Electron Microscopic Radioautographic Study on Mitochondrial DNA Synthesis in Adrenal Cortical Cells of Developing and Aging Mice by Tetsuji Nagata

“…It was shown that the activity of intramitochondrial DNA synthesis in the adrenal cortical cells in developing and aging mice changed due to aging.…”
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TEFM facilitates transition from RNA synthesis to DNA synthesis at H-strand replication origin of mtDNA by Shigeru Matsuda, Masunari Nakayama, Yura Do, Takashi Ishiuchi, Mikako Yagi, Sjoerd Wanrooij, Kazuto Nakada, Fan-Yan Wei, Kenji Ichiyanagi, Hiroyuki Sasaki, Dongchon Kang, Takehiro Yasukawa

“…Transition from RNA synthesis to DNA synthesis at OH is crucial for balancing replication with transcription, yet the mechanism remains unclear. …”
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Phosphoryl guanidine oligonucleotides as primers for RNA-dependent DNA synthesis using murine leukemia virus reverse transcriptase by E. S. Dyudeeva, I. A. Pyshnaya

“…The accuracy and efficiency of cDNA synthesis in the reverse-transcription reaction catalyzed by reverse transcriptase (RNA-dependent DNA polymerase) significantly affect the correctness of the results of PCR diagnostic assays and/or RNA sequencing. …”
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Error-Prone Translesion DNA Synthesis by Escherichia coli DNA Polymerase IV (DinB) on Templates Containing 1,2-dihydro-2-oxoadenine by Masaki Hori, Shin-Ichiro Yonekura, Takehiko Nohmi, Petr Gruz, Hiroshi Sugiyama, Shuji Yonei, Qiu-Mei Zhang-Akiyama

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Common themes in architecture and interactions of prokaryotic PolB2 and Pol V mutasomes inferred from in silico studies by Kęstutis Timinskas, Albertas Timinskas, Česlovas Venclovas

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Inkjet-based oligonucleotide synthesis reagents: Formulation optimization and comparison of acetonitrile and propylene carbonate applications by Yu Xiao, Yongjin Peng, Zhen Rong, Xiaoyang He, Fei Sun, Shengqi Wang

“…This study achieved a new DNA synthesis reagent formulation that supports inkjet-based DNA synthesis and exhibits excellent coupling efficiency. …”
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The Effect of Mitochondrial Dysfunction on Cytosolic Nucleotide Metabolism by Claus Desler, Anne Lykke, Lene Juel Rasmussen

“…Studies described in this paper suggest dysfunction of the mitochondria to affect these metabolic pathways and limit the available levels of cytosolic ribonucleotides and deoxyribonucleotides, which in turn can result in aberrant RNA and DNA synthesis. Mitochondrial dysfunction has been linked to genomic instability, and it is possible that the limiting effect of mitochondrial dysfunction on the levels of nucleotides and resulting aberrant RNA and DNA synthesis in part can be responsible for this link. …”
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DNA Polymerase e - More Than a Polymerase by Helmut Pospiech, Juhani E. Syväoja

“…During this process, DNA polymerase a lays down RNA-DNA primers that are utilized by DNA polymerases d and e for the bulk DNA synthesis. Attempts have been made to assign these two enzymes specifically to the synthesis of the leading and the lagging strand. …”
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Inhibitors of Human Dihydrofolate Reductase: A Computational Design and Docking Studies Using Glide by Lingala Yamini, Manga Vijjulatha

“…Dihydrofolate reductase (DHFR) plays a vital role in the DNA synthesis by reducing dihydrofolic acid to tetrahydrofolic acid which is an essential component. …”
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Resistance of <i>Wolbachia</i> to Trimethoprim: Insights into Genes Encoding Dihydrofolate Reductase, Thymidylate Synthase and Serine Hydroxymethyltransferase in the Rickettsiales by Ann M. Fallon

“…Bacterial and eukaryotic dihydrofolate reductase (DHFR) enzymes are essential for DNA synthesis and are differentially sensitive to the competitive inhibitors trimethoprim and methotrexate. …”
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Multiple Myeloma and B Cell Lymphoma. Investigation of IL-6, IL-6 Receptor Antagonist (IL-6RA), and GP130 Antagonist (GP130A) Using Various Parameters in an In Vitro Model by Eva Kovacs

“…In this study, we investigated the effects of IL-6, IL-6 receptor antagonist (IL-6RA), and gp130 antagonist (gp130A) on the membrane expressions of IL-6R and gp130, on the viability, on the proliferation, on the DNA synthesis, and on the cell cycle phases in several multiple myeloma (MM) cell lines and B cell lymphoma cell lines. …”
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Storing Digital Information in Long-Read DNA by TaeJin Ahn, Hamin Ban, Hyunsoo Park

“…Previous studies tackled technical hurdles due to errors from DNA synthesis and sequencing. Studies also have focused on a strategy that makes use of 100‒150-bp read sizes in both synthesis and sequencing. …”
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Management of Iron Overload in Resource Poor Nations: A Systematic Review of Phlebotomy and Natural Chelators by Orish Ebere Orisakwe, Cecilia Nwadiuto Amadi, Chiara Frazzoli

“…Iron is an essential element and the most abundant trace metal in the body involved in oxygen transport and oxygen sensing, electron transfer, energy metabolism, and DNA synthesis. Excess labile and unchelated iron can catalyze the formation of tissue-damaging radicals and induce oxidative stress. …”
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Exploring the Impact of Cigarette Smoke Extracts on Vitamin B12: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through In Vitro Evaluat... by Mazhar Salim Al Zoubi, Mus’aab A. Al-Oun, Fatima Yacoub Abusahyoun, Manal Issam Abualarja, Asmaa Al Smadi, Bahaa Al-Trad, Sura A. Awadin, Khalid Al-Batayneh, Mai Elaarag, Raed M. Al-Zoubi

“…Vitamin B12 (cobalamin) is a water-soluble molecule required for the proper functioning of metabolism, blood and DNA synthesis, and neurological development. Vitamin B12 exists in several forms: methylcobalamin (MeCbl), adenosylcobalamin (AdoCbl), hydroxycobalamin (OHCbl), and cyanocobalamin (CNCbl). …”
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Entecavir: stability and drug-excipient compatibility by Ariadne Botto Fiorot, Clayton Raynan dos Santos, Thiago Padovani Xavier, Taisa Shimosakai de Lira, Marcelo Antonio de Oliveira

“…Abstract Entecavir is an inhibitor of hepatitis B virus (HBV) DNA synthesis that has been widely prescribed in the treatment of chronic infections caused by the virus. …”
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DNA Polymerase: Structural Homology, Conformational Dynamics, and the Effects of Carcinogenic DNA Adducts by Richard G. Federley, Louis J. Romano

“…This structural homology would predict a relatively unvarying mechanism for DNA synthesis yet various polymerases exhibit markedly different properties on similar substrates, indicative of each type of polymerase being prescribed to a specific role in DNA replication. …”
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A Review on the Antimutagenic and Anticancer Effects of Cysteamine by Chun-Man Lee

“…Although the mechanisms of action are not fully understood, possible explanations are (i) free radical scavenging, (ii) alteration of the tumor cell proliferation by affecting nucleic acid and protein synthesis or inhibition of DNA synthesis, and (iii) hormone regulation. In conclusion, regarding the high safety profile of cysteamine and the current literature data presented in this article, cysteamine might be considered as an interesting molecule for the prevention and the treatment of cancer. …”
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Production of Secretory Leucocyte Protease Inhibitor (SLPI) in Human Pancreatic β-Cells by Max Nyström, Magnus Bergenfeldt, Irena Ljungcrantz, Èsa Lindeheim, Kjell Ohlsson

“…SLPI has also been shown to inhibit HIV-1 infections by blocking viral DNA synthesis. Since SLPI is an inhibitor of pancreatic proteases we wished to investigate whether SLPI was also actually produced in the pancreas. …”
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The DNA Polymerase _-Primase Complex: Multiple Functions and Interactions by Marco Muzi-Falconi, Michele Giannattasio, Marco Foiani, Paolo Plevani

“…In fact, pol _ is associated with DNA primase to form a four subunit complex and, as a consequence, is the only enzyme able to start DNA synthesis de novo. Because of this peculiarity the major role of the DNA polymerase _-primase complex (pol-prim) is in the initiation of DNA replication at chromosomal origins and in the discontinuous synthesis of Okazaki fragments on the lagging strand of the replication fork. …”
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Ion Channel Activities in Neural Stem Cells of the Neuroepithelium by Masayuki Yamashita

“…These movements of Ca2+ are essential for DNA synthesis during S-phase. Spontaneous Ca2+ oscillations also occur synchronously across the cells. …”
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