Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast. by Sophie Rozenzhak, Eva Mejía-Ramírez, Jessica S Williams, Lana Schaffer, Jennifer A Hammond, Steven R Head, Paul Russell

“…Here, we use ChIP-on-chip analysis to map genomic loci decorated by phosphorylated histone H2A (gammaH2A), a Rad3 substrate that establishes a chromatin-based recruitment platform for Crb2 and Brc1 DNA repair/checkpoint proteins. Unexpectedly, gammaH2A marks a diverse array of genomic features during S-phase, including natural replication fork barriers and a fork breakage site, retrotransposons, heterochromatin in the centromeres and telomeres, and ribosomal RNA (rDNA) repeats. gammaH2A formation at the centromeres and telomeres is associated with heterochromatin establishment by Clr4 histone methyltransferase. …”
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Development of a Novel Fluorescence Assay Based on the Use of the Thrombin-Binding Aptamer for the Detection of O6-Alkylguanine-DNA Alkyltransferase Activity by Maria Tintoré, Anna Aviñó, Federico M. Ruiz, Ramón Eritja, Carme Fàbrega

“…Human O6-alkylguanine-DNA alkyltransferase (hAGT) is a DNA repair protein that reverses the effects of alkylating agents by removing DNA adducts from the O6 position of guanine. …”
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High Ano1 expression as key driver of resistance to radiation and cisplatin in HPV-negative head and neck squamous cell carcinoma by Solenne Bourdier, Anne-Sophie Fisch, Keziban Merve Alp, Ridhima Das, Philipp Mertins, Ingeborg Tinhofer

“…The effects of CCND1 and ANO1 knockdown (KD) on radio- and drug sensitivity, along with changes in global protein expression, cell viability, growth, and DNA repair, were studied in an 11q13-amplified HNSCC cell line model of primary cisplatin resistance. …”
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Bioinformation study of immune microenvironment characteristics of disulfidptosis-related subtypes in ovarian cancer and prognostic model construction by Ying Zhou, Yuhong Zhang, Yang Zhou, Yanzheng Gu, Youguo Chen, Juan Wang

“…Despite advancements in understanding DNA repair mechanisms and identifying novel therapeutic targets, additional strategies are still needed. …”
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Candidate Genes Associated with Delayed Neuropsychomotor Development and Seizures in a Patient with Ring Chromosome 20 by Thiago Corrêa, Amanda Cristina Venâncio, Marcial Francis Galera, Mariluce Riegel

“…Gene ontology included microtubule-based movement, nucleosome assembly, DNA repair, and cholinergic synaptic transmission. Defects in these bioprocesses are associated with the development of neurological diseases, intellectual disability, neuropathies, and seizures. …”
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Genistein Implications in Radiotherapy: Kill Two Birds with One Stone by Xiongxiong Liu, Tong Zheng, Yanyu Bao, Ping Li, Ting Zhao, Yan Liu, Hui Wang, Chao Sun

“…Conversely, genistein increases the radiosensitivity of tumor cells through specific mechanisms such as the inhibition of DNA repair, the arrest of the cell cycle in the G₂/M phase, the generation of reactive oxygen species (ROS), and the modulation of apoptosis. …”
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Inhibition of GSK3β is synthetic lethal with FHIT loss in lung cancer by blocking homologous recombination repair by Shishi Tao, Yue Pu, Eun Ju Yang, Guowen Ren, Changxiang Shi, Li-Jie Chen, Liang Chen, Joong Sup Shim

“…Here, we report that inhibitors of glycogen synthase kinase 3 beta (GSK3β) and the homologous recombination DNA repair (HRR) pathway are synthetic lethal with FHIT loss in lung cancer. …”
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FBP1 Is an Interacting Partner of Menin by Shadia Zaman, Karen Sukhodolets, Patricia Wang, Jun Qin, David Levens, Sunita K. Agarwal, Stephen J. Marx

“…Menin interacts with proteins that regulate transcription, DNA repair and processing, and maintenance of cytoskeletal structure. …”
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Repeated ionizing radiation exposure induces TRIP13 expression, conferring radioresistance in lung cancer cells by Wenqing Liu, Qijing Lei, Ans M. M. van Pelt, Geert Hamer

“…This study elucidates a novel mechanism of treatment resistance in NSCLC cells, in which TRIP13 promotes HR mediated DNA repair and resistance to ionizing radiation.…”
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Silver single atoms and nanoparticles on floatable monolithic photocatalysts for synergistic solar water disinfection by Jian Wang, Jiahe Zhang, Yang Li, Xinghui Xia, Hengjing Yang, Jae-Hong Kim, Wen Zhang

“…The photothermal effect of the plasmonic Ag nanoparticles reduces the bacterial resistance to ROS and impairs DNA repair capabilities. Under sunlight irradiation, the synergistic effect of Ag single atoms and nanoparticles enables 4.0 cm2 AgSA+NP/ZIF to achieve over 6.0 log inactivation (99.9999%) for the stress-resistant Escherichia coli (E. coli) in oligotrophic surface water within 30 min. …”
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Role of sirtuins in epigenetic regulation and aging control by E. M. Samoilova, S. E. Romanov, D.  A. Chudakova, P. P. Laktionov

“…This multifactorial regulatory system affects many processes: cellular metabolism, mitochondrial functions, epigenetic regulation, DNA repair and more. As is expected, the activity of sirtuin proteins affects the manifestation of classic signs of aging in the body, such as cellular senescence, metabolic disorders, mitochondrial dysfunction, genomic instability, and the disruption of epigenetic regulation. …”
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Discovery of novel PRMT1 inhibitors: a combined approach using AI classification model and traditional virtual screening by Jungan Zhang, Yixin Ren, Yixin Ren, Yun Teng, Han Wu, Jingsu Xue, Lulu Chen, Xiaoyue Song, Yan Li, Ying Zhou, Zongran Pang, Zongran Pang, Hao Wang, Hao Wang, Hao Wang

“…Protein arginine methyltransferases (PRMTs) play crucial roles in gene regulation, signal transduction, mRNA splicing, DNA repair, cell differentiation, and embryonic development. …”
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Ki-67 and CDK1 control the dynamic association of nuclear lipids with mitotic chromosomes by Hsiao-Tang Hu, Ueh-Ting Tim Wang, Bi-Chang Chen, Yi-Ping Hsueh, Ting-Fang Wang

“…Nuclear lipids play roles in regulatory processes, such as signaling, transcriptional regulation, and DNA repair. In this report, we demonstrate that nuclear lipids may contribute to Ki-67-regulated chromosome integrity during mitosis. …”
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Comprehensive analysis of the prognostic, immunological, and diagnostic roles of SIRT1 in pan-cancer and its validation in KIRC by Qi Liu, Songxian Sun, Chunxiang Zhou, Houxi Xu, Houxi Xu

“…SIRT1, an NAD+-dependent deacetylase, plays a crucial role in maintaining cellular homeostasis through the regulation of processes such as histone posttranslational modifications, DNA repair, and cellular metabolism. However, a comprehensive exploration of SIRT1’s involvement in pan-cancer remains lacking. …”
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Association of Structural Maintenance of Chromosome-1A Phosphorylation with Progression of Breast Cancer by Sushma Yadav, Claudia M. Kowolik, Daniel Schmolze, Yuan Yuan, Min Lin, Arthur D. Riggs, David A. Horne

“…As a core component of the cohesin complex, SMC1A was initially recognized for its involvement in chromosomal cohesion and DNA-repair pathways. However, recent studies have unveiled its pivotal role in epithelial–mesenchymal transition (EMT), metastasis, and chemo- and radio-resistance in cancer cells. …”
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Vitrification affects the post-implantation development of mouse embryos by inducing DNA damage and epigenetic modifications by Yurong Chen, Haibo Zhu, Fucheng Guo, Luyao Wang, Wenli Zhang, Ruizhi Liu, Xiaoling Zhang, Xiangpeng Dai

“…The homologous recombination (NHEJ) is the major DNA repair pathway for vitrified embryos. Vitrification elevated H3K4me2/3, H4K12ac, and H4K16ac levels and reduced m6A modification in blastocysts. …”
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SMR-guided molecular subtyping and machine learning model reveals novel prognostic biomarkers and therapeutic targets in non-small cell lung adenocarcinoma by Baozhen Wang, Yichen Yin, Anqi Wang, Weidi Liu, Jing Chen, Tao Li

“…Functional enrichment analysis revealed the complex interplay of cell cycle regulation, DNA repair, immune response, and metabolic reprogramming in the progression of LUAD. …”
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A Theoretical Study on the Efficacy and Mechanism of Combined YAP-1 and PARP-1 Inhibitors in the Treatment of Glioblastoma Multiforme Using Peruvian Maca <i>Lepidium meyenii</i> by Albert Gabriel Turpo-Peqqueña, Sebastian Luna-Prado, Renato Javier Valencia-Arce, Fabio Leonardo Del-Carpio-Carrazco, Badhin Gómez

“…The proteins YAP-1 (Yes-associated protein 1) and PARP-1 (Poly-(ADP-ribose)–polymerase-1) have been implicated in this resistance, playing crucial roles in cell proliferation and DNA repair mechanisms, respectively. This study explored the inhibitory potential of natural compounds from <i>Lepidium meyenii</i> (Peruvian Maca) on the YAP-1 and PARP-1 protein systems to develop novel therapeutic strategies for GBM. …”
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The combination of polystyrene microplastics and di (2-ethylhexyl) phthalate promotes the conjugative transfer of antibiotic resistance genes between bacteria by Yu Li, Xiaomei Liu, Saisai Guo, Lan Wang, Jingchun Tang

“…Transcriptome analysis indicated that the transfer of ARGs affects bacterial ion binding, oxidative stress, and energy metabolism processes, while the expression of genes related to cell membrane permeability, DNA repair, bacterial drug resistance, and quorum sensing also increase. …”
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[18F]PARPi Imaging Is Not Affected by HPV Status In Vitro by Navjot Guru, Paula Demétrio De Souza França, Giacomo Pirovano, Cien Huang, Snehal G. Patel, Thomas Reiner

“…Results. Differences in DNA repair were detected, showing higher RAD51 and γH2AX expression in HPV-positive cell lines. …”
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