Enhanced effect of the immunosuppressive soluble HLA-G2 homodimer by site-specific PEGylation by Chisato Yamada, Kimiko Kuroki, Naoyoshi Maeda, Hiroshi Watanabe, Ami Takahashi, Katsumi Maenaka

“…The administration of the ectodomain of HLA-G2, designated the soluble HLA-G2 homodimer, showed significant immunosuppressive effects in mouse models of rheumatoid arthritis and systemic lupus erythematosus, presumably by binding to a mouse ortholog of LILRB2, paired immunoglobulin-like receptor B. …”
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The Impact of the 2020 Medicaid Expansion in a Community Clinic Serving the Marshallese Population in a Rural State by Robert Brand, Samantha Robinson, Mohammod Mahmudur Rahman, Alshaimaa Hazaa, Sheena CarlLee, Hanna Jensen

“…Findings from this study can aid health policymakers in designing and implementing new strategies to increase healthcare access and utilization in target populations. …”
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Working Capital Management Practices and Performance of Small and Medium Enterprises in Western Uganda. by Sunday, Arthur, Turyahebwa, Abanis, Byamukama, Eliab Mpora

“…The study adopted a positivist quantitative paradigm with cross sectional and correlational designs. The findings in respect of the main purpose of this study indicated that in Working Capital management practices accounted for 33.8% percent of the variance in performance of SMEs. …”
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Impact of Divorce on Girl Child Education in Nyakinama Sub-County Kisoro District. by Niyobyose, Sarah

“…The study was conducted using cross-sectional survey designs. A sample of 50 respondents was used to gather the required information and both purposeful sampling and simple random methods were employed in selecting the sample size. …”
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“I Desire to Have an HIV‐Free Baby”: Pregnant and Breastfeeding Mothers’ Perceptions of Viral Load Testing and Suppression in HIV Care in Southwestern Uganda. by Kabami, Jane, Akatukwasa, Cecilia, Kabageni, Stella, Nangendo, Joanita, Byamukama, Ambrose, Atwiine, Fredrick, Mftumukiza, Valence, Tamu, Munezero John Bosco, Arinaitwe, Elizabeth, Mutabazi, Andrew, Ssebutinde, Peter, Musoke, Phillipa, Kamya, Moses R., Katahoire, Anne R.

“…Methods This was a qualitative sub-study embedded in a cluster-randomized trial (NCT04122144) designed to improve viral load outcomes among pregnant and breastfeeding mothers living with HIV in four level III/IV health facilities in Southwestern Uganda. …”
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A Deep Learning Enabled Chest X-Ray Abnormality Detection Model for Radiology Assistance. by Ssempeebwa, Phillip, Ainembabazi, Patience

“…Through this methodology, this research is designed to improve the radiologist's workload and enhance the accuracy of chest X-ray diagnosis. …”
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Magnitude and Factors Associated With Risky Sexual Behaviours among Undergraduate Students in Selected Universities in Kigezi Sub Region by Amon, Bahati

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CALPHAD-aided synthesis and characterization of an Al–Co–Cr–Fe–Ni–W high-entropy alloy prepared by arc melting and spark plasma sintering by L. Fenocchio, A. Saviot, S. Gambaro, S. Le Gallet, F. Valenza, M.R. Ardigo-Besnard, G. Cacciamani

“…In the present work, the novel Al0.15CoCrFeNiW0.15 High-Entropy Alloy (HEA) has been designed by CALPHAD (CALculation of PHAse Diagrams) computations with the in-house built Genova High-Entropy Alloys (GHEA) database, aiming to a mostly monophasic face-centered cubic (FCC) alloy strengthened by the precipitation of secondary μ phase. …”
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Protocol for a multicentre, prospective cohort study of clinical, proteomic and genomic patterns associated with osteoporosis to develop a multidimensional fracture assessment tool... by Noushin Fahimfar, Bagher Larijani, Afshin Ostovar, Iraj Nabipour, Patricia Khashayar, Hans Peter Dimai, Nahid Moradi, Safoora Gharibzadeh

“…Based on the gathered information, a multidimensional fracture assessment tool will be designed which will later be added to the PoCOsteo device.…”
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The Effect of Vitamin D3 on Serum Creatine Phosphokinase Level in Patients with Multiple Trauma: A Pilot Randomized Clinical Trial by Mehran Kouchek, Niloufar Taherpour, Mahya Farasat, Mirmohammad Miri, Sara Salarian, Seyedpouzhia Shojaei, Rezvan Hassanpour, Hossein Amini, Mohammad Sistanizad

“…Background: Multiple trauma can cause an increase in creatine phosphokinase (CPK) and subsequently rhabdomyolysis and acute kidney injury (AKI). This study was designed to evaluate the effect of vitamin D3 on the serum CPK level and the incidence of rhabdomyolysis-induced AKI in patients with multiple trauma.Methods: Patients with serum CPK levels <1000 IU/L were followed as the control 1 group. …”
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A multicenter, randomized, double-blind trial comparing LY01011, a biosimilar, with denosumab (Xgeva®) in patients with bone metastasis from solid tumors by Mingchuan Zhao, Xichun Hu, Pengpeng Zhuang, Aiping Zeng, Yan Yu, Zhendong Chen, Hongmei Sun, Weihua Yang, Lili Sheng, Peijian Peng, Jingfen Wang, Tienan Yi, Minghong Bi, Huaqiu Shi, Mingli Ni, Xiumei Dai, Changlu Hu, Hongjie Xu, Dongqing Lv, Qingshan Li, Kaijian Lei, Xia Yuan, Ou Jiang, Xicheng Wang, Baihui Hu, Zhe Hou, Zhaoping Su, Song Zheng, Ming Zhou, Changlin Dou

“…Introduction: Denosumab (Xgeva®) is a standard treatment for the prevention of skeletal-related events (SREs) in patients with bone metastases (BM). This trial was designed to assess the equivalence of LY01011 to denosumab in terms of efficacy and safety. …”
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Novel technique for endoscopic ultrasound-guided gallbladder drainage to skip the needle tract dilation step: Efficacy of a 6-mm antimigration metal stent with a thin, tapered deli... by Keiichi Hatamaru, Masayuki Kitano, Masahiro Itonaga, Yasunobu Yamashita, Takashi Tamura, Yuki Kawaji, Junya Nuta

“…Conclusion : In conclusion, EUS-GBD using the newly designed metal stent showed excellent safety and longterm outcomes, and may be suitable as an alternative treatment in patients who are unsuitable for cholecystectomy.…”
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Fluid structure Interaction analysis for rupture risk assessment in patients with middle cerebral artery aneurysms by Jozsef Nagy, Wolfgang Fenz, Stefan Thumfart, Julia Maier, Zoltan Major, Harald Stefanits, Maria Gollwitzer, Johannes Oberndorfer, Nico Stroh, Michael Giretzlehner, Michael Sonnberger, Andreas Gruber, Philip-Rudolf Rauch, Matthias Gmeiner

“…We also introduce the HGD index, a novel composite metric combining HESA, GLN, and Maximum Wall Displacement, designed to enhance predictive accuracy. With a threshold of 0.075, the HGD index exhibited excellent diagnostic performance; in internal validation, 24 of 25 ruptured aneurysms surpassed this threshold, yielding a sensitivity of 0.96. …”
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CNN-Based Object Recognition and Tracking System to Assist Visually Impaired People by Fahad Ashiq, Muhammad Asif, Maaz Bin Ahmad, Sadia Zafar, Khalid Masood, Toqeer Mahmood, Muhammad Tariq Mahmood, Ik Hyun Lee

“…In this work, a smart and intelligent system is designed for VIPs to assist mobility and ensure their safety. …”
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Discovery of Novel Diagnostic Biomarkers for Common Pathogenic <i>Nocardia</i> Through Pan-Genome and Comparative Genome Analysis, with Preliminary Validation by Chaohong Wang, Xinmiao Jia, Ming Wei, Jun Yan, Qing Sun, Sibo Long, Maike Zheng, Yiheng Shi, Guanglu Jiang, Yan Zhao, Hairong Huang, Xinting Yang, Li Gu, Guirong Wang

“…Finally, candidate gene-specific primers were designed using Snapgene software and DNA samples were obtained from clinical <i>Nocardia</i> strains and closely related species for validation. …”
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Medical care and initial health status of French children returnees from jihadist group operation areas: A cross-sectional study from 2017 to 2020 in one referral French hospital by J. Goutines, L.L. Pham, N. Lucidarme, C. Briand, A. Malka, C. Baker, M. Veyret-Morau, A. Mapelli, A. Klein, T. Baubet, L. De Pontual

“…Since 2017, a national procedure in France has been designed to coordinate their care, including a systematic pediatric medical assessment. …”
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Filtration efficiency of medical and community face masks against particles carrying SARS-CoV-2 by Sara Dalvand, Rasul Nasiri, Rasoul Yarahmadi, Farah Bokharaei-Salim, Ali-Asghar Farshad, Somayeh Soleimani-Alyar

“…Materials and methods: The filtration efficiency of three types of face masks was investigated for particulate matters in a laboratory setup using a custom-designed system, including a human head mannequin and controlled aerosol injection. …”
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Tanshinone IIA Sodium Sulfonate Attenuates LPS-Induced Intestinal Injury in Mice by Xin-Jing Yang, Jin-Xian Qian, Yao Wei, Qiang Guo, Jun Jin, Xue Sun, Sheng-Lan Liu, Chun-Fang Xu, Guo-Xing Zhang

“…The present study is designed to explore the role and possible mechanism of TSS in LPS-induced intestinal injury. …”
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Comparative experimental anesthesia efficacy study of epidural injection at the sacrococcygeal space using ultrasound guidance versus blindness technique in Egyptian donkeys (Equus... by Mohamed A. Hamed, Hazem Hamouda, Mohammed Elmetwally, Foad Farrag, Mohamed Abdo Rizk, Mohamed M. A. Abumandour, Yamen Mohammed Hegazy, Alaa Samy

“…Cadavers were randomly designated to blind (n = 5) or US-guided (n = 5) epidural injections at the sacrococcygeal region in sternal recumbency in donkeys using Methylene Blue (1%) as a diagnostic marker for caudal epidural injection. …”
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Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer by Yaojun Ren, Min Xue, Xinhui Hui, Xiuyu Liu, Muhammad Asad Farooq, Yiran Chen, Yuzhou Ji, Yixin Duan, Iqra Ajmal, Jie Yao, Wenzheng Jiang

“…This study aims to tackle the challenge of TGF-β-mediated tumor immune evasion within the immunosuppressive tumor microenvironment by designing a novel chimeric cytokine receptor TRII/21 R, which consists of extracellular domains of TGF-β receptor II (TRII) and transmembrane and intracellular domains of IL-21 receptor (21 R) and can convert the immunosuppressive signal from TGF-β in the tumor microenvironment (TME) into an NK cell activation signal through the IL-21R-STAT3 pathway. …”
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