A data-driven cluster analysis to explore cognitive reserve and modifiable risk factors in early phases of cognitive decline by Sara Bernini, Alice Valcarenghi, Elena Ballante, Federico Fassio, Marta Picascia, Elena Cavallini, Matteo Cotta Ramusino, Alfredo Costa, Tomaso Vecchi, Cristina Tassorelli, Sara Bottiroli

“…Such a finding is representative of a more positive individual wellbeing for people who adopt protective behaviours. In the field of dementia prevention, these results support the importance to intervene proactively and simultaneously in the management of multiple risk factors during the entire lifespan.…”
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Effects of neurocognitive intervention in older adults. A systematic review by Elizabeth Jiménez Puig, Zoylen Fernández Fleites, Yunier Broche Pérez, Daniela Beatriz Vázquez Martínez

“…<br /><strong>Objective:</strong> to describe, through a systematic review of the scientific literature, the effects of neurocognitive intervention on cognitive health in healthy older adults, and in older adults with mild cognitive impairment or dementia. <br /><strong>Methods:</strong> a descriptive study was carried out, which consisted of a systematic review of the scientific literature on the subject; and started from the search in the databases: PubMed, PsycInfo, Scielo, Cochrane and EBSCO, from August to December 2018. …”
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Variation in Thyroid-Stimulating Hormone and Cognitive Disorders in Unmedicated Middle-Aged Patients with Major Depressive Disorder: A Proton Magnetic Resonance Spectroscopy Study by Hui Zhao, Shunkai Lai, Shuming Zhong, Yiliang Zhang, Hui Yang, Yanbin Jia

“…Middle-aged (45-59 years old) patients with major depressive disorder (MDD) have a predilection for dementia and cognitive disorders (CDs); however, the characteristics and mechanisms of CDs in these patients remain unclear. …”
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Correlation of Visuospatial Ability and EEG Slowing in Patients with Parkinson’s Disease by Dominique Eichelberger, Pasquale Calabrese, Antonia Meyer, Menorca Chaturvedi, Florian Hatz, Peter Fuhr, Ute Gschwandtner

“…Visuospatial dysfunction is among the first cognitive symptoms in Parkinson’s disease (PD) and is often predictive for PD-dementia. Furthermore, cognitive status in PD-patients correlates with quantitative EEG. …”
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Investigating the Therapeutic Mechanisms of Total Saikosaponins in Alzheimer’s Disease: A Metabolomic and Proteomic Approach by Huiling Wei, Tianyi Du, Weiwei Zhang, Wei Ma, Yao Yao, Juan Li

“…Alzheimer’s disease (AD) is the leading cause of dementia among the elderly, yet effective treatments remain elusive. …”
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Influence of Medication on Fatigue Six Months after Stroke by Amélie Ponchel, Julien Labreuche, Stéphanie Bombois, Christine Delmaire, Régis Bordet, Hilde Hénon

“…This study is part of STROKDEM, an ongoing longitudinal cohort study, whose main aim is to determine predictors of poststroke dementia. Patients were included within 72 hours after an ischemic stroke and followed up with standardized evaluations. …”
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An MR Brain Images Classifier System via Particle Swarm Optimization and Kernel Support Vector Machine by Yudong Zhang, Shuihua Wang, Genlin Ji, Zhengchao Dong

“…The abnormal brain MR images consist of the following diseases: glioma, metastatic adenocarcinoma, metastatic bronchogenic carcinoma, meningioma, sarcoma, Alzheimer, Huntington, motor neuron disease, cerebral calcinosis, Pick’s disease, Alzheimer plus visual agnosia, multiple sclerosis, AIDS dementia, Lyme encephalopathy, herpes encephalitis, Creutzfeld-Jakob disease, and cerebral toxoplasmosis. …”
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Attributes of cognitive impairment in patients on maintenance hemodialysis – A cohort study by Geet Gaurav, Deepa Sanjeev Sajjanar, G. V. Naregal, Sanjeev L. Sajjanar

“…About 88.6% of participants (n = 62) showed considerable cognitive impairment and 1.4% had frank dementia. A positive association was noted between cognitive impairment and the conditions of diabetes mellitus and hypertension with a relative risk of 1.02 and 1.11, respectively. …”
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Mini-Mental Parkinson: First Validation Study of a New Bedside Test Constructed for Parkinson’s Disease by F. Mahieux, D. Michelet, M.-J. Manifacier, F. Boller, J. Fermanian, A. Guillard

“…There was a significant difference in the mean scores in cases with confusional event (22.4), even without current signs of dementia, compared with patients with no such history (27.2). …”
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Continuous Professional Oral Health Care Intervention Improves Severe Aspiration Pneumonia by Wakako Nawata, Yojiro Umezaki, Masahiro Yamaguchi, Masato Nakajima, Michiko Makino, Masahiro Yoneda, Takao Hirofuji, Takafumi Yamano, Hiroaki Ooboshi, Hiromitsu Morita

“…A 74-year-old male patient with a brain infarction suffered from severe aspiration pneumonia (PSI: IV, A-DROP: 3) complicated by vascular dementia and severe dysphagia. Because an antimicrobial approach following the treatment guidelines for pneumonia was not effective, we started a POHC intervention to improve his poor oral condition at the request of the attending doctor and the patient’s family. …”
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Modern Imaging Methods in the Diagnosis of Neurodegenerative Diseases by Paulina Dorota Pietrukaniec, Bartosz Omasta, Katarzyna Kamińska-Omasta, Olga Krupa, Daria Rybak, Kuba Borys Romańczuk, Magdalena Agata Czerska, Szymon Przemysław Stolarczyk, Zofia Martyna Wójcik, Kinga Furtak

“… Neurodegenerative diseases, such as Alzheimer's, Parkinson's and other forms of dementia, represent a major global health challenge. …”
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Consensus on the Definition of Advanced Parkinson’s Disease: A Neurologists-Based Delphi Study (CEPA Study) by Maria-Rosario Luquin, Jaime Kulisevsky, Pablo Martinez-Martin, Pablo Mir, Eduardo S. Tolosa

“…Definitive symptoms of APD included disability requiring help for the activities of daily living, presence of motor fluctuations with limitations to perform basic activities of daily living without help, severe dysphagia, recurrent falls, and dementia. These results will help neurologists to identify some key factors in APD diagnosis, thus allowing users to categorize the patients for a homogeneous recognition of this condition.…”
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Relationship between social activities and cognitive impairment in Chinese older adults: the mediating effect of depressive symptoms by Qianke Yang, Shichong Lin, Zhuyun Zhang, Shuhao Du, Dan Zhou

“…BackgroundThe differential impacts of various social activities on dementia prevention and the mediating role of depression in this relationship remain unclear.ObjectivesThis study aimed to identify the effects of different social activities on cognitive function, examine the mediating role of depression, and provide evidence for targeted interventions to prevent cognitive decline.MethodsUsing data from CHARLS, we employed RCS analysis and Structural Equation Modeling to examine the relationships between social activities, depression, and cognitive function in older adults.ResultsSocial activity participation is non-linearly inversely related to both cognitive impairment and depression risk. …”
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Upregulation of PGC-1α Attenuates Oxygen-Glucose Deprivation-Induced Hippocampal Neuronal Injury by Bin Han, Hui Zhao, Xingji Gong, Jinping Sun, Song Chi, Tao Liu, Anmu Xie

“…Hippocampal neuronal damage likely underlies cognitive impairment in vascular dementia (VaD). PPARγ coactivator-1α (PGC-1α) is a master regulator of mitochondrial biogenesis. …”
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IL-34 aggravates myocardial ischemia-reperfusion injury by upregulating the HMGB1-IL-17A-IL-6 axis through the JAK signaling pathway. by Ruisong Ma, Xiaochun Hu, Wenwen Fu, Xiaorong Hu

“…Interleukin-34 (IL-34) was recently reported to be a new biomarker for atherosclerosis diseases, such as coronary artery disease and vascular dementia. IL-34 regulates the expression of proinflammatory cytokines (IL-17A, IL-1 and IL-6), which are classical cytokines involved in myocardial ischemia‒reperfusion (MI/R) injury. …”
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Predicting Cognitive Decline in Parkinson’s Disease with Mild Cognitive Impairment: A One-Year Observational Study by Pei-Hao Chen, Fang-Yu Cheng, Shih-Jung Cheng, Jin-Siang Shaw

“…Patients with PD-MCI had more physical disabilities, including scores of instrumental activities of daily living (IADL), Tinetti balance, and gait scores, and some Timed Up and Go components. Initial Clinical Dementia Rating—Sum of Boxes score was a better predictor of future cognitive decline than MMSE in PD-MCI. …”
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Central Aortic Pressure and Arterial Stiffness in Parkinson’s Disease: A Comparative Study by Mehmet Balal, Meltem Demirkiran, Saime Paydas

“…When NMS were evaluated, patients with psychosis and dementia showed higher baseline parameters. Conclusion. …”
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A case report of fatal familial insomnia with cerebrospinal fluid leukocytosis during the COVID-19 epidemic and review of the literature by Zheng Wang, Yueqi Huang, Shuqi Wang, Jiefang Chen, Gesang Meiduo, Man Jin, Xiaoying Zhang

“…Generally, FFI patients will develop rapidly progressive dementia, sleep disturbance, autonomic dysfunction, and so on. …”
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Finding Neural Biomarkers for Motor Learning and Rehabilitation Using an Explainable Graph Neural Network by J. Han, A. Embs, F. Nardi, S. Haar, A. A. Faisal

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Comorbidities among Patients with Epilepsy Attending Imam Al-Sadiq General Hospital in Babylon Governorate, Iraq by Bilal Hadi Jawad, Khadija Shaban Hassan, Wahab Razzaq Ebdan

“…Among psychiatric comorbidities, 67.1% of them were suffered from anxiety and 61.9% with depression. 7.6% of patient were suffering from Dementia/ Alzheimer’s disease as cognitive comorbidities. …”
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