Real‐world efficacy of transfusion with liberal or restrictive strategy in traumatic brain injury by Liang‐Wen Cui, Nian Liu, Chao Yu, Ming Fang, Rui Huang, Cheng Zhang, Min Shao

“…Compared with the restrictive group, the liberal strategy reduced early death (3 days: 5%, 95% CI: 2%–7%; 7 days: 6%, 95% CI: 3%–11%); however, no significant difference of mortality risk at 28‐day or neurological progression risk at any time points was observed. …”
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Prenatal bisphenol A and/or diethylhexyl phthalate exposure followed by adult estradiol treatment affects behavior and brain monoamines in female rat offspring by Amrita Kaimal, Jessica M. Hooversmith, Maryam H. Al Mansi, Ariana D. Cherry, Jillian T. Garrity, Philip V. Holmes, Puliyur S. MohanKumar, Puliyur S. MohanKumar, Sheba M. J. MohanKumar, Sheba M. J. MohanKumar

“…This study examines the cumulative effects of prenatal EDC exposure combined with chronic low-dose 17β-estradiol (E2) treatment in adulthood on neurobehavioral outcomes.MethodsPregnant Sprague-Dawley rats were orally dosed with vehicle, bisphenol A (BPA) (5 μg/kg body weight (BW)/day), low-dose (LD) diethylhexyl phthalate (DEHP) (5 μg/kg BW/day), high-dose (HD) DEHP (7.5 mg/kg BW/day), or a combination of the two (BPA+DEHP) from gestational days 6-21. At 3 months of age, female offspring were implanted with slow-release E2 pellets or were sham-implanted. …”
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Improving the accUracy of Referrals to the emerGency departmEnt of patieNts with chesT pain using the modified HEART score in Emergency Medical Transport (URGENT 2.0): protocol for... by Joan G Meeder, Frits H M Van Osch, Robert T A Willemsen, Braim M Rahel, Lisa D S Frenk, Cees B de Vos, Fabiana G Prestigiacomo, Marcel J W Janssen, Arnoud W van 't Hof

“…Follow-up will be performed at 30 days, 6 months and 12 months. Both referral rates of NCCP patients and the occurrence of major adverse cardiac events are defined as primary outcome measures.Ethics and dissemination The medical ethics committee Zuyderland-Zuyd Hogeschool (Netherlands) has approved this trial (reference numbers NL71820.096.19 and METCZ20190139). …”
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Conservative Treatment in Uncomplicated Appendicitis in Pediatrics at Tertiary Center Hospital by Essam Alaa Al-Din Abd Al-Aziz, Mohamed Abd – Al Shafy, Ahmed Abd Almonem Elrashidy, Nezar Abdelraouf Abo Halawa

“…Outcomes: 90% symptom resolution, median 4-day hospital stay (range: 2-7 days), 6.67% recurrence, 6.67% appendectomy. Post-intervention, significant improvement in signs/symptoms, ultrasonography, CRP; WBC count improved variably. …”
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Factors associated with delays in seeking tuberculosis treatment among patients at Muhima district hospital, Rwanda by Mercy Nwankwo, Chinenye, Yasmin Omar, Umubyeyi

“…Results: About 49% (24) of the smear- positive TB patients experienced delayed in seeking treatment for more than 180 days (6 months). Also 53% (26) were within the 36-45 age-cohort, while majority 75.5% (37) of the respondents was male. …”
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The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars by Masayo Aoki, Akatsuki Kondo, Noriko Matsunaga, Azusa Honda, Yuri Okubo, Kazuaki Takabe, Rei Ogawa

“…Mechanical force-induced HSs were generated in C57BL6/J mice by suturing a dorsal incision and applying a stretching device on Days 6, 8, 10, and 12. On Days 8, 10, and 12, intracutaneous FTY720 (10 μM) or control vehicle injections were performed. …”
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Safety and efficacy of chocolate balloon in the treatment of infrapopliteal artery disease by Ridong Wu, Qingqi Yang, Mian Wang, Zilun Li, Chen Yao, Guangqi Chang

“…Patients were followed at 30 days, 6 months, and 12 months to assess symptom improvement, vascular patency as determined by dual-function ultrasound or angiography, and survival. …”
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Comparative evaluation of the effect of blue M active oxygen gel and Coe-Pack dressing on postoperative surgical depigmentation healing: A clinical study by Tusharika Sharma, Neeraj Deshpande, Monali Shah, Rashmi Jha

“…A 1-week, 2 weeks, 3 weeks, and 4 weeks long follow-up period was observed, and indices, including the Dummet–Gupta Oral Pigmentation Index and re-epithelization index using toluidine blue dye, were evaluated and the Visual Analog Scale Pain index was also evaluated at 2 h, 24 h, 2 days, 3 days, 4 days, 5 days, 6 days, and 7 days follow-up period. Results: In total, 34 surgical sites were covered in this investigation. …”
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Profiling gene alterations in striatonigral neurons associated with incubation of methamphetamine craving by cholera toxin subunit B-based fluorescence-activated cell sorting by Rachel D. Altshuler, Megan A. M. Burke, Kristine T. Garcia, Kenneth Class, Raffaello Cimbro, Xuan Li, Xuan Li

“…Here we combined a newly developed fluorescence-activated sorting (FACS) protocol with fluorescence-conjugated cholera toxin subunit B-647 (CTb-647, a retrograde tracer) to examine gene alterations in the direct-pathway (striatonigral) medium spiny neurons (MSNs) associated with incubation of Meth craving.MethodsWe injected CTb-647 bilaterally into substantia nigra before or after training rats to self-administer Meth or saline (control condition) for 10 days (6 h/d). On abstinence day 1 or day 28, we collected the DS tissue from both groups for subsequent FACS and examined gene expressions in CTb-positive (striatonigral MSNs) and CTb-negative (primarily non-striatonigral MSNs). …”
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Growth Arrest Specific Gene 6 Protein Concentration in Cerebrospinal Fluid Correlates with Relapse Severity in Multiple Sclerosis by P. P. Sainaghi, L. Collimedaglia, F. Alciato, R. Molinari, D. Sola, E. Ranza, P. Naldi, F. Monaco, M. Leone, M. Pirisi, G. C. Avanzi

“…Higher CSF Gas6 concentrations were observed in relapses lasting ≤60 days (8.7 ± 3.9 ng/mL) versus >60 days (6.5 ± 2.6) or controls (6.5 ± 2.4; P=0.05), with ≤2 FS involved (8.5 ± 3.8) versus >2 FS (5.6 ± 2.5) (P<0.05) and EDSS change ≤2.5 points (8.8 ± 3.7) versus >2.5 (6.5 ± 3.5) (P=0.04). …”
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“Unmasking the Uncommon”: A case series of multi-drug resistant Elizabethkingia meningoseptica causing late-onset sepsis and meningitis in preterm neonates [version 2; peer review:... by Anisha Maria Fernandes, Sinchana Bhat, Suchitra Shenoy M., Prajnha U.P.

“…Follow-up cultures on days 6 and 14 grew Acinetobacter baumannii. A combination of Levofloxacin and Colistin was added, and blood cultures were negative after seven days, with clinical improvement. …”
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Impact of Late Ventricular Arrhythmias on Cardiac Mortality in Patients with Acute Myocardial Infarction by Takuma Takada, Koki Shishido, Takahiro Hayashi, Shohei Yokota, Hirokazu Miyashita, Hiroaki Yokoyama, Takashi Nishimoto, Tomoki Ochiai, Noriaki Moriyama, Kazuki Tobita, Shingo Mizuno, Futoshi Yamanaka, Masato Murakami, Yutaka Tanaka, Saeko Takahashi, Shigeru Saito

“…The frequency of VT/VF occurrence was high between the day of admission and the 2nd day and between days 6 and 10 of hospitalization. The late VT/VF group had a significantly longer onset-to-balloon time, lower ejection fraction, poorer renal function, and higher creatine phosphokinase (CK)-MB level on admission (p< 0.001). …”
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Evaluating the Impacts of Procedural and Patient-Specific Factors on the Outcomes of Transcatheter Aortic Valve Implantation (TAVI) by Abilkhair Kurmanaliyev, Rima Braukylienė, Ali Aldujeli, Rassul Zhumagaliyev, Serik Aitaliyev, Ramunas Unikas

“…Survival and adverse events were assessed at 30 days, 6 months, and 12 months post-TAVI. <i>Results:</i> The study included 224 patients. …”
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Post-COVID-19 manifestations among college students: shedding the light on young adults’ health by Areej Abed Alkhormani, Reema Abdullah Alghamdi, Yara Abdulaziz Damdam, Maria Eissa Almaghrabi, Faisal F. Alamri, Muhammad Anwar Khan, Alqassem Y. Hakami

“…Results According to the inclusion criteria, 428 participants were divided into three groups: those who fully recovered within 14 days of the acute phase (76.4%), those with prolonged symptoms that resolved within 28 days (16.8%), and those with persistent symptoms for more than 28 days (6.8%). The symptom development frequency during the acute phase significantly differed among the three groups: headache (p = 0.038), loss of smell and taste (p = < 0.001), and fatigue (p = 0.009). …”
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The walnut tree as a source of progesterone for reproductive control in goats by P. Chemineau, A.L. Lainé, D. Gennetay, C. Porte, D. Chesneau, C. Laclie, G. Goudet, M. Meunier, M. Delmas, M.L. Greil, P. Liere, A. Pianos, A. Bernard, E. Dirlewanger, J.A. Delgadillo, M. Keller

“…The distribution of 600 g of pellets per day per ovary-intact goat over 3 days, 6 and 4 days before the introduction of males in April allowed us to achieve our objective of a significant increase of P4 plasma concentration to ∼1.5 ng/mL measured by EIA from 24 to 72 h after the first distribution in the walnut pellet group (n = 13). …”
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Epidemiology, Disease Severity and Outcome of Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza Viruses Coinfection Seen at Egypt Integrated Acute Respiratory Infection... by Manal Fahim, Wael H. Roshdy, Ola Deghedy, Reham Kamel, Amel Naguib, Shymaa Showky, Nancy Elguindy, Mohammad Abdel Fattah, Salma Afifi, Amira Mohsen, Amr Kandeel, Khaled Abdelghaffar

“…Patients’ mean age was 33.2 ± 21, 55.8% were males, and 20 (38.5%) were hospitalized, with mean hospital days 6.7 ± 6. At the hospital, 14 (70.0%) developed pneumonia, 6 (30.0%) ICU admitted, and 4 (20.0%) died. …”
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Integrated transcriptomic hypothalamic-pituitary-ovarian axis network analysis reveals the role of energy availability on egg production in layers by Jianling Peng, Yong Cui, Haiping Liang, Shenyijun Xu, Linjian Weng, Meng Ru, Ramlat Ali, Qing Wei, Jiming Ruan, Jianzhen Huang

“…To investigate the mechanism of integrated network regulation of the HPO axis under energy fluctuation, ninety Hy-line brown layers (265-day-old, 1.92 ± 0.02 kg) were randomly divided into three groups for a 17-day experiment: a control group (Con group) fed ad libitum from days 1 to 17, an energy-deprived group (ED group) that was fed ad libitum from days 1 to 12 and then underwent a fasting period from days 13 to 17 to induce a pause in laying, and a re-fed group (Rf group) that fasted for seven days (specifically, days 1 to 5, day 7, and day 9), had ad libitum access to feed on days 6 and 8, and was continuously fed from days 10 to 17. …”
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Ten days of supplementation with a standardized Boswellia serrata extract attenuates soreness and accelerates recovery after repeated bouts of downhill running in recreationally ac... by Dawna Salter, Himana Yalamanchi, Aiswarya Yalamanchi, Amulya Yalamanchi

“…In total, 50 men (mean age 28 ± 4) were randomly allocated to consume 60 mg SBS or PLA once per day for 10 days (6 days before, the day of, and 3 days after DHR). …”
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Clinicodemographic profile and predictors of poor outcome in hospitalised COVID-19 patients: a single-centre, retrospective cohort study from India by Prashant K Singh, Lokesh Tiwari, Alok Ranjan, Prakriti Gupta, Prabhat Kumar Singh, Yogesh Kumar, Yankappa N, Amrita Banerjee, C M Singh

“…Progression in disease severity on days 3–5 of admission or days 6–13 of illness onset acts as ‘turning point’ for timely referral or treatment intensification for optimum use of resources.…”
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The effects of altitude training on hormonal response in professional cyclists by Raphael Faiss, Bastien Krumm, Basile Moreillon, Lena Mettraux, Julian Wackernell, James Spragg, Martin Faulhaber

“…During the 21 days at altitude, a significant increase was observed for testosterone (from 5.2 ± 2.6 to 8.3 ± 2.7 ng/mL, p<0.001)), and it was still elevated 48 h after returning to low altitude (6.8 ± 2.3 ng/mL) but decreased towards baseline after 10 days (6.59 ± 2.6, p= 0.01). IGF-1 was elevated 48 h after the altitude camp when compared to the initial baseline (273.5 ± 65.1 vs. 235.9 ± 51.6 µg/L, p=0.003). …”
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