi J Beverly, Robert P. Friedland

Get full text

An Update on Less Invasive and Endoscopic Techniques Mimicking the Effect of Bariatric Surgery by Froukje J. Verdam, Ruben Schouten, Jan Willem Greve, Ger H. Koek, Nicole D. Bouvy

“…Obesity (BMI 30–35 kg/m2) and its associated disorders such as type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular disease have reached pandemic proportions worldwide. …”
Get full text