Research note: Establishment of a multiplex PCR detection system for different infectious bronchitis virus strain genotypes in laying hens by Changjing Zhao, Cheng Yuan, Qingsen Zhao, Aihong Xia, Yaqing Dong, Shuying Xu, Shihan Chen, Yue Yuan, Yongjuan Wang

“…Based on the spike 1 (S1) glycoprotein gene sequences of the IBV Mass, QX, G Ⅵ-1, 4/91, and LDT3 strains, five sets of customized primers, showing excellent specificity, were designed and synthesized to target the appropriate conserved sequences. …”
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Ion bridging enables high-voltage polyether electrolytes for quasi-solid-state batteries by Tianyi Hou, Donghai Wang, Bowen Jiang, Yi Liu, Jia Kong, Yanbing He, Yunhui Huang, Henghui Xu

“…This work offers a pathway for designing high-voltage polymer electrolytes and a general solution for achieving high-performance quasi-solid-state batteries.…”
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Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults, especially in obese individuals: a prospective cohort study by Juanjuan Zhang, Sabina Rayamajhi, Amrish Thapa, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Yeqing Gu, Shunming Zhang, Tingjing Zhang, Xuena Wang, Zhixia Cao, Jun Dong, Xiaoxi Zheng, Xu Zhang, Xinrong Dong, Xing Wang, Shaomei Sun, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu

“…We speculated that due to its abundant nutrients edible mushrooms might have a beneficial effect on the prevention of subclinical thyroid dysfunction (SCTD). Therefore, we designed a large-scale cohort study to examine whether mushrooms consumption is a protective factor for SCTD in adults. …”
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Polarization-independent high-sensitive metamaterial sensor for chemical sensing and EMI shielding application by Md Kutub Uddin, Shawon Hossen, Touhidul Alam, Mohammad Tariqul Islam, Saleh Albadran, Haitham Alsaif, Ahmed S. Alshammari, Ahmed Alzamil, Mohammad Lutful Hakim

“…Furthermore, To validate the designed MTM, a 40 × 50 mm2 array prototype is fabricated, and the performance of the MTM is investigated in the laboratory, where the real-time investigation results strongly agree with the simulation result. …”
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Hypofractionated radiotherapy combined with a PD-1 inhibitor, granulocyte macrophage-colony stimulating factor, and thymosin-α1 in advanced metastatic solid tumors: a multicenter P... by Jiamin Yu, Li Yin, Wenjie Guo, Qiang Wang, Juying Liu, Lansheng Zhang, Hongxun Ye, Jianhong Xia, Youyou Xia, Jianfeng Wu, Wanwei Wang, Yanguang Yang, Dan Zong, Xia He, Lijun Wang, Hong Jiang

“…Conclusion In conclusion, the trends in efficacy observed in our study are promising; however, well-designed protocols are essential to validate these findings.…”
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Dynamic rationing using agent-based modeling of the assembly process of equipment for nuclear power plants by I. A. Loskutov, D. A. Skvortsova, V. G. Iskandarova

“…The work is raised as an agent-based model designed to calculate the time spent on the assembly stage of the manufacturing process for manufacturing equipment for nuclear power plants. …”
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Advancing Radiobiology: Investigating the Effects of Photon, Proton, and Carbon-Ion Irradiation on PANC-1 Cells in 2D and 3D Tumor Models by Alexandra Charalampopoulou, Amelia Barcellini, Giuseppe Magro, Anna Bellini, Sara Sevan Borgna, Giorgia Fulgini, Giovanni Battista Ivaldi, Alessio Mereghetti, Ester Orlandi, Marco Giuseppe Pullia, Simone Savazzi, Paola Tabarelli De Fatis, Gaia Volpi, Angelica Facoetti

“…<b>Conclusions:</b> Our research highlights the pivotal role of 3D models in unraveling the complexities of pancreatic cancer radiobiology, offering new avenues for designing more effective and precise treatment protocols.…”
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Targeting ASK1 by CS17919 alleviates kidney‐ and liver‐related diseases in murine models by Guoqiang Liao, Qianjiao Yang, Xuhua Mao, Yiru Zhao, Beizhong Chen, Kun Zhang, Yu Zhang, Ping Zhang, Zhengli Chen, Shengjian Huang

“…Abstract Background Apoptosis signal‐regulating kinase 1 (ASK1) is a MAP3K kinase in the MAPK signaling pathway activated by stressors and triggers downstream biological effects such as inflammation and apoptosis; therefore, inhibition of ASK1 kinase activity can protect cells from pathological injury. In this study, we designed and synthesized a novel selective ASK1 inhibitor, CS17919, and investigated its pharmacological effects in various animal models of metabolic injury. …”
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Aetiological research on the health of migrants living in Germany: a systematic literature review by Oliver Razum, Florian Fischer, Ina Danquah, Claudia Hövener, Patricia Nayna Schwerdtle, Tracy Bonsu Osei, Isabel Mank, Raissa Sorgho

“…The main objective was to systematically identify, evaluate and synthesise population-based studies that investigated exposure–outcome relationships among migrant groups in Germany.Methods In November 2019, we searched PubMed and LIVIVO, and updated this search in November 2020, to identify peer-reviewed publications that fulfilled our eligibility criteria: English or German language; study on disease aetiology among major migrant groups in Germany, according to the latest microcensus; publication date from inception to 01 November 2020 and observational or experimental study designs. For quality appraisal, we used the Critical Appraisal Skills Programme checklists. …”
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Cohort profile: maternal and child health and parenting practices during the COVID-19 pandemic in Ceará, Brazil: birth cohort study (Iracema-COVID) by Marcia C Castro, Márcia Maria Tavares Machado, Simone Farías-Antúnez, David Augusto Batista Sá Araújo, Ana Luiza Penna, Francisco Ariclene Oliveira, Camila Machado de Aquino, Antônio Silva Lima Neto, Geziel dos Santos de Sousa

“…Purpose Maternal and child health and parenting practices during the COVID-19 pandemic in Ceará (Iracema-COVID) is a longitudinal, prospective population-based birth cohort designed to understand the effects of the pandemic and social withdrawal in maternal mental health, child development and parenting practices of mothers and families.Participants A sample of mothers who gave birth in July and August 2020 (n=351) was enrolled in the study in January 2021. …”
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Loss of Type 2 Bone Morphogenetic Protein Receptor Activates NOD‐Like Receptor Family Protein 3/Gasdermin E‐Mediated Pyroptosis in Pulmonary Arterial Hypertension by Xiao‐ting Tian, Zhou‐yang‐fan Peng, Yu‐si Wu, Yuan‐yuan Cao, Xue‐chun Li, Ying Li, Si‐Yuan Tang, Alex F. Chen, Xiao‐hui Li

“…Previous research has reported that dysfunction of type 2 bone morphogenetic protein receptor (BMPR2) signaling pathway in endothelium is inclined to prompt inflammation in PAH models, but the underlying mechanism of BMPR2 deficiency‐mediated inflammation needs further investigation. This study was designed to investigate whether BMPR2 deficiency contributes to pulmonary arterial hypertension via the NLRP3 (NOD‐like receptor family protein 3)/GSDME (gasdermin E)‐mediated pyroptosis pathway. …”
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Independent and joint associations of neighbourhood greenness and walkability with transportational and recreational physical activity among youth and adults in Canada by Natalie Doan, Sebastian A. Srugo, Stephanie A. Prince, Rachel C. Colley, Daniel G. Rainham, Taru Manyanga, Gregory P. Butler, Richard Larouche, Sarah E. Turner, Justin J. Lang

“…These novel findings highlight the importance of designing cities that are both greener and more walkable to promote active living.…”
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Influence of lemongrass and oregano essential oils and their combination on in vitro ruminal fermentation and greenhouse gas emissions in total mixed ration for dairy cows by Sara Glorio Patrucco, Alessandro Lotto, Martina Dorigo, Rita Fornaciari, Antonio Sagliano, Nicola Martinelli, Alessandra Cosani, Khalil Abid, Salvatore Barbera, Hatsumi Kaihara, Sonia Tassone

“…Among EOs, lemongrass (Cymbopogon winterianus) and oregano (Origanum vulgare) EOs (LEO and OEO) have attracted attention as modulators of ruminal fermentations, but their role needs to be clarified. The experiment was designed using a randomised setup to assess the effects of LEO and OEO on in vitro ruminal fermentation and GHGs, using total mixed ration (TMR) as substrate (incubation time 24h). …”
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Family-focused intervention programme to foster adolescent mental health and well-being: protocol for a multicountry cluster randomised factorial trial (FLOURISH Phase 2) by Heather M Foran, Marija Raleva, Nina Heinrichs, Graham Moore, Yulia Shenderovich, Xiang Zhao, Judith Simon, Antonio Piolanti, Viorel Babii, Janina Mueller, Franziska Waller, Dennis Wienand, Swetha Sampathkumar, Ivo Kunovski

“…Effective and scalable interventions are urgently needed to address these challenges.Methods and analysis This protocol outlines a multicountry cluster randomised factorial trial, implemented according to the multiphase optimisation strategy (Phase 2), which evaluates the effectiveness and costs of three add-on components for the Parenting for Lifelong Health for Parents and Teens programme: adolescent mental health tools based on UNICEFs Helping Adolescents Thrive comics, adolescent peer support based on UNICEFs ‘I Support My Friends’ intervention and engagement booster designed to enhance attendance and programme completion through incentives. …”
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Exploring the utility of different bulking agents for speeding up the composting process of household kitchen waste by Sania Mussa, Muhammad Farhan, Shoaib Ahmad, Khadija Zahra, Amina Kanwal, Qaiser Farid Khan, Muhammad Afzaal, Abdul Wahid, Pallab K. Sarker, Mohamed A. El-Sheikh, Shafaqat Ali

“…Aerobic composting of HKW is an easy, efficient, cost-effective and eco-friendly method. This study is designed to achieve a zero-waste concept and to convert HKW. …”
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Comprehensive assessment of physicochemical quality, heavy metals, and ecological risks in the Someshwari river water, Netrokona, Bangladesh by Rima Sarker, Md. Sirajul Islam, Md. Humayun Kabir, Shahrina Sultana, Nowara Tamanna Meghla, Mir Md. Mozammal Hoque, Tanmoy Roy Tusher

“…In summary, the results of this investigation suggest that the water quality in the designated area is suitable for various uses. However, to maintain this water quality, it is strongly recommended that effective awareness programs be implemented to prevent water pollution.…”
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Evaluation of the protective efficacy of OlysetPlus ceiling nets for reduction of malaria incidence in children in Homa Bay County, Kenya: a cluster-randomised controlled study pro... by Daisuke Yoneoka, Jesse Gitaka, James Kongere, Wataru Kagaya, Akira Kaneko, Yura K Ko, Chim W Chan, Mariko Kanamori, Bernard N Kanoi, Gordon Odhiambo Okomo, Protus Omondi, Kelvin B Musyoka, Takatsugu Okai, Victor Opiyo, Jared Oginga, Samuel Mungai, Kibor K Keitany, Elijah Songok, Noboru Minakawa

“…With this proposed second trial, we aim to evaluate the impact of this tool in a different eco-epidemiological setting in the lake endemic region of Kenya.Methods A cluster-randomised controlled trial is designed to evaluate the impact of pyrethroid-PBO ceiling nets in Ndhiwa Sub-County, Homa Bay County, Kenya. …”
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Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury by Haoru Dong, Zongxing He, Shiyi Cai, Haiqiang Ma, Lili Su, Jianfeng Li, Huiying Yang, Rong Xie

“…The novel formulation, MP-LNP-C3, is designed for direct administration to the injury site during decompression surgery, offering a targeted therapeutic modality for SCI. …”
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The Equator Project Research School and Mentoring Network: Evaluated Interventions to Improve Equity in Geoscience Research by Natasha Dowey, Anya Lawrence, Munira Raji, Christopher Jackson, Rebecca Williams, Ben Fernando, Sam Giles, Jenni Barclay, Louisa Brotherson, Ethny Childs, Jacqueline Houghton, Anjana Khatwa, Keely Mills, George Jameson, Francisca Rockey, Steven Rogers, Catherine Souch

“…The Research School was designed to facilitate network-building, improve awareness of research careers, enhance confidence in continuing in research, and strengthen a sense of belonging in GEES research for participants. …”
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The effect of electroslag remelting on the cleanliness of CrNiMoWMnV ultrahigh-strength steels by Ali M., Porter D., Kömi J., Heikkinen E.P., Eissa M., El Faramawy H., Mattar T.

“…Three experimental heats of UHSSs with different chemical compositions were designed, melted in an induction furnace, and refined using ESR. …”
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