Machine learning based QSAR and Molecular Dynamics simulations in the structural design and mechanism of action of imidazole derivatives with anti-melanoma activity by Rosalvo Ferreira de Oliveira Neto, Sérgio Ruschi Bergamachi Silva, Cintia Emi Yanaguibashi Leal, Edilson Beserra de Alencar Filho

“…The QSAR model allows for the design and prediction of nine new analogues with favourable predicted IC50 values. …”
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A sustainable HazMat logistic network design considering scale of economy and route sensitivity and solving with Hybrid GA-SA by Razieh Keshavarzfard, Azam Naderi

“…The transportation of Hazardous Materials (HazMat) is particularly complex and has attracted significant attention from scholars. When designing logistics networks for HazMat, factors such as time window constraints, uncertainties, vehicle capacity, and mileage capacity in sub-tours need to be considered to minimize overall transportation and pollution costs. …”
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A review of design factors in steam and gas push for eco-friendly oil sands production and its field application in Canada by Sunghyun Kim, Hyundon Shin, Changhyup Park, Zhuoheng Chen, Kyungbook Lee

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Multilevel Precision-Based Rational Design of Chemical Inhibitors Targeting the Hydrophobic Cleft of Apical Membrane Antigen 1 (AMA1) by Umashankar Vetrivel, Shalini Muralikumar, B Mahalakshmi, K Lily Therese, HN Madhavan, Mohamed Alameen, Indhuja Thirumudi

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Ecological and forestry assessment of the compliance of the composition of forest crops designed for afforestation with the types of forest site conditions in the Steppe climate of Ukraine by Svitlana Raspopina, Anastasiia Suska, Yulia Belay, Vitalii Goroshko

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Optimized recovery of phenolic and flavonoid compounds from medicinal plant extracts for enhanced antioxidant activity: A mixture design approach by Faiza Imtiaz, Dildar Ahmed, Osama A. Mohammed, Umer Younas, Munawar Iqbal

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Holistic approach to adaptive reuse research focused on the design strategy and its extended categories: lessons from a critical review by Yoon-Jeong Shin, Eun Joo Park, Eunki Kang

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Design, synthesis, structural characterization, in vitro anticancer activity, and in silico studies of some new hydroxylated and fluorinated-substituted hydrazone derivatives by Reşit Çakmak, Eyüp Başaran, Ömer Erdoğan, Suraj N. Mali, Semiha Köprü, Haya Yasin, Shailesh S. Gurav, Giray Topal

“…In this study, novel hydroxylated and fluorinated-substituted hydrazone derivatives bearing an aromatic nitro moiety (2a-d and 3a-d) were designed as potential anticancer drug candidates, synthesized for the first time, and evaluated for their anticancer activity against chondrosarcoma (SW1353), a common primary malignant cartilage-forming tumor, neuroblastoma (SH-SY5Y), a type of brain cancer, and healthy (L929) cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method for 24 h. …”
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Design Study for a Quasisynchronous CDMA Sensor Data Collection System: An LEO Satellite Uplink Access Technique Based on GPS by Yijun Chen, Sheng Ding, Zhouchen Xie, Zhuangping Qi, Xuwen Liang

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Screening of SIRT2 inhibitors from natural product databases using computer-aided drug design and molecular dynamics simulation by Tianyi Liu, Hongli Yin, Xue Dong, Qingyang Hu, Xuejiao Hu, Wenxin Yan, Huanhuan Wang, Zhong Li

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Perancangan User Experience Pada Aplikasi Mobile HomeCare Rumah Sakit Semen Gresik Menggunakan Metode Design Thinking by Fara Regina Isadora, Buce Trias Hanggara, Yusi Tyroni Mursityo

“…The design solution is then tested using a user experience questionnaire (UEQ) to find out whether the design solution designed has resolved the problems experienced by potential users. …”
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Improving the Activity and Selectivity of a Scorpion-Derived Peptide, A3a, against Acinetobacter baumannii through Rational Design by Dalton S. Möller, Mandelie van der Walt, Carel Oosthuizen, Miruna Serian, June C. Serem, Christian D. Lorenz, A. James Mason, Megan J. Bester, Anabella R. M. Gaspar

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Co-creation of a toolkit to assist risk communication and clinical decision-making in severe preeclampsia: SPOT-Impact study design by Hannah Brown Amoakoh, Bregje C. De Kok, Linda Lucy Yevoo, Klaartje M. Olde Loohuis, Emmanuel K. Srofenyoh, Daniel K. Arhinful, Koiwah Koi-Larbi, Kwame Adu-Bonsaffoh, Mary Amoakoh-Coleman, Joyce L. Browne

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Design of 3D Hybrid Plant Extract/Marine and Bovine Collagen Matrixes as Potential Dermal Scaffolds for Skin Wound Healing by Aida Lahmar, Maroua Rjab, Fairouz Sioud, Mouna Selmi, Abir Salek, Soumaya Kilani-Jaziri, Leila Chekir Ghedira

“…Highly interconnected 3D scaffolds from collagen from the skin are designed and added by the widely known healing plants Pistacia lentiscus and Calendula officinalis. …”
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Numerical Investigation on Pressure Pulsation Characteristics and Radial Force of a Deep-Sea Electric Lifting Pump at Off-Design Conditions by Yajuan Kang, Shaojun Liu, Weisheng Zou, Xiaozhou Hu

“…To predict the vibrational conditions, the generation mechanism, and action law of pressure pulsation and radial force, a computational fluid dynamics (CFD) study of a deep-sea electric lifting pump operating under different off-design conditions was performed. The time-domain and frequency-domain response of the pressure pulsation at different monitoring points and the radial force of impeller distribution were obtained. …”
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Design Improvements and Best Practices in Small-Scale Biodigesters for Sustainable Biogas Production: A Case Study in the Chillon Valley, Perú by Yoisdel Castillo Alvarez, Reinier Jiménez Borges, Carlos Diego Patiño Vidal, Fanny Mabel Carhuancho Leon, José Santos Pinares Buendia, Jose Alberto Samaniego Nolasco

“…This applied theoretical research seeks to overcome these barriers by improving the design and operation of small-scale biogas plants. …”
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Impact of Spatial Hole Burning and Linewidth Enhancement Factor on Distributed-Feedback Quantum Cascade Lasers: A Comprehensive Design Analysis by Sara Zaminga, Lorenzo Columbo, Carlo Silvestri, Mariangela Gioannini, Frederic Grillot

“…The purpose is to supply designers with a guideline to achieve the optimal structure for efficient single-mode emission, which is a highly required specification in manifold applications, like free-space optical communication. …”
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Design and Implementation of Single Axis Solar Tracking System: Utilizing GPS, Astronomical Equations, and Satellite Dish Actuator for Optimal Efficiency by Rizgar Ahmed Salih, Karzan Qadir Mohammed, Peshawa Osman Hama, Rawaz Othman Hassan, Barham Kamal Noori

“…This is achieved by interconnecting some devices that include GPS sensors and satellite dish actuators as the main components that are managed and controlled using astronomical equations. The designed system is tracked in a discrete manner that can be adjusted automatically during the day related to each degree change of azimuth angle of the sun from sunrise to sunset. …”
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Multiepitope Subunit Vaccine Design against COVID-19 Based on the Spike Protein of SARS-CoV-2: An In Silico Analysis by Hamza Arshad Dar, Yasir Waheed, Muzammil Hasan Najmi, Saba Ismail, Helal F. Hetta, Amjad Ali, Khalid Muhammad

“…Researchers around the globe need to design and develop successful therapeutics as well as vaccines against the novel COVID-19 disease. …”
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Open eco-innovations in sustainable product development: Model framework of design thinking in quality life cycle assessment (DT-QLCA) by Dominika Siwiec, Bożena Gajdzik, Remigiusz Gawlik, Radosław Wolniak, Andrzej Pacana

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