Electroacupuncture Zusanli (ST36) Relieves Somatic Pain in Colitis Rats by Inhibiting Dorsal Root Ganglion Sympathetic-Sensory Coupling and Neurogenic Inflammation by Yi-li Wang, Hai-yan Zhu, Xi-qian Lv, Xing-ying Ren, Ying-chun Peng, Jin-yu Qu, Xue-fang Shen, Ran Sun, Meng-lu Xiao, Hong Zhang, Zhao-hui Chen, Peng Cong

“…The purpose of the study was to explore the potential and mechanism of electroacupuncture (EA) at Zusanli (ST36) for the intervention of colon inflammation and hyperalgesia. Sprague-Dawley (SD) was randomly divided into four groups, including control, model, EA, and sham-EA. …”
Get full text

Radiotherapy Suppresses Bone Cancer Pain through Inhibiting Activation of cAMP Signaling in Rat Dorsal Root Ganglion and Spinal Cord by Guiqin Zhu, Yanbin Dong, Xueming He, Ping Zhao, Aixing Yang, Rubing Zhou, Jianhua Ma, Zhong Xie, Xue-Jun Song

“…Here, we examined the effects of radiotherapy on bone cancer pain and accompanying abnormal activation of cAMP-PKA signaling. Female Sprague-Dawley rats were used and received tumor cell implantation (TCI) in rat tibia (TCI cancer pain model). …”
Get full text

Zinc Supplementation Mitigates High Salt Diet-Induced Bone Damage: A Histological Evaluation of Osteocyte Apoptosis by Kaukab Anjum, Abdullah Qamar, Nomana Mahmood, Muhammad Marghoob Khan, Shazia Imran, Ayesha Ali

“…Thirty female Sprague-Dawley rats were randomly divided into three groups: control (Group C), high-salt diet (Group A), and high-salt diet with zinc supplementation (Group B). …”
Get full text

Nitrogen-containing bisphosphonate for vascular calcification: animal experiments, systematic review and meta-analysis by Wei Xu, Guoyuan Lu, Lifeng Gong, Weigang Tang, Wei Jiang

“…Methods In our animal experiments, Sprague-Dawley (SD) rats were randomly divided into a control group, a VC group, a low-dose zoledronic acid (ZOL) (20 µg/kg) group and a high-dose ZOL (100 µg/kg) group. …”
Get full text

Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic by Jo-Young Son, Jae-Seong Lim, Jae-Hyung Park, Jae-Hyeong Park, Myeong-Shin Kim, Jung-Ho Park, Jun-suk Oh, Hyun-Wu Yoon, Jin-Sook Ju, Dong-Kuk Ahn

“…In this study, we examined the antinociceptive efficacy enhancements of diphenhydramine when combined with mannitol. Male Sprague-Dawley rats weighing 230–260 g were used in a hot plate test to evaluate the antinociceptive effects of diphenhydramine. …”
Get full text

MCP-1-Induced Histamine Release from Mast Cells Is Associated with Development of Interstitial Cystitis/Bladder Pain Syndrome in Rat Models by Jianwei Lv, Yiran Huang, Shiguo Zhu, Ganggang Yang, Yujian Zhang, Jing Leng, Juanjie Bo, Dongming Liu

“…A rat model of IC/BPS was developed by perfusing bladders of nine SPF- grade female Sprague-Dawley rats with protamine sulfate and lipopolysaccharide (PS+LPS). …”
Get full text

Photobiomodulation on Bax and Bcl-2 Proteins and SIRT1/PGC-1α Axis mRNA Expression Levels of Aging Rat Skeletal Muscle by Fang-Hui Li, Yan-Ying Liu, Fei Qin, Qing Luo, Hai-Ping Yang, Quan-Guang Zhang, Timon Cheng-Yi Liu

“…Twenty female Sprague Dawley rats (18 months old) were randomly divided into two groups (n=10 per group): control (CON) and LLLI groups. …”
Get full text

Rauwolfia vomitoria- a promising medical plant for benign prostatic hyperplasia management; yet with challenges by George Awuku Asare, Perpetua Dagadu, Samuel Adjei, Bernice Asiedu, Samkeliso Takaidza, Vivash Naidoo, Brodrick Amoah, Ifeoma Celestina Orabueze, Kwasi Bugyei

“…Methodology: Six groups of male Sprague-Dawley rats were established [N = 7/group]. Group 1 comprised of normal rats whilst group 2 to group 6 comprised of BPH induced rats. …”
Get full text

Anxiety and neurometabolite levels in the hippocampus and amygdala after prolonged exposure to predator-scent stress by O. B. Shevelev, V. E. Tseilikman, N. V. Khotskin, А. S. Khotskina, G. V. Kontsevaya, M. S. Lapshin, M. P. Moshkin, M. V. Komelkova, I. V. Feklicheva, O. B. Tseilikman, E. B. Manukhina, H. F Downey, E. L. Zavjalov

“…Here, to study the relationship between anxiety levels with changes in the neurometabolic profile in the hippocampus and amygdala, an experimental predator stress model was reproduced in which Sprague-Dawley rats were exposed to cat urine for 10 minutes on a daily basis for 10 days. …”
Get full text

Comparison of Platelet-Rich Plasma-Impregnated Suture Material with Low and High Platelet Concentration to Improve Colonic Anastomotic Wound Healing in Rats by Mehmet Akif Aydin, Eray Metin Guler, Ahu Senem Demiroz, Muhammet Fatih Aydin, Gulcan Saglam

“…A total of 24 Sprague Dawley female rats were separated into 3 groups (n=8 for each) including the control group (CON; standard vicryl suture repair), the low platelet concentrate PRP group (L-PRP; suture material impregnated with PRP containing average 2.7-fold (range, 2.0 to 3.1) higher amount of platelets vs. control), and the high platelet concentrate PRP group (H-PRP; suture material impregnated with PRP containing average 5.1-fold (range, 4.8 to 5.4) higher amount of platelets vs. control). …”
Get full text

Bioanalytical method development, in-vivo pharmacokinetic evaluation, ex-vivo platelet aggregation inhibition activity of a novel solid dispersion formulation of ticagrelor by Abhishek Srivastava, Abhishek Srivastava, Simrata Bedi, Abhishesh Kumar Mehata, Datta Maroti Pawde, Ketan Vinayakrao Hatware, Mohammad Ahmad Khan, M. S. Muthu, Uma Bhandari

“…A validated method was used for evaluating the pharmacokinetic profile of the developed formulation and marketed formulation in Sprague Dawley rats. Additionally, the ex-vivo antiplatelet aggregation activity was evaluated.ResultsThe developed method was accurate and linear (100 ng−800 ng) to quantify the drug in plasma. …”
Get full text

Aggravating Effects of Psychological Stress on Ligature-Induced Periodontitis via the Involvement of Local Oxidative Damage and NF-κB Activation by Qiang Li, Yajuan Zhao, Daokun Deng, Jiuhui Yang, Yongjin Chen, Jia Liu, Min Zhang

“…To elucidate the adverse effects of psychological stress on the inflammatory process and redox status of periodontitis tissue, fifty male Sprague-Dawley rats were divided into the control, experimental periodontitis, psychological stress, experimental periodontitis plus psychological stress, and experimental periodontitis plus psychological stress plus fluoxetine groups. …”
Get full text

Development of vitex-derived polymer nanofibers using electrochemical sensors for the treatment of polycystic ovarian syndrome in rats as an animal model by Zaid H. Mahmoud, Uday Abdul-Reda Hussein, Najwa Aljbory, Mohammed Jawad Alnajar, Laleh Maleknia, Abolfazl Mirani, Ehsan kianfar

“…In this study, 42 Sprague-Dawley rats with regular menstrual cycles were divided into five groups: control group (healthy rats), polycarbonate (PC) group (treated with 1 mg/kg letrozole for 28 days to induce PCOS syndrome), and Poly terephthalate (PT) group (treated with PCOS for 30 days). …”
Get full text

Effects of Human Alpha-Synuclein A53T-A30P Mutations on SVZ and Local Olfactory Bulb Cell Proliferation in a Transgenic Rat Model of Parkinson Disease by Faustine Lelan, Cécile Boyer, Reynald Thinard, Séverine Rémy, Claire Usal, Laurent Tesson, Ignacio Anegon, Isabelle Neveu, Philippe Damier, Philippe Naveilhan, Laurent Lescaudron

“…A transgenic Sprague Dawley rat bearing the A30P and A53T α-synuclein (α-syn) human mutations under the control of the tyrosine hydroxylase promoter was generated in order to get a better understanding of the role of the human α-syn mutations on the neuropathological events involved in the progression of the Parkinson’s disease (PD). …”
Get full text

Interplay between Intravitreal RvD1 and Local Endogenous Sirtuin-1 in the Protection from Endotoxin-Induced Uveitis in Rats by S. Rossi, C. Di Filippo, C. Gesualdo, F. Testa, M. C. Trotta, R. Maisto, B. Ferraro, F. Ferraraccio, M. Accardo, F. Simonelli, M. D’Amico

“…In this model, intravitreal injection of resolvin D1 (RvD1, 10–100–1000 ng/kg) 1 hour after subcutaneous treatment of Sprague-Dawley rats with lipopolysaccharide (LPS, 200 μg/rat) significantly prevented the development of uveitis into the eye. …”
Get full text

Carvacrol acetate activated Nrf2 modulates mitophagy for the treatment of neurocyte oxidative stress induced by chlorpyrifos by Hong-Ling Zhou, Bei-Bei Wang, Xu-Li Fan, Xiao-Min Zhang, Ying Song

“…A model of oxidative stimulus damage was established in Sprague–Dawley rats by subcutaneous injection of the CPF poison. …”
Get full text

Pharmacokinetic Analysis of Diosgenin in Rat Plasma by a UPLC-MS/MS Approach by Pei Liu, Lin Xu, Jing-han Guo, Jin-hua Chang, Xi-gang Liu, He-fei Xue, Ru-xing Wang, Zhong-si Li, Guang-xin Miao, Cui-zhe Liu, Jian-yu Zhou

“…The aim of the present study was to establish an efficient, sensitive ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) approach for pharmacokinetic analysis of diosgenin amorphous solid dispersion (ASD) using tanshinone IIA as an internal standard (IS). Male Sprague-Dawley rats were orally administered diosgenin ASD, and orbital blood samples were collected for analysis. …”
Get full text

Effects of coal mine dust on lung function in rats by LIU Yang, LI Meng, LU Liyuan, WANG Ru, YANG He, ZHANG Huifang

“…Methods: Seventy-two SPF-grade 8-week-old male Sprague-Dawley rats were randomly divided into the coal dust group, the coal-silica dust group, the silica dust group and the control group. …”
Get full text

Halofuginone prevents inflammation and proliferation of high-altitude pulmonary hypertension by inhibiting the TGF-β1/Smad signaling pathway by Jiangtao Wang, Lina Guan, Jian Yu, Bohua Ma, Huihua Shen, Guozhu Xing, Yawei Xu, Qiufang Li, Juan Liu, Qin Xu, Wenhui Shi, Jia He, Yixuan Huang, Dongfeng Yin, Wu Li, Rui Wang

“…In the present study, we evaluated the efficacy of HF on HAPH by establishing a 6000 m HAPH rat model. Male Sprague–Dawley rats were divided into normoxia, normoxia + halofuginone (1 mg/kg), hypoxia, and hypoxia + halofuginone (1 mg/kg) groups. …”
Get full text

Effects of Elemental Mercury Vapor Inhalation on Arterial Blood Gases, Lung Histology, and Interleukin-1 Expression in Pulmonary Tissues of Rats by Liqaa A. Raffee, Khaled Z. Alawneh, Ruba A. Alassaf, Abdallah Alzoubi, Musa A. Alshehabat, Nadeem Alabdallah, Abdel-Hameed Al-Mistarehi

“…A total of 42 Sprague Dawley rats were divided randomly into three groups. …”
Get full text