Nineteen years retrospective analysis of epidemiology, antifungal resistance and a nomogram model for 30-day mortality in nosocomial candidemia patients by Zhang Dai, Xuhong Lan, Minjing Cai, Yunhui Liao, Jingwen Zhang, Naifang Ye, Xinxin Lu, Jiajia Wang, Yun Xiao, Yan Zhang, Yihui Yao, Xianming Liang

“…The mortality rate of 30-day discharge for candidemia reached 52.99%. 205 cases of candidemia patients from January 2006 to December 2023 were included as the training set, while 29 cases of candidiasis patients from January to October 2004 were included as the validation set. …”
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Protocol for the enhanced management of multimorbid patients with COPD and severe asthma: role of indoor air quality by Emili Vela, Isaac Cano, Josep Roca, Antoni Sisó-Almirall, Carme Hernandez, Ebymar Arismendi, Ramon Farré, Alba Gómez-López, María Figols, Antonio Montilla-Ibarra, Núria Sánchez-Ruano, Benigno Sánchez, Marta Sorribes, Jordi Piera-Jiménez, Jaume Benavent, Jose Fermoso, Rubèn González-Colom

“…The inconclusive results of preventive strategies in patients with chronic obstructive respiratory disorders and comorbidities are explainable by multifactorial but actionable factors.The current protocol (January 2024–December 2025) relies on the hypothesis that intertwined actions in four dimensions: (1) management change, (2) personalisation of the interventions based on early detection/treatment of acute episodes and enhanced management of comorbidities, (3) mature digital support and (4) comprehensive assessment, can effectively overcome most of the limitations shown by previous preventive strategies. …”
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Can smoking duration alone replace pack-years to predict the risk of smoking-related oncogenic mutations in non-small cell lung cancer? A cross-sectional study in Japan by Masahiko Ando, Yoshihiko Taniguchi, Akihiro Tamiya, Akihide Matsumura, Koichi Ogawa, Yasuhiro Koh, Hiroyasu Kaneda, Motohiro Izumi, Yoshiya Matsumoto, Kenji Sawa, Mitsuru Fukui, Naoki Yoshimoto, Akihito Kubo, Shun-ichi Isa, Hideo Saka, Tomoya Kawaguchi

“…Objective To investigate whether smoking duration alone can replace pack-years to predict the risk of oncogenic mutations in non-small cell lung cancer (NSCLC).Design A cross-sectional study using the baseline dataset from the Japan Molecular Epidemiology for Lung Cancer Study.Setting Forty-three medical institutions nationwide in Japan.Participants From July 2012 to December 2013, 957 patients with newly diagnosed stage I–IIIB NSCLC who underwent surgery were enrolled, and molecular analyses were performed on 876 samples (from 441 ever-smokers and 435 never-smokers).Main outcomes measured We calculated the area under the receiver operating characteristic curve (AUC) values using logistic regression to compare between the predictive values of smoking duration and pack-years for mutational frequencies in the v-Ki-ras2 Kirsten rat sarcoma (KRAS), tumour suppressor p53 (TP53), and epidermal growth factor receptor (EGFR) genes and for cytosine-to-adenine base substitution (C>A).Results For predicting KRAS mutations, the AUC values for smoking duration and pack-years were 0.746 (95% CI 0.682 to 0.800) and 0.759 (95% CI 0.700 to 0.810), respectively (p=0.058). …”
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Leiden mutation (rs6025) in a severe COVID-19 pneumonia patient with Down syndrome: a clinical case by V.I. Pokhylko, Y.I. Cherniavska, L.Y. Fishchuk, Z.I. Rossokha, O.G. Ievseienkova, O.M. Dubitska, O.F. Popova, M.М. Fastovets, O.О. Kaliuzhka, N.G. Gorovenko

“…COVID-19 was first reported in December 2019 in Wuhan (Hubei Province, China). Later, the pandemic of this disease took the world by storm, challenging the medical community. …”
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Clinical novel exploration of intractable fever in stroke rehabilitation: a single-center cross-sectional retrospective study by Huang Jingjie, Wu Bangqi, Qin Peng, Zhang Ziyi, Cheng Yupei, Wang Chaoran, Chen Yuyan, Bai Jing

“…This study evaluated 1,065 stroke patients in the rehabilitation phase who were admitted to the Neurorehabilitation Center between January 1, 2023, and December 31, 2023. Of these, 230 febrile patients met the inclusion criteria and were included in the analysis, comprising 194 cases of acute fever and 36 cases of intractable fever. …”
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Application of modified nursing shift schedule based on SBAR communication model in perioperative management of patients with early gastric cancer (基于SBAR模式改良护理交班表在早期胃癌患者围手术期管理中的应用... by DANG Limei (党李梅), GUAN Chengguo (管成果), ZAI Xiaojuan (宰小娟)

“…Methods Totally 100 patients who received endoscopic submucosal dissection (ESD) for early gastric cancer between January and May 2021 were included as the control group, another 100 patients who received ESD for early gastric cancer between August and December 2021 were included as the observation group. …”
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Hubungan antara Higiene Perorangan dengan Infeksi Cacing Usus (Soil Transmitted Helminths) pada Siswa SDN 25 dan 28 Kelurahan Purus, Kota Padang, Sumatera Barat Tahun 2013 by Rizka Yunidha Anwar, Nuzulia Irawati, Machdawaty Masri

“…This study used an observational analytic design method of cross -sectional study on 122 students in grade 1 to grade 6 in 25 and 28 primary school Purus, Padang in December 2013. Bivariat analysis was done using chi–square test with the confidence interval  95% at the significance level 5% (α=0.05). …”
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Standardization and validation of a novel reverse transcriptase polymerase chain reaction method for detecting virulent strains of the infectious bursal disease virus by Vladimir Longa-Bobadilla, Phillip Ormeño-Vásquez, Manuel Criollo-Orozco, Luis Tataje-Lavanda, Katherine Huamán-Gutierrez, Ángela Montalván, Mirko Zimic, Manolo Fernández-Sanchez, Manolo Fernández-Díaz

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Local Recurrence of Rectal Cancer After Transanal Total Mesorectal Excision and Risk Factors: A Nationwide Multicenter Cohort Study in Japan by Takeru Matsuda, MD, PhD, Ichiro Takemasa, MD, PhD, Hideki Endo, MD, MPH, Shinichiro Mori, MD, PhD, Suguru Hasegawa, MD, PhD, Koya Hida, MD, PhD, Takuya Tokunaga, MD, PhD, Keitaro Tanaka, MD, PhD, Toshiki Mukai, MD, PhD, Jun Watanabe, MD, PhD, Junichiro Kawamura, MD, PhD, Kei Kimura, MD, PhD, Yoshihiro Kakeji, MD, PhD, Masahiko Watanabe, MD, PhD, Seiichiro Yamamoto, MD, PhD, Takeshi Naitoh, MD, PhD, Ta-Ta-Mi study group collaboratives in Japan Society of Laparoscopic Colorectal Surgery

“…A total of 706 patients with primary rectal cancer who underwent TaTME between January 2012 and December 2019 were included for analysis. The primary endpoint was the cumulative 3-year LR rate. …”
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Prevalence of Respiratory Syncytial Virus Infection in Hospitalized COPD Patients in Spain Between 2018–2022 by Rosa María Gómez-García, Javier De-Miguel-Díez, Ana López-de-Andrés, Valentín Hernández-Barrera, Ana Jimenez-Sierra, Natividad Cuadrado-Corrales, José J. Zamorano-León, David Carabantes-Alarcón, Andrés Bodas-Pinedo, Rodrigo Jiménez-García

“…We selected subjects aged ≥40 years diagnosed with COPD, admitted to the hospital from 1 January 2018 to 31 December 2022. The COPD population that met the selection criteria was subdivided based on the presence of an ICD-10 code for RSV infection. …”
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Evaluating the surgical and oncological outcomes of hepatic artery variations in minimally invasive pancreaticoduodenectomy: insights from 2023 data at a high-volume pancreatic cen... by Tianyu Li, Liangbo Dong, Dongming Zhang, Jiashu Han, Menghua Dai, Junchao Guo, Qiang Xu, Weibin Wang, Xianlin Han, Chen Lin

“…Methods We enrolled 267 consecutive patients who underwent MIPD at Peking Union Medical College Hospital between January and December 2023. HAV was identified preoperatively through enhanced abdominal CT and three-dimensional reconstruction, and classified according to the Michels and Hiatt systems. …”
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Impact of co-infections and immune responses on clinical severity of human adenovirus 3 and 7 infections in hospitalized children with lower respiratory tract infections: a compara... by Xiaolin Ma, Yuting Wu, Ri De, Hailan Yao, Feng He, Yi Wang, Wei Wang, Chao Yan, Qinwei Song, Chunjie Guo, Li Wen, Linqing Zhao, Ling Cao, Chunmei Zhu

“…BackgroundThe pathogenic distribution of co-infections and immunological status of patients infected with human adenovirus serotypes 3 or 7 (HAdV-3 or HAdV-7) were poorly understood.MethodsThis study involved a retrospective analysis of respiratory specimens collected from enrolled children with lower respiratory tract infections (LRTIs), positive for HAdV-3 or HAdV-7 from January 2017 to December 2019. Demographic data, clinical features, laboratory and radiographic findings were compared to delineate the impact of co-infections, and immune responses on clinical severity of HAdV-3 or HAdV-7 infections.ResultsAmong 1311cases enrolled, there were 66 infected with HAdV-3 and 58 with HAdV-7. …”
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Microplastic contamination in the gut and gills of commercial marine fish by . Nurhasanah, . Hasrianti, L. Hakim, E. Riani, M.Y. Iswari, M.R. Cordova

“…This study sought to assess the extent of microplastic pollutants in commercially caught marine fish from Jakarta Bay, a densely populated and industrialized coastal area accommodating more than 35 million inhabitants.METHODS: The study was conducted at five nearby fresh seafood markets in the northern part of Jakarta, where marine fish specimens were collected between December 2023 and January 2024. In total, 160 samples were gathered, with 20 individuals representing each of the eight diverse marine fish species. …”
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Intracranial aneurysm instability prediction model based on 4D-Flow MRI and HR-MRI by Fei Peng, Jiaxiang Xia, Fandong Zhang, Shiyu Lu, Hao Wang, Jiashu Li, Xinmin Liu, Yao Zhong, Jiahuan Guo, Yonghong Duan, Binbin Sui, Chuyang Ye, Yi Ju, Shuai Kang, Yizhou Yu, Xin Feng, Xingquan Zhao, Rui Li, Aihua Liu

“…Finally, the Hybrid Model was further validated in the validation cohort (patients enrolled between December 2021 to May 2022). In the primary cohort, 189 patients (144 women [76.2 ​%]; aged 58.90 years ​± ​10.32) with 213 IAs were included. …”
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Catheter‐Related Bloodstream Infections Among Hemodialysis Patients in Northern Tanzania: Insights From a Single‐Centre Retrospective Study by Andrea R. Costantine, Sarah J. Urasa, Abid M. Sadiq, Elichilia R. Shao, Furaha S. Lyamuya, Elieishiupendo M. Niccodem, Eugénie M. Kamabu, Venance P. Maro, Elifuraha W. Mkwizu, Nyasatu G. Chamba, Francis F. Furia, Tumaini E. Mirai, Eliada B. Nziku, Doreen T. Eliah, Ibrahim Ali Ibrahim Muhina, Faryal M. Raza, Modesta P. Mitao, Kajiru G. Kilonzo

“…Methods A hospital‐based retrospective analytical cross‐sectional study involved adult patients with CKD or AKI undergoing hemodialysis at KCMC with tunneled or non‐tunneled central venous catheters who attended from January 1, 2021 to December 31, 2022. Data were collected from the hospital's electronic medical record system. …”
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Myocardial Infarction-Associated Shock: A Comprehensive Analysis of Phenotypes, SCAI Classification, and Outcome Assessment by Stanislav Dil, Maria Kercheva, Oleg Panteleev, Sergey Demianov, Aleksandr Kanev, Nina Belich, Boris Kornienko, Vyacheslav Ryabov

“…<i>Materials and Methods</i>: In this single-center, retrospective observational study, we reviewed the medical records of 1289 patients admitted to the emergency cardiology department from 1 January to 12 December 2020. Among them, 117 patients were identified as having MI-CS and were divided into two groups: MS (<i>n</i> = 48) and isolated CS (<i>n</i> = 69). …”
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Study Protocol of the Korean EGFR Registry: A Multicenter Prospective and Retrospective Cohort Study in Nonsmall Cell Lung Cancer Patients With EGFR Mutation by Chang Dong Yeo, Dong Won Park, Seong Hoon Yoon, Eun Young Kim, Jeong Eun Lee, Shin Yup Lee, Chang‐Min Choi, In‐Jae Oh, Do Jin Kim, Jeong Seon Ryu, Jae Cheol Lee, Young‐Chul Kim, Tae Won Jang, Kye Young Lee, Seung Hun Jang, Seung Joon Kim, for the Korean EGFR Registry Investigators

“…Data collection will include patient demographics, smoking history, quality of life assessments, pathological data, and treatment outcomes, with follow‐up until December 2026. The primary endpoint is disease‐free survival in patients who have undergone radical therapy (surgery and radiotherapy) or progression‐free survival in those receiving targeted therapy (first, second, and subsequent lines), chemotherapy (first and subsequent lines), combination therapy, and palliative/maintenance therapy according to stages of EGFR‐mutated NSCLC. …”
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Hormonal Contraception and Bone Metabolism: Emerging Evidence from a Systematic Review and Meta-Analysis of Studies on Post-Pubertal and Reproductive-Age Women by Alice Tassi, Ambrogio P Londero, Anjeza Xholli, Giulia Lanzolla, Serena Bertozzi, Luca Savelli, Federico Prefumo, Angelo Cagnacci

“…The analysis encompassed accessible papers ranging to December 2024 (i.e., those listed in PubMed/Medline, Embase, Scopus, the Cochrane Database, International Clinical Trials Registry, and ClinicalTrials.gov). …”
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Safety and efficacy of selective RIPK1 inhibitor SIR1-365 in hospitalized patients with severe COVID-19: A multicenter, randomized, double-blind, phase 1b trial by Norberto Chavez-Tapia, Muneeba Ahsan Sayeed, Shobha Luxmi, Douglas J. Kasper, Fenchao Xue, Yang Shen, Weiliang Fan, Wei Yuan, Bin Du

“…Methods: This multicenter, randomized, double-blind, phase 1b study screened patients from December 18, 2020 until November 27, 2021. Adults hospitalized with severe COVID-19 (diagnosed ≤2 weeks before screening) were randomized 1:1 to receive oral placebo or SIR1-365 100 mg three times daily for ≤14 consecutive days, with standard-of-care. …”
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Analysis of the relevant factors for corneal graft rejection in the southern Liaoning region from 2019 to 2023 by Chunxiao Yan, Chunxiao Yan, Zhijian Zhang, Zhijian Zhang, Lin Jin, Mengxin Liu, Tianyi Wang, Tianyi Wang, Jinghao Yang, Jinghao Yang, Lijun Zhang, Lijun Zhang, Lijun Zhang

“…BackgroundThe study aimed to review the etiology of corneal blindness and investigate the relative risk of corneal graft rejection (CGR) in the southern Liaoning region.MethodsThe clinical records of 359 patients (394 eyes) who underwent corneal transplantation at the Department of Keratoconus of the Third People’s Hospital of Dalian from January 2019 to December 2023 were retrospectively analyzed. The data included patients’ age, gender, occupation, diagnosis, surgical procedure, postoperative immune rejection, and neovascularization. …”
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