Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies by Liu S, Li H, Xi S, Zhang Y, Sun T

“…Gene therapy involves altering or manipulating gene expression and can be enhanced by NPs designed to carry various genetic materials. Similarly, NPs can improve the efficacy of ERT for lysosomal storage disorders (LSDs) by facilitating enzyme delivery to the brain, overcoming issues like immunogenicity and instability. …”
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Comparative analysis of efficacy and quality of life between totally extraperitoneal sublay and intraperitoneal onlay mesh repair for ventral hernia by Miaofeng Wang, Wei Chen, Xiufeng Chu

“…Abstract Ventral hernias pose a prevalent challenge in abdominal wall surgery, with ongoing advancements in repair techniques designed to enhance patient outcomes. This study evaluates the efficacy, safety, and socio-economic impact of Totally Extraperitoneal Sublay Repair (TES) versus Laparoscopic Intraperitoneal Onlay Mesh Repair (IPOM) for small to medium-sized ventral hernias, with a particular focus on postoperative quality of life and patient satisfaction. …”
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Segmentasi Wilayah Terdampak Bencana Berdasarkan Fitur Geo-Posisi by Ade Sutedi, Indri Tri Julianto, Leni Fitriani

“…Abstract   This research introduces a prototype Disaster-affected Area Segmentation Application (DAS-Apps) designed to perform segmentation of disaster-affected areas based on latitude and longitude features (geo-positioning). …”
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SCovid v2.0: a comprehensive resource to decipher the molecular characteristics across tissues in COVID-19 and other human coronaviruses by Zijun Zhu, Xinyu Chen, Guoyou He, Rui Yu, Chao Wang, Changlu Qi, Liang Cheng

“…ABSTRACT SCovid v2.0 (http://bio-annotation.cn/scovid or http://bio-computing.hrbmu.edu.cn/scovid/) is an updated database designed to assist researchers in uncovering the molecular characteristics of coronavirus disease 2019 (COVID-19) across various tissues through transcriptome sequencing. …”
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High-Frequency Power Reflects Dual Intentions of Time and Movement for Active Brain–Computer Interface by Jiayuan Meng, Xiaoyu Li, Simiao Li, Xinan Fan, Minpeng Xu, Dong Ming

“…A time-movement synchronization experiment was designed, which contained the intentions of both time (500 ms vs. 1000 ms) and movement (left vs. right). …”
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Resetting the Hsc70-mediated lysosomal degradation of PD-L1 via a supramolecular meso peptide for the restoration of acquired anti-tumor T cell immunity by Yujia Zhao, Dan Liu, Wenguang Yang, Wangxiao He, Jin Yan, Leiqing Yao

“…To overcome this issue, a meso chimeric peptide PEPPDL1 was designed to specifically bind the PD-1 binding domain of PD-L1 instead of the Hsc70/CMTM6 binding domain, while also binding to Hsc70 to facilitate the dragging of PD-L1 into Hsc70-mediated chaperone-mediated autophagy (CMA), thereby achieving lysosomal degradation. …”
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Comparing Balance Performance on Force Platform Measures in Individuals with Parkinson’s Disease and Healthy Adults by Cathy C. Harro, Amanda Kelch, Cora Hargis, Abigail DeWitt

“…FP measures may inform clinicians regarding intrinsic balance deficits and guide them in designing targeted balance interventions to reduce fall risk in persons with PD.…”
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Analyzing frequency spectrum and Total Harmonic Distortion for high switching frequency operation of GaN-based filter-less multilevel cascaded H-bridge inverter by Ramkrishna Mishan, Xingang Fu, Chanakya Hingu, Poria Fajri

“…Despite the advantageous electrical properties of GaN switches for switching operation, their assimilation into high multilevel CHB inverter designs at MHz frequencies poses considerable challenges regarding efficiency, control, and the minimization of THD. …”
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YTHDF1 Regulates RELA m6A Modification and Activates the NF‐Kappa B Signaling Pathway to Promote the Mechanism of Gastric Cancer by Yangyuan Huang, Shihao Liang, Liping Li, Qingyu Zeng, Bin Li

“…In vitro experimental study of GC, other mechanisms and functional analyses were specifically designed and performed too. Results Online data and clinical samples analysis showed that the expression of YTHDF1 in GC was markedly elevated compared to surrounding tissues. …”
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Vagal nerve stimulation dynamically alters anxiety-like behavior in rats by A.G. Butler, J.K. Bassi, A.A. Connelly, M.R. Melo, A.M. Allen, S.J. McDougall

“…Background: Electrical vagal nerve stimulation (VNS), at currents designed to target sensory, interoceptive neurons, decreases anxiety-like behavior. …”
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Association of Septic Shock with Mortality in Hospitalized COVID-19 Patients in Wuhan, China by Shaoqiu Chen, Zitong Gao, Ling Hu, Yi Zuo, Yuanyuan Fu, Meilin Wei, Emory Zitello, Gang Huang, Youping Deng

“…Clinical outcomes were designated as nonseptic shock and septic shock. Log-rank test was conducted to determine any association with clinical progression. …”
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Clinical Characteristics of COVID-19 Patients with and without Diabetes in Wuhan Red Cross Hospital by Guozhen Li, Qin Deng, Jiali Feng, Fang Li, Nian Xiong, Qiong He

“…Since the end of December 2019, novel coronavirus- (SARS-CoV-2-) infected pneumonia (COVID-19) has spread rapidly in China. The study was designed to describe the clinical characteristics of COVID-19 patients with and without diabetes in Wuhan. …”
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CULTURAL REPRESENTATION IN THE PRACTICE OF ANDRAGOGY IN THE ACADEMIC by Janawi, Yusra Jamali, Dinar Pratama, Musa, Saiful Anwar, Subardi

“…Through a mixed-methods approach, this research evaluates the effectiveness of a professional development program designed to enhance lecturers' understanding and application of andragogical principles. …”
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Revealing speckle obscured living human retinal cells with artificial intelligence assisted adaptive optics optical coherence tomography by Vineeta Das, Furu Zhang, Andrew J. Bower, Joanne Li, Tao Liu, Nancy Aguilera, Bruno Alvisio, Zhuolin Liu, Daniel X. Hammer, Johnny Tam

“…Methods Here, we introduce parallel discriminator generative adversarial network (P-GAN), an artificial intelligence (AI) method designed to recover speckle-obscured cellular features from a single AO-OCT volume, circumventing the need for acquiring a large number of volumes for averaging. …”
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How to Coordinate Urban Ecological Networks and Street Green Space Construction? Insights from a Multi-Scale Perspective by Shujun Hou, Ying Yu, Taeyeol Jung, Xin Han

“…Ecological pinch points were located near urban rivers and surrounding woodlands, while ecological barrier points were concentrated in areas with dense buildings and complex transportation networks. (2) Higher street GVI values were observed around university campuses, urban parks, and river-adjacent streets, while lower GVI values were found near commercial areas and transportation hubs. (3) To coordinate the construction of ecological networks and street green spaces, the central area of the First Ring Road and the northwestern region of the Second and Third Ring Roads were identified as priority restoration areas, while the northern, western, and southeastern areas of the Second and Third Ring Roads were designated as priority protection areas. This study adopts a multi-scale spatial perspective to identify priority areas for protection and restoration, aiming to coordinate the construction of urban ecological networks and street green spaces and provide new insights for advancing ecological civilization in high-density urban areas.…”
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Archival and Newly Isolated Historical <i>Bacillus anthracis</i> Strains Populate the Deeper Phylogeny of the A.Br.075(Sterne) Clade by Markus Antwerpen, Peter Braun, Wolfgang Beyer, Dirk Aldenkortt, Michael Seidel, Gregor Grass

“…From the accrued new phylogenetic information, we designed and tested a variety of new SNP-PCR assays for rapid and facile genotyping of unassigned <i>B. anthracis</i> genomes. …”
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Application of suture-stretching technique in repairing skin defect of lower limb by Yuan Pan, Yingying Deng, Chaoran Hu, Kunzhi Zhu, Chao Feng

“…Among them, 77 cases were repaired using our novel technique (suture-stretching technique, we designed a simple and feasible skin traction device that used 2–0 (polydioxanone sutures) PDS sutures, 2.0 mm Kirschner wires, and nylon binding tapes to repair skin defects and accommodate irregular wounds according to Ilizarov’s “tension-stress” law, SS group); skin grafting (SG group) was used for repairing 48 cases of wounds. …”
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A solution at the doorsteps: Improved biofertilizer enhances soil fertility and yield of Chili ( Capsicum an-nuumL.) in Bhutan by Sonam Tashi, Kesang Wangchuk, Erica Udas, Sonam Gaki, Kamal Aryal

“…The experiments were Randomized Complete Block Designs (RCBD) consisting of three treatments (cattle dung/ urine: Jholmal 1, cattle urine: Jholmal 2, and Control), and each treatment was replicated four times. …”
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Evaluation of the role of hydroxychloroquine as a lipid profile improving and glucose adjusting drug in Egyptian females with inactive rheumatoid arthritis by Aliaa O. El-Hady, Mai M. Kamel, Yasmin T. Mosaad, Maha A. Ali, Soad S. El Molla

“…A disease-modifying antirheumatic drugs (DMARD) hydroxychloroquine (HCQ) with a good safety profile and low cost has been reported to improve lipid profiles and glucose level in RA. The study was designed to evaluate the responsibility of HCQ in the improvement of lipid profile and glucose level in Egyptian Inactive Rheumatoid Arthritis (RA) females. …”
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The Effectiveness of Drying on Residual Droplets, Microorganisms, and Biofilms in Gastrointestinal Endoscope Reprocessing: A Systematic Review by Hefeng Tian, Jiao Sun, Shaoning Guo, Xuanrui Zhu, Han Feng, Yijin Zhuang, Xiu Wang

“…Inadequate drying of gastrointestinal endoscope working channels may promote microbial reproduction and biofilm formation, increasing the risk of infection in patients. This review was designed to provide the current status of gastrointestinal endoscope drying, emphasize the importance of gastrointestinal endoscope drying, and evaluate the effectiveness of different drying methods of gastrointestinal endoscope in reducing residual droplets and microbial growth risk. …”
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