Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen by Michael L. McCaleb, Steven G. Hughes, Tamar R. Grossman, Ashley Frazer-Abel, Bill Jung, Lixuan Yin, Scott P. Henry, Brett P. Monia, Eugene Schneider, Richard Geary, Gary T. Brice

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Acute Reciprocal Changes Distant from the Site of Spinal Osteotomies Affect Global Postoperative Alignment by Eric Klineberg, Frank Schwab, Christopher Ames, Richard Hostin, Shay Bess, Justin S. Smith, Munish C. Gupta, Oheneba Boachie, Robert A. Hart, Behrooz A. Akbarnia, Douglas C. Burton, Virginie Lafage

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Donor age contributes more to the rheological properties of stored red blood cells than donor sex and biological age distribution by Olga Mykhailova, Mackenzie Brandon-Coatham, Sanaz Hemmatibardehshahi, Mahsa Yazdanbakhsh, Carly Olafson, Qi-Long Yi, Tamir Kanias, Jason P. Acker

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Development and validation of a pragmatic measure of cocreation in research engagement: a study protocol by Bethany M Kwan, Carter Sevick, Cathleen Willging, Bryan J Weiner, Janice Tufte, Brooke Dorsey Holliman, Monica Perez Jolles, Danielle Ostendorf

“…Construct validity will be assessed by examining survey data using confirmatory and exploratory factor analysis.Ethics and dissemination This funded study (years 2024–2025) has been approved by the Institutional Review Board at the University of Colorado, Denver. The team will share the study findings online, with key partners, and by publishing results in a peer-reviewed journal.…”
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The effect of psychosocial stimulation on the development, nutrition, and treatment outcomes of hospitalised children with severe acute malnutrition in Southern Ethiopia: a cluster... by Tesfalem Teshome Tessema, Andamlak Gizaw Alamdo, Eyoel B. Mekonnen, Tewodros G. Yirtaw, Fanna A. Debele, Teklu Gemechu, Tefera Belachew

“…Child development and nutrition outcomes were assessed four times using Denver II-Jimma and anthropometric measurements while the length of hospitalisation was used to measure treatment outcome. …”
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A patient choice‐driven lifestyle intervention lowers HbA1c in type 2 diabetes: A feasibility study by Nathan R. Weeldreyer, Mindy L. McEntee, Matthew P. Martin, Chong D. Lee, Farshad Fani Marvasti, Glenn A. Gaesser, Rodger Kessler, Siddhartha S. Angadi

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Melatonin supplementation for the treatment of infantile spasms: protocol for a randomised placebo-controlled triple-blind trial by Jing Wang, Tao Xu, Miao Liu, Jian Chen, Guang Yang, Weiwei Feng, Yulin Sun, Xiuyu Shi, Liping Zou

“…Secondary outcomes include the response rate (the rate of spasms-free), electroencephalogram hypsarrhythmia assessment and the psychomotor development assessment (Denver Developmental Screening Test). Sleep quality and safety will also be assessed.Ethics and dissemination The protocol for this study was approved by the Ethics Committee of Chinese PLA General Hospital (reference number S2020-337-01) and was reported according to the Standard Protocol Items: Recommendations for Interventional Trials statement. …”
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Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing by Barbro Lernmark, Kristian Lynch, Judith Baxter, Roswith Roth, Tuula Simell, Laura Smith, Ulrica Swartling, Suzanne Bennett Johnson, TEDDY Study Group

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Linking a distal ejecta with its source crater: a probabilistic approach applied to tektites by Rochette, Pierre, Baratoux, David, Braucher, Regis, Cornec, Jean, Debaille, Vinciane, Devouard, Bertrand, Gattacceca, Jerome, Gounelle, Matthieu, Jourdan, Fred, Moustard, Fabien, Nomade, Sébastien

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Protecting the American dream for socially vulnerable families: An evaluation of state-level policies to improve housing security and protect mobile home communities by Morgan Clennin, Denise Hartsock, Olivia Goodman, Stacie Daugherty, Cheryl Kelly

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Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 antitrypsin deficiency by Jungnam Lee, Naweed Mohammad, Kyudong Han, Kyudong Han, Tammy Flagg-Dowie, Maria Magallon, Mark L. Brantly, Karina A. Serban, Karina A. Serban

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How can the buffalo carcass be used rationally? by Ricardo Alexandre Silva Pessoa

“…The percentages observed for the cuts (in each half carcass) were: soft drumstick, 5.3%; hard cushion, 3.7%; duckling, 3.8%; lizard, 1.8%; sirloin steak, 1.1%; grill flank steak, 0.75%; red flank steak, 0.61%; breast, 0.96%; rump baby beef, 1.3%; rump bonbon, 0.8%; ossobuco, 4.2%; muscle, 2.0%; turkey bone, 1.1%; duckling bone, 0.5%; oxtail, 0.38%; ancho steak, 1.3%; chorizo steak, 1.9%; filet mignon, 1.2%; fillet shell, 0.35%; chest, 3.9%; neck, 4.2%; acm, 4.3%; window rib, 8.7%; strip roast, 2.5%; banana, 0.23%; goldfish, 0.87%; palette heart, 0.77%; flat iron, 0.95%; Denver stake, 0.6%; beef steak, 0.40%; edible shavings, 19.43%; fat, 1.8%; scraps of disposal, 0.4%; discard bones, 17.9%. …”
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“Doctor, I Want to Be Like This!”: Exploring Global Beauty Body Standards Through a Multicenter Survey by Damiano Tambasco, MD, Jordi Mir, MD, Alfredo Hoyos, MD, David Sieber, MD, Mauricio Viaro, MD, Jack Zamora, MD, Carlos Manfrim, MD, Edwin Zara, MD, Federica Tomaselli, MD, Christian Montes, MD, Miriam Isola, MD, Maria De Martino, MD, Pier Camillo Parodi, MD, Roberta Albanese, MD, Mario Mendanha, MD

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Efficacy of a new treatment algorithm for capsulitis of the fingers in rock climbers by Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Christoph Lutter, Christoph Lutter, Hans-Christoph Lang, Mario Perl, Othmar Moser, Michael Simon

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Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial by Hugh Taylor, Hao Huang, Lubna Pal, Heping Zhang, Howard J Li, Sandra Carson, Valerie Flores, Jared Robbins, Nanette F Santoro, James H Segars, David Seifer, Steven Young

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Blood absolute lymphocyte count and trajectory are important in understanding severe COVID-19 by Catharine I. Paules, Jacqueline A. Nordwall, Kathryn Shaw-Saliba, Judith A. Aberg, Edward M. Gardner, Anna L. Goodman, N. Kumarasamy, Shikha Vasudeva, David M. Vock, Crystal M. North, Jens Lundgren, Neil R. Aggarwal, for the STRIVE Network and TICO Trial Study Group

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Use of Cesarean Birth among Robson Groups 2 and 4 at Mizan-Tepi University Hospital, Ethiopia by Margo S. Harrison, Tewodros Liyew, Ephrem Kirub, Biruk Teshome, Andrea Jimenez-Zambrano, Margaret Muldrow, Teklemariam Yarinbab

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I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations by Carolyn S Calfee, Michael A Matthay, Paul Henderson, Martin Eklund, Laura J Esserman, Chirag Patel, Angela Haczku, Michelle Jung, Tony Oliver, Alessio Crippa, Andrea Discacciati, Kathleen D Liu, Ellen L Burnham, Nuala J Meyer, Fady A Youssef, Derek W Russell, Julie Lang, Kevin W Gibbs, Daniel C Files, Sheetal Gandotra, Purnema Madahar, Nathan K Cobb, Timothy E Albertson, Rajiv Sonti, John P Reilly, Alejandra Jauregui, Iván García, Luis E Huerta, Daniel Clark Files, Neil R Aggarwal, Adam L Asare, Jeremy R Beitler, Paul A Berger, George Cimino, Melissa H Coleman, Paul T Henderson, Caroline A G Ittner, Kashif T Khan, Jonathan L Koff, Mary LaRose, Joe Levitt, Ruixiao Lu, Jeffrey D McKeehan, Karl W Thomas, Aaron M Mittel, Albert F Yen, Alexis E Suarez, Alexis L Serra, Alpesh N Amin, Amanda Rosen, Amy L Dzierba, Anna D Barker, Ariel R Weisman, Brian M Daniel, Brian M Morrissey, Caroline AG Ittner, Chayse Jones, Christina Creel-Bulos, Christina M Angelucci, Diana Ng, Fredy Chaparro-Rojas, Gavin H Harris, Harsh V Barot, Heny Su, Jacqueline B Sutter, Jamal Dodin, Jerry S Lee, John Kazianis, Joshua F Detelich, Julie E Lang, Justin Muir, Katarzyna Gosek, Katherine L Nugent, Kimberly Yee, Laura G Rodrigues, Laura R Macias, Lindsey A Orr, Lindsie L Boerger, Lissette Rosario-Remigio, Lucia Kufa, Maged Tanios, Maria B Reyes, Max W Adelman, Maya M Juarez, Michelle Meyers, Mitchell P Sternlieb, Neil Aggarwal, Nilam S Mangalmurti, Patrice Jones, Paul L Saban, Peter S Marshall, Philiip A Robinson, Philip Yang, Rahul Nair, Richard Anthony Lee, Richard G Wunderink, Romina Wahab, Roxana A Lupu, Santhi I Kumar, Sara C Auld, Scott Fields, Se Fum Wong, Skyler J Pearson, Spencer Whealon, Timothy F Obermiller, Anita Darmanian, John Schicchi, Esmeralda Martinez, Farjad Sarafian, Julie Nguyen, Bethany Weiler-Lisowski, Jaime Wyatt, Daniel Blevins, Marylee Melendrez, Brenda Lopez, Hiwet Tzehaie, Omowunmi Amosu, Austin Simonson, Erin Hardy, Brett Lindgren, Gregory Peterfreund, Leigha Landreth, Lisa Parks

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Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design by Haiying Qin, Nirali N Shah, Terry J Fry, Lila Yang, John A Chukinas, Samiksha Tarun, Marie Pouzolles, Christopher D Chien, Lisa M Niswander, Anthony R Welch, Sarah K Tasian, Naomi A Taylor

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Peripheral neuropathy in the phase 3 ASPEN study of Bruton tyrosine kinase inhibitors for Waldenström macroglobulinemia by Benjamin M. Heyman, Stephen S. Opat, Björn E. Wahlin, Meletios-Athanasios C. Dimopoulos, Jorge J. Castillo, Alessandra Tedeschi, Constantine S. Tam, Christian Buske, Roger G. Owen, Véronique Leblond, Judith Trotman, Gisoo Barnes, Wai Y. Chan, Jingjing Schneider, Heather Allewelt, Aileen Cohen, Jeffrey V. Matous

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