Association of body composition with neuroimaging biomarkers and cognitive function; a population-based study of 70-year-oldsResearch in context by Jessica Samuelsson, Anna Marseglia, Ola Wallengren, Olof Lindberg, Caroline Dartora, Nira Cedres, Sara Shams, Silke Kern, Anna Zettergren, Eric Westman, Ingmar Skoog

“…The aim was to explore associations of body composition with neuroimaging biomarkers and cognitive function among dementia-free 70-year-olds. Methods: Dual-energy X-ray absorptiometry body composition measures in relation to neuroimaging measures of cortical thickness, hippocampal volume, small vessel disease, predicted brain age, and cognitive performance were explored in a cross-sectional study of 674 dementia-free 70-year-olds from the Swedish Gothenburg H70 Birth Cohort study. …”
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Enhanced Neuroplasticity by the Metabolic Enhancer Piracetam Associated with Improved Mitochondrial Dynamics and Altered Permeability Transition Pore Function by Carola Stockburger, Davide Miano, Thea Pallas, Kristina Friedland, Walter E. Müller

“…The mitochondrial cascade hypothesis of dementia assumes mitochondrial dysfunction leading to reduced energy supply, impaired neuroplasticity, and finally cell death as one major pathomechanism underlying the continuum from brain aging over mild cognitive impairment to initial and advanced late onset Alzheimer’s disease. …”
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Clinical observation of VR virtual reality rehabilitation training combined with acupuncture in the treatment of mild cognitive impairment by Ying Fu, Hui Wang

“…Mild cognitive impairment (MCI) is an intermediate state between normal aging and dementia, and its symptoms include easy forgetting, distraction, and mental deterioration. …”
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Functional MRI Assessment of Task-Induced Deactivation of the Default Mode Network in Alzheimer’s Disease and At-Risk Older Individuals by Maija Pihlajamäki, Reisa A. Sperling

“…Alzheimer’s disease (AD) is the most common form of dementia in old age, and is characterized by prominent impairment of episodic memory. …”
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Weighted Mortality Method According to Multiple Causes of Death by Lisbeth Fernández González, Armando Humberto Seuc Jo, Carlos Antonio Rodríguez García

“…<strong><br />Results:</strong> diseases such as heart disease, dementia and Alzheimer's, malignant tumors and asthma did not show differences between the rates calculated by both methods; diseases such as primary essential hypertension, diabetes mellitus and pneumonia, showed important differences. …”
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BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex by Emily Petrus, Hey-Kyoung Lee

“…Alzheimer’s disease (AD) is the most common form of age-related dementia, which is thought to result from overproduction and/or reduced clearance of amyloid-beta (Aβ) peptides. …”
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Wernicke’s Encephalopathy: An Unusual Consequence of the Acquired Immune Deficiency Syndrome—Case Report and Literature Review by Timothy R. Larsen, Dritan Dragu, Michael Williams

“…However, given the relative safety of thiamine supplementation, there should be a low threshold for initiating therapy in order to reverse the symptoms and prevent progression to Korsakoff dementia, which is permanent.…”
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Alzheimer's disease and gut-brain axis: Drosophila melanogaster as a model by Samuel de Mattos Alves, Paulo Noronha Lisboa-Filho, Carolina Letícia Zilli Vieira, Marina Piacenti-Silva

“…This model facilitates the investigation of how gut-derived metabolites contribute to neurocognitive impairment and dementia. Understanding the role of direct and indirect bacterial by-products, such as lactate and acetate, in glial cell activation and tau protein dynamics may provide insights into the mechanisms of AD progression and contribute to more effective treatments. …”
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Drug-induced Leukocytoclastic Vasculitis Secondary to Trimethoprim/Sulfamethoxazole: A Case Report by Ambika Shivarajpur, Simon Londono, Justin Shaw, Christopher Boccio, Leonid Melnitsky, Jheanelle McKay, Brian Kohen, Eric Boccio

“…Case Report: A 91-year-old female with past medical history of Alzheimer dementia and hypertension, being treated for lower extremity cellulitis, presented to the emergency department for an allergic reaction. …”
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Exploring ethical considerations in medical research: Harnessing pre-generated transformers for AI-powered ethics discussions. by Takuya Mori, Takuya Watanabe, Shinji Kosugi

“…<h4>Results</h4>The AI successfully highlighted considerations for informed consent regarding individuals with dementia and mental illness, as well as concerns about invasiveness in research. …”
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Digital Words of Wisdom? Digital Storytelling with Older People – Ponderings of a (fairly) new PhD Research Candidate and a (growing) older Digital Storytelling practitioner by Jenkins Tricia

“…The paper discusses questions concerning the benefits of Digital Storytelling with older people – both active older people and those who have dependency needs associated with ageing, such as dementia. The questions focus on the measurement of value, both in terms of participation in Digital Storytelling as a process and in the stories themselves. …”
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Psychological health among institutionalized senior citizens of Ernakulam district by Mary Ancy. N. Xavier, V. K. Usha

“…Introduction: Institutionalized senior citizens are facing a lot of psychosocial issues, of which dementia and depression are the most common ones. The present study intends to assess psychological health (cognition, depressive symptoms, self-esteem, sleep quality, and quality of life) among institutionalized senior citizens of Ernakulam district. …”
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Clinical and pathogenetic prediction of the dynamics of the course of psychoses in epilepsy by S.G.  Nosov, L.М. Yuryeva, T.Y. Shusterman, O.V. Nekrasova

“…The prognostic value of clinical and neurophysiological factors regarding increasing of the psychotic process duration has been noticed, clinical patterns of transformation of short-term psychosis into long-term (changes in the dynamics and structure of psychosis, features of the relationship with organic personality disorder and dementia in epilepsy, as well as epileptic seizures) have been shown. …”
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Modeling Alzheimer’s Disease with Induced Pluripotent Stem Cells: Current Challenges and Future Concerns by Weiwei Zhang, Bin Jiao, Miaojin Zhou, Tao Zhou, Lu Shen

“…Alzheimer’s disease (AD) is the most prevalent type of dementia and its pathology is characterized by deposition of extracellular β-amyloid plaques, intracellular neurofibrillary tangles, and extensive neuron loss. …”
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Suvorexant, a Novel Dual Orexin Receptor Antagonist, for the Management of Insomnia by Andrew H. Han, Caroline R. Burroughs, Evan P. Falgoust, Jamal Hasoon, Grace Hunt, Juyeon Kakazu, Tim Lee, Adam M. Kaye, Alan D. Kaye, Latha Ganti

“…In addition to helping improve isolated insomnia, Suvorexant helps improve sleep in patients that have other comorbidities such as obstructive sleep apnea, Alzheimer's disease, dementia, acute stroke, and delirium. While Suvorexant is safe, there are still adverse effects associated with the drug that needs to be considered. …”
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Connecting Cerebral White Matter Lesions and Hypertensive Target Organ Damage by Cristina Sierra, Alfons López-Soto, Antonio Coca

“…After age, hypertension is the most-important risk factor for cerebral white matter lesions, which are an important prognostic factor for stroke, cognitive impairment, dementia, and death. Studies have shown an association between white matter lesions and a number of extracranial systems affected by high BP and also suggest that correct antihypertensive treatment could slow white matter lesions progression. …”
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Patterns of Objective and Subjective Burden of Informal Caregivers in Multiple Sclerosis by E. Bayen, C. Papeix, P. Pradat-Diehl, C. Lubetzki, M. E. Joël

“…We assessed ICs objective burden (Resource Utilization in Dementia measuring informal care time (ICT)) and ICs subjective burden (Zarit Burden Inventory (ZBI)). …”
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Medical foods in Alzheimer’s disease by Klaus W. Lange, Jianjun Guo, Shigehiko Kanaya, Katharina M. Lange, Yukiko Nakamura, Shiming Li

“…Alzheimer’s disease (AD) is the most prevalent cause of dementia worldwide. Treatments achieving a marked improvement in symptoms or preventing or delaying the progression of the disease are not available. …”
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Successful Fitting of a Complete Maxillary Denture in a Patient with Severe Alzheimer’s Disease Complicated by Oral Dyskinesia by Hiromitsu Morita, Akie Hashimoto, Ryosuke Inoue, Shohei Yoshimoto, Masahiro Yoneda, Takao Hirofuji

“…There is an increasing population of elderly patients suffering from Alzheimer’s disease (AD), the most common form of dementia. In dentistry, a critical problem associated with these patients is the use of a new denture, as AD patients often refuse dental management and are disturbed by minor changes in their oral environment. …”
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Antibody-mediated degradation of 4R-tau restores mitochondrial membrane polarization in human induced pluripotent stem cell-derived neurons with the MAPT 10+16 mutation by Dale O. Starkie, Charles Arber, Terry Baker, Daniel J. Lightwood, Selina Wray

“…An imbalance causing excess 4 R tau is associated with diseases such as progressive supranuclear palsy and frontotemporal dementia. The mechanisms by which increased 4 R results in neuronal dysfunction and neurodegeneration are not fully understood, and progress has been limited partly by a lack of suitable tools to investigate tau isoform imbalance. …”
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