Reproductive and genotoxic effects of dinotefuran in male Sprague Dawley rats by A. G. Abdelkader, W. H. Mohamed, M. Abou-Ellail, K. A. Amein

“…The objective of the current study was the evaluation of the genotoxic and reproductive effects of dinotefuran (DIN) insecticide in male Sprague Dawley rats. To achieve these objectives, forty male 10–12 weeks old Sprague Dawley rats were randomly divided into four equal groups; the first group was used as a control group; the other three groups were exposed to 40, 61, and 122 mg/kg body weight DIN by oral gavage for 8 weeks. …”

Probiotic Amelioration of Azotemia in 5/6th Nephrectomized Sprague-Dawley Rats by Natarajan Ranganathan, Beena Patel, Pari Ranganathan, Joseph Marczely, Rahul Dheer, Tushar Chordia, Stephen R. Dunn, Eli A. Friedman

“…Herein we describe a prospective, blinded, placebo-controlled pilot study, using 5/6th nephrectomized Sprague Dawley rat as a chronic renal failure model. The study group consisted of 36 nephrectomized and 7 non-nephrectomized (control) rats. …”
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Effect of chronic restraint stress on body weight of male Sprague Dawley rats by Sadia Moazzam, Irfan Afzal Mughal, Noor Ul Ain Irfan, Ilqa Attique, Fareeha Zaheer, Asma Irfan

“…Study design:  Experimental     Materials and Methods:  The study was conducted in  National  Institute  of  Health  (NIH),  Islamabad Sixty male Sprague Dawley rats (mean wt 250 ± 50 grams) were used and divided into 2 groups.   …”
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Anticancer Activity of Rhizophora mucronata Leaves Extract on Sprague–Dawley Rats: In Vivo Model by Asbin Mary X, Syed Ali Mohamed Yacoob, Anuradha Venkatraman, Ruban Packiasamy, Meivelu Moovendhan, Murugesan Gnanadesigan, Yogananth Nagarajan

“…In accordance with OECD guiding principles, the study was approved to evaluate the toxicity, including acute and subacute effects and anticancer activities of methanolic extract of Rhizophora mucronata leaves on Sprague–Dawley rats. In acute toxicity trials, the dose of 1000 mg/kg body weight was determined to be safe and nontoxic even at high dose levels and did not result in any indicators of toxicity or death in the tested groups compared to controls for 14 days. …”
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Status Epilepticus due to Intraperitoneal Injection of Vehicle Containing Propylene Glycol in Sprague Dawley Rats by Evon S. Ereifej, Seth M. Meade, Cara S. Smith, Keying Chen, Nanette Kleinman, Jeffrey R. Capadona

“…We report here a case of unexpected seizures in Sprague Dawley rats after receiving an intraperitoneal injection containing propylene glycol. …”
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Ameliorating Effects of Arsenic-Induced Toxicity On The Histology Of Vagina And Reproductive Hormones Of Female Sprague Dawley Rats by Amaidah Mir, Urfa Zaryab Mir, Maria Yasmeen, Mushtaq Ahmad, Kanwal Huma, Iram Kehkashan Khurshid

“… Objective: To find out the toxic effects of arsenic on the histology of the vagina and reproductive hormones of female Sprague Dawley rats. Methods: 60 female Sprague Dawley rats were divided into control group A and experimental group B with 30 rats in each group. …”
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Validating the Hypoglycaemic and Hypotensive Roles of Salvia serotina (Chicken Weed) in Normal Healthy Sprague–Dawley Rats by Tameika Bartley, Paul Reese, Sophie Turfus, Ruby Alexander-Lindo

“…Aqueous, hexane, ethyl acetate, and methanol crude extracts of S. serotina L. were investigated for their anti-oxidant activities and hypoglycaemic and hypotensive effects in normal, healthy Sprague–Dawley rats using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, oral glucose tolerance test (OGTT), and the CODA noninvasive blood pressure system to determine systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and heart rate (HR). …”
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Subacute toxicity of isoliquiritigenin-zein phosphatidylcholine nanoparticles on biochemical, hematological, and histopathological parameters in Sprague-Dawley rats by Ke Yang, Kumar Ganesan, Fei Gao, Chunguang Xie, Jianping Chen

“…The present study aimed to evaluate the acute and subacute toxicity of ISL@ZLH NPs in Sprague-Dawley (SD) rats. Methods: The ISL@ZLH NPs were prepared by the solvent evaporation method. …”
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Pengaruh Pemberian Kefir Madu terhadap Profil Lipid Tikus Galur Sprague Dawley Sindroma Metabolik by Ibnu Malkan Bakhrul Ilmi, Angga Hardiansyah, Nikmatul Luailiya, Putri Aria Avrilian, Avliya Quratul Marjan, Dina Sugiyanti, Nur Hayati

“…Metode: Penelitian ini menggunakan desain true experimental dengan pre-post test with control group design terhadap 42 ekor tikus Sprague Dawley jantan yang dikelompokkan menjadi 6 kelompok secara acak yaitu Kontrol Sehat (KS), Kontrol Negatif (KN), Kelompok Positif Quercertin (K1), Kelompok Metformin (K2), Kelompok Kefir (P1), dan Kelompok Preventif (P2). …”
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Acute and Subchronic Toxicity Assessment of Conventional Soxhlet Cymbopogon citratus Leaves Extracts in Sprague–Dawley Rats by Jacob Apibilla Ayembilla, Abdul Raouf Khalid, Sharif Buari Abubakari, Abdul Rashid Adams, Felix Abekah Botchway, Stephen Antwi, Phyllis Naa Yarley Otu, Michael Appiah, George Osei-Adjei, Kwame Owen Kottoh, Peace Ahiabenu-Williams, Olga Quasie

“…The acute and subchronic toxicities of the conventional Soxhlet ethanolic Cymbopogon citratus leaves extract in Sprague–Dawley rats were investigated. Methods. Pulverized Cymbopogon citratus leaves were extracted with 98% ethanol using the conventional Soxhlet extraction (CSE) method and dried. …”
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Seventy-Day Toxicity Study in Juvenile Sprague-Dawley Rats with Semicarbazide (SEM) from Weaning to Sexual Maturity by Vijaykumar Malashetty, Raghunandan Deshpande, Somnathreddy Patil

“…The study was conducted to evaluate the toxicological effects, functional observation battery tests, and sexual maturity of semicarbazide oral gavage administration to juvenile Sprague-Dawley rats for 70 days at 0, 15, 30, and 60 mg/kg/day weaning to sexual maturity. …”
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Acute and Subchronic Toxicity Study of Flavonoid Rich Extract of Glycyrrhiza glabra (GutGard®) in Sprague Dawley Rats by Ranjit M. Bhide, Bharathi Bethapudi, Nehru Sai Suresh Chalichem, Muruganantham Nithyanantham, Sasi Kumar Murugan, Deepak Mundkinajeddu

“…The study was designed to evaluate the acute and subchronic oral toxicity of GutGard in Sprague Dawley rats according to the procedures and methods of Organisation for Economic Cooperation and Development (OECD) test guidelines for acute and subchronic toxicity. …”
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Protective Effects of Tamarillo (Cyphomandra betacea) Extract against High Fat Diet Induced Obesity in Sprague-Dawley Rats by Noor Atiqah Aizan Abdul Kadir, Asmah Rahmat, Hawa Z. E. Jaafar

“…This study aims to investigate the protective effect of Cyphomandra betacea in adult male Sprague-Dawley rats fed with high fat diet. Rats were fed on either normal chow or high fat diet for 10 weeks for obesity induction phase and subsequently received C. betacea extract at low dose (150 mg kg−1), medium dose (200 mg kg−1), or high dose (300 mg kg−1) or placebo via oral gavages for another 7 weeks for treatment phase. …”
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Feasibility and Safety of Continuous and Chronic Bilateral Deep Brain Stimulation of the Medial Forebrain Bundle in the Naïve Sprague-Dawley Rat by Luciano L. Furlanetti, Máté D. Döbrössy, Iñigo A. Aranda, Volker A. Coenen

“…Early intracranial self-stimulation experiments of the MFB suggested detrimental side effects on the animals’ health; therefore, the current study looked at the viability of chronic and continuous MFB-DBS in rodents, with particular attention given to welfare issues and identification of stimulated pathways. Methods. Sprague-Dawley female rats were submitted to stereotactic microelectrode implantation into the MFB. …”
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The Role of Epoxyeicosatrienoic Acids in Diabetes Mellitus-Induced Impaired Vascular Relaxation of Aortic Rings in Ovariectomized Sprague-Dawley Rats by Dragan Manojlović, Ana Stupin, Anita Matić, Zrinka Mihaljević, Sanja Novak, Ines Drenjančević

“…The present study was aimed at determining if type 1 diabetes mellitus (DM) affects vascular function and at elucidating the mechanisms mediating vasorelaxation in both nonovariectomized and ovariectomized Sprague-Dawley (SD) rats. Materials and Methods. Eighty female SD rats were divided into four groups: nonovariectomized healthy (non-OVX-CTR) and diabetic (non-OVX-DM) rats and ovariectomized healthy (OVX-CTR) and diabetic (OVX-DM) rats. …”
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Transient Decrease in Circulatory Testosterone and Homocysteine Precedes the Development of Metabolic Syndrome Features in Fructose-Fed Sprague Dawley Rats by Anil Sakamuri, Sujatha Pitla, Uday Kumar Putcha, Sugeedha Jayapal, Sailaja Pothana, Sai Santosh Vadakattu, Nagabhushan Reddy Konapalli, Siva Sankara Vara Prasad Sakamuri, Ahamed Ibrahim

“…Here we investigated the time course of development of MS features in high-fructose-fed Sprague Dawley rats along with circulatory testosterone and homocysteine levels. …”
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Comparative Biochemical and Histopathological Studies on the Efficacy of Metformin and Virgin Olive Oil against Streptozotocin-Induced Diabetes in Sprague-Dawley Rats by Khadijah Saeed Balamash, Huda Mohammed Alkreathy, Elham Hamed Al Gahdali, Sawsan Omer Khoja, Aftab Ahmad

“…Thirty-six healthy male Sprague-Dawley rats were divided into six groups (6 rats per group) including nondiabetic control (NC), diabetic control (DC), and animals treated with metformin, olive oil, and a combination of olive oil and metformin, respectively. …”
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Novel Organic Mineral Complex Prevents High-Fat Diet-Induced Changes in the Gut and Liver of Male Sprague-Dawley Rats by M. S. Crawford, A. E. Mohr, K. L. Sweazea

“…Six-week-old male Sprague-Dawley rats (n = 36) were divided into two dietary groups: Chow or HFD fed for 10 weeks. …”
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Quantification of DNA through the NanoDrop Spectrophotometer: Methodological Validation Using Standard Reference Material and Sprague Dawley Rat and Human DNA by Alejandro Monserrat García-Alegría, Iván Anduro-Corona, Cinthia Jhovanna Pérez-Martínez, María Alba Guadalupe Corella-Madueño, María Lucila Rascón-Durán, Humberto Astiazaran-Garcia

“…This study aimed to validate an analytical method to determine DNA concentration using standard reference material (NIST SRM 2372) and Sprague Dawley rat and human DNA. Microvolumes were used to analyse DNA samples. …”
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Environmental enrichment with nylon gnaw sticks introduces variation in Sprague Dawley rat immune and lower gastrointestinal parameters with differences between sexes by Mark Wulczynski, Stephen P. J. Brooks, Judy Green, Fernando Matias, Martin Kalmokoff, Julia M. Green-Johnson, Sandra T. Clarke

“…In the present study, nylon chew bones (gnaw sticks, GS) were evaluated for their effects on fermentation profiles, microbial community structure, and cytokine profiles of gastrointestinal and systemic tissues in pair-housed female and male Sprague Dawley (SD) rats. Results Food consumption and weight gain were not significantly altered by access to GS. …”
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