PD-L1 Immunohistochemistry Comparability and Their Correlation with Clinical Characteristics in NSCLC by Chiao-En Wu, Ching-Fu Chang, Liao Kou-Sheng, Ju Chiang, Shih-Wei Lee, Yu-Chi Chiu

“…PD-L1 expression is an important predictive factor of response to therapy with immune checkpoint inhibitors (ICIs). This study was designed to retrospectively analyze the concordance of PD-L1 measurements using three different assays (Dako22C3, Dako28-8, and SP142) in NSCLC patients and to find possible predictors of high PD-L1 expression. …”
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The sulfur-related metabolic status of Aspergillus fumigatus during infection reveals cytosolic serine hydroxymethyltransferase as a promising antifungal target by Reem Alharthi, Monica Sueiro-Olivares, Isabelle Storer, Hajer Bin Shuraym, Jennifer Scott, Reem Al-Shidhani, Rachael Fortune-Grant, Elaine Bignell, Lydia Tabernero, Michael Bromley, Can Zhao, Jorge Amich

“…We further showed that the structure of the ligand-binding pocket of the fungal enzyme differs significantly from its human counterpart, suggesting that specific inhibitors can be designed. Therefore, in vivo transcriptomics is a powerful tool for identifying genes crucial for fungal pathogenicity that may encode promising antifungal target candidates.…”
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Dietary γ-Aminobutyric Acid Promotes Growth and Immune System Performance and Improves Erythropoiesis and Angiogenesis in Gibel Carp (<i>Carassius auratus gibelio</i>) by Xinlan Bai, Lu Zhang, Hualiang Liang, Dongyu Huang, Mingchun Ren, Haifeng Mi

“…An eight-week culturing experiment was designed with five experimental diets, with the actual GABA content being 368 mg/kg (G1, control group), 449 mg/kg (G2), 527 mg/kg (G3), 602 mg/kg (G4), and 675 mg/kg (G5). …”
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Enhancing Remote Sensing Semantic Segmentation Accuracy and Efficiency Through Transformer and Knowledge Distillation by Kang Zheng, Yu Chen, Jingrong Wang, Zhifei Liu, Shuai Bao, Jiao Zhan, Nan Shen

“…To address these issues, this study designs a hybrid approach that integrates knowledge distillation with a combination of CNN and transformer to enhance semantic segmentation in remote sensing images. …”
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FreshWater Watch: Investigating the Health of Freshwater Ecosystems, from the Bottom Up by Isabel Bishop, Amedeo Boldrini, Wim Clymans, Charlotte Hall, Heather Moorhouse, Stephen Parkinson, Kesella Scott-Somme, Ian Thornhill, Steven Loiselle

“…Herein, we outline the criteria used to develop a citizen science monitoring program for water quality, based on a standardized methodology designed to support the Agenda 2030 indicator 6.3.2 and the EU’s Water Framework Directive. …”
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The Influence of the Cu-Al₂O₃ Ratio of the Receiving Tube in a 50 MW Hybrid Solar Plant by Guillermo Benítez-Olivares, Alejandro Torres-Aldaco, Raúl Lugo-Leyte, José Javier Valencia-López, Luis Alberto Romero-Vázquez, Helen D. Lugo-Méndez

“…A 50 MWe hybrid solar thermal plant is proposed for Mulegé, Baja California Sur, Mexico, including a solar field designed to analyze the production of superheated steam during peak solar irradiance hours. …”
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The variability and predictability of summer southwest monsoon intensity measurement index across mainland indochina: from local synoptic to large scale perspectives by Kyaw Than Oo, Yinshuo Dong, Kazora Jonah

“…This study introduces a new Southwest Monsoon Intensity Index (SMII), based on sea level pressure (SLP), which offers a more comprehensive understanding of the monsoon’s intraseasonal to interannual variability and its associated climate anomalies. The SMII is designed to overtake the limitations of local indices, which often rely on data from only two costal stations and may lack the resolution necessary for seasonal outlooks or long-term forecast modeling. …”
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The availability of drugs for stable COPD treatment in China: a cross-sectional survey by Dongru Du, Xueru Hu, Qiunan Zuo, Dan Xu, Tao Zhu, Tao Fan, Jiao Yang, Weiguo Xu, Hailong Wei, Kangzhuo Baima, Ying Zhang, Yanhui Gu, Lei Chen, Fengming Luo, Yongchun Shen, Fuqiang Wen

“…A well-constructed questionnaire was designed according to the Chinese Guidelines for the Diagnosis and Management of COPD (revised version 2021). …”
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An “initial-engineering-end use” quasi-market pricing mechanism under cascading risk for cross-regional water rights trading by Xuxia Li, Huimin Wang, Gang Liu, Liu Yang, Zhou Fang, Yi Xiao, Xiaoying Lai, Li Gao, Ying Teng

“…The mechanism comprises three stages, each designed to address specific risks. To support these stages, data from field studies is used to calibrate three unique pricing models: the stochastic differential game, incomplete contract theory, and the Nash-bargaining model. …”
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VEGFR-2 Expression in Glioblastoma Multiforme Depends on Inflammatory Tumor Microenvironment by Jana Jaal, Marju Kase, Ave Minajeva, Mikk Saretok, Aidi Adamson, Jelizaveta Junninen, Tõnis Metsaots, Tõnu Jõgi, Madis Joonsalu, Markus Vardja, Toomas Asser

“…Target dependence on inflammatory tumor microenvironment has to be taken into consideration when treatment approaches that block VEGFR-2 signaling are designed.…”
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The philosophical foundations of digital twinning by David J Wagg, Christopher Burr, Jason Shepherd, Zack Xuereb Conti, Mark Enzer, Steven Niederer

“…We further argue that in order to enable emergent behaviors, digital twins should be designed to reconstruct the behavior of a physical twin by “dynamically assembling” multiple digital “components”. …”
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Enhanced Optical and Thermal Stability of Blue Pyrrole Derivatives for Color Filter in Image Sensors by Sunwoo Park, Sangwook Park, Saeyoung Oh, Hyukmin Kwon, Hayoon Lee, Kiho Lee, Chun Yoon, Jongwook Park

“…We designed and synthesized two novel blue pyrrole derivatives, 2-(3-cyano-4-(4-(dibutylamino)phenyl)-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)malononitrile (BAPCP) and 2-(3-cyano-4-(4-(dihexylamino)phenyl)-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)malononitrile (HAPCP), as potential candidates for use in image sensor color filters. …”
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Adaptive cognitive control in 4 to 7-year-old children and potential effects of school-based yoga-mindfulness interventions: an exploratory study in Italy by Lisa Toffoli, Giulia Stefanelli, Giulia Manca, Fiorella Del Popolo Cristaldi, Gian Marco Duma, Michele Guidi, Francesca Incagli, Luca Sbernini, Luca Sbernini, Vincenza Tarantino, Giovanni Mento, Giovanni Mento

“…Furthermore, as part of an exploratory study designed to evaluate the feasibility of a school-based program in Italy, all children underwent a re-testing session after an 8-week intervention involving yoga-mindfulness.ResultsResults suggested that young children can exploit global probabilistic changes to optimize motor preparation/ inhibition while counterbalancing fatigue effects. …”
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Bionic nanovesicles sequentially treat flaps with different durations of ischemia by thrombolysis and prevention of ischemia-reperfusion injury by Linzhong Yang, Yuanchen Liu, Cheng Tao, Zichen Cao, Shilin Guo, Zheng Wei, Yanyi Wang, Tao Liu, Lin Chen, Ke Xiong, Xingyu Luo, Jianchuan Ran, Wei Han

“…In this study, based on an in-depth investigation of the ischemia time and prognosis of transplanted flaps, we propose a treatment strategy using sequential thrombolysis and ischemia-reperfusion injury prevention tailored to the ischemia time. This approach is designed to minimize the likelihood of thrombus formation and to clear the intravascular inflammatory microenvironment, with the aim of preventing and salvaging ischemic flaps. …”
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Study on the influence of working environment on the insulation of fuel cell by Ji Pu, Qianya Xie, Kang Li, Jun Li, Mengmeng Zhang, Chen Ge, Lichang Zhang

“…When the pipe diameter of the purge shell was designed to be approximately 20 % of the main pipe diameter, the relative humidity of fresh air entering the shell was lower than 60 % when the ambient relative humidity outside the shell was 95 %. …”
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Automatic Segmentation of Abdominal Aortic Aneurysm From Computed Tomography Angiography Using a Patch-Based Dilated UNet Model by Merjulah Roby, Juan C. Restrepo, Haehwan Park, Satish C. Muluk, Mark K. Eskandari, Seungik Baek, Ender A. Finol

“…The deep-learning pipeline proposed in this work is designed to automatically segment AAA CTA images. The framework adapted a fully developed patch-based dilated modified U-Net model, which shows remarkable efficiency in accurately delineating AAA regions within the CTA scans. …”
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Experimental and Modeling Study for the Solar-Driven CO₂ Electrochemical Reduction to CO by Matteo Agliuzza, Roberto Speranza, Andrea Lamberti, Candido Fabrizio Pirri, Adriano Sacco

“…COMSOL^® Multiphysics 6.3 was used to develop a detailed finite element method model of the electrochemical cell integrated with a photovoltaic module, validated with the experimental results that demonstrated a strong correlation. A 2D model was designed, incorporating cathode and anode regions divided by an ion-exchange membrane. …”
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Clinical Research Network: JHCRN Infrastructure and Lessons Learned by Rahul Kashyap, Gayane Yenokyan, Robert Joyner, Melissa Gerstenhaber, Mary Alderfer, Erika Siegrist, Joan Moore, Channing J. Paller, Hanan Aboumatar, James J. Potter, Stanley Watkins Jr, John E. Niederhuber, Daniel E. Ford, Adrian Dobs

“…We have discussed vision, governance, infrastructure, participating hospitals' characteristics, and lessons learned in creating this partnership. Designed to leverage organized patient communities, community‐based investigators, and academic researchers, the JHCRN provides expedited research across nine health systems in the mid‐Atlantic region. …”
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Hierarchical graph-based integration network for propaganda detection in textual news articles on social media by Pir Noman Ahmad, Jiequn Guo, Nagwa M. AboElenein, Qazi Mazhar ul Haq, Sadique Ahmad, Abeer D. Algarni, Abdelhamied A. Ateya

“…In this study, we propose a Hierarchical Graph-based Integration Network (H-GIN) designed for detecting propaganda in text within a defined domain using multilabel classification. …”
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Divergent Adsorption Regulation in Metal–Organic Frameworks for Highly Efficient CF4/C2F6 Separation by Guihong Xu, Tian Ke, Rongrong Fan, Kaiyuan Tan, Wenjun Zhang, Baogen Su, Zhiguo Zhang, Zongbi Bao, Qilong Ren, Qiwei Yang

“…Comprehensive insights into the unique separation mechanism are illustrated through a combination of solid‐state MAS nuclear magnetic resonance (SSNMR), molecular simulations, and meticulously designed comparative experiments. As a result, benchmark C2F6/CF4 separation performance is achieved, as demonstrated by the unprecedented electronic‐grade (over 99.999%) CF4 productivity (401 L kg−1) obtained from an industrially relevant C2F6/CF4 (3:97) mixture, as well as the excellent water/air/heat stability and recyclability.…”
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