Non-motor Disorders and their Neuro-anatomical Substrate in Parkinson's Disease by Julio López Argüelles, Leydi María Sosa Águila

“…These include all those disorders that are not motor symptoms: behavioral neuropsychiatric disorders (dementia, depression, anxiety, psychosis); autonomic alteration (postural hypotension, gastrointestinal and genitourinary disorders, diaphoresis); sleep disorders; sensory-motor symptoms (fatigue, restless legs syndrome). …”
Get full text

Structural and functional brain correlates of the neutrophil- and monocyte-to-lymphocyte ratio in neuropsychiatric disorders by Roger McIntosh

“…The studies reviewed in this special edition implicate neutrophil and monocyte expansion relative to lymphocytopenia in the sequelae of depression, cognitive and functional decline, as well as provide support from a range of neuroimaging techniques that identify brain alteartions concommitant with expansion of the NLR or MLR and the sequelae of depression, dementia, and functional decline.…”
Get full text

Treatment of Advanced Parkinson's Disease by Sara Varanese, Zoe Birnbaum, Roger Rossi, Alessandro Di Rocco

“…These complications include motor fluctuations, dyskinesia, unpredictable or absent response to medications, falls, dysautonomia, dementia, hallucinations, sleep disorders, depression, and psychosis. …”
Get full text

A Review of the Healthcare and Social Care Needs of the Older Prisoner Population in England and Wales by Paul Gavin, Cody Normitta Porter, Finley MacDonald

“…This paper provides an overview of the main challenges facing older prisoners in the context of their health and social care needs, including the development of mental health problems such as Alzheimer’s and dementia, as well as challenges related to mobility and engaging in structured activities in prison. …”
Get full text

Features of diagnostics and treatment of constipation at patients of elderly age by A. V. Kalinin, L. I. Butorova

“…Risk factors of constipation at people of elderly age include: change of pattern of nutrition (decrease of alimentary fibers content in ration); still lifestyle (compelled bed rest); presence of concomitant diseases (endocrine, neurologic, mental disorders – depression, dementia); drug-induced constipations; age-related changes of the large intestine. …”
Get full text

Cognitive Phenotypes, Brain Morphometry and the Detection of Cognitive Decline in Preclinical AD by Mark W. Jacobson, Linda K. McEvoy, Anders Dale, Christine Fennema-Notestine

“…We review several approaches to defining cognitive subgroups, and we consider the possibility that cognitive asymmetry might provide one means of identifying both functional and structural changes associated with aging and dementia.…”
Get full text

Role of visual function and performance of activities of daily living in cognitive function in patients with mild cognitive impairment: a cross-sectional study by Chunhui Zhou, Ganfeng Yang, Marc Theeboom, Hua Yang, Ruiting Zhu, Zijian Zhou, Dong Zhu

“…BackgroundMild cognitive impairment (MCI) is a precursor to dementia, with many patients showing early decline in activities of daily living (ADLs). …”
Get full text

Using Health Utility Index (HUI) for Measuring the Impact on Health-Related Quality of Life (HRQL) Among Individuals with Chronic Diseases by Frank Mo, Bernard C.K. Choi, Felix C.K. Li, Joav Merrick

“…Urinary incontinence, Alzheimer/other dementia, effects of stroke, cancers, thyroid condition, and back problems have a moderate impact. …”
Get full text

Presence and Absence in Margaret Atwood’s Dearly by Pilar Sánchez-Calle

“…Many of these poems are dedicated to her partner Graeme Gibson, who was diagnosed with vascular dementia in 2017 and passed away in 2019. Through close readings and formal analysis, I aim to demonstrate how these elegiac poems articulate a psychic landscape of mourning where separation after death is rejected and an alternative space for reunion with the deceased is created. …”
Get full text

A Case of Tick-Borne Paralysis in a Traveling Patient by Kevin Ha, Kathryn Lewis, Vandan Patel, Jennifer Grinceri

“…An 88-year-old man with dementia and dyslipidemia presented with new onset gait instability and was admitted for suspected cerebellar stroke. …”
Get full text

Potential Synergies of β-Hydroxybutyrate and Butyrate on the Modulation of Metabolism, Inflammation, Cognition, and General Health by Franco Cavaleri, Emran Bashar

“…The low-carbohydrate high-fat diet (LCHFD), also known as the ketogenic diet, has cycled in and out of popularity for decades as a therapeutic program to treat metabolic syndrome, weight mismanagement, and drug-resistant disorders as complex as epilepsy, cancer, dementia, and depression. Despite the benefits of this diet, health care professionals still question its safety due to the elevated serum ketones it induces and the limited dietary fiber. …”
Get full text

Uma carta para Mark Freeman sobre a “promessa trágica” de doenças neurodegenerativas by Will Lucas Silva Pena

“…Nela, debato elementos que o autor traz em seu artigo Beyond narrative: dementia’s tragic promise (2008a), em especial a associação entre “narrativas”, “subjetividade” e “processos de adoecimento”. …”
Get full text

Clinical Interaction between Brain and Kidney in Small Vessel Disease by Masaki Mogi, Masatsugu Horiuchi

“…Recently, changes in the vascular system of the brain have been shown to contribute to the onset and progression of cognitive impairment, not only vascular dementia but also Alzheimer's disease. Patients with CKD are also reported to have higher risk of impaired cognitive function in the future compared with non-CKD subjects. …”
Get full text

Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches by Almudena Fuster-Matanzo, María Llorens-Martín, Félix Hernández, Jesús Avila

“…Neuroinflammation, a specialized immune response that takes place in the central nervous system, has been linked to neurodegenerative diseases, and specially, it has been considered as a hallmark of Alzheimer disease, the most common cause of dementia in the elderly nowadays. Furthermore, neuroinflammation has been demonstrated to affect important processes in the brain, such as the formation of new neurons, commonly known as adult neurogenesis. …”
Get full text

CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease by J. Thome, A. N. Coogan, A. G. Woods, C. C. Darie, F. Häßler

“…Presently, more and more data are emerging demonstrating how alterations of the CLOCK gene system might contribute to the pathophysiology of AD and other forms of dementia. At the same time, the impact of neuropsychiatric medication on CLOCK gene expression is under investigation.…”
Get full text

Dietary inflammatory index and disability among older adults in Guangzhou: a cross-sectional analysis by Junbin Liao, Junbin Liao, Wenfeng Cai, Danrong Lin, Yuanyun Xiao, Yanxi Liu, Yahui Wang, Yuquan Zhong, Fan Xiao, Heng Fang, Yilu Yao, Yunfeng Lin, Jiewen Su, Siyu Sun, Bo Zhang, Yan Wang, Wei Zhu, Wei Zhu

“…After adjusting for confounding factors, a higher DII was linked to a greater degree of disability, with the highest DII quartile showing a notably higher risk (OR = 2.61, 95% CI = 1.21–5.61) compared to the lowest quartile.ConclusionLack of exercise, previous exercise, stroke, and dementia are correlated with increased disability among older adults. …”
Get full text

Inferior Frontal Gyrus Activation Underlies the Perception of Emotions, While Precuneus Activation Underlies the Feeling of Emotions during Music Listening by Ken-ichi Tabei

Get full text

Effectiveness of a specialist palliative home care nurse–patient consultation followed by an interprofessional telephone case conference compared with usual care among patients wit... by Judith Dams, Hans-Helmut König, Tim Friede, Nils Schneider, Stephanie Stiel, Martin Scherer, Silke Böttcher, Gabriella Marx, Ingmar Schäfer, Nadine Janis Pohontsch, Hendrik van den Bussche, Friedemann Nauck, Michael Freitag, Eva Hummers, Tina Mallon, Franziska Schade, Manuel Zimansky, Thomas Asendorf, Christiane A Mueller

“…Introduction Progressive chronic, non-malignant diseases (CNMD) like congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD) and dementia are of growing relevance in primary care. …”
Get full text

Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by dopaminergic treatment by Katharina Bolsewig, Eline A. J. Willemse, Pascual Sánchez-Juan, Alberto Rábano, Minerva Martínez, James D. Doecke, Giovanni Bellomo, Lisa Vermunt, Daniel Alcolea, Steffen Halbgebauer, Sjors in ‘t Veld, Niklas Mattsson-Carlgren, Katerina Veverova, Christopher J. Fowler, Lynn Boonkamp, Marleen Koel-Simmelink, Zulaiga Hussainali, Daimy N. Ruiters, Lorenzo Gaetani, Andrea Toja, Juan Fortea, Yolande Pijnenburg, Afina W. Lemstra, Wiesje M. van der Flier, Jakub Hort, Markus Otto, Oskar Hansson, Lucilla Parnetti, Colin L. Masters, Alberto Lleó, Charlotte E. Teunissen, Marta Del Campo Milán

“…Here we evaluate plasma DDC, measured by proximity extension assay, and the effect of dopaminergic treatment in three independent LBD (with a focus on dementia with Lewy bodies (DLB) and Parkinson’s disease (PD)) cohorts: an autopsy-confirmed cohort (n = 71), a large multicenter, cross-dementia cohort (n = 1498) and a longitudinal cohort with detailed treatment information (n = 66, median follow-up time[IQR] = 4[4, 4] years). …”
Get full text

Long-Term Impact of Using Mobile Phones and Playing Computer Games on the Brain Structure and the Risk of Neurodegenerative Diseases: Large Population-Based Study by Yi Xiao, Sirui Zhang, Yuanzheng Ma, Shichan Wang, Chunyu Li, Yan Liang, Huifang Shang

“…MethodsWe used data from the UK Biobank, a longitudinal population-based cohort study, to analyze the impact of mobile phone use duration, weekly usage time, and playing computer games on the future brain structure and the future risk of various neurodegenerative diseases, including all-cause dementia (ACD), Alzheimer disease (AD), vascular dementia (VD), all-cause parkinsonism (ACP), and Parkinson disease (PD). …”
Get full text