Suggested Topics within your search.
Suggested Topics within your search.
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KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition
Published 2025-02-01“…The causal relationships between these features and DNA replication timing (RT), especially during cell fate changes, are largely unknown. …”
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22
Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates
Published 2025-01-01“…Abstract Human DNA licensing initiates replication fork assembly and DNA replication. This reaction promotes the loading of the hMCM2-7 complex on DNA, which represents the core of the replicative helicase that unwinds DNA during S-phase. …”
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23
MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis
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24
Replication timing in Drosophila and its peculiarities in polytene chromosomes
Published 2019-03-01“…Drosophila melanogaster is one of the popular model organisms in DNA replication studies. Since the 1960s, DNA replication of polytene chromosomes has been extensively studied by cytological methods. …”
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25
Replication-IDentifier links epigenetic and metabolic pathways to the replication stress response
Published 2025-02-01“…Abstract Perturbation of DNA replication, for instance by hydroxyurea-dependent dNTP exhaustion, often leads to stalling or collapse of replication forks. …”
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26
Nucleosome wrapping states encode principles of 3D genome organization
Published 2025-01-01“…During processes like DNA replication and gene transcription, the conformation of nucleosomes undergoes dynamic changes, including DNA unwrapping and rewrapping, as well as histone disassembly and assembly. …”
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27
Metabolic Analysis of the Mode of Action and Mode of Resistance for Novobiocin in Staphylococcus aureus
Published 2025-01-01“…Targeting of bacterial gyrase, specifically the gyrB subunit, is a promising approach because of this enzyme’s essential role in bacterial DNA replication and its absence in higher eukaryotes. …”
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28
Dimerization-dependent serine protease activity of FAM111A prevents replication fork stalling at topoisomerase 1 cleavage complexes
Published 2024-03-01“…Abstract FAM111A, a serine protease, plays roles in DNA replication and antiviral defense. Missense mutations in the catalytic domain cause hyper-autocleavage and are associated with genetic disorders with developmental defects. …”
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29
Genetics : analysis of genes and genomes /
Published 2019Table of Contents: “…Genes, genomes and genetic analysis -- DNA structure and genetic variation -- Transmission genetics : the principle of segregation -- The chromosomal basis of inheritance -- Genetic linkage and chromosome mapping -- Human karyotypes and chromosome behavior -- The genetics of complex characters -- Genetics of the bacteria and their viruses -- Molecular organization of chromosomes and genomes -- DNA replication and sequencing -- Mutation, repair, and recombination -- Molecular biology of gene expression -- Molecular mechanisms of gene regulation -- Manipulating genes and genomes -- Genetic control of development -- The genetics of cancer -- Extranuclear inheritance -- Genetics of populations -- Human evolution.…”
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30
Decoding mitochondrial DNA damage and repair associated with H. pylori infection
Published 2025-01-01“…In this review, we summarize the molecular mechanisms of spontaneous and H. pylori infection-associated oxidative mtDNA damage, mtDNA replication stress, and its impact on innate immune signaling. …”
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31
DNA Polymerase e - More Than a Polymerase
Published 2003-01-01“…In addition to its role in DNA replication, DNA polymerase e fulfils roles in the DNA synthesis step of nucleotide excision and base excision repair, and has been implicated in recombinational processes in the cell.…”
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32
Aspergillus section Versicolores: nine new species and multilocus DNA sequence based phylogeny
Published 2012-06-01“…β-tubulin, calmodulin, internal transcribed spacer and partial lsu-rDNA, RNA polymerase 2, DNA replication licensing factor Mcm7, and pre-rRNA processing protein Tsr1 were amplified and sequenced from numerous isolates belonging to Aspergillus sect. versicolor. …”
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33
Phage Therapy -- Everything Old Is New again
Published 2006-01-01“…The study of bacterial viruses (bacteriophages or phages) proved pivotal in the nascence of the disciplines of molecular biology and microbial genetics, providing important information on the central processes of the bacterial cell (DNA replication, transcription and translation) and on how DNA can be transferred from one cell to another. …”
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34
The Mitochondrial Aminoacyl tRNA Synthetases: Genes and Syndromes
Published 2014-01-01“…In addition, the biogenesis and maintenance of mitochondria, including mitochondrial DNA (mtDNA) replication, transcription, and translation, require nuclear-encoded genes. …”
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35
Effects of elongation delay in transcription dynamics
Published 2014-08-01“…This paper studies the transcription dynamics that involved the elongation delay and effects of cell division and DNA replication. The stochastic process of gene expression is modeled with delay chemical master equation with periodic coefficients, and is studied numerically through the stochastic simulation algorithm with delay. …”
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36
Fluorescently Labeled Adenovirus with pIX-EGFP for Vector Detection
Published 2004-04-01“…DNA packaging and thermostability were marginally hampered by the modification while DNA replication, cytopathic effect, and CAR-dependent binding were not affected. …”
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37
CHEK2∗1100delC Mutation and Risk of Prostate Cancer
Published 2014-01-01“…CHEK2 plays a critical role in DNA replication by responding to double-stranded breaks. …”
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38
The kinetics of uracil-N-glycosylase distribution inside replication foci
Published 2025-01-01“…The data presented in this study strongly indicate that the nuclear uracil-N-glycosylase activity and nuclear protein content in human cell lines is highest in the S phase of the cell cycle and that its distribution kinetics partially reflect the DNA replication activity in replication foci. In this respect, the data demonstrate structural changes of the replication focus related to the uracil-N-glycosylase distribution several dozens of minutes before end of its replication. …”
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39
Physiological Roles of DNA Double-Strand Breaks
Published 2017-01-01“…Under tight spatiotemporal regulation, DSBs serve as a tool for genetic modification, widely used across cellular biology to generate diverse functionalities, ranging from the fundamental upkeep of DNA replication, transcription, and the chromatin landscape to the diversification of immunity and the germline. …”
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40
DNA Polymerase: Structural Homology, Conformational Dynamics, and the Effects of Carcinogenic DNA Adducts
Published 2010-01-01“…DNA replication is vital for an organism to proliferate and lying at the heart of this process is the enzyme DNA polymerase. …”
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