Development and validation of a five-year cardiovascular risk assessment tool for Asian adults aged 75 years and older by Meng-Chen Hsu, Yu-Hua Fu, Chi-Chuan Wang, Chau-Chung Wu, Fang-Ju Lin

“…Predictors for women included advanced age, smoking, atrial fibrillation, cancer, dementia, osteoarthritis, systemic lupus erythematosus, use of antihypertensives, and use of oral anticoagulants. …”
Get full text

“We are Performance Philosophy Problems” by Janet Gibson, Kate Maguire-Rosier, Tony McCaffrey

“…Although we keep the offerings separate, both advance the idea that learning-disabled theatre and theatres where people show and share disability and diagnoses of dementia disturb some of the key assumptions of theatre and performance studies, notably ‘withness’ and ‘aboutness’. …”
Get full text

From Mild Ataxia to Huntington Disease Phenocopy: The Multiple Faces of Spinocerebellar Ataxia 17 by Georgios Koutsis, Marios Panas, George P. Paraskevas, Anastasia M. Bougea, Athina Kladi, Georgia Karadima, Elisabeth Kapaki

“…Among 3 affected members, one presented with HD phenocopy; one with progressive ataxia, dementia, chorea, dystonia, and seizures, and one with mild slowly progressive ataxia with minor cognitive and affective symptoms. …”
Get full text

Brain-derived tau oligomer polymorphs: distinct aggregations, stability profiles, and biological activities by Filippa Lo Cascio, Suhyeorn Park, Urmi Sengupta, Nicha Puangmalai, Nemil Bhatt, Nikita Shchankin, Cynthia Jerez, Naomi Moreno, Alice Bittar, Rhea Xavier, Yingxin Zhao, Cankun Wang, Hongjun Fu, Qin Ma, Mauro Montalbano, Rakez Kayed

“…Abstract Aggregation of microtubule-associated tau protein is a distinct hallmark of several neurodegenerative disorders such as Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and progressive supranuclear palsy (PSP). …”
Get full text

Models of provider care in long-term care: A rapid scoping review. by Candyce Hamel, Chantelle Garritty, Mona Hersi, Claire Butler, Leila Esmaeilisaraji, Danielle Rice, Sharon Straus, Becky Skidmore, Brian Hutton

“…Well represented interventions (e.g., dementia care, exercise/mobility, optimal/appropriate medication) may present opportunities for future systematic reviews. …”
Get full text

Kaempferol enhances ER-mitochondria coupling and protects motor neurons from mitochondrial dysfunction and ER stress in C9ORF72-ALS by Federica Pilotto, Paulien Hermine Smeele, Olivier Scheidegger, Rim Diab, Martina Schobesberger, Julieth Andrea Sierra-Delgado, Smita Saxena

“…Abstract Repeat expansions in the C9ORF72 gene are a frequent cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Considerable progress has been made in identifying C9ORF72-mediated disease and resolving its underlying etiopathogenesis. …”
Get full text

The heart rate on admission was associated with the mortality in elderly patients with hip fractures: a retrospective cohort study from a trauma centre in northwestern China by Zhi Yang, Wei-Song Zhang, Shao-Hua Chen, Bin-Fei Zhang

“…Age, coronary heart disease, cancer, dementia and time to operation were introduced in multivariate regression analysis. …”
Get full text

Risk of Venous Thromboembolism in Patients Nursed at Home or in Long-Term Care Residential Facilities by Guido Arpaia, Federico Ambrogi, Maristella Penza, Aladar Bruno Ianes, Alessandra Serras, Patrizia Boracchi, Claudio Cimminiello

“…The risk of DVT for patients with reduced mobility due to cognitive impairment was about half that of patients with cognitive impairment/dementia. Conclusions. This is a first estimate of the prevalence of DVT among bedridden or low-mobility patients. …”
Get full text

Robust self management classification via sparse representation based discriminative model for mild cognitive impairment associated with diabetes mellitus by Yun-xian Wang, Rong Lin, Hao Liang, Yuan-jiao Yan, Ji-xing Liang, Ming-feng Chen, Hong Li

“…Patients with DM-MCI have considerably higher risk of dementia, whose daily self-care and life management (i.e. self-management) have a significant impact on the development of their condition. …”
Get full text

A randomised trial comparing the clinical effectiveness of different emergency department healthcare professionals in soft tissue injury management by Jonathan Richard Benger, Jane Powell, Fiona Cramp, Carey Middleton McClellan

“…Patients were excluded if they had any of the following: injury greater than 72 hours old; systemic disease; dislocated joints; recent surgery; unable to give informed consent (eg, dementia), open wounds; major deformities; opiate analgesia required; concurrent chest/rib injury; neurovascular deficits and associated fracture.Interventions Patients were randomised to treatment by ESPs, ENPs or routine care provided by doctors (of all grades).Main outcome measures Upper-limb and lower-limb functional scores, quality of life, physical well-being, preference-based health measures and the number of days off work.Results The clinical outcomes of soft tissue injury treated by ESPs and ENPs in the ED were equivalent to routine care provided by doctors.Conclusions As all groups were clinically equivalent it is other factors such as cost, workforce sustainability, service provision and skill mix that become important. …”
Get full text

Validation of the advance care planning engagement survey in Singapore by Gwendoline Wan Hua Tan, Ginny Si Min Quek, Nathaniel Jun Xian Lum, Lian Leng Low, Yu Xian Loo

“…We recruited patients 21 years and older, who were able to understand and speak English, without a diagnosis of dementia, and who were not admitted under the palliative care service. …”
Get full text

Utility of AD8 for Cognitive Impairment in a Chinese Physical Examination Population: A Preliminary Study by Yue Xie, Ya Gao, Jianjun Jia, Xiaohong Wang, Zhenfu Wang, Hengge Xie

“…All the participants were stratified into 9 groups by age; the prevalence of dementia was highly correlated with age (P<0.01). Conclusion. …”
Get full text

Occurrence of severe cognitive impairment in elderly individuals with poor glycemic control Vs elderly individuals with good glycemic control or no DM: a case control study” by Basma Salman, Fatima Jehangir, Aroosa Jahan, Saira Aslam, Nadra Ansari

“… ABSTRACT: Background: There is substantiatial corroboration that diabetes (both T1DM and T2DM) plays an essential role in predisposition to cognitive decline thus leading to dementia in both human and animal studies. (1,2,3). …”
Get full text

Exploring the Effectiveness of Machine Learning and Deep Learning Techniques for EEG Signal Classification in Neurological Disorders by Souhaila Khalfallah, William Puech, Mehdi Tlija, Kais Bouallegue

“…Hence, our findings show impressive accuracy, with the random forest model achieving 99.85% accuracy in classifying autism vs. healthy subjects and 100% accuracy in distinguishing healthy individuals from those with dementia using Support Vector Machines (SVM). Moreover, deep learning models, including Convolutional Neural Networks (CNN) and ChronoNet, demonstrated accuracy rates ranging from 92.5% to 100%. …”
Get full text

Mitochondrial- and Endoplasmic Reticulum-Associated Oxidative Stress in Alzheimer's Disease: From Pathogenesis to Biomarkers by E. Ferreiro, I. Baldeiras, I. L. Ferreira, R. O. Costa, A. C. Rego, C. F. Pereira, C. R. Oliveira

“…Alzheimer's disease (AD) is the most common cause of dementia in the elderly, affecting several million of people worldwide. …”
Get full text

Cognitive enhancing effect of an extract of Swertia chirata against memory impairment induced by aluminum chloride by Reena Deshmukh, Manisha Jaiswal, Anshita Shukla, Umesh Patil, Mukesh Sharma

“…Its anti-inflammatory and antioxidant properties may contribute to its potential in treating cognitive disorders, including dementia and Alzheimer's disease.…”
Get full text

Sleep in Genetically Confirmed Pantothenate Kinase-Associated Neurodegeneration: A Video-Polysomnographic Study by Maria Livia Fantini, Giovanni Cossu, Andrea Molari, Monia Cabinio, Ozlem Uyanik, Roberto Cilia, Maurizio Melis, Angelo Antonini, Luigi Ferini-Strambi

“…Pantothenate kinase-associated neurodegeneration (PKAN) is a familial or sporadic disease characterized by extrapyramidal and corticospinal signs with dementia. Patients show iron accumulation in the basal ganglia, with neuronal loss and gliosis. …”
Get full text

Multi-functional role of apolipoprotein E in neurodegenerative diseases by Sadequl Islam, Arshad Noorani, Yang Sun, Makoto Michikawa, Kun Zou

“…It also covers ApoE’s influence in other neurodegenerative diseases like Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), Huntington’s disease (HD), vascular dementia (VD), and multiple sclerosis (MS). New research highlights the interaction between ApoE and presenilin (PS), suggesting connections between familial AD (FAD) and SAD. …”
Get full text

Chlamydophila pneumoniae Infection and Its Role in Neurological Disorders by Carlo Contini, Silva Seraceni, Rosario Cultrera, Massimiliano Castellazzi, Enrico Granieri, Enrico Fainardi

“…The demonstration of C. pneumoniae by histopathological, molecular and culture techniques in the late-onset AD dementia has suggested a relationship between CNS infection with C. pneumoniae and the AD neuropathogenesis. …”
Get full text

Fatigue and Mental Status of Caregivers of Severely Chronically Ill Patients by Sung-Goo Kang, Sang-Wook Song, Se-Hong Kim, Yi-Jin Kang, Young-Rye Kim, Youngmi Eun

“…The study enrolled 100 caregivers of patients providing home care nursing at a university hospital in Gyeonggi-do of Korea, including 47 caregivers caring for cancer patients and 53 caregivers caring for chronic disease patients (e.g., dementia, amyotrophic lateral sclerosis, and Parkinson’s disease). …”
Get full text