Analytical and clinical validation of a novel MeltPlus TB-NTM/RIF platform for simultaneous detection of Mycobacterium tuberculosis complex, Non-Tuberculous Mycobacteria and rifamp... by Zhuo Wang, Yuanwu Zou, Zihan Wei, Guanghong Bai, Xiaolin Wang, Shaoyi Qu, Jie Shi, Yaping Jiang, Cuijiao Gu

“…BackgroundRapid and accurate diagnosis of tuberculosis, particularly rifampin (RIF)-resistant tuberculosis (RR-TB) and Non-Tuberculous Mycobacteria (NTM), is essential for implementing appropriate proper therapy to benefit patients and improve TB/NTM patient management.MethodsIn this study, we developed a novel MeltPlus MTB-NTM/RIF platform, designed to simultaneously detect Mycobacterium tuberculosis complex (MTBC), NTM and RIF resistance. …”
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Developing a virtual reality application for online arts and psychomotor therapies using action research by Nathalie Jans, Nathalie Jans, Hans Wouters, Joep Kolijn, Suzanne Haeyen, Suzanne Haeyen, Suzanne Haeyen

“…The Action Research concerned a one-year co-creation project involving 17 arts and psychomotor therapists (Mean age 44.1 years, SD 11.3) together with input from media designers in education and technical VR developers. …”
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Minimally important change on the Columbia Impairment Scale and Strengths and Difficulties Questionnaire in youths seeking mental healthcare by Peter Szatmari, Claire de Oliveira, Myla E Moretti, Kristin Cleverley, Lisa D Hawke, Amy H Cheung, Meaghen Quinlan-Davidson, Clement Ma, Karolin R Krause, Alina Lee, Di Shan, Katherine Tombeau Cost, Jo L Henderson

“…The minimally important change (MIC) indicator designates change as meaningful to patients, yet is rarely reported in youth mental health trials.Objective This study aimed to establish MIC thresholds for two patient-reported outcome measures (PROMs), the Columbia Impairment Scale (CIS) and the Strengths and Difficulties Questionnaire (SDQ), using different estimation methods.Methods A sample of 247 youths (14–17 years) completed the CIS and SDQ at baseline and at 6 months in a youth mental health and substance use trial. …”
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Twelve-Month Retention in and Impact of Enhance®Fitness on Older Adults in Hawai‘i by Michiyo Tomioka, Kathryn L. Braun, Yan Yan Wu, Kay Holt, Paula Keele, Lori Tsuhako, Johnny Yago

“…Enhance®Fitness is a low-cost group exercise program designed specifically for older adults (60+ years) to improve physical performance. …”
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Intestinal Microbiome Changes in Fecal Microbiota Transplant (FMT) vs. FMT Enriched with Lactobacillus in the Treatment of Recurrent Clostridioides difficile Infection by Elvira Garza-González, Soraya Mendoza-Olazarán, Rayo Morfin-Otero, Andrea Ramírez-Fontes, Patricia Rodríguez-Zulueta, Samantha Flores-Treviño, Paola Bocanegra-Ibarias, Héctor Maldonado-Garza, Adrián Camacho-Ortiz

“…FMT in addition with Lactobacillus (FMT-L) for treatment of recurrent Clostridioides difficile infection (R-CDI). Methods. We designed a double-blinded randomized comparative two-arm pilot multicenter study to assess the efficacy and impact in the intestinal microbiome of standard capsules of FMT vs. …”
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Research on pipeline-type power frequency electromagnetic heating system and multi-layer winding based power regulation method by Feng Zhou, Longyun Liu, Zixuan Wang, Xin Tong, Yanping Liu

“…Aiming at the issues of complexity, high investment costs, limited heating efficiency improvement, high failure rate, and poor reliability of traditional intermediate and high frequency electromagnetic heating systems, we propose a pipeline-type power-frequency electromagnetic coupling heating device. This device is designed based on transformer principles and utilizes Maxwell's equations and Fourier's heat conduction equation theory to achieve high efficiency and uniform heating. …”
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Liquid crystal template-assisted electrodeposition of nanoporous nickel microspheres: A sensitive electrochemical sensing platform for electrocatalytic oxidation and quantitative d... by R. Dehdari Vais, M. Negahdary, S.R. Rasouli Nasrabadi, A. Rahi, S.A. Dastgheib, H. Heli

“…The proposed sensor was then employed as a sensitive amperometric sensor for determination of LC with a linear dynamic range of 25 to 217 μmol L−1, a calibration sensitivity of 67.85 mA L mol−1, and a detection limit of 3.2 μmol L−1. The designed sensing platform depicted a stable and reproducible response and insignificant interference from the common species found in the biological fluids and pharmaceutical formulations. …”
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The implementation and side effect management of immune checkpoint inhibitors in gynecologic oncology: a JAGO/NOGGO survey by Maximilian Riedel, Helene Herrmann, Thomas Bartl, Anna-Maria Rossner, Anna Tatzber, Chiara Flethe, Dario Zocholl, Barbara Schmalfeldt, Jalid Sehouli, Klaus Pietzner

“…The aim of this survey was to provide a real-world overview of the experiences and the current state of irAE management of ICIs in Germany, Switzerland, and Austria. Methods We designed a questionnaire consisting of 34 items focused on physicans’ clinical experiences with ICIs and their management of irAEs. …”
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The association of RBP4 with chronic kidney diseases in southern Chinese population by Tong Chen, Tong Chen, Tong Chen, Yu Liu, Yu Liu, Shiquan Wu, Siyu Long, Ling Feng, Wenqian Lu, Wenya Chen, Guoai Hong, Li Zhou, Fang Wang, Yuechan Luo, Hequn Zou, Hequn Zou, Weihua Liu

“…However, there is a lack of sufficient studies to explore the relationship between RBP4 and CKD, and no reports have described the predictive value of RBP4 for CKD. This study was designed to clarify the relationship between RBP4 and CKD and its potential predictive value.MethodsOur team has conducted a large-scale cross-sectional survey that contained 2117 individuals on the southern coast of China. …”
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Sources of PM2.5 Oxidative Potential during Haze and Non-haze Seasons in Chiang Mai, Thailand by Pitakchon Ponsawansong, Tippawan Prapamontol, Kittipan Rerkasem, Somporn Chantara, Kraichat Tantrakarnapa, Sawaeng Kawichai, Guoxing Li, Cao Fang, Xiaochuan Pan, Yanlin Zhang

“…In this study, the source contributions of 16 high priority polycyclic aromatic hydrocarbons (PAHs), designated by the United States Environmental Protection Agency (U.S. …”
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Creation of body color mutants by CRISPR/Cas9 gene editing in largemouth bass, Micropterus salmoides by Lina Sun, Tian Gao, Zhiqiang Li, Xiaolong Yang, Zuliang Qin, Mingxiao Ye, Ying Li, Feilong Wang, Deshou Wang

“…The target site was designed on the first exon of tyrb and the second exon of csf1ra, respectively. …”
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Lifecycle environmental benefits of integrated rational fertilization, biochar, and constructed wetland in mitigating nutrient loading by Yu-Ning Chen, Chihhao Fan, Michal Šereš, Markéta Šerešová, Jan Vymazal, Shu-Yuan Pan

“…Four assessment scenarios were designed: (S1) conventional cultivation, (S2) rational fertilization with biochar amendment, (S3) conventional cultivation with a simulated CWs system, and (S4) rational fertilization with biochar amendment and a simulated CWs system. …”
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Co-administration of coenzyme Q10 and curcumin mitigates cognitive deficits and exerts neuroprotective effects in aluminum chloride-induced Alzheimer's disease in aged mice by Nida Rasheed, Hafiza Khushbakht Hussain, Zohabia Rehman, Azka Sabir, Waseem Ashraf, Tanveer Ahmad, Faleh Alqahtani, Imran Imran

“…The current study was designed to unveil the long-term neuroprotective outcomes and efficacy of CoQ10 and curcumin low dose (100 mg/kg each) combination in 18-months old geriatric male Balb/c mice subjected to AlCl3-prompted memory derangements (200 mg/kg in water bottles) for 28 days. …”
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Avian influenza mRNA vaccine encoding hemagglutinin provides complete protection against divergent H5N1 viruses in specific-pathogen-free chickens by Zhaoyang Wang, Chongyu Tian, Jiahang Zhu, Shiqian Wang, Xiang Ao, Yanjuan He, Huixin Chen, Xiuying Liao, Deming Kong, Yongfei Zhou, Wanbo Tai, Ming Liao, Huiying Fan

“…To enhance the immune efficacy of the candidate vaccine, we designed 6 sequences with different secondary structures and screened out the candidate sequence with the highest expression (SY2-HA mRNA). …”
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Beyond variance: simple random distributions are not a good proxy for intraspecific variability in systems with environmental structure by Girard-Tercieux, Camille, Vieilledent, Ghislain, Clark, Adam, Clark, James S., Courbaud, Benoit, Fortunel, Claire, Kunstler, Georges, Pélissier, Raphaël, Rüger, Nadja, Maréchaux, Isabelle

“…To test the impact of this strong assumption on the outcome of community dynamics models, we designed a simulation experiment where we varied the level of knowledge of the environment in virtual communities, resulting in different relative importance of explained vs unexplained spatial individual variation in performance. …”
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Effectiveness of a web-based virtual journal club to promote medical education (Web-Ed): protocol of a multicentre pragmatic randomised trial by Mohamed Abdelrahman, Neil Cowan, Meera Ramcharn, Bassel H Al Wattar, William Parry-Smith, Sarah McRobbie, Michael Rimmer, Nagla Elfaki, Cheryl Dunlop, Damien Coleburt, Olivia Raglan, Jhia Jiat Teh, Maria Fisher, Nilaani Murugesu, Yazid Jibrel, Matthew Wood

“…Where relevant, we will adjust for predetermined characteristics (age, grade of training and session duration) using multivariate regression analyses.Ethics and dissemination Web-Ed was designed by doctors in training to address their learning needs and evaluate the preferred mode of learning. …”
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Higher education students' perceptions of ChatGPT: A global study of early reactions. by Dejan Ravšelj, Damijana Keržič, Nina Tomaževič, Lan Umek, Nejc Brezovar, Noorminshah A Iahad, Ali Abdulla Abdulla, Anait Akopyan, Magdalena Waleska Aldana Segura, Jehan AlHumaid, Mohamed Farouk Allam, Maria Alló, Raphael Papa Kweku Andoh, Octavian Andronic, Yarhands Dissou Arthur, Fatih Aydın, Amira Badran, Roxana Balbontín-Alvarado, Helmi Ben Saad, Andrea Bencsik, Isaac Benning, Adrian Besimi, Denilson da Silva Bezerra, Chiara Buizza, Roberto Burro, Anthony Bwalya, Cristina Cachero, Patricia Castillo-Briceno, Harold Castro, Ching Sing Chai, Constadina Charalambous, Thomas K F Chiu, Otilia Clipa, Ruggero Colombari, Luis José H Corral Escobedo, Elísio Costa, Radu George Crețulescu, Marta Crispino, Nicola Cucari, Fergus Dalton, Meva Demir Kaya, Ivo Dumić-Čule, Diena Dwidienawati, Ryan Ebardo, Daniel Lawer Egbenya, MoezAlIslam Ezzat Faris, Miroslav Fečko, Paulo Ferrinho, Adrian Florea, Chun Yuen Fong, Zoë Francis, Alberto Ghilardi, Belinka González-Fernández, Daniela Hau, Md Shamim Hossain, Theo Hug, Fany Inasius, Maryam Jaffar Ismail, Hatidža Jahić, Morrison Omokiniovo Jessa, Marika Kapanadze, Sujita Kumar Kar, Elham Talib Kateeb, Feridun Kaya, Hanaa Ouda Khadri, Masao Kikuchi, Vitaliy Mykolayovych Kobets, Katerina Metodieva Kostova, Evita Krasmane, Jesus Lau, Wai Him Crystal Law, Florin Lazăr, Lejla Lazović-Pita, Vivian Wing Yan Lee, Jingtai Li, Diego Vinicio López-Aguilar, Adrian Luca, Ruth Garcia Luciano, Juan D Machin-Mastromatteo, Marwa Madi, Alexandre Lourenço Manguele, Rubén Francisco Manrique, Thumah Mapulanga, Frederic Marimon, Galia Ilieva Marinova, Marta Mas-Machuca, Oliva Mejía-Rodríguez, Maria Meletiou-Mavrotheris, Silvia Mariela Méndez-Prado, José Manuel Meza-Cano, Evija Mirķe, Alpana Mishra, Ondrej Mital, Cristina Mollica, Daniel Ionel Morariu, Natalia Mospan, Angel Mukuka, Silvana Guadalupe Navarro Jiménez, Irena Nikaj, Maria Mihaylova Nisheva, Efi Nisiforou, Joseph Njiku, Singhanat Nomnian, Lulzime Nuredini-Mehmedi, Ernest Nyamekye, Alka Obadić, Abdelmohsen Hamed Okela, Dorit Olenik-Shemesh, Izabela Ostoj, Kevin Javier Peralta-Rizzo, Almir Peštek, Amila Pilav-Velić, Dilma Rosanda Miranda Pires, Eyal Rabin, Daniela Raccanello, Agustine Ramie, Md Mamun Ur Rashid, Robert A P Reuter, Valentina Reyes, Ana Sofia Rodrigues, Paul Rodway, Silvia Ručinská, Shorena Sadzaglishvili, Ashraf Atta M S Salem, Gordana Savić, Astrid Schepman, Samia Mokhtar Shahpo, Abdelmajid Snouber, Emma Soler, Bengi Sonyel, Eliza Stefanova, Anna Stone, Artur Strzelecki, Tetsuji Tanaka, Carolina Tapia Cortes, Andrea Teira-Fachado, Henri Tilga, Jelena Titko, Maryna Tolmach, Dedi Turmudi, Laura Varela-Candamio, Ioanna Vekiri, Giada Vicentini, Erisher Woyo, Özlem Yorulmaz, Said A S Yunus, Ana-Maria Zamfir, Munyaradzi Zhou, Aleksander Aristovnik

“…Higher education institutions' managers and teachers may benefit from these findings while formulating the curricula and instructions/regulations for ChatGPT use, as well as when designing the teaching methods and assessment tools. …”
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The impact of multiple exposures and movement on the fear response of poultry by Alexandra Jackson, Marcela Quino, Anusha Gautam, Melissa Gilpin, Katie Still, Denise Landers, Bethany Baker-Cook

“…This impact of repeated exposure is important to recognize when designing experiments that utilize fear tests.…”
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Molecular cloning and expression dynamics of Atrogin-1 in muscle tissue of Russian sturgeon (Acipenser gueldenstaedtii) under high salt stress by Yong-Juan Mo, Yi-Li Gao, Shi-Jjian Xu, Bin Wang, Jingping Wu, Peng Yu, Ming Li, Xiangtao Kang, Zhi-Qiang Han

“…Utilizing the sequence of Russian sturgeon atrogin-1, we designed novel primers and a specific anti-peptide antibody for our study, confirming that atrogin-1 is selectively expressed in skeletal muscle and heart tissues. …”
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Development of a recombinant infectious bronchitis virus vaccine expressing infectious laryngotracheitis virus multiple epitopes by Guanming Shao, Jun Fu, Yun Pan, Shiying Gong, Chaoyi Song, Sheng Chen, Keyu Feng, Xinheng Zhang, Qingmei Xie

“…Infectious bronchitis virus (IBV) is considered a potential vector for vaccine development, but the issue of poor stability in recombinant IBV expressing foreign genes has not yet been resolved. In this study, we designed a multi-epitope cassette (gD-T/B) containing multiple T and B cell epitopes of ILTV gD protein. …”
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