Comparative Evaluation of the Antidiabetic Effects of Different Parts of Cassia fistula Linn, a Southeast Asian Plant by John Wilking Einstein, Mustafa Mohd Rais, Mustafa Ali Mohd

“…Diabetes was induced in Sprague Dawley rats by the administration of streptozotocin-nictotinamide (50, 110 mg/kg b.w., resp.) intraperitoneally. …”
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The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice by J. N. Boampong, E. O. Ameyaw, B. Aboagye, K. Asare, S. Kyei, J. H. Donfack, E. Woode

“…Furthermore, it significantly (P<0.05) reduced the lipopolysaccharide- (LPS-) induced fever in Sprague-Dawley rats similar to prednisolone. Xylopic acid therefore possesses prophylactic and curative antimalarial as well as antipyretic properties which makes it an ideal antimalarial agent.…”
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Acute toxicity test of Rhizophora apiculata bark extract on rat liver and kidney histology using fixed dose method by Syazili Mustofa, Ilma Puteri Hutami, Dwi Sarwindah

“…Method: The ethanol extract of R. apiculata bark was administered using a fixed-dose approach in preliminary and primary tests, focusing on the kidneys and liver of male Sprague Dawley rats. Four treatment groups received doses of 5, 50, 300, and 2000 mg/kg BW, while one group served as the control. …”
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Effect of iron fortification and prebiotics on iron biomarkers in anemic rats by S. Iqbal, S. Zafar, W. Ahmed, S. H. B. U. Shah, J. Abid, U. Farooq, A. M. R. Ahmad

“…A total of 126 Sprague Dawley rats were fed with sixteen different types of fortified feed containing prebiotics (Inulin + Galacto Oligosaccharides) and Iron Fortificants (Sodium Ferric Ethylenediaminetetraacetate + Ferrous Sulphate). …”
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Pharmacokinetic Comparison of Isoalantolactone and Alantolactone in Rats after Administration Separately by Optimization of an UPLC-MS2 Method by Renjie Xu, Mengyue Wang, Ying Peng, Xiaobo Li

“…This method was used to compare the pharmacokinetic characteristics of isoalantolactone and alantolactone at a single dose of 5 mg/kg into male Sprague-Dawley rats by intravenous administration separately. …”
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NUCB2/Nesfatin-1 Regulation of Chronic Visceral Hyperalgesia by Qiaoyan Gu, Yuan Lei, Jianming Wu, Ting He, Juanjuan Li, Shanshan Song

“…Neonatal and mature Sprague-Dawley rats were randomly divided into the healthy control and chronic visceral hyperalgesia model groups. …”
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Effect of quercetin on the transport of ritonavir to the central nervous system in vitro and in vivo by Liang Gongwen, Li Na, Ma Liping, Qian Zhonglian, Sun Yuwen, Shi Luwen, Zhao Libo

“…An in vivo experiment on Sprague-Dawley rats was then designed to further determine the flavonoid’s impact on the pharmacokinetics and tissue distribution of ritonavir. …”
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Caloric Restriction Prevents Lead-Induced Oxidative Stress and Inflammation in Rat Liver by Mustafa Mohammadi, Rana Ghaznavi, Rana Keyhanmanesh, Hamid Reza Sadeghipour, Roya Naderi, Hossein Mohammadi

“…The aim of the present study is to investigate the effects of caloric restriction on liver of lead-administered rat. Male Sprague-Dawley rats were randomly divided into two groups: Ad libitum fed group (AL, free access to normal rat chow) and caloric restriction group (CR, fed 65% of AL animals’ food intake). …”
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Effects of Resveratrol on Methotrexate-Induced Testicular Damage in Rats by Esin Yuluğ, Sibel Türedi, Ahmet Alver, Süleyman Türedi, Cemil Kahraman

“…Twenty-four male Sprague Dawley rats were randomly divided into four groups: control, RES, MTX, and MTX + RES groups. …”
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Influence of Rosiglitazone on the Expression of PPARγ, NF-κB, and TNF-α in Rat Model of Ulcerative Colitis by Jing-Wei Mao, Hai-Ying Tang, Ying-De Wang

“…To observe the disease activity index (DAI) and the colonic mucosa damage index (CMDI), detect the colonic mucosal expression of PPARγ, NF-κB, and TNF-α in rats with ulcerative colitis (UC), and to investigate the protective role of rosiglitazone in UC. Methods. Sprague-Dawley (SD) rats were divided into three groups: a control group, a rosiglitazone treatment group, and a UC model group. …”
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Effects of Pentoxifylline in a Rat Model of Manganism: Evaluation of the Possible Toxicity by Romina Tanideh, Omid Farshad, Akram Jamshidzadeh, Aida Iraji

“…Thirty adult male Sprague Dawley rats received MnCl2 (100 mg/kg, i.p. on days 1, 3, and 7) during a week alone or in combination with PTX (300 mg/kg, i.p. every day for 8 consecutive days on manganism rat model). …”
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Trigonelline exerts its neuroprotective effects in experimental spinal cord injury through modulation of inflammation, apoptosis, and neurotrophic factors by Zhi-Lan Ye, Yuan Cao

“…Methods: Rats (Sprague-Dawley, male) were randomly assigned to seven groups (n=15 per group): normal, sham, SCI control (1% DMSO), methylprednisolone (30 mg/kg), and trigonelline (50, 100, and 200 mg/kg). …”
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Therapeutic potential of 4-hexylresorcinol in reducing sarcopenia in diabetic masseter muscle by Dhouha Gaida, Young-Wook Park, Yei-Jin Kang, Seong-Gon Kim

“…Methods A controlled, parallel-arm study was conducted using 38 Sprague–Dawley rats divided into diabetic and non-diabetic groups. …”
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A combination of ursodeoxycholic acid and Allium sativum prevents liver cirrhosis in cholestatic rats by Pratama Nurmalik Adhuri, Neni Susilaningsih, Sigit Adi Prasetyo, Nani Maharani, Trilaksana Nugroho

“…The current study was carried out with 35 male Sprague Dawley rats, which were randomly assigned into healthy, negative, and positive control groups, and three treatments of UDCA and graded doses of A. sativum extract. …”
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Blockade of Piezo2 Pathway Attenuates Inflammatory and Neuropathic Pain in the Orofacial Area by Min-Jeong Jo, Jo-Young Son, Yu-Mi Kim, Jin-Sook Ju, Min-Kyoung Park, Min-Kyung Lee, Dong-Kuk Ahn

“…In this study, we used male Sprague Dawley rats to investigate the role of the Piezo2 pathway in the development of inflammatory and neuropathic pain. …”
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Correlations between Endothelial Functions and ROS Detection in Diabetic Microvascular Wall: Early and Late Ascorbic Acid Supplementation by Pattarin Sridulyakul, Natchaya Wongeak-in, Suthiluk Patumraj

“…The correlation between endothelial function and reactive oxygen species detecting from diabetic microvascular wall and the antioxidant effect of ascorbic acid (AA) during early and late phases of diabetic induction were determined. Male Spraque-Dawley rats were divided into four groups: control, diabetes rats (DM, using iv.injection of 55 mg/kg BW streptozotocin, (STZ)), and two groups of DM rats treated with AA (1 g/L, (STZ)) starting on day 2 (DM + AAday2) and week 6th (DM + AA6wk). …”
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Hypobaric Hypoxia Imbalances Mitochondrial Dynamics in Rat Brain Hippocampus by Khushbu Jain, Dipti Prasad, Shashi Bala Singh, Ekta Kohli

“…Hence, the study investigated the temporal alteration and involvement of abnormal mitochondrial dynamics (fusion/fission) along with disturbed mitochondrial functionality during chronic exposure to hypobaric hypoxia (HH). The Sprague-Dawley rats were exposed to simulated high altitude equivalent to 25000 ft for 3, 7, 14, 21, and 28 days. …”
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The Effect of a Synthetic Heparan Sulfate on the Healing of Colonic Anastomoses by Malene Nerstrøm, Peter-Martin Krarup, Lars Nannestad Jorgensen, Magnus S. Ågren

“…We evaluated the following two treatment groups of male Sprague Dawley rats (220–256 g): control-treated colonic anastomoses (n=25) and OTR4120-treated colonic anastomoses (n=25). …”
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Nerve root magnetic stimulation regulates the synaptic plasticity of injured spinal cord by ascending sensory pathway by Ya Zheng, Lingyun Cao, Dan Zhao, Qi Yang, Chunya Gu, Yeran Mao, Guangyue Zhu, Yulian Zhu, Jing Zhao, Dongsheng Xu

“…In this study, we established a model of spinal cord injury in adult male Sprague–Dawley rats by applying moderate compression at the T10 vertebra. …”
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Can Spinal Bupivacaine Analgesia Treatment Make a Difference on Urinary Bladder Healing According to the Intramuscular Pethidine Analgesia Treatment in Rats? by Yeswim Senayli, Atilla Senayli, R. Dogan Koseoglu, Ziya Kaya, Fatih Özkan, Ilker Etikan

“…Nineteen male, Sprague-Dawley rats weighing 200–300 g were used in this study. …”
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