Pathology of Synapses and Dendritic Spines by Shira Knafo, Gunnar K. Gouras, Xiao-Xin Yan, Tara Spires-Jones

Get full text

Upper and Lower Face and Ideomotor Apraxia in Patients with Alzheimer’s Disease by Jay Guido Capone, Sergio Della Sala, Hans Spinnler, Annalena Venneri

“…This study aimed at investigating the frequency of lower (mouth, tongue and throat) and upper (eyes and eyebrows) face apraxia, in AD and its relationship with limb apraxia and severity of dementia.…”
Get full text

Topographic Mapping of P300 and Frontal Cognitive Function in Parkinson’s Disease by Mutsumi Iijima, Mikio Osawa, Makoto Iwata, Akiko Miyazaki, Hideaki Tei

“…The purpose of this study was to evaluate the relationship between P300 that is one of the event-related potentials and frontal cognitive functions in Parkinson’s disease (PD) without clinically apparent dementia.…”
Get full text

Cognitive Retardation in a Patient with Preservation of Psychomotor Speed by J. R. Willison, E. K. Warrington

“…He showed many similarities with patients previously described as having subcortical dementia. The selective preservation of psychomotor responding in the context of his gross bradyphrenia, however, was unexpected.…”
Get full text

A Review of the Effects of Physical Activity and Exercise on Cognitive and Brain Functions in Older Adults by Louis Bherer, Kirk I. Erickson, Teresa Liu-Ambrose

“…Results from cross-sectional, longitudinal, and intervention studies with healthy older adults, frail patients, and persons suffering from mild cognitive impairment and dementia are reviewed and discussed. Together these finding suggest that physical exercise is a promising nonpharmaceutical intervention to prevent age-related cognitive decline and neurodegenerative diseases.…”
Get full text

UK Biobank MRI data can power the development of generalizable brain clocks: A study of standard ML/DL methodologies and performance analysis on external databases by Marco Capó, Silvia Vitali, Georgios Athanasiou, Nicole Cusimano, Daniel García, Garth Cruickshank, Bipin Patel

“…Additionally, these models show strong potential as biomarkers for neurodegenerative conditions, such as dementia, where brain age prediction achieved an AUROC of up to 0.90 in distinguishing healthy individuals from those with dementia.…”
Get full text

Designing an intervention to improve cognitive evaluations in primary care by Kyra S. O’Brien, Kristin Harkins, MaryAnne Peifer, Melanie Kleid, Cameron Coykendall, Judy Shea, Jason Karlawish, Robert E. Burke

“…Abstract Background Early diagnosis is crucial to the optimal management of patients with cognitive impairment due to Alzheimer’s disease (AD) or AD-related dementias. For some patients, early detection of cognitive impairment enables access to disease-modifying therapies. …”
Get full text

A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson’s Disease by Yuan Zhang, Li Shu, Xun Zhou, Hongxu Pan, Qian Xu, Jifeng Guo, Beisha Tang, Qiying Sun

“…Besides, clinical features like family history, AAO, UPDRS-III, H-Y, and dementia previously analyzed were updated with new data added. …”
Get full text

Association between retinal markers and cognition in older adults: a systematic review by Gerald Liew, Bamini Gopinath, Joyce Chan, Joyce Siette, Varshanie Jeevakumar, Rebekah Sefton, Tejal M Shah

“…Further longitudinal studies are required to validate our synthesis and understand underlying mechanisms before recommending implementation of OCT as a dementia screening tool in clinical practice.PROSPERO registration number CRD42020176757.…”
Get full text

The Effect of Physical Activity on Alzheimer’s Disease - Systematic Review by Julia Lachowska, Karolina Senior, Jerzy Smandek, Maja Mielczarek, Paulina Sroczyńska, Jan Sroczyński

“… Dementia, particularly Alzheimer's disease (AD), is a growing global health concern, with an estimated 50 million people affected worldwide. …”
Get full text

Studying Alzheimer’s disease through an integrative serum metabolomic and lipoproteomic approach by Alessia Vignoli, Giovanni Bellomo, Federico Paolini Paoletti, Claudio Luchinat, Leonardo Tenori, Lucilla Parnetti

“…Methods This pilot study proposes a serum investigation via nuclear magnetic resonance (NMR) spectroscopy in a consecutive series of AD patients including 57 patients affected by Alzheimer’s disease at dementia stage (AD-dem) and 45 patients with mild cognitive impairment (MCI) due to AD (MCI-AD). …”
Get full text

Investigating ITM2B‐associated ataxia in a Taiwanese cerebellar ataxia cohort by Shih‐Yu Fang, Cheng‐Tsung Hsiao, Kang‐Yang Jih, Yu‐Sheun Tsai, Kuan‐Lin Lai, Cheng‐Ta Chou, Yi‐Chu Liao, Yi‐Chung Lee

“…Variations in the ITM2B gene, typically linked to dominantly inherited dementia, can sometimes present with cerebellar ataxia as an early symptom. …”
Get full text

Transdermal Physostigmine—Absence of Effect on Topographic Brain Mapping by M. Y. Neufeld, F. Mawassi, A. Levy, T. A. Treves, A. D. Korczyn

“…Nine patients with primary degenerative dementia (PDD) participated in an open trial of transdermal physostigmine (TPh). …”
Get full text

Inspired by struggle: A personal journey to global precision brain health by Agustin Ibanez

“…He advocates for integrating diversity in neurodegeneration studies, crucial for understanding conditions like dementia. He founded ReDLat and BrainLat, advancing research across Latin America and empowering underrepresented voices. …”
Get full text

Frontostriatal Cognitive Staging in Parkinson's Disease by Raúl de la Fuente-Fernández

“…Executive dysfunction and mental fatigue (stage I), depression/anxiety (stage IIa), apathy/pain (stage IIb), and dementia (stage III) reflect a sequential process of dopamine depletion occurring in different regions of the striatum (stages I and II) and the frontal cortex (stage III). …”
Get full text

Age-Related White Matter Changes by Yun Yun Xiong, Vincent Mok

“…Most recent studies have shown that WMC are associated with a host of poor outcomes, including cognitive impairment, dementia, urinary incontinence, gait disturbances, depression, and increased risk of stroke and death. …”
Get full text

Complete Renal Artery Embolization in a Comorbid Patient with an Arteriovenous Malformation by Anthony Thayaparan, Tarik Amer, Eamon Mahdi, Omar Aboumarzouk, Owen Hughes

“…We present a case of an elderly female who underwent a complete left renal artery embolization, following a difficult presentation complicated by advanced dementia and multiple comorbidities. This is the first documented case of complete renal artery embolisation used to treat a renal AVM.…”
Get full text

A Middle-Aged Woman with Logopenic Progressive Aphasia as a Precursor of Alzheimer's Disease: Case Report and Review of the Literature by Stephanie M. Awad, Amer M. Awad

“…The logopenic variant is the least common one and is closely related to Alzheimer's disease in comparison to the other two variants that are closely related to frontotemporal dementia. We report the case of a middle-aged woman who presented to our center with progressive aphasia that was undiagnosed for two years. …”
Get full text

Correlation analysis between mild cognitive impairment and the traditional Chinese medicine body constitution types among the elderly in a community in Changning District, Shanghai by XU Lei, ZHANG Min, WANG Wenwen, YU Li, ZHU Xuting, LYU Xiaorui

“…The cognitive function was assessed by using the Clock Drawing Test combined with the Ascertain Dementia 8-item Questionnaire (AD8), the Montreal Cognitive Assessment (MoCA) and the Mini-mental State Examination (MMSE). …”
Get full text

Transcranial Doppler sonography follow-up study in mild vascular cognitive impairment. by Mariagiovanna Cantone, Manuela Pennisi, Giuseppe Lanza, Raffaele Ferri, Francesco Fisicaro, Francesco Cappellani, Emanuele David, Vito Nicosia, Klizia Cortese, Giovanni Pennisi, Valentina Puglisi, Rita Bella

“…<h4>Background</h4>To date, few data to transcranial Doppler sonography (TCD) are available in patients with mild vascular cognitive impairment (VCI) at risk for vascular or mixed dementia. In a previous study in patients with mild VCI and cerebral small vessels disease, a hemodynamic pattern of cerebral hypoperfusion and enhanced vascular resistance were observed; however, longitudinal data are currently lacking. …”
Get full text