A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson’s disease by Lijun Dou, Zhenxing Xu, Jielin Xu, Chengxi Zang, Chang Su, Andrew A. Pieper, James B. Leverenz, Fei Wang, Xiongwei Zhu, Jeffrey Cummings, Feixiong Cheng

“…Integrating network proximity-based drug repurposing and patient electronic health record (EHR) data observations, we identified Simvastatin as being significantly associated with reduced incidence of PD (hazard ratio (HR) = 0.91 for fall outcome, 95% confidence interval (CI): 0.87–0.94; HR = 0.88 for dementia outcome, 95% CI: 0.86–0.89) after adjusting for 267 covariates. …”
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Protocol for a meta-review of interventions to prevent and manage ICU delirium by Andrew Booth, Maria Pufulete, Ben Gibbison, Burak Kundakci, Katherine Louise Jones

“…ICU delirium is also associated with increased mortality and dementia in the longer term. ICU delirium prevention and management strategies are likely to include both pharmacological and non-pharmacological components as part of a complex intervention, but it is unclear which components should be included. …”
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Endogenous Estrogen Influences Predator Odor-Induced Impairment of Cognitive and Social Behaviors in Aromatase Gene Deficiency Mice by Yaner Gao, Lei Ma, Feng Gao, Zuoli Sun, Zhengrong Zhang, Yuhong Li, Rena Li

“…Epidemiological studies have suggested that traumatic stress increases vulnerability to various mental disorders, such as dementia and psychiatric disorders. While women are more vulnerable than men to depression and anxiety, it is unclear whether endogenous estrogens are responsible for the underlying sex-specific mechanisms. …”
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Changes in the transcriptome of the prefrontal cortex of OXYS rats as the signs of Alzheimer’s disease development by N. A. Stefanova, E. E. Korbolina, N. I. Ershov, E. I. Rogaev, N. G. Kolosova

“…It produces atrophic changes in the brain, which cause dementia. The incidence of AD is increasing with increasing life expectancy and gradual aging of the population in developed countries. …”
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Experiences and practices of people categorised as being ‘at risk’ based on age during the COVID-19 pandemic: a qualitative study in the UK and Germany by Susannah Mayhew, Stephanie Drössler, Katharina Wabnitz

“…Inclusion criteria: to be at risk for a severe course of COVID-19 due to age ≥50 years (Germany) and ≥70 years (UK) based on official communication by the respective national public health authority.Exclusion criteria: any form of dementia, pre-existing mental health issues, congenital physical or mental disabilities, being resident in a care home, having a personal relationship to the principal investigator.Methods Semistructured in-depth interviews were conducted remotely. …”
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Identification of Cognitive Training for Individuals with Parkinson’s Disease: A Systematic Review by Marina Francesca Gattoni, Silvia Gobbo, Sarah Feroldi, Anna Salvatore, Jorge Navarro, Sandro Sorbi, Francesca Lea Saibene

“…Among them, cognitive impairment in PD has been recognised as a defined clinical entity, and it might lead to an increased risk of developing dementia. Consequently, the present review aimed to ascertain the available interventions for the training of cognitive abilities in persons with PD (PwPD). …”
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Alzheimer’s Disease and Cardiovascular Disease: A Particular Association by Giacomo Tini, Riccardo Scagliola, Fiammetta Monacelli, Giovanni La Malfa, Italo Porto, Claudio Brunelli, Gian Marco Rosa

“…During ageing, the prevalence of dementia, and especially of Alzheimer’s disease (AD) and cardiovascular disease (CVD), increases. …”
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The association of biological sex and long-term outcomes in older patients with physical restraint at the emergency department by Laetitia Manfredini, Marion Pépin, Pradeebane Vaittinada Ayar, Matthieu Gay, Marie Certin, Prabakar Vaittinada Ayar

“…Women more often presented dementia (93 vs. 80%, P = 0.031). Both sexes presented the same limited independence. …”
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“Nobody Seemed to Notice My Work”: The Lived Experiences of Home Care Workers Assisting People With Chronic Diseases: A Phenomenological Study by Valentina Cacciapuoti, Silvio Simeone, Michele Virgolesi, Medeline R. Sterling, Elisa Dallago, Ercole Vellone, Rosaria Alvaro, Gianluca Pucciarelli

“…Although several qualitative studies have been conducted on HCWs, they focused more on studying prevalently the lived experiences about the workplace violence, the end of life, stressor and resilience, during the COVID-19 pandemic or focused more in dementia and heart failure, but not on feelings and working conditions. …”
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Effects of a Cognitive-Functional Intervention Method on Improving Executive Function and Self-Directed Learning in School-Aged Children with Attention Deficit Hyperactivity Disord... by Mi Ji Kim, Hae Yean Park, Eun-Young Yoo, Jung-Ran Kim

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Hypovitaminosis D3, Leukopenia, and Human Serotonin Transporter Polymorphism in Anorexia Nervosa and Bulimia Nervosa by Anna Tasegian, Francesco Curcio, Laura Dalla Ragione, Francesca Rossetti, Samuela Cataldi, Michela Codini, Francesco Saverio Ambesi-Impiombato, Tommaso Beccari, Elisabetta Albi

“…Vitamin D3 has been described to have different extraskeletal roles by acting as parahormone in obesity, diabetes, cancer, cognitive impairment, and dementia and to have important regulatory functions in innate immunity. …”
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Association of serum neurofilament light chain with cognitive impairment: findings from the National Health and Nutrition Examination Survey by Tianjiao Meng, Qinwen Fei, Tian Lv, Shiqin Chen

“…Thus, NfL may serve as a serum biomarker for dementia monitoring.…”
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Electroacupuncture Mitigates Hippocampal Cognitive Impairments by Reducing BACE1 Deposition and Activating PKA in APP/PS1 Double Transgenic Mice by Yinshan Tang, Shujun Shao, Yu Guo, You Zhou, Jin Cao, Anping Xu, Jihong Wu, Zhigang Li, Dulian Xiang

“…Therefore, revealing the underlying mechanism of BACE1 in the pathogenesis of AD might have a significant impact on the future development of therapeutic agents targeting dementia. This study examined the effects of electroacupuncture (EA) stimulation on BACE1, APP, and p-PKA protein levels in hippocampal tissue samples. …”
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What are the training and support needs for homelessness hostel staff supporting older residents with memory and cognitive problems? A qualitative study by Luna Zalc, Sophie N. Gaber, Penny Rapaport

“…Results We identified three main themes: (a) Emotional and psychoeducational support needs within hostel staff teams, including training on memory and cognitive problems, responsive behaviours, communication strategies, and reflective spaces for hostel staff to manage their emotional responses (b) Training and support needs to deliver a person-centred approach, including tools and support packages to enhance hostel residents’ independence, multidisciplinary meetings to evaluate hostel residents’ needs, and communication strategies tailored to hostel residents’ understanding and (c) Support to facilitate collaboration with external agencies, including training on professional language, capacity assessment, dementia case studies, improved communication skills to bring external services into hostels, and reflective practices to advocate for hostel residents with dual diagnoses. …”
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Pimavanserin Treatment for Parkinson’s Disease Psychosis in Clinical Practice by Khashayar Dashtipour, Fiona Gupta, Robert A. Hauser, Cherian A. Karunapuzha, John C. Morgan

“…Issues addressed include distinguishing PDP from similar symptoms caused by other disorders such as dementia, coordinating pimavanserin with other PD medications and with deep brain stimulation, adapting pimavanserin dosing for optimal benefit and tolerability, and recognizing variability of PDP symptoms due to patients’ changing life circumstances. …”
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Assessment of Cognitive Functions in Multimorbid Patients in Lithuanian Primary Care Settings: A Cross-Sectional Study Using MMSE and LT-GPCOG by Silvija Valdonė Alšauskė, Ingrida Grabauskytė, Ida Liseckienė, Jūratė Macijauskienė

“…<i>Background and Objectives</i>: The aging population has led to a rise in cognitive impairments, including dementia, often associated with multimorbidity. Early diagnosis of cognitive decline is crucial, especially in primary care, where time constraints and the limitations of diagnostic tools may hinder accurate detection. …”
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Screening of Some Sulfonamide and Sulfonylurea Derivatives as Anti-Alzheimer’s Agents Targeting BACE1 and PPARγ by Ning Li, Yan Wang, Wensheng Li, Haiyan Li, Liu Yang, Jun Wang, Hazem A. Mahdy, Ahmed B. M. Mehany, Dareen A. Jaiash, Eman Y. Santali, Ibrahim H. Eissa

“…In the last few decades, Alzheimer’s disease (AD) has emerged as a serious global problem, and it has been considered as the most common type of dementia. PPARγ and beta-secretase 1 (BACE1) are considered as potential targets for Alzheimer’s disease management. …”
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Can Table Tennis Extend Lifespan? An Analysis of Its Impact on Physical Health, Brain Function, and Mental Well-being by Patrycja Marta, Agata Ossolińska, Filip Huzarski, Gabriela Ferfecka, Klaudia Pawełek, Lucyna Stolarska, Magdalena Rosa-Bończak, Natalia Morawiecka, Olivier Carlton, Weronika Kłosowicz

“…The sport stimulates cognitive functions such as reflexes, anticipation, and memory, with studies confirming its positive effects on individuals with Parkinson's disease, dementia, or mild cognitive impairment. Table tennis also enhances mental well-being by reducing stress levels and improving quality of life through social integration and satisfaction from the game. …”
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Correlation of MRI Visual Scales with Neuropsychological Profile in Mild Cognitive Impairment of Parkinson’s Disease by Luiz Felipe Vasconcellos, João Santos Pereira, Marcelo Adachi, Denise Greca, Manuela Cruz, Ana Lara Malak, Helenice Charchat-Fichman, Mariana Spitz

“…Visual scales by MRI in MCI should be evaluated by cognitive domain and might be more useful in more severely impaired MCI or dementia patients.…”
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Experiences of community-dwelling older adults living with multiple chronic conditions: a qualitative study by Sharon Kaasalainen, Jenny Ploeg, Marta Canesi, Kimberly D Fraser, Carrie McAiney, Maureen Markle-Reid, Sinead Dufour, Lisa Garland Baird, Tracey Chambers

“…Objectives The aim of the study was to understand the experiences of living with multiple chronic conditions (MCC) from the perspective of community-living older adults with MCC.Design A qualitative study using an interpretive description approach.Setting Participants were recruited from southern Ontario, Canada.Participants 21 community-living, older adults (≥65 years) with an average of 7.4 chronic conditions including one of diabetes, dementia or stroke.Methods Data were collected through digitally-recorded, in-depth, semi-structured in-person interviews. …”
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