Regional risk factors associated with adverse outcomes of COVID-19 infection among the older adult: A systematic review and meta-analysis by Olunike Rebecca Abodunrin, Mobolaji Timothy Olagunju, Xinyi Huang, Jianming Wang, Zhibin Hu, Chong Shen

“…Key factors include old age (above 65 years), male gender, symptoms such as fever and dyspnea, and comorbidities like dementia, chronic obstructive pulmonary disease (COPD), chronic heart disease, hypertension, chronic kidney disease, and malnutrition. …”
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Resting-state functional magnetic resonance imaging study on cerebrovascular reactivity changes in the precuneus of Alzheimer’s disease and mild cognitive impairment patients by Xue Tang, Luoyu Wang, Qi Feng, Hanjun Hu, Yidi Zhu, Zhengluan Liao, Zhongxiang Ding, Xiufang Xu

“…Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment and cognitive decline, ultimately culminating in dementia. This study aims to evaluate cerebrovascular reactivity (CVR) and functional connectivity (FC) in patients with AD and mild cognitive impairment (MCI) using resting-state functional magnetic resonance imaging (rs-fMRI), bypassing the requirement for hypercapnia. …”
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The collaborative cross mouse for studying the effect of host genetic background on memory impairments due to obesity and diabetes by Avia Paz, Kareem Midlej, Osayd Zohud, Iqbal M. Lone, Fuad A. Iraqi

“…Previous studies have shown correlations between obesity, T2D, and neurodegenerative diseases, including dementia. It is imperative to further understand the relationship between obesity, T2D, and cognitive deficits. …”
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Reduction of orexin-expressing neurons and a unique sleep phenotype in the Tg-SwDI mouse model of Alzheimer’s disease by Yan Wu, Narayan R. Bhat, Meng Liu

“…Sleep disturbances are common in Alzheimer’s disease (AD) and AD-related dementia (ADRD). We performed a sleep study on Tg-SwDI mice, a cerebral amyloid angiopathy (CAA) model, and age-matched wild-type (WT) control mice. …”
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Altered Intrinsic Coupling between Functional Connectivity Density and Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment with Depressive Symptoms by Xiaozheng Liu, Jiuzun Chen, Bangli Shen, Gang Wang, Jiapeng Li, Hongtao Hou, Xingli Chen, Zhongwei Guo, Chuanwan Mao

“…Neuroimaging studies have demonstrated that major depressive disorder increases the risk of dementia in older individuals with mild cognitive impairment. …”
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Does outsourcing enable the survival of good care homes? A longitudinal analysis of all care homes in England, 2011–2023 by Anders Malthe Bach-Mortensen, Michelle Degli Esposti, Benjamin Goodair

“…Using logistic regression, we investigated determinants of care home closures including care home characteristics (eg, number of beds), service registrations (eg, dementia and nursing), quality (inspection ratings) and area deprivation. …”
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Megestrol acetate for appetite stimulation and weight gain in older adults with unintentional weight loss: a systematic review and meta-analysis by Larissa de Freitas do Lago-Abreu, Raphael Lopes Olegário, Luciana Lilian Louzada Martini, Einstein Francisco Camargos

“…Unintentional weight loss in older adults is linked to multiple factors, being most often associated with comorbidities such as cancer, dementia syndromes, chronic obstructive pulmonary disease, and chronic kidney disease. …”
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Tripchlorolide May Improve Spatial Cognition Dysfunction and Synaptic Plasticity after Chronic Cerebral Hypoperfusion by Zhao-Hui Yao, Xiao-li Yao, Shao-feng Zhang, Ji-chang Hu, Yong Zhang

“…Chronic cerebral hypoperfusion (CCH) is a common pathophysiological mechanism that underlies cognitive decline and degenerative processes in dementia and other neurodegenerative diseases. Low cerebral blood flow (CBF) during CCH leads to disturbances in the homeostasis of hemodynamics and energy metabolism, which in turn results in oxidative stress, astroglia overactivation, and synaptic protein downregulation. …”
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A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson’s disease by Lijun Dou, Zhenxing Xu, Jielin Xu, Chengxi Zang, Chang Su, Andrew A. Pieper, James B. Leverenz, Fei Wang, Xiongwei Zhu, Jeffrey Cummings, Feixiong Cheng

“…Integrating network proximity-based drug repurposing and patient electronic health record (EHR) data observations, we identified Simvastatin as being significantly associated with reduced incidence of PD (hazard ratio (HR) = 0.91 for fall outcome, 95% confidence interval (CI): 0.87–0.94; HR = 0.88 for dementia outcome, 95% CI: 0.86–0.89) after adjusting for 267 covariates. …”
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Protocol for a meta-review of interventions to prevent and manage ICU delirium by Andrew Booth, Maria Pufulete, Ben Gibbison, Burak Kundakci, Katherine Louise Jones

“…ICU delirium is also associated with increased mortality and dementia in the longer term. ICU delirium prevention and management strategies are likely to include both pharmacological and non-pharmacological components as part of a complex intervention, but it is unclear which components should be included. …”
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Endogenous Estrogen Influences Predator Odor-Induced Impairment of Cognitive and Social Behaviors in Aromatase Gene Deficiency Mice by Yaner Gao, Lei Ma, Feng Gao, Zuoli Sun, Zhengrong Zhang, Yuhong Li, Rena Li

“…Epidemiological studies have suggested that traumatic stress increases vulnerability to various mental disorders, such as dementia and psychiatric disorders. While women are more vulnerable than men to depression and anxiety, it is unclear whether endogenous estrogens are responsible for the underlying sex-specific mechanisms. …”
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Changes in the transcriptome of the prefrontal cortex of OXYS rats as the signs of Alzheimer’s disease development by N. A. Stefanova, E. E. Korbolina, N. I. Ershov, E. I. Rogaev, N. G. Kolosova

“…It produces atrophic changes in the brain, which cause dementia. The incidence of AD is increasing with increasing life expectancy and gradual aging of the population in developed countries. …”
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Experiences and practices of people categorised as being ‘at risk’ based on age during the COVID-19 pandemic: a qualitative study in the UK and Germany by Susannah Mayhew, Stephanie Drössler, Katharina Wabnitz

“…Inclusion criteria: to be at risk for a severe course of COVID-19 due to age ≥50 years (Germany) and ≥70 years (UK) based on official communication by the respective national public health authority.Exclusion criteria: any form of dementia, pre-existing mental health issues, congenital physical or mental disabilities, being resident in a care home, having a personal relationship to the principal investigator.Methods Semistructured in-depth interviews were conducted remotely. …”
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Identification of Cognitive Training for Individuals with Parkinson’s Disease: A Systematic Review by Marina Francesca Gattoni, Silvia Gobbo, Sarah Feroldi, Anna Salvatore, Jorge Navarro, Sandro Sorbi, Francesca Lea Saibene

“…Among them, cognitive impairment in PD has been recognised as a defined clinical entity, and it might lead to an increased risk of developing dementia. Consequently, the present review aimed to ascertain the available interventions for the training of cognitive abilities in persons with PD (PwPD). …”
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Alzheimer’s Disease and Cardiovascular Disease: A Particular Association by Giacomo Tini, Riccardo Scagliola, Fiammetta Monacelli, Giovanni La Malfa, Italo Porto, Claudio Brunelli, Gian Marco Rosa

“…During ageing, the prevalence of dementia, and especially of Alzheimer’s disease (AD) and cardiovascular disease (CVD), increases. …”
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The association of biological sex and long-term outcomes in older patients with physical restraint at the emergency department by Laetitia Manfredini, Marion Pépin, Pradeebane Vaittinada Ayar, Matthieu Gay, Marie Certin, Prabakar Vaittinada Ayar

“…Women more often presented dementia (93 vs. 80%, P = 0.031). Both sexes presented the same limited independence. …”
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“Nobody Seemed to Notice My Work”: The Lived Experiences of Home Care Workers Assisting People With Chronic Diseases: A Phenomenological Study by Valentina Cacciapuoti, Silvio Simeone, Michele Virgolesi, Medeline R. Sterling, Elisa Dallago, Ercole Vellone, Rosaria Alvaro, Gianluca Pucciarelli

“…Although several qualitative studies have been conducted on HCWs, they focused more on studying prevalently the lived experiences about the workplace violence, the end of life, stressor and resilience, during the COVID-19 pandemic or focused more in dementia and heart failure, but not on feelings and working conditions. …”
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Effects of a Cognitive-Functional Intervention Method on Improving Executive Function and Self-Directed Learning in School-Aged Children with Attention Deficit Hyperactivity Disord... by Mi Ji Kim, Hae Yean Park, Eun-Young Yoo, Jung-Ran Kim

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Hypovitaminosis D3, Leukopenia, and Human Serotonin Transporter Polymorphism in Anorexia Nervosa and Bulimia Nervosa by Anna Tasegian, Francesco Curcio, Laura Dalla Ragione, Francesca Rossetti, Samuela Cataldi, Michela Codini, Francesco Saverio Ambesi-Impiombato, Tommaso Beccari, Elisabetta Albi

“…Vitamin D3 has been described to have different extraskeletal roles by acting as parahormone in obesity, diabetes, cancer, cognitive impairment, and dementia and to have important regulatory functions in innate immunity. …”
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Frailty as a mediator between sleep quality and cognitive impairment among the rural older adults: a cross-sectional study by Ping Dong, Cheng Cheng, Wenqiang Yin, Ziyuan Li, Yongli Shi, Min Gao, Xiaona Li, Dongping Ma, Hongwei Guo, Yan Wei, Zhongming Chen

“…We assessed cognitive impairment using the Dementia Screening Interview (AD8). Logistic regression analyse was used to assess the relationship between sleep quality and cognitive impairment. …”
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