Anti-HER2 biparatopic antibody KJ015 has near-native structure, functional balanced high affinity, and synergistic efficacy with anti-PD-1 treatment in vivo by Zheng Wang, Yu Liu, Yunxia Xu, Lin Lu, Zhen Zhu, Baojie Lv, Xin Fang, Yao Tang, Jinhua Wang, Yu Cheng, Ying Hu, Junwen Lou, Peican Wu, Chendan Liu, Yanjun Liu, Xin Zeng, Qing Xu

“…In this study, we rationally designed a bpAb, KJ015, that shares a common light chain with two Fab arms and exhibits functionally balanced high affinity for two HER2 non-overlapping epitopes. …”
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3D Fusion Framework for Infarction and Angiogenesis Analysis in a Myocardial Infarct Minipig Model by Xu Zhenzhen PhD, Bo Tao PhD, MD, Yu Li MSc, Jun Zhang PhD, Xiaochao Qu PhD, Feng Cao PhD, Jimin Liang PhD

“…In this study, a 3D fusion framework is designed to integrate coronary computed tomography (CT) angiography (CTA), 2-deoxy-2-[ 18 F]fluoro-D-glucose ([ 18 F]DG) positron emission tomography (PET)/CT, and [ 68 Ga]-1,4,7-triazacyclononane-1,4,7-triacetic acid-(Arg-Gly-Asp)2 ([ 68 Ga]-NOTA-PRGD2) PET/CT images of the myocardial infarction model in minipigs. …”
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Maternal dietary patterns associated with bone density in Chinese lactating women and infants at 6 months postpartum: a prospective study using data from 2018-2019 by Yalin Zhou, Xiaoyu Zhu, Ying Lü, Runlong Zhao, Hanxu Shi, Wanyun Ye, Zhang Wen, Rui Li, Hanming Huang, Yajun Xu

“…This cohort study was designed to explore the relationship between maternal dietary patterns (DPs) and bone health in Chinese lactating mothers and infants. …”
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SCM-YOLO for Lightweight Small Object Detection in Remote Sensing Images by Hao Qiang, Wei Hao, Meilin Xie, Qiang Tang, Heng Shi, Yixin Zhao, Xiaoteng Han

“…Currently, small object detection in complex remote sensing environments faces significant challenges. The detectors designed for this scenario have limitations, such as insufficient extraction of spatial local information, inflexible feature fusion, and limited global feature acquisition capability. …”
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Thermospheric Neutral Density Variation During the “SpaceX” Storm: Implications From Physics‐Based Whole Geospace Modeling by Dong Lin, Wenbin Wang, Katherine Garcia‐Sage, Jia Yue, Viacheslav Merkin, Joseph M. McInerney, Kevin Pham, Kareem Sorathia

“…Abstract The Starlink satellites launched on 3 February 2022 were lost before they fully arrived in their designated orbits. The loss was attributed to two moderate geomagnetic storms that occurred consecutively on 3–4 February. …”
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The Impact of Astaxanthin Supplementation on the Lipid Profile by Filip Arczewski, Michalina Wójcikiewicz, Witold Czyż, Julia Kacperczyk, Karol Dziedzic, Marta Chuncia, Maciej Wojszczyk, Damian Zys, Piotr Pasek, Julia Ryniecka, Wiktor Czaja, Michał Krzciuk

“…Future research should focus on robust methodological designs and standardized supplementation protocols to clarify AST’s role in managing dyslipidemia and enhancing cardiovascular health.  …”
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Machine learning-based modelling and analysis of carbonation depth of recycled aggregate concrete by Xuyong Chen, Xuan Liu, Shukai Cheng, Xiaoya Bian, Xixuan Bai, Xin Zheng, Xiong Xu, Zhifeng Xu

“…In addition, a graphical user interface (GUI) for RAC carbonation depth prediction was designed.…”
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Is Everyone Beating Around the Bush?: A Qualitative Study Examining the Status of Shared Decision-Making Between Veterans Affairs Providers and Surgical Patients in the ICU by M. Andrew Millis, MD, MPH, C. Ann Vitous, MA, MPH, Cara Ferguson, BS, Maedeh Marzoughi, BS, Erin Kim, BS, Sarah E. Bradley, PhD, MPH, CPH, Ashley Duby, MS, Pasithorn A. Suwanabol, MD, MS

“…Qualitative interviews were conducted with providers who provide ICU-level care to surgical patients in Veterans Affairs hospitals. Interviews were designed to examine end-of-life care among veterans who have undergone surgery and require ICU-level care. …”
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Investigating the formation and evolution of plant diversity patterns in the Qiangtang Plateau based on phylofloristics approach by Xiaoping Li, Yun Han, Lei Miao, Hao Xu, Jingya Yu, Shuang Han, Faqi Zhang

“…Our analysis identified two distinct phyloregions, designated CⅠ and CⅡ, corresponding to the southeastern and northwestern sectors of the plateau, respectively, as delineated by their beta diversity. …”
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Which Positions Optimize Pelvic Floor Activation in Female Athletes? by Elena Sonsoles Rodríguez-López, Luz María Martín-Márquez, María Barbaño Acevedo-Gómez, África López-Illescas, María Benito-de-Pedro, Cristina Ojedo-Martín

“…Contrary to previous recommendations, these exercises do not appear to have significant negative effects; therefore, consideration should be given to the implementation of these exercises for the management of pelvic floor dysfunction and as part of comprehensive exercise programs designed to improve overall core and pelvic floor function.…”
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Risk of Nipah Virus Seroprevalence in Healthcare Workers: A Systematic Review with Meta-Analysis by Matteo Riccò, Antonio Cascio, Claudio Costantino, Silvia Corrado, Ilaria Zanella, Pasquale Gianluca Giuri, Susanna Esposito

“…According to the PRISMA statement, four medical databases (PubMed, CINAHL, EMBASE, and Scopus) and the preprint repository medRixv were inquired through a specifically designed searching strategy. A total of 2593 entries were identified; of them, 16 studies were included in qualitative and quantitative analysis detailing the outcome of NiV infection on HCWs and estimates of seroprevalence among healthcare professions. …”
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Pressure-relief and anti-impact technology of near-fault blasting by high-level roadway in deep pressure bumps mine by REN Wentao, WANG Hao, YU Bingbing, ZUO Jinjing, GU Peng, ZHANG Yuantong, ZHENG Xingbo, WANG Bo, ZHANG Bin, WAN Xiao

“…The results show that: the maximum expansion radius of the explosive fracture zone obtained by in-situ monitoring was 1.5 m, and the hole bottom distance and the charge quantity designed accordingly can ensure the breaking effect of the fault; the microseismic event of 104 energy level decreased from 5.2 % before stopping mining to 1.5 % after recovering mining, and no 105 and 106 energy level events occurred. …”
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Optimization of CuO_x/Ga₂O₃ Heterojunction Diodes for High-Voltage Power Electronics by Xiaohui Wang, Mujun Li, Minghao He, Honghao Lu, Chun-Zhang Chen, Yang Jiang, Kangyao Wen, Fangzhou Du, Yi Zhang, Chenkai Deng, Zilong Xiong, Haozhe Yu, Qing Wang, Hongyu Yu

“…Additionally, a double-layer CuO_x structure (p⁺ CuO_x/p⁻ CuO_x) was designed and optimized to achieve an ideal balance between the V_B and specific on-resistance (R_on,sp). …”
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Investigating the vascular structure of the conjunctiva in patients using spherical mini-scleral contact lenses utilizing OCT-A imaging by Fateme Alipour, Parisa Abdi, Hassan Asadigandomani, Mehdi Khodaparast, Zahra Montazeriani, Marzieh Sajedi

“…The scleral region in the quadrants (superior, inferior, temporal, and nasal) was designated as the region of interest (ROI), located 3 mm from the limbus. …”
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Applied pharmacogenetics to predict response to treatment of first psychotic episode: study protocol by Sergi Mas, Sergi Mas, Sergi Mas, Laura Julià, Manuel J. Cuesta, Manuel J. Cuesta, Manuel J. Cuesta, Benedicto Crespo-Facorro, Benedicto Crespo-Facorro, Benedicto Crespo-Facorro, Benedicto Crespo-Facorro, Javier Vázquez-Bourgon, Javier Vázquez-Bourgon, Javier Vázquez-Bourgon, Carlos Spuch, Carlos Spuch, Ana Gonzalez-Pinto, Ana Gonzalez-Pinto, Angela Ibañez, Angela Ibañez, Judith Usall, Judith Usall, Cristina Romero-López-Alberca, Cristina Romero-López-Alberca, Ana Catalan, Ana Catalan, Ana Catalan, Ana Catalan, Ana Catalan, Anna Mané, Anna Mané, Anna Mané, Anna Mané, Miquel Bernardo, Miquel Bernardo, Miquel Bernardo, Miquel Bernardo

“…The FarmaPRED-PEP project has been designed to overcome several of the limitations identified in pharmacogenetic studies in psychiatry: (1) the sample size; (2) the phenotype heterogeneity and its definition; (3) the complexity of the phenotype and (4) the gender perspective. …”
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ASD-YOLO: a lightweight network for coffee fruit ripening detection in complex scenarios by Baofeng Ye, Baofeng Ye, Renzheng Xue, Renzheng Xue, Haiqiang Xu, Haiqiang Xu

“…Firstly, a new dot product attention mechanism (L-Norm Attention) is designed to embed attention into the head structure, which enhances the ability of the model to extract coffee fruit features. …”
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Hole-selective-molecule doping improves the layer thickness tolerance of PEDOT:PSS for efficient organic solar cells by Bin Zhao, Xiaozhen Huang, Sein Chung, Min Zhang, Yufei Zhong, Anhai Liang, Zhenmin Zhao, Chaofeng Zhu, Jingjing Zhao, Seunghyun Kim, Jimin Kim, Ming Wang, Shilin Chen, Kilwon Cho, Yang Wang, Zhipeng Kan

“…Specifically, the performance of PM6:Y6 devices with a 2FPP layer of 170 ​nm remains at > 15%, providing valuable guidance for designing a thickness-insensitive hole transport layer for high-efficiency organic solar cells.…”
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Association between vascular endothelial growth factor and atrial fibrillation: a systematic review by Nikhil Sharma, Mahalaqua Nazli Khatib, R. Roopashree, Mandeep Kaur, Manish Srivastava, Amit Barwal, G. V. Siva Prasad, Pranchal Rajput, Rukshar Syed, Kamal Kundra, Vinamra Mittal, Muhammed Shabil, Amit Kumar, Pancham Cajla, Ganesh Bushi, Rachana Mehta, Zaid Khan, Prakasini Satapathy, Shilpa Gaidhane, Afukonyo Shidoiku Daniel, Renu Sah

“…The selected studies included observational and experimental designs, excluding non-English and methodologically insufficient publications. …”
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Temporal segmentation method for 30-meter long-term mapping of abandoned and reclaimed croplands in Inner Mongolia, China by Deji Wuyun, Liang Sun, Zhongxin Chen, Luís Guilherme Teixeira Crusiol, Jinwei Dong, Nitu Wu, Junwei Bao, Ruiqing Chen, Zheng Sun, Hasituya, Hongwei Zhao

“…Considering regional climatic, hydrological, and phenological conditions improves sample collection efficiency and cropland status monitoring. While designed for northern China, this method is also applicable to other single-season agricultural regions for varied agricultural land use monitoring.…”
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Resveratrol Supplementation Prevents Hypertension in Hypertensive Pregnant Rats by Increasing Sodium Excretion and Serum Nitric Oxide Level by Xiaowen Jia, Rong Zhang, Jinzhu Guo, Hua Yue, Qiuxia Liu, Lipei Guo, Qunchang Zhang

“…Pregnancy-induced hypertension (PIH) remains a major cause of morbidity and mortality in pregnancy worldwide. This study was designed to study the blood pressure-lowering effect of resveratrol (RES) in a salt-induced hypertensive pregnant rat model. …”
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