Suggested Topics within your search.
Suggested Topics within your search.
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Genetics : analysis of genes and genomes /
Published 2019Table of Contents: “…Genes, genomes and genetic analysis -- DNA structure and genetic variation -- Transmission genetics : the principle of segregation -- The chromosomal basis of inheritance -- Genetic linkage and chromosome mapping -- Human karyotypes and chromosome behavior -- The genetics of complex characters -- Genetics of the bacteria and their viruses -- Molecular organization of chromosomes and genomes -- DNA replication and sequencing -- Mutation, repair, and recombination -- Molecular biology of gene expression -- Molecular mechanisms of gene regulation -- Manipulating genes and genomes -- Genetic control of development -- The genetics of cancer -- Extranuclear inheritance -- Genetics of populations -- Human evolution.…”
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22
Decoding mitochondrial DNA damage and repair associated with H. pylori infection
Published 2025-01-01“…In this review, we summarize the molecular mechanisms of spontaneous and H. pylori infection-associated oxidative mtDNA damage, mtDNA replication stress, and its impact on innate immune signaling. …”
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23
DNA Polymerase e - More Than a Polymerase
Published 2003-01-01“…In addition to its role in DNA replication, DNA polymerase e fulfils roles in the DNA synthesis step of nucleotide excision and base excision repair, and has been implicated in recombinational processes in the cell.…”
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24
Aspergillus section Versicolores: nine new species and multilocus DNA sequence based phylogeny
Published 2012-06-01“…β-tubulin, calmodulin, internal transcribed spacer and partial lsu-rDNA, RNA polymerase 2, DNA replication licensing factor Mcm7, and pre-rRNA processing protein Tsr1 were amplified and sequenced from numerous isolates belonging to Aspergillus sect. versicolor. …”
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25
The Mitochondrial Aminoacyl tRNA Synthetases: Genes and Syndromes
Published 2014-01-01“…In addition, the biogenesis and maintenance of mitochondria, including mitochondrial DNA (mtDNA) replication, transcription, and translation, require nuclear-encoded genes. …”
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26
Effects of elongation delay in transcription dynamics
Published 2014-08-01“…This paper studies the transcription dynamics that involved the elongation delay and effects of cell division and DNA replication. The stochastic process of gene expression is modeled with delay chemical master equation with periodic coefficients, and is studied numerically through the stochastic simulation algorithm with delay. …”
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27
CHEK2∗1100delC Mutation and Risk of Prostate Cancer
Published 2014-01-01“…CHEK2 plays a critical role in DNA replication by responding to double-stranded breaks. …”
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28
The kinetics of uracil-N-glycosylase distribution inside replication foci
Published 2025-01-01“…The data presented in this study strongly indicate that the nuclear uracil-N-glycosylase activity and nuclear protein content in human cell lines is highest in the S phase of the cell cycle and that its distribution kinetics partially reflect the DNA replication activity in replication foci. In this respect, the data demonstrate structural changes of the replication focus related to the uracil-N-glycosylase distribution several dozens of minutes before end of its replication. …”
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Physiological Roles of DNA Double-Strand Breaks
Published 2017-01-01“…Under tight spatiotemporal regulation, DSBs serve as a tool for genetic modification, widely used across cellular biology to generate diverse functionalities, ranging from the fundamental upkeep of DNA replication, transcription, and the chromatin landscape to the diversification of immunity and the germline. …”
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DNA Polymerase: Structural Homology, Conformational Dynamics, and the Effects of Carcinogenic DNA Adducts
Published 2010-01-01“…DNA replication is vital for an organism to proliferate and lying at the heart of this process is the enzyme DNA polymerase. …”
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31
Ensuring the Stability of the Genome: DNA Damage Checkpoints
Published 2001-01-01“…A key component of the DNA damage response is checkpoint signalling, which monitors the state of the genome prior to DNA replication (G1/S) and chromosome segregation (G2/M). …”
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SMC translocation is unaffected by an excess of nucleoid associated proteins in vivo
Published 2025-01-01“…Abstract Genome organization is important for DNA replication, gene expression, and chromosome segregation. …”
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The DNA Polymerase _-Primase Complex: Multiple Functions and Interactions
Published 2003-01-01“…Because of this peculiarity the major role of the DNA polymerase _-primase complex (pol-prim) is in the initiation of DNA replication at chromosomal origins and in the discontinuous synthesis of Okazaki fragments on the lagging strand of the replication fork. …”
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34
Gene Expression during Survival of Escherichia coli O157:H7 in Soil and Water
Published 2011-01-01“…Cells incubated in soil microcosms for 14 days expressed genes for antibiotic resistance, biosynthesis, DNA replication and modification, metabolism, phages, transposons, plasmids, pathogenesis and virulence, antibiotic resistance, ribosomal proteins, the stress response, transcription, translation, and transport and binding proteins at significantly higher levels than cells grown in Luria broth. …”
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The consistency of vitamin B12 in marketed microalgae powders
Published 2024-12-01“…Vitamin B12 is a water nutrient that plays a key role, in DNA replication and the production of red blood cells as well as maintaining proper neuron function in the body system. …”
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Mechanism of Gene Amplification via Yeast Autonomously Replicating Sequences
Published 2015-01-01“…These specific bindings at ORC promote repeated rounds of DNA replication leading to gene amplification.…”
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Identification of the Immune Cell Infiltration Landscape in Head and Neck Squamous Cell Carcinoma (HNSC) for the Exploration of Immunotherapy and Prognosis
Published 2022-01-01“…The potential pathways that are associated with ZAP70 were found to have included adaptive immune response, response to oxidative stress, DNA replication, and lipid binding. This study provides a theoretical foundation for developing immunotherapy drugs for HNSC patients. …”
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Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage
Published 2010-01-01“…One of these pathways supports DNA replication events by in a sense adopting the mantra that one must “make the best of a bad situation” and tolerating covalent modification to DNA through less accurate copying of the damaged region. …”
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High-Throughput Screening and Molecular Dynamics Simulation of Natural Products for the Identification of Anticancer Agents against MCM7 Protein
Published 2022-01-01“…Minichromosome maintenance complex component 7 (MCM7) belongs to the minichromosome maintenance family that is necessary for the initiation of eukaryotic DNA replication. Overexpression of the MCM7 protein is linked to cellular proliferation and is accountable for critical malignancy in many cancers. …”
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The Possible Crystallization Process in the Origin of Bacteria, Archaea, Viruses, and Mobile Elements
Published 2024-12-01“…Error catastrophe can be overcome by the parallel gain of DNA replication and DNA repair mechanisms in both genomes. …”
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