Value of ctDNA in surveillance of adjuvant chemosensitivity and regimen adjustment in stage III colon cancer: a protocol for phase II multicentre randomised controlled trial (REVIS... by Jun Huang, Rui Fan, Ziqiang Wang, Meng Qiu, Jiahao Zhou, Zikai Zhou, Xiangbing Deng, Qingbin Wu

“…This sequential approach is designed to escalate treatment for patients with persistent ctDNA positivity while avoiding overtreatment in those who may respond well to standard chemotherapy. …”
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A 3D Clinical Face Phenotype Space of Genetic Syndromes Using a Triplet-Based Singular Geometric Autoencoder by Soha S. Mahdi, Eduarda Caldeira, Harold Matthews, Michiel Vanneste, Nele Nauwelaers, Meng Yuan, Giorgos Bouritsas, Gareth S. Baynam, Peter Hammond, Richard Spritz, Ophir D. Klein, Michael Bronstein, Benedikt Hallgrimsson, Hilde Peeters, Peter Claes

“…In this paper, a triplet loss-based autoencoder developed by geometric deep learning (GDL) is trained using multi-task learning, which combines supervised and unsupervised learning approaches. Experiments are designed to illustrate the following properties of CFPSs that can aid clinicians in narrowing down their search space: a CFPS can 1) classify syndromes accurately, 2) generalize to novel syndromes, and 3) preserve the relatedness of genetic diseases, meaning that clusters of phenotypically similar disorders reflect functional relationships between genes. …”
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Preliminary analysis of the role of small hepatitis B surface proteins mutations in the pathogenesis of occult hepatitis B infection via the endoplasmic reticulum stress-induced UP... by Huang Chengrong, Zhang Hao, Wang Jing, Li Jianfei, Liu Qian, Zong Qiyin, Zhang Yunyun, Wang Qin, Zhou Qiang

“…The mechanistic basis for these results, however, remains unclear. This study was designed to explore the potential impact and mechanisms of OBI-related SHBs mutations on serum HBsAg. …”
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Work ability following breast cancer – the MyHealth randomized controlled trial by Trine A. Horsbøl, Lena Saltbæk, Caroline Urhammer, Randi V. Karlsen, Christoffer Johansen, Pernille E. Bidstrup, Beverley L. Høeg, Vibeke Zoffmann, Federica Belmonte, Ingelise Andersen, Anne S. Friberg, Mads N. Svendsen, Helle G. Christensen, Vesna Glavicic, Dorte L. Nielsen, Susanne O. Dalton

“…Future interventions should target patients with poor work ability and include components specifically designed to enhance work ability. …”
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Anticancer activity of Ilex khasiana, a rare and endemic species of holly in Northeast India, against murine lymphoma by Charles Lalnunfela, Pawi Bawitlung Lalthanpuii, Hmar Tlawmte Lalremsanga, Zothansiama, Chhaihlo Lalmuansangi, Mary Zosangzuali, Nachimuthu Senthil Kumar, Tochhawng Lalhriatpuii, Kholhring Lalchhandama

“…Ilex khasiana Purkay. is a lesser-known species of holly (family Aquifoliaceae) that is endemic to Northeast India. Designated as critically endangered, the plant is used in the treatments of bacterial infections, cancer, intestinal helminthiasis, tuberculosis, and viral infections. …”
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MnS/MnO heterostructures with dual ion defects for high-performance aqueous magnesium ion capacitors by Minghui Liu, Mudi Li, Siwen Zhang, Yaxi Ding, Ying Sun, Jiazhuo Li, Haixi Gu, Bosi Yin, Hui Li, Tianyi Ma

“…Hence, DID-MnS/MnO offers insightful perspectives for designing alternative clean energy sources and is expected to contribute significantly to the advancement of the clean energy sector.…”
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Daratumumab followed by tocilizumab for treatment of late antibody-mediated rejection in renal transplant recipients with high or moderate levels of de novo donor-specific antibodi... by Zhiliang Guo, Rula Sa, Daqiang Zhao, Songxia Li, Hui Guo, Lan Zhu, Gang Chen

“…Conclusions This new therapy combining Dara and TCZ achieved a good desensitization effect, providing an important reference point for designing better-optimized treatment of late or chronic active AMR in the future. …”
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Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α by Jie Yu, Haibin Liu, Shuli He, Pingping Li, Chunxiao Ma, Minglei Ma, Yiwen Liu, Lu Lv, Fan Ping, Huabing Zhang, Wei Li, Qi Sun, Lingling Xu, Yuxiu Li

“…In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL). Designs. The current cross-sectional analysis was based on data collected within a type 2 diabetes project. …”
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Prebiotics as an adjunct therapy for posttraumatic stress disorder: a pilot randomized controlled trial by Robin M. Voigt, Robin M. Voigt, Robin M. Voigt, Phillip A. Engen, Michelle Villanueva, Simona A. Bambi, Stefan J. Green, Stefan J. Green, Ankur Naqib, Ankur Naqib, Shohreh Raeisi, Maliha Shaikh, Bruce R. Hamaker, Bruce R. Hamaker, Thaisa M. Cantu-Jungles, Thaisa M. Cantu-Jungles, Sarah A. Pridgen, Philip Held, Ali Keshavarzian, Ali Keshavarzian, Ali Keshavarzian, Ali Keshavarzian

“…This proof-of-concept, pilot trial was designed to assess: (1) the relationship between severity of PTSD symptoms and microbiota composition and SCFA levels (i.e., acetate, propionate, butyrate), (2) if CBT treatment with a concomitant prebiotic fiber intervention would beneficially impact clinical outcomes in veterans with PTSD, (3) evaluate the feasibility and acceptability of a prebiotic intervention as an adjunct treatment to CBT, and (4) assess the impact of treatment on the intestinal microbiota and stool SCFA (i.e., mechanism).ResultsThis study found that PTSD severity may be associated with reduced abundance of taxa capable of producing the SCFA propionate, and that a subset of individuals with PTSD may benefit from a microbiota-modifying prebiotic intervention.ConclusionThis study suggests that targeting the intestinal microbiome through prebiotic supplementation could represent a promising avenue for enhancing treatment outcomes in some individuals with PTSD.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT05424146.…”
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Evidence-based exercise recommendations to improve functional mobility in older adults - A study protocol for living systematic review and meta-analysis [version 2; peer review: 2... by Claudia Volecker-Rehage, Uros Marusic, Bettina Wollesen, Antoine Langeard, Tamar Yellon, Anna Wunderlich, Vera Belkin, Guoping Qian, Eleftheria Giannouli, Zbigniew Ossowski, Rafael A. Bernades, Yael Netz, Rajesh Sighdel

“…This review will assess the effects of state-of-the-art exercise interventions designed to promote functional mobility. Therefore, after identifying all potential interventions, we will use the F.I.T.T. principles (frequency, intensity, time, type) as well as the physical and health status of the participants as moderators to analyse the mechanisms for the positive benefits of exercise interventions. …”
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Age-specific reference ranges and variation of anti-mülerian hormone in healthy Chinese women of reproductive and perimenopausal age: a nationwide population-based prospective mult... by Linli Hu, Hongyi Yang, Haining Luo, Yuexiang Zhang, Xiaohong Wang, Sanhua Wei, Qiongfang Wu, Ying Jiang, Xiaoyan Liang, Jianhui Chen, Yingpu Sun†

“…Objective To determine the variation of serum AMH levels in healthy Chinese women and establish AMH reference ranges accordingly.Methods This prospective cross-sectional multicenter study was designed to enroll healthy Chinese women of reproductive age (20–39 years) and perimenopausal age (40–49 years) from five reproductive centers in different regions of China. …”
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Protocol for project recovery after cardiac surgery: a single-center cohort study leveraging digital platform to characterise longitudinal patient-reported postoperative recovery p... by Harlan M Krumholz, Erica Spatz, Sanket S Dhruva, Yawei Zhang, Makoto Mori, Cornell Brooks, Bobak J Mortazavi, George C Linderman, Lawrence A Grab, Arnar Geirsson, Sarwat I Chaudhry

“…We are using a health-information exchange platform to collect patient-reported outcome measures (PROMs) and wearable device data to phenotype recovery patterns in the 30-day period after cardiac surgery hospital discharge, to identify factors associated with these phenotypes and to investigate phenotype associations with clinical outcomes.Methods and analysis We designed a prospective cohort study to enrol 200 patients undergoing valve, coronary artery bypass graft or aortic surgery at a tertiary centre in the USA. …”
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Can nebulised heparin reduce acute lung injury in patients with SARS‑CoV‑2 requiring advanced respiratory support in Ireland: the CHARTER‑Ireland phase Ib/IIa, randomised, parallel... by David Cosgrave, Bairbre McNicholas, Ciara Hanley, John Robert Sheehan, Padraig Calpin, Maeve Kernan, Darragh Murphy, Alberto Alvarez‑Iglesias, John Ferguson, Camilla Giacomini, Christine Greene, Catriona Cody, Shane McGeary, Marion Murphy, Marianne Fitzgerald, Gerard Curley, Barry Dixon, Roger J. Smith, Claire Masterson, Daniel O’Toole, Frank van Haren, John G. Laffey

“…Methods This was a phase Ib/IIa open-label multi-centre, randomised controlled trial. The study was designed to evaluate whether nebulised unfractionated heparin decreased d-dimer concentrations, with safety as a co-primary outcome. …”
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Evaluation of cumulative rainfall and rainfall event–duration threshold based on triggering and non-triggering rainfalls: Northern Thailand case by Chinkulkijniwat Avirut, Salee Rattana, Yubonchit Somjai, La Duong Hai, Horpibulsuk Suksun, Hoy Menglim

“…The performance of this threshold, designated as the negative-CED (CEDN) threshold, was compared with the positive-CED (CEDP) threshold based on landslide-triggering rainfall data. …”
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Multi-centre comparison between device-independent web-browser perimetry (Melbourne Rapid Fields-web) and SITA-Faster for glaucoma by Joyce Tiang, Algis J. Vingrys, Algis J. Vingrys, Sarah Lin, Selwyn M. Prea, Adam Ahmed Moktar, Allan Bank, Ashish Agar, Ashish Agar, Yu Xiang George Kong, Yu Xiang George Kong, Yu Xiang George Kong

“…Melbourne Rapid Fields-web (MRF-web) perimeter is designed to address these limitations by allowing perimetry testing on the flat screen of your personal computer.MethodsThis study is a retrospective, cross-sectional study involving two locations in Australia, one in metropolitan Melbourne and one in rural Dubbo NSW. 232 patients with stable glaucoma, glaucoma suspect or normal eyes were tested with MRF-web and outcomes were compared to the most recent Humphrey Field Analyzer (HFA) 24-2 SITA Faster test. …”
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NIR-triggered programmable nanomotor with H2S and NO generation for cascading oncotherapy by three-pronged reinforcing ICD by Jinlong Zhang, Quan Jing, Longlong Yuan, Xianhui Zhou, Duolong Di, Jinyao Li, Dong Pei, Zhongxiong Fan, Jun Hai

“…In this study, a near-infrared (NIR)-triggered programmable nanomotor with hydrogen sulfide (H2S) and nitric oxide (NO) generation is well designed to achieve oncotherapy by cascading mild photothermal, gas, and reactive oxygen species (ROS)-reinforced immunogenic cell death. …”
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From Natural Hosts to Agricultural Threats: The Evolutionary Journey of Phytopathogenic Fungi by Asanka Madhushan, Dulan Bhanuka Weerasingha, Evgeny Ilyukhin, Paul W. J. Taylor, Amila Sandaruwan Ratnayake, Jian-Kui Liu, Sajeewa S. N. Maharachchikumbura

“…Understanding their evolutionary trends is crucial for predicting and designing control measures against future disease outbreaks. …”
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Photon sensor-based monitoring of spatial variations in canopy FIPAR for crop growth assessment by Jian Wang, Zhenggui Zhang, Xin Li, Lu Feng, Xiaofei Li, Minghua Xin, Shiwu Xiong, Yingchun Han, Shijie Zhang, Xiaoyu Zhi, Beifang Yang, Guoping Wang, Yaping Lei, Zhanbiao Wang, Yabing Li

“…The photon sensor-based fraction of intercepted photosynthetically active radiation (FIPAR) monitoring system was demonstrated to provide accurate real-time tracking of crop growth. It was designed to capture spatial variations in FIPAR across the canopy profile throughout the entire crop growth season. …”
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Perceptions of swine euthanasia among Brazilian caretakers from non-integrated swine farms by Laya Kannan Silva Alves, Laya Kannan Silva Alves, Monique Danielle Pairis-Garcia, Andréia Gonçalves Arruda, Cecília Archangelo Ferreira de Melo, Nadia de Almeida Ciriaco Gomes, Roberta Yukari Hoshino, Cesar Augusto Pospissil Garbossa

“…A total of 117 people directly working with pigs participated in a survey designed to evaluate their decision-making skills, euthanasia competencies, and understanding of Brazilian guidelines for euthanasia methods. …”
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CC-96673 (BMS-986358), an affinity-tuned anti-CD47 and CD20 bispecific antibody with fully functional fc, selectively targets and depletes non-Hodgkin’s lymphoma by Dan Zhu, Haralambos Hadjivassiliou, Catherine Jennings, David Mikolon, Massimo Ammirante, Sharmistha Acharya, Jon Lloyd, Mahan Abbasian, Rama Krishna Narla, Joseph R. Piccotti, Katie Stamp, Ho Cho, Kandasamy Hariharan

“…CC-96673, a humanized IgG1 bispecific antibody co-targeting CD47 and CD20, is designed to bind CD20 with high affinity and CD47 with optimally lowered affinity. …”
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