Feasibility and potential diagnostic value of [18F]PI-2620 PET in patients with down syndrome and Alzheimer’s disease: a case series by Olivia Wagemann, Olivia Wagemann, Matthias Brendel, Nicolai Franzmeier, Nicolai Franzmeier, Nicolai Franzmeier, Georg Nübling, Georg Nübling, Johannes Gnörich, Mirlind Zaganjori, Catharina Prix, Anna Stockbauer, Anna Stockbauer, Elisabeth Wlasich, Sandra V. Loosli, Sandra V. Loosli, Katja Sandkühler, Lukas Frontzkowski, Günter Höglinger, Günter Höglinger, Günter Höglinger, Johannes Levin, Johannes Levin, Johannes Levin

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Long-Term Impact of Using Mobile Phones and Playing Computer Games on the Brain Structure and the Risk of Neurodegenerative Diseases: Large Population-Based Study by Yi Xiao, Sirui Zhang, Yuanzheng Ma, Shichan Wang, Chunyu Li, Yan Liang, Huifang Shang

“…MethodsWe used data from the UK Biobank, a longitudinal population-based cohort study, to analyze the impact of mobile phone use duration, weekly usage time, and playing computer games on the future brain structure and the future risk of various neurodegenerative diseases, including all-cause dementia (ACD), Alzheimer disease (AD), vascular dementia (VD), all-cause parkinsonism (ACP), and Parkinson disease (PD). …”
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COMPARISON OF COGNITIVE FUNCTION AND DEPRESSIVE SYMPTOMS IN INSTITUTIONALIZED HEALTHY AND OLDER PERSON WITH ALZHEIMER’S DISEASE by Carla M. Teixeira, Ana Filipa Pinto

“…It seems that Alzheimer’s disease, typically associated with cognitive abilities decline and incidence of depressive symptoms, and physical activity influence cognitive performance and depressive symptoms in older people with Alzheimer’s disease and without dementia. …”
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Optimizing Neuropsychological Assessments for Cognitive, Behavioral, and Functional Impairment Classification: A Machine Learning Study by Petronilla Battista, Christian Salvatore, Isabella Castiglioni

“…We investigated the role of twelve state-of-the-art neuropsychological tests in the automatic classification of subjects with none, mild, or severe impairment as measured by the clinical dementia rating (CDR). Data were obtained from the ADNI database. …”
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Cognitive Impairment Involving Social Cognition in SPG4 Hereditary Spastic Paraplegia by Ludivine Chamard, Sabrina Ferreira, Alexa Pijoff, Manon Silvestre, Eric Berger, Eloi Magnin

“…None of our patients presented with mental retardation or dementia. All presented with mild cognitive impairment with a high frequency of attention deficit (100%), executive disorders (89%), and social cognition impairment (78%). …”
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Psychosis as an Isolated Manifestation of COVID-19 in Non-Demented Patients with Parkinson's Disease: Clinical Cases and Literature Review by G. Lokominaitė, R. Kaladytė Lokominienė

“…Despite the recognition of cognitive deficit as a major risk factor for psychosis in Parkinson's disease, psychotic events have been reported in patients without dementia. SARS-CoV-2 is now recognized as a harmful invader of the nervous system, and defining its consequences still requires multidirectional research. …”
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The Science of Memory Loss: Insights into Alzheimer’s Disease by Agnieszka Starzyk, Piotr Charzewski

“… Alzheimer’s disease (AD), the leading cause of dementia, is a growing public health crisis and one of the most burdensome diseases of the 21st century. …”
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Aduhelm, a novel anti-amyloid monoclonal antibody, for the treatment of Alzheimer’s Disease: A comprehensive review by Hannah W. Haddad, Garett W. Malone, Nicholas J. Comardelle, Arielle E. Degueure, Salomon Poliwoda, Rachel J. Kaye, Kevin S. Murnane, Adam M Kaye, Alan D. Kaye

“…Alzheimer's disease (AD) is the most common form of dementia affecting millions of individuals, including family members who often take on the role of caregivers. …”
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Disparity in attitudes regarding assisted dying among physicians and the general public in Japan by Yoshiyuki Takimoto, Tadanori Nabeshima

“…Japan stands out as the most aged country in the developed world, and while the need for palliative care for older adults with dementia has been noted, there has been reluctance to openly address VAE and PAS. …”
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A Case of Cognitive Decline Resulting from Aging, Temporal Lobe Epilepsy, and Environmental Factors by Nikhila Veluri

“…The degree and rate of cognitive decline are crucial as they differentiate normal aging from dementia or memory loss secondary to medical conditions. …”
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Inhibition of Glycogen Synthase Kinase and the Neuroprotective Function of Conjugated ZnO-Osthol Nanoparticles in Alzheimer’s Disease by Nahed S. Alharthi, Fahad M. Aldakheel, Abdulkarim S. Binshaya

“…The mechanism of this effect is still unknown, although the effect of osthol on Aβ-induced inflammation is neuroprotective in AD and supplementation with zinc might prevent or delay the onset of dementia. In the current study, by inducing APP vector in human BE (2)-M17 cells, we established a cellular model of AD and investigated the protective effect of osthol (7-methoxy-8-3-methyl-2-butenyl-2H-1-benzopyran-2-one)-zinc oxide nanoparticles. …”
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A Community-Based Walk-In Screening of Depression in Taiwan by Shu-Yu Tai, Tzu-Chiao Ma, Ling-Chun Wang, Yuan-Han Yang

“…Depression is a crucial public health problem because of its relatively high association with suicidal attempts, prolonged social isolation, poor physical health, and dementia. However, the available data and study on the prevalence of depression in Taiwan were mostly completed within the previous 1 to 2 decades, and these studies were limited to certain areas or populations. …”
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FLAIR Hyperintense Vessel Sign of Both MCAs with Severe Heart Failure by Donghee Kim, Seung-Yul Lee, Kwon-Duk Seo

“…She had a history of hypertension, heart failure, and dementia. Brain MRI demonstrated FHVs within both middle cerebral arteries (MCAs). …”
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Rational Suicide, Euthanasia, and the Very Old: Two Case Reports by Anne Pamela Frances Wand, Carmelle Peisah, Brian Draper, Carolyn Jones, Henry Brodaty

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Iron Homeostasis Dysregulation, Oro-Gastrointestinal Microbial Inflammatory Factors, and Alzheimer’s Disease: A Narrative Review by Agata Kuziak, Piotr Heczko, Agata Pietrzyk, Magdalena Strus

“…Alzheimer’s disease (AD), the most common form of dementia, is a progressive neurodegenerative disorder that profoundly impacts cognitive function and the nervous system. …”
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Navigating the Role and Approach of Gut Microbiota in Addressing Alzheimer's Disease Pathogenesis by Imrana Jazuli, Akeela Jazeel, Lakshmi Selvaratnam, Deepa Alex, Yatinesh Kumari

“…Recent studies have shown promise in using anti-Aβ antibodies to reduce amyloid accumulation and slow dementia progression. However, diversifying therapeutic strategies is crucial for making meaningful progress. …”
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Finite Element Analysis of Normal Pressure Hydrocephalus: Influence of CSF Content and Anisotropy in Permeability by K. Shahim, J.-M. Drezet, J.-F. Molinari, R. Sinkus, S. Momjian

“…Hydrocephalus is a cerebral disease where brain ventricles enlarge and compress the brain parenchyma towards the skull leading to symptoms like dementia, walking disorder and incontinence. The origin of normal pressure hydrocephalus is still obscure. …”
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The Role of Lifestyle Behaviors on 20-Year Cognitive Decline by D. Cadar, H. Pikhart, G. Mishra, A. Stephen, D. Kuh, M. Richards

“…Adopting positive health behaviors from early midlife may be beneficial in reducing the rate of cognitive decline and ultimately reducing the risk of dementia.…”
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Being young and resilient in times of AI, disasters, and crises by Veselin Mitrović

“…Ultimately, the dystopian vision of a mindless and non-resilient young populace within an already susceptible context of an aging society—particularly with the increasing prevalence of dementia—reveals novel vulnerabilities, signalling the onset of an impending disaster. …”
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Analysis of polypharmacy in elderly patients with decreased kidney and liver function: Case Report by Rina Widiyawati, Khoirul Anam, Nur Oktafiyani, M. Hari Pristantiningtyas, Herya Putra Dharma, Muhammad Muchlis, Jainuri Erik Pratama, Fauna Herawati, Adji Prayitno, Marisca Evalina Gondokesumo

“…Elderly patients are at a high risk of developing chronic diseases, including cardiovascular disease, cancer, dementia, and diabetes. Additionally, many elderly individuals experience multimorbidity, having more than one chronic condition, contributing to the phenomenon of polypharmacy. …”
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