Advanced Magnetic Resonance Imaging for Early Diagnosis and Monitoring of Movement Disorders by Emmanuel Ortega-Robles, Benito de Celis Alonso, Jessica Cantillo-Negrete, Ruben I. Carino-Escobar, Oscar Arias-Carrión

“…These techniques enable earlier and more accurate differentiation of movement disorders, including Parkinson’s disease, progressive supranuclear palsy, multiple system atrophy, corticobasal degeneration, Lewy body and frontotemporal dementia, Huntington’s disease, and dystonia. Furthermore, MRI provides objective metrics for tracking disease progression and assessing therapeutic efficacy, making it an indispensable tool in clinical trials. …”
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The antioxidant potential of bacoside and its derivatives in Alzheimer's disease: The molecular mechanistic paths and therapeutic prospects by Dipanjan Karati, Swarupananda Mukherjee, Souvik Roy

“…The key physiological dysfunctions linked to tau aggregates, which contribute to dementia and behavioral inconsistencies, include the formation of reactive oxygen species, augmented neuronal swelling, and neurotoxicity. …”
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Joint analysis of blood pressure changes over time and survival of hypertensive patients under treatment at Sawula hospital in Southern Ethiopia by Markos Abiso Erango, Tademe Fiseha, Galgalo Jaba Nura

“…High blood pressure, or hypertension, has been associated with severe health consequences, including death, aneurysms, stroke, chronic renal disease, eye damage, heart attack, heart failure, peripheral artery disease, and vascular dementia. Consequently, this study aimed to investigate the predictors linked to survival time and the progression of blood pressure measurements in hypertensive patients. …”
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Hyperhomocysteinemia-induced VCID results in visual deficits, reduced neuroinflammation and vascular alterations in the retina by Erica M. Weekman, Colin B. Rogers, Tiffany L. Sudduth, Donna M. Wilcock

“…Abstract Over recent years, the retina has been increasingly investigated as a potential biomarker for dementia. A number of studies have looked at the effect of Alzheimer’s disease (AD) pathology on the retina and the associations of AD with visual deficits. …”
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Mutations in human prion-like domains: pathogenic but not always amyloidogenic by Andrea Bartolomé-Nafría, Javier García-Pardo, Salvador Ventura

“…To date, over 60 mutations targeting the LCDs of hnRNPs have been identified and associated with a spectrum of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer’s disease (AD). The cryo-EM structures of pathological and functional fibrils formed by different hnRNPs have been recently elucidated, including those of hnRNPA1, hnRNPA2, hnRNPDL-2, TDP-43, and FUS. …”
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Identification of Potential Herbal Inhibitor of Acetylcholinesterase Associated Alzheimer’s Disorders Using Molecular Docking and Molecular Dynamics Simulation by Chandrabhan Seniya, Ghulam Jilani Khan, Kuldeep Uchadia

“…Additionally, acetylcholinesterase (AChE) is the target for many Alzheimer’s dementia drugs which block the function of AChE but have some side effects. …”
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Recognizing Cognitive and Psychiatric Changes in the Post-Highly Active Antiretroviral Therapy Era by Adriana Carvalhal, Jean-Guy Baril, Frederic Crouzat, Joss De Wet, Patrice Junod, Colin Kovacs, Nancy Sheehan

“…Specifically addressed in the present review are the International HIV Dementia Scale, a novel screening equation and algorithm for HAND, as well as brief, validated, verbal questionnaires for detection of depression and substance abuse. …”
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Influence of immune cells and inflammatory factors on Alzheimer’s disease axis: evidence from mediation Mendelian randomization study by Linzhu, Jianxin Zhang, Wenhui Fan, Chen Su, Zhi Jin

“…Abstract Background Alzheimer’s disease (AD) is one of the most common forms of dementia in the elderly, characterized by progressive neurodegeneration. …”
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Transforming Alzheimer’s Disease Diagnosis: Implementing Vision Transformer (ViT) for MRI Images Classification by Dian Kurniasari, Muhammad Dwi Pratama, Akmal Junaidi, Ahmad Faisol

“… Alzheimer’s disease (AD) is a progressive neurological disorder and the leading cause of dementia, accounting for 60-80% of cases. Early detection of AD is crucial for timely intervention, as the disease significantly impacts cognitive functions and daily activities. …”
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Diogenes Syndrome: A Case Report by Projna Biswas, Anusree Ganguly, Sanchaita Bala, Falguni Nag, Nidhi Choudhary, Sumit Sen

“…These patients may have psychiatric disorders like paranoid disorders, mood affection, or temporofrontal dementia. Subjects are mainly the elderly but few cases in younger age group of patients have also been reported. …”
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Clustering-based binary Grey Wolf Optimisation model with 6LDCNNet for prediction of heart disease using patient data by Lella Kranthi Kumar, K. G. Suma, Pamula Udayaraju, Venkateswarlu Gundu, Srihari Varma Mantena, B. N. Jagadesh

“…Heart disease remains a leading cause of death in developed countries, often leading to consequential outcomes such as dementia, which can be mitigated through early detection and treatment of cardiovascular issues. …”
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Oligonucleotide-Based Therapy for FTD/ALS Caused by the C9orf72 Repeat Expansion: A Perspective by Stephanie A. Fernandes, Andrew G. L. Douglas, Miguel A. Varela, Matthew J. A. Wood, Yoshitsugu Aoki

“…Amyotrophic lateral sclerosis (ALS) is a progressive and lethal disease of motor neuron degeneration, leading to paralysis of voluntary muscles and death by respiratory failure within five years of onset. Frontotemporal dementia (FTD) is characterised by degeneration of frontal and temporal lobes, leading to changes in personality, behaviour, and language, culminating in death within 5–10 years. …”
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Evaluation of Imaging Windows for Tau PET Imaging Using F-PI2620 in Cognitively Normal Individuals, Mild Cognitive Impairment, and Alzheimer’s Disease Patients by Chanisa Chotipanich, Monchaya Nivorn, Anchisa Kunawudhi, Chetsadaporn Promteangtrong, Natphimol Boonkawin, Attapon Jantarato

“…Conclusion: Short uptake time around 30-40 minutes post-injection would be more comfortable and convenient for all patients, especially in those with dementia who were unable to stay motionless for long periods of scanning time in the scanner.…”
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APOE4 and sedentary lifestyle synergistically impair neurovascular function in the visual cortex of awake mice by Silvia Anderle, Orla Bonnar, Joseph Henderson, Kira Shaw, Andre M. Chagas, Letitia McMullan, Alexandra Webber, Kirsty McGowan, Sarah L. King, Catherine N. Hall

“…Promotion of physical activity may therefore be particularly important to improve cerebrovascular function and reduce dementia risk in APOE4 carriers.…”
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The role of microRNAs in learning and long-term memory by L. N. Grinkevich

“…Moreover, impaired microRNA biogenesis is one of the causes of the pathogenesis of mental disorders, neurodegenerative illnesses and senile dementia, which are often accompanied by deterioration in the learning ability and by memory impairment. …”
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Metabolic Derangements Contribute to Reduced sRAGE Isoforms in Subjects with Alzheimer’s Disease by Kelly N. Z. Fuller, Edwin R. Miranda, John P. Thyfault, Jill K. Morris, Jacob M. Haus

“…Cognitively healthy elderly and AD participants with and without type 2 diabetes (n=135) were stratified according to the clinical dementia rating (CDR; 0 = normal cognition (NC); ≥0.5 = AD). …”
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A data-driven cluster analysis to explore cognitive reserve and modifiable risk factors in early phases of cognitive decline by Sara Bernini, Alice Valcarenghi, Elena Ballante, Federico Fassio, Marta Picascia, Elena Cavallini, Matteo Cotta Ramusino, Alfredo Costa, Tomaso Vecchi, Cristina Tassorelli, Sara Bottiroli

“…Such a finding is representative of a more positive individual wellbeing for people who adopt protective behaviours. In the field of dementia prevention, these results support the importance to intervene proactively and simultaneously in the management of multiple risk factors during the entire lifespan.…”
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Effects of neurocognitive intervention in older adults. A systematic review by Elizabeth Jiménez Puig, Zoylen Fernández Fleites, Yunier Broche Pérez, Daniela Beatriz Vázquez Martínez

“…<br /><strong>Objective:</strong> to describe, through a systematic review of the scientific literature, the effects of neurocognitive intervention on cognitive health in healthy older adults, and in older adults with mild cognitive impairment or dementia. <br /><strong>Methods:</strong> a descriptive study was carried out, which consisted of a systematic review of the scientific literature on the subject; and started from the search in the databases: PubMed, PsycInfo, Scielo, Cochrane and EBSCO, from August to December 2018. …”
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Variation in Thyroid-Stimulating Hormone and Cognitive Disorders in Unmedicated Middle-Aged Patients with Major Depressive Disorder: A Proton Magnetic Resonance Spectroscopy Study by Hui Zhao, Shunkai Lai, Shuming Zhong, Yiliang Zhang, Hui Yang, Yanbin Jia

“…Middle-aged (45-59 years old) patients with major depressive disorder (MDD) have a predilection for dementia and cognitive disorders (CDs); however, the characteristics and mechanisms of CDs in these patients remain unclear. …”
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Immunoassay detection of multiphosphorylated tau proteoforms as cerebrospinal fluid and plasma Alzheimer’s disease biomarkers by Anna L. Wojdała, Giovanni Bellomo, Lorenzo Gaetani, Charlotte E. Teunissen, Lucilla Parnetti, Davide Chiasserini

“…Subsequently, we measured CSF and plasma p-tau181&231, p-tau217&231, p-tau181, p-tau217, and p-tau231 levels in two cohorts across the AD continuum and in frontotemporal dementia (FTD) patients (discovery n = 55, validation n = 118). …”
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