Alternative buffer systems in biopharmaceutical formulations and their effect on protein stability by Lebar Blaž, Zidar Mitja, Mravljak Janez, Šink Roman, Žula Aleš, Pajk Stane

“…The formulation of biopharmaceutical drugs is designed to eliminate chemical instabilities, increase conformational and colloidal stability of proteins, and optimize interfacial stability. …”
Get full text

A self-activated and protective module enhances the preclinical performance of allogeneic anti-CD70 CAR-T cells by Zhao Zhang, Lianfeng Zhao, Tinghui Huang, Zhengliang Chen, Zhengliang Chen, Yaoyao Zhao, Yaoyao Zhao, Junqing Liang, Xudong Ao, Xiaoqiong Jia, Lei Kang, Linghui Kong, Qi Jing, Jianhua Hu, Lili Gu, Feiyan Pan, Zhigang Hu, Lingfeng He, Muya Zhou, Jiannan Chen, Zhigang Guo

“…The SAP module consists of the CD47 extracellular domain, a mutant interleukin 7 receptor alpha (IL7Rα) transmembrane domain, and the IL7Rα intracellular domain, designed to protect UCAR-T cells from host immune attacks and enhance their survival. …”
Get full text

Development of a comprehensive sustainability index for extractive and mining companies: Integrating the Sustainable Development Goals by Marta Fernández-Hernández, Pedro Mora, Marcelo F. Ortega, Juan Pous Cabello

“…This research introduces an innovative, scientific index-based assessment methodology designed to quantify the contribution of companies in these sectors to the SDGs. …”
Get full text

Infrared dim tiny-sized target detection based on feature fusion by Peng Zhang, Yaman Jing, Guodong Liu, Ziyang Chen, Xiaoyan Wu, Osami Sasaki, Jixiong Pu

“…Furthermore, to tackle the problem of the fuzzy and ambiguous shape of the target caused by a weak signal and tiny dimension, a residual-based pyramid-like (RBPL) module is designed, which extracts the deep information (i.e. the shape information) from the images to compensate for the lack of expressive ability of the fixed convolution kernel for shape information. …”
Get full text

Adsorptive Removal of Malachite Green Dye onto Coal-Associated Soil and Conditions Optimization by T. R. Sundararaman, A. Saravanan, P. Senthil Kumar, M. Millicent Mabel, R. V. Hemavathy, S. Karishma, S. Jeevanantham, R. Hemavathi, A. Ishwariya, S. Kowsalya

“…The adsorption isotherm was studied with four different isotherm models and results showed that the Freundlich isotherm model gave the best fit than the other nonlinear models to designate the isotherm behaviours with R2 value of 0.9568, and the maximum adsorption capacity of coal-associated soil for MG dye adsorption is 89.97 mg/g. …”
Get full text

Vertical and spatial differences in ozone formation sensitivities under different ozone pollution levels in eastern Chinese cities by Zhuang Wang, Hao Zhang, Chune Shi, Xianguang Ji, Yizhi Zhu, Congzi Xia, Xiaoyun Sun, Meng Zhang, Xinfeng Lin, Shaowei Yan, Yuan Zhou, Chengzhi Xing, Yujia Chen, Cheng Liu

“…The shifts in the ozone formation sensitivity under different ozone pollution levels implies that controlling only one of the precursors cannot achieve the best O3 prevention effect, and the most appropriate ratio of O3 precursor emission reductions should be designed according to ozone formation sensitivity in the different regions.…”
Get full text

Comparative evaluation of ACetic - MEthanol high salt dissociation approach for single-cell transcriptomics of frozen human tissues by Marina Utkina, Anastasia Shcherbakova, Ruslan Deviatiiarov, Ruslan Deviatiiarov, Ruslan Deviatiiarov, Alina Ryabova, Marina Loguinova, Valentin Trofimov, Anna Kuznetsova, Mikhail Petropavlovskiy, Rustam Salimkhanov, Denis Maksimov, Eugene Albert, Alexandra Golubeva, Walaa Asaad, Lilia Urusova, Ekaterina Bondarenko, Anastasia Lapshina, Alexandra Shutova, Dmitry Beltsevich, Oleg Gusev, Oleg Gusev, Oleg Gusev, Oleg Gusev, Larisa Dzeranova, Galina Melnichenko, Ildar Minniakhmetov, Ivan Dedov, Natalya Mokrysheva, Sergey Popov

“…We incorporated a high-salt washing buffer instead of the standard PBS to stabilize RNA and prevent RNases reactivation during rehydration. We have designated this optimized protocol as ACME HS (ACetic acid-MEthanol High Salt). …”
Get full text

Research progress of exercise rehabilitation in patients undergoing percutaneous coronary intervention for acute myocardial infarction (急性心肌梗死患者经皮冠状动脉介入术后运动康复的研究进展)... by JIA Hongwei (贾红薇), XING Zheng (邢政), DONG Yujie (董玉洁), SHAN Li (单立), LIU Yanjie (刘艳杰), WANG Jing (王晶), YI jiaxin (益嘉欣), YANG Lin (杨林)

“…Based on the analysis of individual’s condition, early exercise rehabilitation plan should be designed systematically and logically to reduce the mortality due to acute myocardial infarction, prevent complications, promote the early rehabilitation and improve the exercise tolerance and quality of life of the patient. …”
Get full text

Performance improvement of transcritical vapor generator by a novel double-heated annular configuration by Yue Pan, Yuling Zhai, Zhouhang Li, Nan Hu

“…Overall, the novel configuration can effectively improve supercritical heat transfer once designed as recommended, substantiating itself as a feasible option for transcritical heat exchangers.…”
Get full text

The Peroxisome Proliferator-Activated Receptor γ Agonist Pioglitazone Protects Vascular Endothelial Function in Hypercholesterolemic Rats by Inhibiting Myeloperoxidase by Dapeng Zhang, Yehong Wang, Ming Yi, Suli Zhang, Ye Wu

“…The present study was designed to determine whether myeloperoxidase (MPO) mediates HC-induced endothelial dysfunction and the role of the PPARγ agonist pioglitazone (PIO) in attenuating endothelial dysfunction. …”
Get full text

Paddy straw collector-cum-chopper for in situ paddy straw management: A sustainable approach by Mohd. Muzamil, Indra Mani, Sehreen Rasool, Livleen Shukla, Shyam Nath

“…The intention was to increase the amount of straw cut at size below 5 cm for nutrient recycling.Method A paddy straw collector-cum-chopper comprised of three sub-systems i.e. straw collection and conveying unit, straw chopping device and discharging mechanism was designed and developed. The performance evaluation, economic assessment of paddy straw collector-cum-chopper and fertility status of soil was recorded.Results The results revealed that operating the machine at 40% moisture content, forward speed 3 kmph and 40 cm height of cut resulted into percentage of paddy straw <5 cm, 5-10 cm, 10-15 cm and > 15 cm as 63.5 %, 8.12 %, 6.44 % and 17.92 percent. …”
Get full text

Impact of clinical pharmacist integration on diabetes management: a prospective cohort by Nur Burcu Kutluay, Muhammed Yunus Bektay, Betul Sumbul-Sekerci, Abdusselam Sekerci, Fikret Vehbi Izzettin

“…Methods A Prospective cohort study designed to evaluate the effects of pharmacist intervention on prediabetes (pDG) and type II diabetes mellitus (DMG) patients. …”
Get full text

Posttraumatic stress disorder in disaster-exposed youth: examining diagnostic concordance and model fit using ICD-11 and DSM-5 criteria by BreAnne A. Danzi, Ellen A. Knowles, Rachel C. Bock

“…Although other studies have predicted the impact of these models by approximating the criteria using older measures, this study advances the research by comparing measures designed to assess ICD-11 and DSM-5 criteria in hurricane-exposed youth. …”
Get full text

The role of Pharmaceutical Marketing in Prescribing Decisions in a Developing Country: A Comprehensive Study Exploiting Theory of Planned Behaviour by Mahmoud Al-Areefi, Mohamed Izham Mohamed Ibrahim, Abubakr Abdelraouf Alfadl

“…A structured questionnaire was designed to measure the influence of drug-promoting marketing techniques on physicians’ prescribing decisions. …”
Get full text

Genome-wide identification and expression analysis of the PIN gene family in the pepper pedicel abscission zone and during root development by HE Lei, YAN Xi, LAI Wei, LIU Chongzheng, YANG Hong, HE Jianwen

“…[Results] 9 members of the PIN gene family were identified in the pepper genome and designated as CaPIN1 through CaPIN9. These genes are distributed across seven chromosomes, with CaPIN9 remaining unanchored. …”
Get full text

Assessing the impact of mindfulness programs on attention-deficit/ hyperactivity disorder in children and adolescents: a systematic review by Meshal A. Sultan, Faisal A. Nawaz, Batol Alattar, Eman Khalaf, Sidra Shadan, Naila El-Abiary, Shakeel Tegginmani, Rakhtan K. Qasba, Jigar Jogia

“…We included studies focusing on mindfulness for pediatric ADHD, comprising various study designs with a minimum 8-week duration. Descriptive statistics summarized results, while risk of bias was assessed using Cochrane RoB and ROBANS tools. …”
Get full text

6G: The Intelligent Network of Everything by Harri Pennanen, Tuomo Hanninen, Oskari Tervo, Antti Tolli, Matti Latva-Aho

“…This will revolutionize the way how devices, systems, and applications are designed; how they operate and interact with humans and each other; and how they can be used for the benefit of people, society, and the world in general. …”
Get full text

Oral Hygiene Practices and Associated Factors among Patients Visiting Private Dental Clinics at Hawassa City, Southern Ethiopia, 2018 by Desalegn Humna Beyene, Bereket Beyene Shashamo, Lankamo Ena Digesa, Eshetu Zerihun Tariku

“…This study was, therefore, designed to identify an oral hygiene practice on patients/clients visiting dental clinics in Hawassa City, Southern Ethiopia. …”
Get full text

Telehealth and people with disabilities in the United Kingdom: a scoping review by Mezhen Ko, Mezhen Ko, Matthew Azzopardi, Constantinos Loizou, Abison Logeswaran, Benjamin Ng, Agata Pacho, Yu Jeat Chong

“…Future efforts must focus on improving technological accessibility, training healthcare providers, and co-designing solutions with patients to promote equitable healthcare access for people with disabilities.…”
Get full text

Coordinated charging of EV fleets in community parking lots to maximize benefits using a three-stage energy management system by Isha Chandra, Navneet Kumar Singh, Paulson Samuel, Mohit Bajaj, Ievgen Zaitsev

“…This paper presents a novel three-stage real-time Energy Management System (EMS) designed to coordinate EV charging in CPLs, integrating solar photovoltaics, wind energy, ESSs, and building backup units. …”
Get full text