evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomat... by Jeffrey L. Cummings, Alireza Atri, Howard H. Feldman, Oskar Hansson, Mary Sano, Filip K. Knop, Peter Johannsen, Teresa León, Philip Scheltens

“…Eligible participants were men or women aged 55–85 years with mild cognitive impairment or mild dementia due to AD with confirmed amyloid abnormalities (assessed by positron emission tomography or cerebrospinal fluid [CSF] analysis). …”
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Postural imbalance without visual input is associated with specific neuropsychological deficits in older adults – results from the LIFE-adult study by Eva Grill, Andreas Zwergal, Andreas Zwergal, Dorothee Saur, Julian Klingbeil, Christopher Fricke, Florian Schöberl, Karim Felfela, Karim Felfela, Andrea Zülke, Steffi Riedel-Heller, Joseph Classen

“…IntroductionModifiable risk factors play an important role in preventing dementia and reducing its progression. Regular physical activity already in midlife, which relies on intact multisensory balance control, can help to decrease the risk of dementia. …”
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A User-Centered Design Approach for a Screening App for People With Cognitive Impairment (digiDEM-SCREEN): Development and Usability Study by Michael Zeiler, Nikolas Dietzel, Fabian Haug, Julian Haug, Klaus Kammerer, Rüdiger Pryss, Peter Heuschmann, Elmar Graessel, Peter L Kolominsky-Rabas, Hans-Ulrich Prokosch

“… Abstract BackgroundDementia is a widespread syndrome that currently affects more than 55 million people worldwide. …”
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Assessing the health implications of anticholinergic drugs in older people by Mariangela Boccardi, Virginia Boccardi

“…We propose practical guidelines for their use in clinical contexts such as dementia, schizophrenia, depression, anxiety, Parkinson’s disease, cardiovascular conditions, and urinary incontinence. …”
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Advanced Asymptomatic Carotid Disease and Cognitive Impairment: An Understated Link? by Irena Martinić-Popović, Arijana Lovrenčić-Huzjan, Vida Demarin

“…However, cognitive decline often occurs in patients with advanced carotid stenosis without clinically evident stroke or TIA, so it is also suspected to be an independent risk factor for dementia. Neurosonological methods enable simple and noninvasive assessment of carotid stenosis in patients at risk of advanced atherosclerosis. …”
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Educational Needs of Health Care Providers Working in Long-Term Care Facilities with Regard to Pain Management by Yannick Tousignant-Laflamme, Michel Tousignant, David Lussier, Paule Lebel, Maryse Savoie, Lyne Lalonde, Manon Choinière

“…BACKGROUND: The prevalence of chronic pain ranges from 40% to 80% in long-term care facilities (LTCF), with the highest proportion being found among older adults and residents with dementia. Unfortunately, pain in older adults is underdiagnosed, undertreated, inadequately treated or not treated at all. …”
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Long-Term Perseveration in Alzheimer’s Disease: A Case Report by Edith V. Sullivan

“…Presented here is a case of AD who, despite ultimate profound dementia with severe amnesia, showed retention of a perseverative response she developed during 26 encounters, over 4.5 years, with the Brown–Peterson distractor test. …”
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Mistreatment or not the best treatment to the elder. Reality and challenge by Miguel Angel Serra Valdés, Girelda Cordero López, Marleny Viera García

“…Cuba is not exempted of this situation; the Cuban population ages and chronic non communicable diseases are a challenge to be concerned, mainly cancer, dementia, disability and prostration due to different causes which are the most frequent illnesses in elder people.…”
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From pixels to prognosis: radiomics and AI in Alzheimer’s disease management by Danting Peng, Weiju Huang, Ren Liu, Wenlong Zhong

“…Alzheimer’s disease (AD), the leading cause of dementia, poses a growing global health challenge due to an aging population. …”
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Synaptic Paths to Neurodegeneration: The Emerging Role of TDP-43 and FUS in Synaptic Functions by Shuo-Chien Ling

“…TAR DNA-binding protein-43 KDa (TDP-43) and fused in sarcoma (FUS) as the defining pathological hallmarks for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), coupled with ALS-FTD-causing mutations in both genes, indicate that their dysfunctions damage the motor system and cognition. …”
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Therapeutic Application of rTMS in Atypical Parkinsonian Disorders by Chrysi Petsani, Athina-Maria Aloizou, Vasileios Siokas, Lambros Messinis, Eleni Peristeri, Christos Bakirtzis, Grigorios Nasios, Efthimios Dardiotis

“…The terms atypical parkinsonian disorders (APDs) and Parkinson plus syndromes are mainly used to describe the four major entities of sporadic neuronal multisystem degeneration: progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), multiple system atrophy (MSA), and dementia with Lewy bodies (LBD). APDs are characterized by a variety of symptoms and a lack of disease modifying therapies; their treatment thus remains mainly symptomatic. …”
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Early-Onset Alzheimer’s Disease Masquerading as Catatonia by Aljoharah Alakkas, Aaron Meyer, Eric Debbold, Raisa Yagudayeva, Jonathan Bui

“…This case is a cautionary reminder for clinicians that end stages of dementia can present similar to catatonia with mutism, lack of spontaneous movement, and refusal to eat. …”
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Cholecystoduodenal Fistula and Urosepsis in A Febrile Emergency Department Patient: A Case Report by Amna Nawaz, Denise Elizondo, Bushra Hussein, Rebecca Theophanous

“…Case Report: We highlight the important POCUS findings of cholecystoduodenal fistula and staghorn calculus in a febrile, elderly patient with dementia. Conclusion: Early recognition of cholecystoduodenal fistula and staghorn calculus using POCUS can expedite appropriate antibiotic and interventional treatment for improved patient outcomes.…”
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Non-motor Disorders and their Neuro-anatomical Substrate in Parkinson's Disease by Julio López Argüelles, Leydi María Sosa Águila

“…These include all those disorders that are not motor symptoms: behavioral neuropsychiatric disorders (dementia, depression, anxiety, psychosis); autonomic alteration (postural hypotension, gastrointestinal and genitourinary disorders, diaphoresis); sleep disorders; sensory-motor symptoms (fatigue, restless legs syndrome). …”
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Structural and functional brain correlates of the neutrophil- and monocyte-to-lymphocyte ratio in neuropsychiatric disorders by Roger McIntosh

“…The studies reviewed in this special edition implicate neutrophil and monocyte expansion relative to lymphocytopenia in the sequelae of depression, cognitive and functional decline, as well as provide support from a range of neuroimaging techniques that identify brain alteartions concommitant with expansion of the NLR or MLR and the sequelae of depression, dementia, and functional decline.…”
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Treatment of Advanced Parkinson's Disease by Sara Varanese, Zoe Birnbaum, Roger Rossi, Alessandro Di Rocco

“…These complications include motor fluctuations, dyskinesia, unpredictable or absent response to medications, falls, dysautonomia, dementia, hallucinations, sleep disorders, depression, and psychosis. …”
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A Review of the Healthcare and Social Care Needs of the Older Prisoner Population in England and Wales by Paul Gavin, Cody Normitta Porter, Finley MacDonald

“…This paper provides an overview of the main challenges facing older prisoners in the context of their health and social care needs, including the development of mental health problems such as Alzheimer’s and dementia, as well as challenges related to mobility and engaging in structured activities in prison. …”
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Features of diagnostics and treatment of constipation at patients of elderly age by A. V. Kalinin, L. I. Butorova

“…Risk factors of constipation at people of elderly age include: change of pattern of nutrition (decrease of alimentary fibers content in ration); still lifestyle (compelled bed rest); presence of concomitant diseases (endocrine, neurologic, mental disorders – depression, dementia); drug-induced constipations; age-related changes of the large intestine. …”
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Cognitive Phenotypes, Brain Morphometry and the Detection of Cognitive Decline in Preclinical AD by Mark W. Jacobson, Linda K. McEvoy, Anders Dale, Christine Fennema-Notestine

“…We review several approaches to defining cognitive subgroups, and we consider the possibility that cognitive asymmetry might provide one means of identifying both functional and structural changes associated with aging and dementia.…”
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Role of visual function and performance of activities of daily living in cognitive function in patients with mild cognitive impairment: a cross-sectional study by Chunhui Zhou, Ganfeng Yang, Marc Theeboom, Hua Yang, Ruiting Zhu, Zijian Zhou, Dong Zhu

“…BackgroundMild cognitive impairment (MCI) is a precursor to dementia, with many patients showing early decline in activities of daily living (ADLs). …”
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