Gut microbiota in the association between obesity and kidney function decline: a metagenomics-based study in a rat model by Akehu Alemasi, Lijiang Gu, Yilun Zhou

“…Hence, the objective of this study was to investigate the alterations in the gut microbiota composition that take place during obesity and their correlations with renal function utilizing a rat model.Methods For 20 weeks, 25 Sprague–Dawley rats were fed either a high-fat diet (HFD) or a normal-fat normal diet (ND). …”
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The Anticonvulsant Enaminone E139 Attenuates Paclitaxel-Induced Neuropathic Pain in Rodents by Dhandapani Thangamani, Ivan Ogheneochuko Edafiogho, Willias Masocha

“…Mechanical allodynia in paclitaxel-treated Sprague Dawley (SD) rats was measured using a dynamic plantar aesthesiometer before and after treatment with E139 (10 and 20 mg/kg) or its vehicle for four consecutive days from day 7 after first administration of paclitaxel (16 mg/kg on two alternate days). …”
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The Effect of Mechanical Ventilation on TASK-1 Expression in the Brain in a Rat Model by Buqi Na, Hong Zhang, Guangfa Wang, Li Dai, Guoguang Xia

“…Methods. Male Sprague-Dawley rats were randomized to three groups: (1) high tidal volume (HVt): MV for four hours with Vt at 10 mL/kg; (2) low Vt (LVt): MV for four hours with Vt at 5 mL/kg; (3) basal (BAS): anesthetized and unventilated animals. …”
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Ultrastructural changes in the common carotid artery in terms of age and gender-related in Rat model by Nejat Ünlükal

“…A total of 28 Sprague-Dawley rats, 14 males and 14 females, were planned to be used in the study. …”
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Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic rats by Fan Zhang, Ken K.L. Yung, Chi KongYeung

“…The objectives of this study were to determine the effects of common commercially-available prebiotics including fructooligosaccharide (FOS), inulin, FOS-inulin mixture, galactooligosaccharide (GOS), and lactulose on the iron status of anemic rats, and to monitor changes in the production of colonic SCFA. Anemic Sprague-Dawley rats receiving a low-iron diet (12 μg Fe/g diet) were supplemented with or without prebiotics (5% m/V in drinking water) for 5 weeks. …”
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Heating Has No Effect on the Net Protein Utilisation from Egg Whites in Rats by Ryosuke Matsuoka, Yayoi Takahashi, Mamoru Kimura, Yasunobu Masuda, Masaaki Kunou

“…Therefore, we investigated the effects of different heating conditions on the protein utilisation rate of EW. Male Sprague-Dawley rats (n=36, 198±1 g) were divided into six groups and fed American Institute of Nutrition-76 chow containing unheated EW, soft-boiled EW, boiled EW, milk whey protein, soybean protein, or no protein over a 10-day period using pair-feeding. …”
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WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis by Enrico Briguglio, Rosanna Di Paola, Irene Paterniti, Emanuela Mazzon, Giacomo Oteri, Giancarlo Cordasco, Salvatore Cuzzocrea

“…We have investigated the effects of WY14643, a potent peroxisome proliferator activator receptor-α (PPAR-α) agonist, in a rat model of ligature-induced periodontitis. Male Sprague-Dawley rats were lightly anaesthetized with pentobarbitone (35 mg/kg). …”
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Notoginsenoside Fc Accelerates Reendothelialization following Vascular Injury in Diabetic Rats by Promoting Endothelial Cell Autophagy by Jingjing Liu, Chunyu Jiang, Xu Ma, Lishuai Feng, Jianbo Wang

“…In this study, we present novel findings that show the benefit of Fc in accelerating reendothelialization and alleviating excessive neointimal formation following carotid artery injury in diabetic Sprague–Dawley rats in vivo. Simultaneously, the decreased autophagy of the injured carotid artery in diabetic rats was restored by Fc treatment. …”
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Dexamethasone potentiates the insulin-induced Srebp-1c expression in primary rat hepatocytes by Yan Zhang, Xiangming Fang, Fen Shuang, Guoxun Chen

“…Primary hepatocytes from Sprague-Dawley rats were isolated, cultured and treated with insulin in the presence or absence of the indicated reagents over time. …”
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New Paradigm in Cell Therapy Using Sperm Head to Restore Brain Function and Structure in Animal Model of Alzheimer’s Disease: Support for Boosting Constructive Inflammation vs. Ant... by Nafiseh Pakravan, Ardeshir Abbasi, Zuhair Mohammad Hassan

“…To do so, SVF, sperm, or sperm head (from Wistar rat) was administered via intra-cerebro-ventricular route to Sprague Dawley rat AD model. Behavioral and histological examination were made and treatment groups were compared with control AD model and normal groups. …”
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Detection of Dose Response in Chronic Doxorubicin-Mediated Cell Death with Cardiac Technetium 99m Annexin V Single-Photon Emission Computed Tomography by Kathleen L. Gabrielson, Greta S.P. Mok, Srihdar Nimmagadda, Djahida Bedja, Scott Pin, Allison Tsao, Yuchuan Wang, Dhrtti Sooryakumar, S. Jianhua Yu, Martin G. Pomper, Benjamin M.W. Tsui

“…Adult female Sprague-Dawley rats were treated with DOX (cumulative dose of 15 or 7.5 mg/kg) or saline ( n = 7) and monitored by echocardiography. …”
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Carvacrol attenuated haloperidol-induced Parkinson’s disease via TNF/NFκβ-NLRP3-mediated pyroptosis by Faisal Albaqami, Khawaja Waqas Ahmad, Fawad Ali Shah

“…In this study, we investigated the potential neuroprotective properties of carvacrol in a haloperidol-induced Parkinson’s model. In female Sprague-Dawley rats, the animal Parkinson model was induced by intraperitoneally administering 1 mg / kg of haloperidol once daily for fifteen days. …”
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Emerging Role of PPAR-β/δ in Inflammatory Process Associated to Experimental Periodontitis by Rosanna Di Paola, Francesco Briguglio, Irene Paterniti, Emanuela Mazzon, Giacomo Oteri, David Militi, Giancarlo Cordasco, Salvatore Cuzzocrea

“…The aim of the present study was to evaluate the contribution of peroxisome proliferator-activated receptor (PPAR-β/δ) in animal model of periodontitis. Male Sprague-Dawley rats were lightly anaesthetized with pentobarbitone (35 mg/kg). …”
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Vasorelaxant effects and its mechanisms of the rhizome of Acorus gramineus on isolated rat thoracic aorta by Jueon Lee, Sujin Shin, Junkyu Park, Ho-Young Choi, Kyungjin Lee

“…We assessed the vasorelaxant effect of a 50% ethanol extract of AGR (AGRE) using aortic rings from Sprague–Dawley rats pre-constricted with phenylephrine (PE) and potassium chloride (KCl). …”
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Combined Inositol Hexakisphosphate and Inositol Supplement Consumption Improves Serum Alpha-Amylase Activity and Hematological Parameters in Streptozotocin-Induced Type 2 Diabetic... by Shadae R. Foster, Lowell L. Dilworth, Jean Sparks, Ruby L. Alexander-Lindo, Felix O. Omoruyi

“…High-fat diet and a single intraperitoneal injection of streptozotocin (35 mg/kg body weight) were used to induce type 2 diabetes mellitus in Sprague–Dawley rats. The diabetic groups were then treated with either combined IP6 and inositol supplement or glibenclamide for four weeks. …”
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Dexamethasone Suppressed LPS-Induced Matrix Metalloproteinase and Its Effect on Endothelial Glycocalyx Shedding by Na Cui, Hao Wang, Yun Long, Longxiang Su, Dawei Liu

“…The aim of this study is to determine the mechanism of sepsis-induced vascular hyperpermeability and the beneficial effect of glucocorticoid in protecting vascular endothelium. Male Sprague-Dawley rats were given either a bolus intraperitoneal injection of a nonlethal dose of LPS (Escherichia coli 055:B5, 10 mg/kg, Sigma) or vehicle (pyrogen-free water). …”
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Metformin Ameliorates Podocyte Damage by Restoring Renal Tissue Podocalyxin Expression in Type 2 Diabetic Rats by Limin Zhai, Junfei Gu, Di Yang, Wei Wang, Shandong Ye

“…Type 2 diabetic Sprague-Dawley (SD) rats in which diabetes was induced by high-fat diet/streptozotocin (HFD-STZ) were treated with different doses of metformin (150, 300, and 500 mg/kg per day, resp.) for 8 weeks. …”
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Neuroprotective Effect of DAHP via Antiapoptosis in Cerebral Ischemia by Yanhua Qin, Weiming Hu, Yang Yang, Zhiying Hu, Weiyun Li, Marong Fang

“…Herein, we evaluated antiapoptotic and anti-inflammatory effects of diamino-6-hydroxypyrimidine (DAHP), a guanosine 5′-triphosphate cyclohydrolase 1 (GTPCH1) inhibitor on focal cerebral ischemia-reperfusion injury by middle cerebral artery occlusion and reperfusion (MCAO) and investigated the underlying mechanism. Sprague-Dawley rats were divided into five groups. Experimental groups were subjected to 1.5 h transient MCAO. …”
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The Antifibrosis Effects of Peroxisome Proliferator-Activated Receptor δ on Rat Corneal Wound Healing after Excimer Laser Keratectomy by Yun Gu, Xuan Li, Tiangeng He, Zhixin Jiang, Peng Hao, Xin Tang

“…The present study tested the hypothesis that the ligand activation of peroxisome proliferator-activated receptor (PPAR) δ had antifibrosis effects in a rat model of corneal damage. Adult Sprague-Dawley rats underwent bilateral phototherapeutic keratectomy (PTK). …”
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Antipleuritic and Vascular Permeability Inhibition of the Ethyl Acetate-Petroleum Ether Stem Bark Extract of Maerua angolensis DC (Capparaceae) in Murine by Felix Agyei Ampadu, Eric Boakye-Gyasi, Newman Osafo, Charles Kwaku Benneh, Edmund Ekuadzi, Eric Woode

“…The effects of MAE (30-300 mg kg−1) on neutrophil infiltration, exudate volume, and endogenous antioxidant enzymes in lung tissues and lung morphology were evaluated with the carrageenan induced pleurisy model in Sprague Dawley rats. The effects of MAE (30-300 mg kg−1) on vascular permeability were also evaluated in the acetic acid induced vascular permeability in ICR mice. …”
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